Innovative Lipids for Your Nucleic Acid Delivery Research

Posted on November 22, 2022


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Lipid-based therapeutic delivery systems have been evolving for many years. From delivering naked mRNA, to using liposomes, and now lipid nanoparticles, Avanti is here to provide you with the most innovative lipids for your nucleic acid delivery research. In this article discover considerations for each component in an LNP, as well as some new alternatives to commonly used LNP components such as PEG-lipids and cholesterol.

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Lipid Leaders: Dennis Christensen

Posted on November 15, 2022


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In this Lipid Leaders interview, we get insight from Croda Pharma's own Global Head of R&D - Adjuvant Systems, Dennis Christensen, PhD. Keep reading to learn more about adjuvants and the role they play in vaccines, as well as where the technology may be headed.

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Lipids in Small-Molecule Pro-Drugs

Posted on October 24, 2022


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Lipids are used in a variety of ways in therapeutics. Recently, lipids have garnered a lot of attention for their role in mRNA delivery, but that's not all they're good for. At least four types of lipids are being investigated as pro-moieties in pro-drugs - fatty acids, glycerides, steroids, and phospholipids. Keep reading to learn more!

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Lipids in Action: Gravity Defying Geckos

Posted on October 21, 2022


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Lipids are abundant in nature and important in many different ways. Our focus is usually placed on their functions in human biology and therapeutic applications, but this research spotlight is a little different. Keep reading to find out how lipids make geckos the climbing creatures they are!

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Lipid Leaders: Kim Ekroos

Posted on October 03, 2022


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Kim Ekroos is currently the CEO of Lipidomics Consulting Ltd and the President of the International Lipidomics Society (iLS). After receiving a PhD in Biology for his work in glycerophospholipid characterization by quadrupole time-of-flight mass spectrometry from the Technical University in Dresden, Germany, Kim's lipidomics career began. Keep reading to find out what he believes to be the greatest breakthroughs in lipid technology have been, as well as where he thinks the field of lipidomics is headed, and more!

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Ceramides and Clinical Depression: How They're Linked

Posted on September 28, 2022


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October 3-10 is Mental Illness Awareness Week! To help raise awareness and fight the stigma associated with mental illness we want to share some exciting research. Dive into this research spotlight to find out how ceramides are linked to clinical depression and how future treatments could take advantage of this link.

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Breast Cancer Warriors - Jackie Truss

Posted on September 26, 2022


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Jackie's annual mammogram turned into a scary situation in February 2019 when she was diagnosed with Stage I breast cancer. After going through chemotherapy and radiation, Jackie can now say that she is cancer free! She says "Receiving a cancer diagnosis is scary, but it is important to be informed and proactive." Keep reading for the rest of her story!

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Breast Cancer Warriors - Ileana Machado

Posted on September 26, 2022


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During the midst of a pandemic, Ileana also dealt with breast cancer. After two surgeries and radiation treatments, Ileana was able to ring the bell symbolizing that she won the fight with cancer. Keep reading for Ileana's full story!

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Breast Cancer Warriors - Lisa Adams

Posted on September 26, 2022


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Lisa's breast cancer journey started just over one year ago, in September of 2021. On October 11, 2021, she got confirmation that she had Stage I, Triple Positive IDC/DCIS Breast Cancer. After surgery and chemotherapy, Lisa was able to say that she was cancer free on April 19, 2022, only a few months after her original diagnosis. Lisa now acts as an advocate for Aesthetic Flat Closure (AFC). Keep reading for Lisa's full story!

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Unraveling the Secrets of the Double Bond

Posted on September 22, 2022


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Stearoyl-CoA desaturase (SCD) 1 is a key enzyme in double bond formation. It is also known to be involved in stress signaling but the mechanism by which it does so has been a mystery - until now! PI (18:1/18:1) is the primary SCD1-derived metabolite that modulates stress signaling. Keep reading to learn more!

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EV - Li, Na, Fe, Si, Mg, S?

Posted on September 19, 2022


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Electric Vehicles (EVs) have been a hot topic for a while now, but California's recent EV mandate thrust this technology back into the spotlight. We have a long way to go before we are able to support the estimated 70 million EVs on the road by 2040. What are some of the challenges we face? And how is science attempting to revolutionize EV batteries to better support the widespread adoption of EVs? Find out in this month's Sustainability Seconds!

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The Skinny: An endogenous metabolite found to induce brown adipocytes

Posted on August 23, 2022


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Obesity is a major problem across the globe. One driver of obesity is white adipocytes and their primary function as energy storage centers. When energy intake is chronically greater than energy output, the excess energy is stored as triglycerides in white adipose tissue (WAT). Brown adipose tissue (BAT), unlike WAT, works to expend energy. Those at higher risk of obesity typically have lower levels of BAT, and our levels of BAT tend to decline as we age. Historically, pharmaceutical treatments have been aimed towards energy intake rather than attempting to increase the energy expended by BAT. A recent study has found a specific endogenous metabolite capable of inducing production of BAT. Keep reading to learn more!

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Sustainability Seconds: People Positive by 2030

Posted on August 17, 2022


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Croda and Avanti are dedicated to making a positive impact on the planet and those inhabiting it. Through science and innovation, we will continue to increase our positive impact through the year 2030 and beyond. Keep reading to find out how we plan to be People Positive by 2030, including our goals and progress as of 2021!

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Sustainability Expert Aris Vrettos Joins Croda

Posted on July 22, 2022


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The new position will see the sustainability expert challenge us to stretch our already industry-leading sustainability ambitions and commitments as well as support our business sectors in further enhancing their sustainability strategies by working in partnership with their customers and suppliers.

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22:0 Trehalose: A Powerful Synthetic Adjuvant

Posted on July 22, 2022


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22:0 Trehalose (TDB) has been one of our most popular products so far this year. Let's take a look at how it can be used to enhance your adjuvanted vaccine research! TDB is commonly combined with dimethyldioctadecylammonium bromide (DDAB) to create a powerful adjuvant system. Research has shown that it elicits a strong cell-mediated immune response desirable for many disease targets. New research has also identified improved formulations processes to better control particle size and polydispersity of the resultant liposomes. Keep reading to learn more!

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Novel Homeostatic Mechanism Tunes PI(4,5)P2-dependent Signaling at the PM

Posted on July 20, 2022


Website Rachel Wills Research Spotlight
This research spotlight features research conducted by our Junior Lipid Leader Rachel Wills. Rachel, along with the rest of Dr. Hammond's lab at the University of Pittsburgh, is interested in phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and its regulation in mammalian plasma membrane. In this spotlight, Rachel and Dr. Hammond elucidate a novel mechanism by which PI(4,5)P2 is regulated. This insight can be used in the future to find potential therapeutic targets for diseases resulting from genetic defects of PI(4,5)P2 synthesis. Keep reading to learn more about this novel mechanism!

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DHA: The Vitamin C of the Brain

Posted on July 15, 2022


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In honor of World Brain Day 2022, the METLIN Molecule of the Month is Docosahexaenoic Acid (DHA). DHA has many many roles in the brain giving it the nickname "the brain's vitamin C". Keep reading to find out what roles DHA plays in the brain, how DHA and its metabolites are affected by Influenza A virus and Staphyloccocus Pneumoniae, and more!

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Capturing the Ceramide Complexity of the Stratum Corneum

Posted on July 14, 2022


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Atopic dermatitis and psoriasis are caused by changes in ceramide levels in the skin. Understanding the complexity and identifying the exact ceramide components in the skin is important to work towards cures and treatments for these skin diseases. Researchers at Hokaido University used a recently developed method involving the combination of multiple reaction monitoring (MRM) mode of LC-MS/MS with Avanti's ceramide standards to identify 400 species of ceramides in the stratum cornuem. Keep reading to see what they found!

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Rachel Wills: Junior Lipid Leaders Interview Series

Posted on July 14, 2022


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Rachel is a lipid researcher working on her PhD at the University of Pittsburgh. She works in Gerry Hammond's lab in the Cell Biology program. She successfully defended her PhD in July 2022 just before conducting this interview. She is also the recipient of a FASEB Phospholipids 2022 travel award. Continue reading Rachel's interview to find out how she became interested in lipid research, what she believes is the biggest breakthrough in lipid research in recent years, and the best advice she would give a new grad student, and more!

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7-Dehydrocholesterol: Cholesterol Precursor, Previtamin, and Smith-Lemli-Opitz Biomarker

Posted on June 21, 2022


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You may have never heard of 7-dehydrocholesterol (7-DHC) but that doesn’t mean that it’s not important! Not only is 7-DHC an important precursor to cholesterol, but it is also necessary to produce vitamin D3 in your skin. 7-DHC enables your skin to manufacture vitamin D3 from ultraviolet B (UV-B) rays from sun light – so, 7-DHC is also considered a provitamin of vitamin D3. Continue reading to learn how 7-DHC is now considered a biomarker of Smith-Lemli-Opitz syndrome!

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Could antibiotic resistance be linked to the lipidome?

Posted on June 16, 2022


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The CDC’s Antibiotic Resistance Threats in the United States, 2019 presented data showing more than 2.8 million antibiotic-resistant infections occur annually in the US. And of these 2.8 million infections, more than 35,000 people died as a result. The emergence and spread of new antibiotic-resistant forms is alarming. Investing in the development of new vaccines, improving existing therapeutics, and discovering better ways of diagnosing infections caused by these pathogens hinge on one underlying principle – understanding the pathogens themselves. Enter Dr. Hines and her team at UGA! Read the full article to find out how they are researching the lipidome of Staphylococcus Aureus to better understand its antibiotic resistance.

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Lipid Leaders - Kelly Hines

Posted on June 13, 2022


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Dr. Kelly Hines took the time to answer a few questions about her research interests and inspirations, as well as her life outside the lab. Find out what she believes to be the greatest breakthrough in lipid research, why she chose to focus on ion mobility - mass spectrometry to study the lipidome, and more!

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How is Avanti Committed to Positively Impacting the Climate?

Posted on May 24, 2022


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So far, this series has been devoted to personal lifestyle changes that we can individually adopt to make a positive impact on our planet. For the next couple of months, we want to focus on sustainability from a different perspective. You’ve heard us say that we are committed to being Climate, Land, and People Positive by 2030, but what does that mean and how are we planning to accomplish it?

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It's Not All About Drugs... Endogenous Molecules Can Be Therapeutics Too

Posted on May 23, 2022


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Until recently, bile acids were primarily known as digestive surfactants to aid the absorption of lipids or as the primary pathway for cholesterol catabolism. But we now recognize bile acids as hormones. Lithocholic acid (LCA) is a secondary bile acid that acts like many other bile acids and aids the absorption of lipids in digestion. But that’s not all this bile acid does. Research has indicated that LCA can activate vitamin D receptor without raising calcium levels as high as Vitamin D itself. LCA has also been shown to bind with the NAPE-PLD enzyme and catalyze the release of anandamide and other N-acetylethanolamines. But one of the more interesting applications of LCA was discovered just last year. Read the full story!

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Now Offering Plant-Based, Parenteral Grade Cholesterol

Posted on May 18, 2022


Cholesterol Parenteral Grade Product Spotlight
Avanti’s new parenteral grade cholesterol is USP-NF, EP (2397), and JP compliant. Plant-based cholesterol provides a high-purity alternative to traditional egg- and animal-based cholesterol and is available for research and development work as well as parental applications. Cholesterol-based drug carriers have been designed as nanoparticles, micelles, and liposomal formulations for delivering antivirals, antimalarials, anticancer treatments, genetic material (DNA, mRNA, siRNA), and gene therapies.

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Conversations with Lipid Leaders: Dr. Julie Saba

Posted on May 11, 2022


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The Conversations with Lipid Leaders Interview Series brings forward insights and experiences from the community's most influential and upcoming scientists. In this interview, Dr. Julie Saba discusses her research experiences while studying sphingolipid metabolism and signaling for the past three decades. Find out how Dr. Saba became interested in sphingosine-1-phosphate, what influenced her to dive into medical research, and more!

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Could An Injection One Day Protect You From Stress and Stress-Related Depression?

Posted on May 09, 2022


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Stress – most of us experience it in some way every day. Some stress is good, but the longer we experience stress, the more taxed our physiological stress response becomes until it is taxed beyond its capabilities. Chronic stress not only taxes our stress response but can also lead to other health problems such as depression. Research conducted in 2021 suggests that treating depression at the source is a viable treatment option. Studies recently identified lipopolysaccharide (LPS) as a possible treatment for depression in chronically stressed mice. LPS has several adverse side effects, but Avanti offers Phosphorylated Hexaacyl Disaccharide (PHAD) which could be a safe and effective alternative! Check out the full article to learn more.

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Sustainability Seconds: Earth Day 2022

Posted on April 18, 2022


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Today is Earth Day so, we decided to post our next sustainability seconds article a little early! In honor of Earth Day 2022, we wanted to make this sustainability seconds blog a little different than usual. This time, let us look at a few statistics regarding sustainability, goals that have been set, and progress made towards accomplishing those goals.

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Using Polymer-Lipid Nanodiscs to Better Understand Alzheimer's Disease

Posted on April 18, 2022


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Our Lipid Leader Research Spotlight Series highlights recent research conducted by leaders in the field. This month, Dr. Ayyalusamy Ramamoorthy was kind enough to join us as our Lipid Leader. Dr. Rams works to develop new polymer lipid-nanodiscs and uses these nanodiscs to investigate biochemical and biophysical properties of membrane proteins and amyloidogenic proteins. Check out this spotlight to learn more about why they are developing new polymers for these nanodiscs and how they are using them to better understand neurodegenerative disease such as Alzheimer's Disease!

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How A Lipid Garnered Two Academy Awards

Posted on April 15, 2022


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The Oscar winning film “Lorenzo’s Oil” garnering two Academy Awards, the olive oil sitting on your kitchen counter, Avanti Polar Lipids, and Croda – what do these all have in common? Find out the answer in this month's METLIN Molecule of the Month!

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Lipid Leaders: Ayyalusamy Ramamoorthy

Posted on April 14, 2022


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The Conversations with Lipid Leaders Interview Series brings forward insights and experiences from the community's most influential and upcoming scientists. In this interview, Dr. Ayyalusamy Ramamoorthy discusses his research to develop polymers for lipid-nanodiscs and their applications in studying membrane proteins. Keep reading to find out what he had to say!

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Combatting the Opioid Crisis with Liposomal Adjuvant Systems

Posted on April 05, 2022


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Headlines across the globe have largely been dominated by the COVID-19 pandemic for the last two-plus years – and rightly so. But infectious diseases such as COVID-19 are not the only public health crises that we face. Heart disease, cancer, and diabetes affect millions of lives every day, and we hear about the research being done to combat them regularly. In this research spotlight, let’s take a look at a public health crisis that we don’t focus on as much – the opioid addiction crisis.

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Attacking global pandemics, cancer, and rare diseases with lipid-based adjuvant systems

Posted on April 01, 2022


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Vaccine research has been rapidly increasing since the early 1990s. Between 1993 and 1997, less than 20,000 papers and patents were published related to vaccines. Fast forward twenty years, between 2013 and 2017, nearly 90,000 papers and patents were published related to vaccines (Global Science and Technology Trends Report, CAS, n.d.). And with the recent COVID-19 pandemic and subsequent race to find a vaccine, these numbers are sure to soar even higher between 2018 and 2022. Avanti's primary role in the pandemic has been as a supplier of lipids for the lipid nanoparticle delivery system, but our lipid-based adjuvant systems are also being investigated for COVID-19 vaccines, as well as cancer treatments and rare virus vaccines. Read the full story by clicking the link!

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Let's Stop Running Water While We Brush Our Teeth

Posted on March 08, 2022


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Water usage accounts for 6% of all carbon dioxide emissions in the UK. And annually, U.S. residents produce 320 million tons of CO2 from the energy needed to move, treat, and use water. That's why our most recent Sustainability Seconds blog reviews an article titled "The Hidden Impact of Your Daily Water Use." Keep reading to learn what habits lead to a larger impact on our environment, and what you can do to fix it!

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Lipidome Variability Within Subjects Leads to Novel Insights Into Specific Coronary Plaque Phenotypes

Posted on March 04, 2022


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Since the early 2000s, lipidomic analysis has become an increasingly hot research topic. The development of newer, better mass spectrometry technologies and standardized lipids and lipid mixtures continues to allow the lipidomics research community to get closer and closer to their goal – clinical translation of lipidomic research for the development of diagnostic and therapeutic tools. Avanti is a leader in the development of standardized lipids and lipid mixtures used in lipidomics research. We continue to develop our offerings to align with the needs of the research community. Federico Torta, a dear customer and leader in the lipidomic analysis community, recently published research linking visit-to-visit variability of certain lipid classes to the burden of coronary atherosclerosis in humans.

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Federico Torta - Conversations with Lipid Leaders

Posted on March 02, 2022


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Federico Torta is an assistant professor at the National University of Singapore and is part of the Singapore Lipidomics Incubator (SLING). His research is focused on automation, high-throughput technologies for the assessment of the lipidome and sphingolipidome. Dr. Torta took the time to answer a few questions for us related to his research and the path he took to become one of the leaders in lipidomic analysis research.

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Your Air Conditioner Has a Greater Impact on the Environment Than Your Wallet

Posted on February 28, 2022


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We all know that cooling is energy expensive, especially air conditioning in warm climates. So, it should come as no shock to learn that the cooling industry is responsible for 10% of global CO2 emissions. For comparison, aviation and shipping combined produce about one-third this amount. This is really a double-edged sword, too: the more refrigeration that occurs, the greater the impact on global warming making refrigerants more and more necessary as the climate warms up. So, the sooner we make positive changes to our refrigeration and cooling habits, the better chance we have of reducing their negative impacts.

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Positive Charge Leads to Positive Results: DOTAP and MC3 in Lipid-Polymer Hybrid Nanoparticles

Posted on February 28, 2022


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mRNA therapeutics are being investigated for various diseases such as cancer immunotherapy, protein replacement, and infectious diseases. One of the key benefits of using mRNA compared to non-viral DNA or adeno-associated virus (AAV) gene delivery systems is that mRNA does not have to gain access to the nucleus to undergo transcription. This usually means that protein production is more robust and much faster. mRNA therapy also has a lower risk of mutagenesis and thus has a safer genotoxic profile. Many of our previous articles have described the challenges associated with protecting mRNA in extracellular environments. Lipids have emerged as a highly attractive delivery vehicle for mRNA.

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Investigating New Treatment Options for Triple Negative Breast Cancer

Posted on February 28, 2022


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Triple negative breast cancer (TNBC) accounts for 10-15% of all breast cancers. TNBC is a particularly dangerous type of cancer due to its rapid growth and spreading, but also because of limited treatment options currently available. TNBC lacks estrogen and progesterone receptors which means that hormone therapy is not a viable treatment option. And the absence of high levels of HER2 protein means that HER2 targeted drugs are not a treatment option either. Thus, the “triple negative” designation for this cancer, and the reason that treatment options are currently limited to mainly chemotherapies. Finding a better treatment option for TNBC is imperative.

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Desmosterol - Master Regulator of Lipid Metabolism

Posted on February 18, 2022


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Cholesterol is the sterol that gets most of the attention in human biology, however desmosterol is an underappreciated cousin. For example, desmosterol is the immediate precursor to cholesterol in one of two cholesterol biosynthesis pathways - the Bloch pathway of cholesterol biosynthesis. As the immediate precursor to cholesterol, desmosterol is structurally very similar to cholesterol with the only difference being a double bond located on the side chain between C24 and C25. Despite the similar structures of these two molecules, they have surprisingly different physiological roles, desmosterol demonstrating itself as a master regulator of lipid metabolism.

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Product Spotlight: Oxysterols

Posted on February 09, 2022


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Recently, Dr. William Griffiths along with his co-worker Dr. Yuqin Wang published a fascinating review of cholesterol metabolism in immunology. Keep reading to learn what has led to recent advancements and the role that oxysterols play in the immune system!

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Research Spotlight: AdipoAtlas: A reference lipidome for human white adipose tissue

Posted on February 03, 2022


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Since 1975, worldwide obesity has nearly tripled. As of 2016, almost 2 billion adults are overweight, and about one-third of those are obese. Even children under the age of five are becoming obese at an alarming rate. At least 2.8 million people die every year as a result of being overweight or obese. How can we discover biomarkers for obesity? Keep reading to learn what our February Lipid Leader, Dr. Maria Fedorova, and her team at TU-Dresden uncovered!

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Conversations with Lipid Leaders: Dr. Maria Fedorova

Posted on February 02, 2022


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The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Maria Fedorova!

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Sustainability Seconds: Review: "Can fashion ever be sustainable?"

Posted on January 25, 2022


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How many clothing items did you buy last year? The fashion industry accounts for nearly 10% of total carbon emissions around the world. If that doesn’t sound like much, this is more than the global aviation and shipping carbon emission totals combined. Keep reading to learn more about how we can change our habits to be more sustainable fashionistas!

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N,N-Dimethyl Sphingosine: What a Pain!

Posted on January 18, 2022


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Our first METLIN Molecule of the Month is N,N-dimethylsphingosine (DMS), a lipid with multiple physiological activities. DMS and its relationship to neuropathic pain was first released in Nature Chemical Biology 2012 using an approach now called “activity metabolomics”. In 2017, DMS was also shown to have therapeutic impact on chronic Chagas disease cardiomyopathy, a disease caused by the parasite Trypanasoma cruzi.

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Conversations with Lipid Leaders: Dr. Robert Ahrends

Posted on January 04, 2022


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The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Robert Ahrends!

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Sustainability Seconds: Review: “The Smart Way to Stay Warm this Winter”

Posted on January 03, 2022


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We are in the middle of winter in the US and staying warm is a challenge for many. Heating usually requires energy - a lot of it. In the United States, nearly 40% of greenhouse gas emissions come from heating and cooling residential housing. Another 15% comes from heating water. So, heating is by far one of the most carbon intensive daily needs that we have. Why do our heating needs have such a high carbon footprint, and how can we address it? Keep reading to learn more!

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Research Spotlight: PMP2/FABP8 Induces PI(4,5)P2-Dependent Transbilayer Reorganization of Sphingomyelin in the Plasma Membrane

Posted on December 14, 2021


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We love to read research results published by our valued customers, and we love to share those results with you! Toshihide Kobayashi, National Center for Scientific Research/University of Strasbourg, said this about our lipids “We cannot publish these results without Avanti lipids. Thank you very much for the high-quality lipids.” Thank you, Toshihide, for being a loyal Avanti customer! Okay, let’s dive into the fantastic research that Toshihide has been doing! Keep reading to learn more!

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Sustainability Seconds: Review "The Surprising Cost of Being Online”

Posted on December 03, 2021


Sustainability Internet
“Am I doing enough?” That is a question that most people ask themselves daily. Am I doing enough for my significant other? Am I doing enough for my children? Am I doing enough for my employer? Am I doing enough for the planet, and the millions, and billions, of people that will live after me? Okay, we may not ask ourselves that last one every day, but we should! Every action that we take every single day has an impact on the future. And the small actions that we take as individuals to protect our planet can add up to an enormous positive impact on the quality of life for future generations. Keep reading to learn more!

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Formulations Insights: Using Natural Sterol Alternatives to Replace Cholesterol in LNP Drug-Delivery Formulations

Posted on December 03, 2021


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If you’re trying to package, protect, and deliver genetic material to the inside of a cell, it is now common practice to use a lipid nanoparticle (LNP) delivery system. And who better to trust with your lipid delivery systems research than Avanti? With a quality standard that accepts nothing less than the best, Avanti’s lipid products are the best choice for preparing lipid delivery systems used in vaccine research. Keep reading to learn more!

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Conversations with Lipid Leaders: Dr. Richard Schwarz

Posted on November 22, 2021


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The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Richard Schwarz!

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Product Spotlight: PHAD® Adjuvants

Posted on November 16, 2021


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Avanti has you covered when it comes to lipid-based adjuvants. As you’ve seen in our research spotlights, our PHAD adjuvants can be used individually or in combination with other adjuvants to elicit stronger immune responses when compared to vaccines relying on an antigen alone. Regardless of which type of adjuvant(s) you choose for your vaccine research, you can rest assured that when you choose Avanti and Croda, you’re choosing safe and effective adjuvants. Let’s take a quick look at some of our lipid-based adjuvant products in the PHAD line.

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Research Spotlight: Combinatorial Liposomal Peptide Vaccine Induces IgA and Confers Protection Against Influenza Virus and Bacterial Super-Infection

Posted on November 12, 2021


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3D-PHAD… sounds cool, right? Well, there’s more to this Avanti Lipid product than a cool name. Avanti’s PHAD is the first fully synthetic monophosphoryl lipid A (MPLA) available for use in human vaccines. But what does the 3D stand for? 3D means that this PHAD product is a 3-deacylated form of MPLA. Avanti’s PHAD products are great adjuvants for human vaccine applications due to their ability to elicit a strong immune response while also exhibiting a lower pyrogenic profile than the naturally occurring bacterial agent. Enough about this product’s name, keep reading to learn how it’s being used!

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Veterans Day

Posted on November 01, 2021


Thank You Veterans
Not that we don't remember and appreciate what our veterans have done for us every day, but today is a special day to honor and remember those who have served in our Armed Forces! November 11th is a day to honor our veterans as a day that marks the ending of World War I. Join us in celebrating all of Avanti's veterans today! Keep reading to learn more about what Avanti team member, Roddie Thurman, had to say about his military service!

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Research Spotlight: A Potent Cancer Vaccine Adjuvant System for Particleization of Short, Synthetic CD8+ T Cell Epitopes

Posted on October 29, 2021


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To kill cancer cells, short-tumor-derived peptides (8-10 amino acids in length) must be recognized by the CD8+ T cell receptors. This promising method for killing cancer cells has not produced the desired results in clinical studies. Keep reading to learn how researchers at the University of Buffalo are working to improve this method!

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Conversations with Lipid Leaders: Dr. Jon Lovell

Posted on October 29, 2021


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The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Jon Lovell!

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Adjuvants & Vaccine Technology

Posted on October 22, 2021


Adjuvants are a promising component in new vaccine technologies. Adjuvants improve our immune response to antigens via several mechanisms. Many times the full mechanism of action is not understood and rather difficult to elucidate. Check out the infographic for a simplified explanation of the mechanisms by which adjuvants amplify our immune response when added to vaccines!

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Research Spotlight: Prophylactic efficacy against Mycobacterium tuberculosis using ID93 and lipid-based adjuvant formulations in the mouse model

Posted on October 22, 2021


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Globally, tuberculosis, a treatable and preventable disease, kills 1.6 million people every year. A latent form of tuberculosis, Mycobacterium tuberculosis (Mtb), is estimated to infect nearly a quarter of the world’s total population. It is imperative that we as a scientific community find alternatives to the current TB vaccines being used today. Keep reading to learn more about a research team doing just that!

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Conversations with Lipid Leaders: Dr. Susan Baldwin

Posted on October 22, 2021


Susan Baldwin
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Susan Baldwin!

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Product Spotlight: Photoswitchable AzoPC

Posted on October 16, 2021


Photoswitchable Lipids
Azobenzenes are prototypical molecular “switches” that exist in two distinct states – cis and trans. These states have different physical properties. The trans isomer is energetically preferred in solution but adding a source of energy can cause the azobenzene moiety to “switch” from trans to cis resulting in an on-and-off molecular switch. Keep reading to learn more about one such product from Avanti!

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Conversations with Avanti Award Winners: Dr. Elina Ikonen

Posted on October 14, 2021


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We would like to congratulate Dr. Elina Ikonen on being the recipient of the 2021 European Biophysical Societies' Association (EBSA) Avanti Lipids Award! We caught up with Dr. Ikonen to find out more about her research and what winning the EBSA Avanti Lipids Award means to her! Keep reading to find out what she had to say!

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Research Spotlight: An Improved and Highly Selective Fluorescence Assay for Measuring Phosphatidylserine Decarboxylase Activity

Posted on October 05, 2021


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Hopefully, you’ve had the opportunity to read our interview with Dr. Dennis Voelker. If you haven’t, SPOILER ALERT! In the interview, Dr. Voelker describes the significance that a recently developed fluorescence assay has in future diagnostic and therapeutic research. He says “The field of lipid biochemistry is ripe for expansion into the realm of screening for- and identifying- novel inhibitors of essential enzymes for application as new drugs for treating all types of microbial infections, including viruses, bacteria and fungi.” Keep reading to learn more about this highly selective fluorescence assay for measuring phosphatidylserine decarboxylase activity!

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Conversations with Lipid Leaders: Dr. Dennis Voelker

Posted on September 29, 2021


Dennis Voelker
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Dennis Voelker!

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Division Spotlight: Human Resources

Posted on September 03, 2021


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Britt Pietruszewski, Senior HR Business Partner, took time to chat with us and provide insight into the employee-centric world of Avanti's Human Resources department! Keep reading to learn more!

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Conversations with Lipid Leaders: Dr. Bruno Antonny

Posted on September 02, 2021


Bruno Antonny
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Bruno Antonny!

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Conversations with Lipid Leaders: Dr. Yusuf Hannun

Posted on August 06, 2021


Yufuf Hannun
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Yusuf Hannun!

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Division Spotlight: Customer Service

Posted on August 06, 2021


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Jennifer Mayo, Customer Service Manager, took time to chat with us and provide insight into the friendly representatives that interact with our customers in Avanti's Customer Service Department! Keep reading to learn more!

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Research Spotlight: World Brain Day!

Posted on July 07, 2021


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World Brain Day is July 22, 2021! Keep reading to learn about research, from one of our former lipid leaders, aimed at identifying metabolites that contribute to neurodegeneration resulting from Cerebrotendinous xanthomatosis (CTX)!

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Research Spotlight: 1-Stearoyl-2-docosahexaenoyl-phosphatidic acid interacts with and activates Praja-1, the E3 ubiquitin ligase acting on the serotonin transporter in the brain

Posted on July 07, 2021


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We hope you had a chance to read our most recent Lipid Leaders Interview with Dr. Fumio Sakane. To follow that great interview, we wanted to share one of his recent publications investigating the importance of lipid composition on the regulation of serotonin levels and how this contributes to the pathophysiology/therapeutics of various psychiatric disorders such as OCD, depression, autism, and schizophrenia. Keep reading to learn more!

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Conversations with Lipid Leaders: Dr. Fumio Sakane

Posted on July 01, 2021


Fumio Sakane
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Fumio Sakane!

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Research Spotlight: The Acyl Chains of Phosphoinositide PIP3 Alter the Structure and Function of Nuclear Receptor Steroidogenic Factor-1

Posted on June 23, 2021


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Nuclear receptor steroidogenic factor-1 (SF-1, NR5A1) specifically binds the signaling phosphoinositides, PI(4,5)P2 and PI(3,4,5)P3. Research has previously shown how the headgroups of these PIP lipids interact with and regulate SF-1 function. But what role do the acyl chains of these PIPs play in this interaction? Keep reading to see what researchers at Vanderbilt University School of Medicine found out.

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Product Spotlight: Lipids for GUVs

Posted on June 16, 2021


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Current events reinforce the importance of lipid-based delivery systems, and Avanti products are perfect for lipid-based particle formulations. Keep reading to learn about a special class of particles, Giant Unilamellar Vesicles (GUVs) and their interesting applications!

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International Women in Engineering Day

Posted on June 10, 2021


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At Avanti, we are incredibly proud of our women engineers. In order to celebrate International Women in Engineering Day on June 23rd, we spoke to a couple of our own women engineers to find out about their current projects and what inspired them to choose this rewarding career path! Keep reading to learn more!

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Research Spotlight: Cardiolipin-Induced Activation of Pyruvate Dehydrogenase Links Mitochondrial Lipid Biosynthesis to TCA Cycle Function

Posted on June 10, 2021


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Hopefully, you’ve had time to read our interview with Dr. Miriam Greenberg, but if you haven’t it’s a MUST read! If you’re wondering what type of research she has been engaged in recently, keep reading this review of an article she published in 2019 titled “Cardiolipin-Induced Activation of Pyruvate Dehydrogenase Links Mitochondrial Lipid Biosynthesis to TCA Cycle Function”

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