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Conversations with Lipid Leaders: Dr. Robert Ahrends

Posted on January 04, 2022

Robert Ahrends Ll For Website
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Robert Ahrends!

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Sustainability Seconds: Review: “The Smart Way to Stay Warm this Winter”

Posted on January 03, 2022

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We are in the middle of winter in the US and staying warm is a challenge for many. Heating usually requires energy - a lot of it. In the United States, nearly 40% of greenhouse gas emissions come from heating and cooling residential housing. Another 15% comes from heating water. So, heating is by far one of the most carbon intensive daily needs that we have. Why do our heating needs have such a high carbon footprint, and how can we address it? Keep reading to learn more!

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Research Spotlight: PMP2/FABP8 Induces PI(4,5)P2-Dependent Transbilayer Reorganization of Sphingomyelin in the Plasma Membrane

Posted on December 14, 2021

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We love to read research results published by our valued customers, and we love to share those results with you! Toshihide Kobayashi, National Center for Scientific Research/University of Strasbourg, said this about our lipids “We cannot publish these results without Avanti lipids. Thank you very much for the high-quality lipids.” Thank you, Toshihide, for being a loyal Avanti customer! Okay, let’s dive into the fantastic research that Toshihide has been doing! Keep reading to learn more!

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Sustainability Seconds: Review "The Surprising Cost of Being Online”

Posted on December 03, 2021

Sustainability Internet
“Am I doing enough?” That is a question that most people ask themselves daily. Am I doing enough for my significant other? Am I doing enough for my children? Am I doing enough for my employer? Am I doing enough for the planet, and the millions, and billions, of people that will live after me? Okay, we may not ask ourselves that last one every day, but we should! Every action that we take every single day has an impact on the future. And the small actions that we take as individuals to protect our planet can add up to an enormous positive impact on the quality of life for future generations. Keep reading to learn more!

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Formulations Insights: Using Natural Sterol Alternatives to Replace Cholesterol in LNP Drug-Delivery Formulations

Posted on December 03, 2021

Sterol Lnp Formulations
If you’re trying to package, protect, and deliver genetic material to the inside of a cell, it is now common practice to use a lipid nanoparticle (LNP) delivery system. And who better to trust with your lipid delivery systems research than Avanti? With a quality standard that accepts nothing less than the best, Avanti’s lipid products are the best choice for preparing lipid delivery systems used in vaccine research. Keep reading to learn more!

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Conversations with Lipid Leaders: Dr. Richard Schwarz

Posted on November 22, 2021

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The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Richard Schwarz!

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Product Spotlight: PHAD® Adjuvants

Posted on November 16, 2021

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Avanti has you covered when it comes to lipid-based adjuvants. As you’ve seen in our research spotlights, our PHAD adjuvants can be used individually or in combination with other adjuvants to elicit stronger immune responses when compared to vaccines relying on an antigen alone. Regardless of which type of adjuvant(s) you choose for your vaccine research, you can rest assured that when you choose Avanti and Croda, you’re choosing safe and effective adjuvants. Let’s take a quick look at some of our lipid-based adjuvant products in the PHAD line.

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Research Spotlight: Combinatorial Liposomal Peptide Vaccine Induces IgA and Confers Protection Against Influenza Virus and Bacterial Super-Infection

Posted on November 12, 2021

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3D-PHAD… sounds cool, right? Well, there’s more to this Avanti Lipid product than a cool name. Avanti’s PHAD is the first fully synthetic monophosphoryl lipid A (MPLA) available for use in human vaccines. But what does the 3D stand for? 3D means that this PHAD product is a 3-deacylated form of MPLA. Avanti’s PHAD products are great adjuvants for human vaccine applications due to their ability to elicit a strong immune response while also exhibiting a lower pyrogenic profile than the naturally occurring bacterial agent. Enough about this product’s name, keep reading to learn how it’s being used!

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Veterans Day

Posted on November 01, 2021

Thank You Veterans
Not that we don't remember and appreciate what our veterans have done for us every day, but today is a special day to honor and remember those who have served in our Armed Forces! November 11th is a day to honor our veterans as a day that marks the ending of World War I. Join us in celebrating all of Avanti's veterans today! Keep reading to learn more about what Avanti team member, Roddie Thurman, had to say about his military service!

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Research Spotlight: A Potent Cancer Vaccine Adjuvant System for Particleization of Short, Synthetic CD8+ T Cell Epitopes

Posted on October 29, 2021

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To kill cancer cells, short-tumor-derived peptides (8-10 amino acids in length) must be recognized by the CD8+ T cell receptors. This promising method for killing cancer cells has not produced the desired results in clinical studies. Keep reading to learn how researchers at the University of Buffalo are working to improve this method!

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Conversations with Lipid Leaders: Dr. Jon Lovell

Posted on October 29, 2021

Jon Lovell
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Jon Lovell!

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Adjuvants & Vaccine Technology

Posted on October 22, 2021

Adjuvants are a promising component in new vaccine technologies. Adjuvants improve our immune response to antigens via several mechanisms. Many times the full mechanism of action is not understood and rather difficult to elucidate. Check out the infographic for a simplified explanation of the mechanisms by which adjuvants amplify our immune response when added to vaccines!

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Research Spotlight: Prophylactic efficacy against Mycobacterium tuberculosis using ID93 and lipid-based adjuvant formulations in the mouse model

Posted on October 22, 2021

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Globally, tuberculosis, a treatable and preventable disease, kills 1.6 million people every year. A latent form of tuberculosis, Mycobacterium tuberculosis (Mtb), is estimated to infect nearly a quarter of the world’s total population. It is imperative that we as a scientific community find alternatives to the current TB vaccines being used today. Keep reading to learn more about a research team doing just that!

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Conversations with Lipid Leaders: Dr. Susan Baldwin

Posted on October 22, 2021

Susan Baldwin
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Susan Baldwin!

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Product Spotlight: Photoswitchable AzoPC

Posted on October 16, 2021

Photoswitchable Lipids
Azobenzenes are prototypical molecular “switches” that exist in two distinct states – cis and trans. These states have different physical properties. The trans isomer is energetically preferred in solution but adding a source of energy can cause the azobenzene moiety to “switch” from trans to cis resulting in an on-and-off molecular switch. Keep reading to learn more about one such product from Avanti!

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Conversations with Avanti Award Winners: Dr. Elina Ikonen

Posted on October 14, 2021

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We would like to congratulate Dr. Elina Ikonen on being the recipient of the 2021 European Biophysical Societies' Association (EBSA) Avanti Lipids Award! We caught up with Dr. Ikonen to find out more about her research and what winning the EBSA Avanti Lipids Award means to her! Keep reading to find out what she had to say!

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Research Spotlight: An Improved and Highly Selective Fluorescence Assay for Measuring Phosphatidylserine Decarboxylase Activity

Posted on October 05, 2021

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Hopefully, you’ve had the opportunity to read our interview with Dr. Dennis Voelker. If you haven’t, SPOILER ALERT! In the interview, Dr. Voelker describes the significance that a recently developed fluorescence assay has in future diagnostic and therapeutic research. He says “The field of lipid biochemistry is ripe for expansion into the realm of screening for- and identifying- novel inhibitors of essential enzymes for application as new drugs for treating all types of microbial infections, including viruses, bacteria and fungi.” Keep reading to learn more about this highly selective fluorescence assay for measuring phosphatidylserine decarboxylase activity!

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Conversations with Lipid Leaders: Dr. Dennis Voelker

Posted on September 29, 2021

Dennis Voelker
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Dennis Voelker!

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Division Spotlight: Human Resources

Posted on September 03, 2021

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Britt Pietruszewski, Senior HR Business Partner, took time to chat with us and provide insight into the employee-centric world of Avanti's Human Resources department! Keep reading to learn more!

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Conversations with Lipid Leaders: Dr. Bruno Antonny

Posted on September 02, 2021

Bruno Antonny
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Bruno Antonny!

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Conversations with Lipid Leaders: Dr. Yusuf Hannun

Posted on August 06, 2021

Yufuf Hannun
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Yusuf Hannun!

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Division Spotlight: Customer Service

Posted on August 06, 2021

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Jennifer Mayo, Customer Service Manager, took time to chat with us and provide insight into the friendly representatives that interact with our customers in Avanti's Customer Service Department! Keep reading to learn more!

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Research Spotlight: World Brain Day!

Posted on July 07, 2021

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World Brain Day is July 22, 2021! Keep reading to learn about research, from one of our former lipid leaders, aimed at identifying metabolites that contribute to neurodegeneration resulting from Cerebrotendinous xanthomatosis (CTX)!

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Research Spotlight: 1-Stearoyl-2-docosahexaenoyl-phosphatidic acid interacts with and activates Praja-1, the E3 ubiquitin ligase acting on the serotonin transporter in the brain

Posted on July 07, 2021

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We hope you had a chance to read our most recent Lipid Leaders Interview with Dr. Fumio Sakane. To follow that great interview, we wanted to share one of his recent publications investigating the importance of lipid composition on the regulation of serotonin levels and how this contributes to the pathophysiology/therapeutics of various psychiatric disorders such as OCD, depression, autism, and schizophrenia. Keep reading to learn more!

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Conversations with Lipid Leaders: Dr. Fumio Sakane

Posted on July 01, 2021

Fumio Sakane
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Fumio Sakane!

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Research Spotlight: The Acyl Chains of Phosphoinositide PIP3 Alter the Structure and Function of Nuclear Receptor Steroidogenic Factor-1

Posted on June 23, 2021

Sf1 Crystal Structure
Nuclear receptor steroidogenic factor-1 (SF-1, NR5A1) specifically binds the signaling phosphoinositides, PI(4,5)P2 and PI(3,4,5)P3. Research has previously shown how the headgroups of these PIP lipids interact with and regulate SF-1 function. But what role do the acyl chains of these PIPs play in this interaction? Keep reading to see what researchers at Vanderbilt University School of Medicine found out.

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Product Spotlight: Lipids for GUVs

Posted on June 16, 2021

Lnp Illustrations
Current events reinforce the importance of lipid-based delivery systems, and Avanti products are perfect for lipid-based particle formulations. Keep reading to learn about a special class of particles, Giant Unilamellar Vesicles (GUVs) and their interesting applications!

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International Women in Engineering Day

Posted on June 10, 2021

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At Avanti, we are incredibly proud of our women engineers. In order to celebrate International Women in Engineering Day on June 23rd, we spoke to a couple of our own women engineers to find out about their current projects and what inspired them to choose this rewarding career path! Keep reading to learn more!

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Research Spotlight: Cardiolipin-Induced Activation of Pyruvate Dehydrogenase Links Mitochondrial Lipid Biosynthesis to TCA Cycle Function

Posted on June 10, 2021

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Hopefully, you’ve had time to read our interview with Dr. Miriam Greenberg, but if you haven’t it’s a MUST read! If you’re wondering what type of research she has been engaged in recently, keep reading this review of an article she published in 2019 titled “Cardiolipin-Induced Activation of Pyruvate Dehydrogenase Links Mitochondrial Lipid Biosynthesis to TCA Cycle Function”

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Conversations with Lipid Leaders: Dr. Miriam Greenberg

Posted on May 19, 2021

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The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Miriam Greenberg!

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Product Spotlight: Understanding the Role of Oxysterols in the Brain

Posted on May 12, 2021

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Oxysterols are an important class of regulatory lipids involved in a wide variety of biological functions. Oxysterols have huge potential in pharmaceutical applications due to their role in cholesterol metabolism, cell growth, and many other biological processes. Chances are slim that you won’t be able to find the oxysterol that you’re looking for on our website. And if you can’t, just contact us about custom synthesizing the oxysterol you need! Keep reading to find out how oxysterols are being used in Alzheimer’s disease and brain sterol homeostasis research right now!

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Research Spotlight: C24:0 and C24:1 Sphingolipids in Cholesterol-Containing, Five- and Six-Component Lipid Membranes

Posted on May 12, 2021

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We hope you had a chance to read our most recent Lipid Leaders Interview with Dr. Felix Goni. In the interview, Dr. Goni gave us some great insight into his research at the University of the Basque Country and Instituto Biofisika. To follow that, we wanted to share one of his recent publications investigating C24:0 and C24:1 Sphingolipids in Cholesterol-Containing, Five- and Six-Component Lipid Membranes. Dr. Goni has been a loyal Avanti customer and friend for many years, and it is always exciting to see what his group accomplishes! Keep reading to learn more!

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Research Spotlight: Sex Differences in Insulin Sensitivity are Related to Muscle Tissue Acylcarnitine But Not Subcellular Lipid Distribution

Posted on April 26, 2021

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Our first May Research Spotlight uses Avanti's Lipidomic Standards to investigate lipid subspecies distribution as a contributor to differences in insulin sensitivity between men and women with obesity. Keep reading to check out the great work going on at University of Colorado Anschutz Medical Campus in Aurora, Colorado!

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Conversations with Lipid Leaders: Dr. Felix Goni

Posted on April 26, 2021

Felix Goni
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Felix Goni!

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Conversations with Lipid Award Winners: Dr. William Griffiths

Posted on April 19, 2021

Bill Griffiths
We would like to congratulate Dr. William Griffiths on being the recipient of the 2021 the American Oil Chemists’ Society’s Schroepfer Medal which recognizes a scientist who has made significant and distinguished advances in the steroid or sterols field. We caught up with Dr. Griffiths to find out more about his research and what winning the Schroepfer Medal means to him! Keep reading to find out what he had to say!

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Conversations with Avanti Award Winners: Dr. Jean Schaffer

Posted on April 14, 2021

Jean Schaffer
We would like to congratulate Dr. Jean Schaffer on being the recipient of the 2020/2021 American Society for Biochemistry and Molecular Biology Avanti Award in Lipids for her pioneering work in understanding and preventing lipotoxicity. We caught up with Dr. Schaffer to find out more about her research and what winning the Avanti Award means to her! Keep reading to find out what she had to say!

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Conversations with Avanti Award Winners: Dr. Jeremy Baskin

Posted on April 14, 2021

Jeremy Baskin
We would like to congratulate Dr. Jeremy Baskin on being the recipient of the 2020/2021 ASBMB Walter A. Shaw Young Investigator in Lipid Research Award unique blend of chemical biology, biochemistry, and cell biology approaches to develop innovative methods for imaging and probing various classes of lipids in vivo. We caught up with Dr. Baskin to find out more about his research and what winning the Walter A. Shaw Young Investigator Award means to him! Keep reading to find out what he had to say!

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Research Spotlight: Investigating the Impact of Delivery System Design on the Efficacy of Self-Amplifying RNA Vaccines

Posted on April 12, 2021

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We hope you had a chance to read our most recent Lipid Leaders Interview with Dr. Yvonne Perrie. In the interview, Dr. Perrie gave us some great insight into her current research. To follow that, we wanted to share one of her recent publications investigating the impact of different delivery systems on the efficacy of self-amplifying mRNA (SAM) vaccines. Dr. Perrie and her team prepared and compared four different cationic SAM delivery platforms including liposomes, solid lipid nanoparticles (SLNs), polymeric nanoparticles (NPs), and emulsions. These lipid-based delivery platforms were prepared using Avanti’s DOTAP and DDA products. Keep reading to find out what this investigation uncovered!

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Research Spotlight: Lipopolymers and Lipids from Lung Surfactants in Association with N-acetyl-l-cysteine: Characterization and Cytotoxicity

Posted on March 30, 2021

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Our first April Research Spotlight comes from Nadia Chiaramoni. Nadia connected with us on Twitter and shared one of her recent works where she utilized our diacetylene lipids to form polymeric liposomes as a possible N-acetyl-I-cysteine (NAC) delivery system. Keep reading to check out Nadia’s publication in the Chemistry and Physics of Lipids journal and the great work that she is doing at the Universidad Nacional de Quilmes in Buenos Aires, Argentina.

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Conversations with Avanti Award Winners: Dr. Richard Pastor

Posted on March 27, 2021

Richard Pastor
We would like to congratulate Dr. Richard Pastor on being the recipient of the 2021 Biophysical Society Avanti Award in Lipids for his pioneering Molecular Dynamics Simulations of lipids and the development of the widely used lipid forcefield. We caught up with Dr. Pastor to find out more about his research and what winning the Avanti Award means to him! Keep reading to find out what he had to say!

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Conversations with Lipid Leaders: Professor Yvonne Perrie

Posted on March 22, 2021

Yvonne Perrie
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Professor Yvonne Perrie!

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Research Spotlight: Deep Mining of Oxysterols and Cholestenoic Acids in Human Plasma and Cerebrospinal Fluid: Quantification using Isotope Dilution Mass Spectrometry

Posted on March 15, 2021

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Our second citation promotion for March comes from Dr. William Griffiths at Swansea University Medical School in Wales. Dr. Griffiths and his team of collaborators used Avanti’s oxysterolSPLASH and individual oxysterol standards to develop methodology to identify and quantify multiple sterols (oxysterols and sterol-acids) in plasma and cerebrospinal fluid. Avanti’s own, Lisa Connell, Director of the Lipidomics Division, is included as an author on the paper for her work in developing these standards. Keep reading to learn more about this exciting work!

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Division Spotlight: Formulations

Posted on March 15, 2021

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Amy Druschitz, Production Manager for the Formulations Division, took time to chat with us and provide insight into the Avanti's Formulations Division! Keep reading to learn more!

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Conversations with Lipid Leaders: Dr. Dan Raben

Posted on February 22, 2021

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The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Dan Raben!

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Research Spotlight: Mono- and Poly-unsaturated Phosphatidic Acid Regulates Distinct Steps of Regulated Exocytoses in Neuroendocrine Cells

Posted on February 16, 2021

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We would like to thank Nick Vitale from the Universite de Strasbourg in France for submitting this publication to the Citation Promotion Contest! Nick and his team are loyal customers of Avanti, and it’s exciting to see what they have been able to accomplish in the work titled “Mono- and Poly-Unsaturated Phosphatidic Acid Regulates Distinct Steps of Regulated Exocytoses in Neuroendocrine Cells.” Keep reading for more!

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Product Spotlight: Exclusive Detergents

Posted on February 16, 2021

Protein Crystallography
Avanti is in no short supply of products to aid in your projects and applications. This month, we are taking a closer look at Avanti’s Exclusive Detergents for your protein crystallography research.

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Research Spotlight: Using Avanti LIPIDOMIX® Standards to Create Lipidomics Software

Posted on February 01, 2021

Mass Spectrometry
As we continue our Citation Promotion series, check out how Jeremy Koelmel and his research team use Avanti LIPIDOMIX® Standards to create lipidomics software for the semi-quantification of lipids! They have released the LipidMatch Flow, LipidMatch Normalizer, and Lipid Annotator software platforms. Keep reading to find out how to access their software and how you can use it for analysis in your lipidomics research!

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Research Spotlight: Localization of Cyclopropane Modifications in Bacterial Lipids via 213 nm Ultraviolet Photodissociation Mass Spectrometry

Posted on January 21, 2021

Mass Spectrometry
Check out this exciting research submitted, as part of our Citation Promotion, by Molly Blevins from the Department of Chemistry, University of Texas at Austin! The work is titled “Localization of Cyclopropane Modifications in Bacterial Lipids via 213 nm Ultraviolet Photodissociation Mass Spectrometry”. Molly and the rest of the Brodbelt research group were able to employ 213 nm ultraviolet photodissociation mass spectrometry (UVPD-MS) for structural characterization of cyclopropane rings in bacterial phospholipids and mycolic acids.

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MRI Contrasting Agents: Broader Applications

Posted on January 08, 2021

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Magnetic resonance imaging (MRI) is one of the top ten most common medical diagnostic tests conducted around the world with tens of millions of contrast enhanced MRI exams performed annually. Read on to find out how Avanti Lipids are being used in these routine procedures!

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Product Spotlight: Photoswitchable Lipids

Posted on December 10, 2020

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Until recently lipidomics has been overshadowed by advancements in proteomics and genomics technologies. Research related to lipidome analysis over the last several years has given a greater insight and understanding of the roles that lipids play in biochemistry.

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MRI Contrasting Agents: Broader Applications

Posted on December 03, 2020

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Magnetic resonance imaging (MRI) is one of the top ten most common medical diagnostic tests conducted around the world with tens of millions of contrast enhanced MRI exams performed annually. Contrasting agents are used for MRI exams to enhance diagnostic accuracy and information that often cannot be obtained from other noninvasive techniques.

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The Latest From Avanti

Posted on October 08, 2020

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It’s been business as usual this month at Avanti—which means we’ve been busy brewing up new products for R&D and more! Keep reading for October 2020 news.

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The Latest From Avanti

Posted on September 08, 2020

Avanti Site Logo
Busy season hasn’t shown any signs of slowing this September. In fact, Avanti has been abuzz with news that we’ve been more than itching to share. Read on!

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The Latest From Avanti

Posted on August 11, 2020

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As usual, Avanti has had a busy August! Keep reading to find out what we’ve been up to—including products featured in peer-reviewed journals and job opportunities.

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Avanti Polar Lipids Agrees to be Acquired by Croda

Posted on July 06, 2020

Avanti Polar Lipids, Inc. (“Avanti” or the “Company”) today announces it has agreed to be acquired by Croda International, Plc (“Croda”). The combination of two life science leaders brings together Avanti’s expertise in lipid-based drug delivery solutions through its research products and pharmaceutical services and Croda’s range of life science products and cGMP manufacturing capabilities to expand their respective breadth of products and services for biotechnology businesses, academic institutions and pharmaceutical companies globally.

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