880228 | DSPE-PEG(2000) Azide

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[azido(polyethylene glycol)-2000] (ammonium salt)

DSPE-PEG(2000) Azide

Chloroform

Size SKU Packaging Price
10mg 880228C-10mg 880228C-10mg 1 x 10mg 10mg/mL 1mL $149.50
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Powder

Size SKU Packaging Price
10mg 880228P-10mg 880228P-10mg 1 x 10mg $149.50 149.5
25mg 880228P-25mg 880228P-25mg 1 x 25mg $217.25 217.25
50mg 880228P-50mg 880228P-50mg 1 x 50mg $311.00 311
100mg 880228P-100mg 880228P-100mg 1 x 100mg $545.00 545
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Info

DSPE-PEG(2000) Azide

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[azido(polyethylene glycol)-2000] (ammonium salt)

Cu-free click chemistry with readily synthesized biarylazacyclooctynones. The reaction of azides with strained alkynes, such as cyclooctynes, readily forms a triazole product without the need for a toxic catalyst.
Also, refer to DSPE-PEG DBCO Avanti Number 880229

Representative Structure

The molecular weight and exact mass are averages based on the polydispersity of PEG.

Data
Hygroscopic
Yes
Light Sensitive
No
Molecular Formula

C132H264N5O54P (average MW due to polydispersity of PEG)

Percent Composition

C 56.29%, H 9.45%, N 2.49%, O 30.67%, P 1.10%

Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
1938081-40-3
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
2816.519
Exact Mass
2814.78
Synonyms
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carbonyl-azido(polyethylene glycol)-2000] (ammonium salt)
Solubility in Different Solvents
Insoluble in DMSO, soluble in ethanol and Chloroform:Methanol (85:15) at 5mg/mL
References

Xiao Y, Liu Q, Clulow AJ, Li T, Manohar M, Gilbert EP, de Campo L, Hawley A, Boyd BJ. PEGylation and surface functionalization of liposomes containing drug nanocrystals for cell-targeted delivery. Colloids Surf B Biointerfaces. 2019 Jul 15;182:110362. doi: 10.1016/j.colsurfb.2019.110362. [Epub ahead of print]

PubMed ID: 31351271

Girish A, Hickman DA, Banerjee A, Luc N, Ma Y, Miyazawa K, Sekhon UDS, Sun M, Huang S, Sen Gupta A. Trauma-targeted delivery of tranexamic acid improves hemostasis and survival in rat liver hemorrhage model. J Thromb Haemost. 2019 Jun 20. doi: 10.1111/jth.14552. [Epub ahead of print]

PubMed ID: 31220416

Paek J, Park SE, Lu Q, Park KT, Cho M, Oh JM, Kwon KW, Yi YS, Song JW, Edelstein HI, Ishibashi J, Yang W, Myerson JW, Kiseleva RY, Aprelev P, Hood ED, Stambolian D, Seale P, Muzykantov VR, Huh D. Microphysiological Engineering of Self-Assembled and Perfusable Microvascular Beds for the Production of Vascularized Three-Dimensional Human Microtissues. ACS Nano. 2019 Jun 18. doi: 10.1021/acsnano.9b00686. [Epub ahead of print]

PubMed ID: 31194909

Hood ED, Greineder CF, Shuvaeva T, Walsh L, Villa CH, Muzykantov VR. Vascular targeting of radiolabeled liposomes with bio-orthogonally conjugated ligands: single chain fragments provide higher specificity than antibodies. Bioconjug Chem. 2018 Sep 21. doi: 10.1021/acs.bioconjchem.8b00564. [Epub ahead of print]

PubMed ID: 30240185

Jewett, J.C., E.M. Sletten, and C.R. Bertozzi. (2010). Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones. J Am Chem Soc 132:3688-90.

PubMed ID: 20187640
Certificates of Analysis

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