Phase Transition Temperatures for Glycerophospholipids

Formulating with lipids has many nuances, with perhaps temperature considerations being the most important processing aid. Individually, phase transition temperatures are provided as Tm and Th. Let’s discuss what these terms meanings and how these characteristics impact processing, as well as how you may want to delve into temperature changes during formulation troubleshooting.

Click here for our blog, Navigating Tm and Th for Optimal Processing and Troubleshooting Success!

Phosphatidylcholine Phosphatidylglycerol (Sodium Salt)
Product Tm (°C) Product Tm (°C)
12:0 PC (DLPC) -2 12:0 PG (DLPG) -3
13:0 PC 14 14:0 PG (DMPG) 23
14:0 PC (DMPC) 24 16:0 PG (DPPG) 41
15:0 PC 35 18:0 PG (DSPG) 55
16:0 PC (DPPC) 41 18:1 PG (DOPG) -18
17:0 PC 50 16:0-18:1 PG (POPG) -2
18:0 PC (DSPC) 55 Phosphatidylserine (Sodium Salt)
19:0 PC 62 14:0 PS (DMPS) 35
20:0 PC 66 16:0 PS (DPPS) 54
21:0 PC 71 18:0 PS (DSPS) 68
22:0 PC 75 18:1 PS (DOPS) -11
23:0 PC 79.5 16:0-18:1 PS (POPS) 14
24:0 PC 80.3 Phosphatidic Acid (Sodium Salt)
16:1 PC -36 12:0 PA (DLPA) 31
18:1c9 PC (DOPC) -17 14:0 PA (DMPA) 52

18:1t9 PC

 12 16:0 PA (DPPA) 65
18:1c6 PC 1 18:0 PA (DSPA) 75
22:1c13 PC 13 18:1 PA (DOPA) -4
18:2 PC -57 16:0-18:1 PA (POPA) 28
18:3 PC -60 Cardiolipin
14:0 CL 47
16:0 CL 62.2
20:4 PC -69 Phosphatidylethanolamine
14:0-16:0 PC 35 Tm (°C) Th (°C)
14:0-18:0 PC 40 12:0 PE (DLPE) 29
16:0-14:0 PC 27 14:0 PE (DMPE) 50
16:0-18:0 PC 49 16:0 PE (DPPE) 63 118
16:0-18:1 PC (POPC) -2 18:0 PE(DSPE) 74 100
16:0-22:6 PC -27 20:0 PE 83 96
18:0-14:0 PC 30 18:1c9 PE (DOPE) -16 10
18:0-16:0 PC 44 18:1t9 PE 38 64
18:0-18:1 PC 6 18:2 PE -40 -15
18:1-16:0 PC -9 18:3 PE -30
18:1-18:0 PC 9 16:0-18:1 PE (POPE) 25 71

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REFERENCES

Thermotropic Phase Transitions of Pure Lipids in Model Membranes and Their Modifications by Membrane Proteins, Dr. John R. Silvius, Lipid-Protein Interactions, John Wiley & Sons, Inc., New York, 1982. Reprinted with permission from John Wiley & Sons, Inc.

Lipid Thermotropic Phase Transition Database (LIPIDAT) – NIST Standard Reference Database 34