880229 | 8DSPE-PEG(2000)-DBCO

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[dibenzocyclooctyl(polyethylene glycol)-2000] (ammonium salt)


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Size SKU Packaging Price
10mg 880229P-10mg 880229P-10mg 1 x 10mg $158.30
25mg 880229P-25mg 880229P-25mg 1 x 25mg $316.50
50mg 880229P-50mg 880229P-50mg 1 x 50mg $559.50
100mg 880229P-100mg 880229P-100mg 1 x 100mg $1,039.00
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8DSPE-PEG(2000)-DBCO

8DSPE-PEG(2000)-DBCO

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[dibenzocyclooctyl(polyethylene glycol)-2000] (ammonium salt)

Cu-free click chemistry with readily synthesized biarylazacyclooctynones. The reaction of azides with strained alkynes, such as cyclooctynes, readily forms a triazole product without the need for a toxic catalyst.
Refer also to DSPE-PEG Azide Avanti Number 880228

Representative Structure

The molecular weight and exact mass are averages based on the polydispersity of PEG. 

Hygroscopic
Yes
Light Sensitive
No
Molecular Formula

C151H279N4O56P (average MW due to polydispersity of PEG)

Percent Composition

C 58.93%, H 9.14%, N 1.82%, O 29.11%, P 1.01%

Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
2052955-83-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
3077.839
Exact Mass
3075.884

Wong P, Li L, Chea J, Hu W, Poku E, Ebner T, Bowles N, Wong JYC, Yazaki PJ, Sligar S, Shively JE. Antibody Targeted PET Imaging of 64Cu-DOTA-Anti-CEA PEGylated Lipid Nanodiscs in CEA Positive Tumors. Bioconjug Chem. 2020 Jan 30:10.1021/acs.bioconjchem.9b00854. doi: 10.1021/acs.bioconjchem.9b00854. Epub ahead of print. PMID: 31961138.

PubMed ID: 31961138

Umlauf BJ, Clark PA, Lajoie JM, Georgieva JV, Bremner S, Herrin BR, Kuo JS, Shusta EV. Identification of variable lymphocyte receptors that can target therapeutics to pathologically exposed brain extracellular matrix. Sci Adv. 2019 May 15;5(5):eaau4245. doi: 10.1126/sciadv.aau4245. eCollection 2019 May.

PubMed ID: 31106264

Gupta A, Shin JH, Lee MS, Park JY, Kim K, Kim JH, Suh M, Park CR, Kim YJ, Song MG, Jeong JM, Lee DS, Lee YS, Lee JS. Voxel-Based Dosimetry of Iron Oxide Nanoparticle-Conjugated 177Lu-Labeled Folic Acid Using SPECT/CT Imaging of Mice. Mol Pharm. 2019 Apr 1;16(4):1498-1506. doi: 10.1021/acs.molpharmaceut.8b01125. Epub 2019 Mar 18.

PubMed ID: 30821463

Jewett JC, Sletten EM, Bertozzi CR. Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones. J Am Chem Soc. 2010 Mar 24;132(11):3688-90. doi: 10.1021/ja100014q.

PubMed ID: 20187640

Whitehead SA, McNitt CD, Mattern-Schain SI, Carr AJ, Alam S, Popik VV, Best MD. Artificial Membrane Fusion Triggered by Strain-Promoted Alkyne-Azide Cycloaddition. Bioconjug Chem. 2017 Apr 19;28(4):923-932. doi: 10.1021/acs.bioconjchem.6b00578. Epub 2017 Mar 14.

PubMed ID: 28248084