Click Reagents

Pharmaceutical science often relies on the ability to synthesize and purify molecules that exhibit specific properties. Click-chemistry offers some hope for easier linking of synthetic molecular fragments to synthesize larger, more complex molecular structures. Click reactions must exhibit properties such as being modular in nature, wide in scope, high yielding, and stereospecific, as well as producing little to no byproducts that can be removed by nonchromatographic methods. These reactions are usually conducted with simple conditions such as insensitive to water or oxygen, using readily available reagents, little or no solvent waste, and simple product isolation. The most common click reaction is a 1,3-dipolar cycloaddition of azides to terminal alkynes. These molecules come together to form 1,2,3-triazoles. Avanti offers a wide variety of lipids that have been installed with terminal alkyne or azide moieties. Look through the products below and find what you need to start your click reactions!

Hein, C. D., Liu, X. M., & Wang, D. (2008). Click chemistry, a powerful tool for pharmaceutical sciences. Pharmaceutical research, 25(10), 2216–2230.