Lipid-based therapeutic delivery systems have been evolving for many years. From delivering naked mRNA, to using liposomes, and now lipid nanoparticles, Avanti is here to provide you with the most innovative lipids for your nucleic acid delivery research. In this article discover considerations for each component in an LNP, as well as some new alternatives to commonly used LNP components such as PEG-lipids and cholesterol.
In this Lipid Leaders interview, we get insight from Croda Pharma's own Global Head of R&D - Adjuvant Systems, Dennis Christensen, PhD. Keep reading to learn more about adjuvants and the role they play in vaccines, as well as where the technology may be headed.
November 15, 2022 is National Recycling Day! We are committed to being Climate, Land, and People Positive by 2030. Keep reading to find out how we plan to increase our recycling efforts and reduce food waste worldwide!
Lipids are used in a variety of ways in therapeutics. Recently, lipids have garnered a lot of attention for their role in mRNA delivery, but that's not all they're good for. At least four types of lipids are being investigated as pro-moieties in pro-drugs - fatty acids, glycerides, steroids, and phospholipids. Keep reading to learn more!
Lipids are abundant in nature and important in many different ways. Our focus is usually placed on their functions in human biology and therapeutic applications, but this research spotlight is a little different. Keep reading to find out how lipids make geckos the climbing creatures they are!
Kim Ekroos is currently the CEO of Lipidomics Consulting Ltd and the President of the International Lipidomics Society (iLS). After receiving a PhD in Biology for his work in glycerophospholipid characterization by quadrupole time-of-flight mass spectrometry from the Technical University in Dresden, Germany, Kim's lipidomics career began. Keep reading to find out what he believes to be the greatest breakthroughs in lipid technology have been, as well as where he thinks the field of lipidomics is headed, and more!
October 3-10 is Mental Illness Awareness Week! To help raise awareness and fight the stigma associated with mental illness we want to share some exciting research. Dive into this research spotlight to find out how ceramides are linked to clinical depression and how future treatments could take advantage of this link.
Jackie's annual mammogram turned into a scary situation in February 2019 when she was diagnosed with Stage I breast cancer. After going through chemotherapy and radiation, Jackie can now say that she is cancer free! She says "Receiving a cancer diagnosis is scary, but it is important to be informed and proactive." Keep reading for the rest of her story!
During the midst of a pandemic, Ileana also dealt with breast cancer. After two surgeries and radiation treatments, Ileana was able to ring the bell symbolizing that she won the fight with cancer. Keep reading for Ileana's full story!
Lisa's breast cancer journey started just over one year ago, in September of 2021. On October 11, 2021, she got confirmation that she had Stage I, Triple Positive IDC/DCIS Breast Cancer. After surgery and chemotherapy, Lisa was able to say that she was cancer free on April 19, 2022, only a few months after her original diagnosis. Lisa now acts as an advocate for Aesthetic Flat Closure (AFC). Keep reading for Lisa's full story!
Stearoyl-CoA desaturase (SCD) 1 is a key enzyme in double bond formation. It is also known to be involved in stress signaling but the mechanism by which it does so has been a mystery - until now! PI (18:1/18:1) is the primary SCD1-derived metabolite that modulates stress signaling. Keep reading to learn more!
Electric Vehicles (EVs) have been a hot topic for a while now, but California's recent EV mandate thrust this technology back into the spotlight. We have a long way to go before we are able to support the estimated 70 million EVs on the road by 2040. What are some of the challenges we face? And how is science attempting to revolutionize EV batteries to better support the widespread adoption of EVs? Find out in this month's Sustainability Seconds!
Obesity is a major problem across the globe. One driver of obesity is white adipocytes and their primary function as energy storage centers. When energy intake is chronically greater than energy output, the excess energy is stored as triglycerides in white adipose tissue (WAT). Brown adipose tissue (BAT), unlike WAT, works to expend energy. Those at higher risk of obesity typically have lower levels of BAT, and our levels of BAT tend to decline as we age. Historically, pharmaceutical treatments have been aimed towards energy intake rather than attempting to increase the energy expended by BAT. A recent study has found a specific endogenous metabolite capable of inducing production of BAT. Keep reading to learn more!
Croda and Avanti are dedicated to making a positive impact on the planet and those inhabiting it. Through science and innovation, we will continue to increase our positive impact through the year 2030 and beyond. Keep reading to find out how we plan to be People Positive by 2030, including our goals and progress as of 2021!
The new position will see the sustainability expert challenge us to stretch our already industry-leading sustainability ambitions and commitments as well as support our business sectors in further enhancing their sustainability strategies by working in partnership with their customers and suppliers.
22:0 Trehalose (TDB) has been one of our most popular products so far this year. Let's take a look at how it can be used to enhance your adjuvanted vaccine research!
TDB is commonly combined with dimethyldioctadecylammonium bromide (DDAB) to create a powerful adjuvant system. Research has shown that it elicits a strong cell-mediated immune response desirable for many disease targets. New research has also identified improved formulations processes to better control particle size and polydispersity of the resultant liposomes. Keep reading to learn more!
This research spotlight features research conducted by our Junior Lipid Leader Rachel Wills. Rachel, along with the rest of Dr. Hammond's lab at the University of Pittsburgh, is interested in phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and its regulation in mammalian plasma membrane. In this spotlight, Rachel and Dr. Hammond elucidate a novel mechanism by which PI(4,5)P2 is regulated. This insight can be used in the future to find potential therapeutic targets for diseases resulting from genetic defects of PI(4,5)P2 synthesis. Keep reading to learn more about this novel mechanism!
In honor of World Brain Day 2022, the METLIN Molecule of the Month is Docosahexaenoic Acid (DHA). DHA has many many roles in the brain giving it the nickname "the brain's vitamin C". Keep reading to find out what roles DHA plays in the brain, how DHA and its metabolites are affected by Influenza A virus and Staphyloccocus Pneumoniae, and more!
July 22nd is the 9th annual World Brain Day! The brain lipidome is complex. The metabolic mechanisms associated with its lipidome even more so. In honor of World Brain Day let's dive into a recently published review of lipid metabolism and its links to Alzheimer's disease!
Atopic dermatitis and psoriasis are caused by changes in ceramide levels in the skin. Understanding the complexity and identifying the exact ceramide components in the skin is important to work towards cures and treatments for these skin diseases. Researchers at Hokaido University used a recently developed method involving the combination of multiple reaction monitoring (MRM) mode of LC-MS/MS with Avanti's ceramide standards to identify 400 species of ceramides in the stratum cornuem. Keep reading to see what they found!
Rachel is a lipid researcher working on her PhD at the University of Pittsburgh. She works in Gerry Hammond's lab in the Cell Biology program. She successfully defended her PhD in July 2022 just before conducting this interview. She is also the recipient of a FASEB Phospholipids 2022 travel award. Continue reading Rachel's interview to find out how she became interested in lipid research, what she believes is the biggest breakthrough in lipid research in recent years, and the best advice she would give a new grad student, and more!
The US government are investing $75 million to support us with the development of a new cGMP facility in Pennsylvania. This facility scales our Avanti Polar Lipids to give us global manufacturing capability. Keep reading to learn more!
You may have never heard of 7-dehydrocholesterol (7-DHC) but that doesn’t mean that it’s not important! Not only is 7-DHC an important precursor to cholesterol, but it is also necessary to produce vitamin D3 in your skin. 7-DHC enables your skin to manufacture vitamin D3 from ultraviolet B (UV-B) rays from sun light – so, 7-DHC is also considered a provitamin of vitamin D3. Continue reading to learn how 7-DHC is now considered a biomarker of Smith-Lemli-Opitz syndrome!
The CDC’s Antibiotic Resistance Threats in the United States, 2019 presented data showing more than 2.8 million antibiotic-resistant infections occur annually in the US. And of these 2.8 million infections, more than 35,000 people died as a result. The emergence and spread of new antibiotic-resistant forms is alarming.
Investing in the development of new vaccines, improving existing therapeutics, and discovering better ways of diagnosing infections caused by these pathogens hinge on one underlying principle – understanding the pathogens themselves. Enter Dr. Hines and her team at UGA! Read the full article to find out how they are researching the lipidome of Staphylococcus Aureus to better understand its antibiotic resistance.
Dr. Kelly Hines took the time to answer a few questions about her research interests and inspirations, as well as her life outside the lab. Find out what she believes to be the greatest breakthrough in lipid research, why she chose to focus on ion mobility - mass spectrometry to study the lipidome, and more!
So far, this series has been devoted to personal lifestyle changes that we can individually adopt to make a positive impact on our planet. For the next couple of months, we want to focus on sustainability from a different perspective. You’ve heard us say that we are committed to being Climate, Land, and People Positive by 2030, but what does that mean and how are we planning to accomplish it?
Until recently, bile acids were primarily known as digestive surfactants to aid the absorption of lipids or as the primary pathway for cholesterol catabolism. But we now recognize bile acids as hormones. Lithocholic acid (LCA) is a secondary bile acid that acts like many other bile acids and aids the absorption of lipids in digestion. But that’s not all this bile acid does. Research has indicated that LCA can activate vitamin D receptor without raising calcium levels as high as Vitamin D itself. LCA has also been shown to bind with the NAPE-PLD enzyme and catalyze the release of anandamide and other N-acetylethanolamines. But one of the more interesting applications of LCA was discovered just last year. Read the full story!
Avanti’s new parenteral grade cholesterol is USP-NF, EP (2397), and JP compliant. Plant-based cholesterol provides a high-purity alternative to traditional egg- and animal-based cholesterol and is available for research and development work as well as parental applications. Cholesterol-based drug carriers have been designed as nanoparticles, micelles, and liposomal formulations for delivering antivirals, antimalarials, anticancer treatments, genetic material (DNA, mRNA, siRNA), and gene therapies.
The Conversations with Lipid Leaders Interview Series brings forward insights and experiences from the community's most influential and upcoming scientists. In this interview, Dr. Julie Saba discusses her research experiences while studying sphingolipid metabolism and signaling for the past three decades. Find out how Dr. Saba became interested in sphingosine-1-phosphate, what influenced her to dive into medical research, and more!
Stress – most of us experience it in some way every day. Some stress is good, but the longer we experience stress, the more taxed our physiological stress response becomes until it is taxed beyond its capabilities. Chronic stress not only taxes our stress response but can also lead to other health problems such as depression.
Research conducted in 2021 suggests that treating depression at the source is a viable treatment option. Studies recently identified lipopolysaccharide (LPS) as a possible treatment for depression in chronically stressed mice. LPS has several adverse side effects, but Avanti offers Phosphorylated Hexaacyl Disaccharide (PHAD) which could be a safe and effective alternative! Check out the full article to learn more.
Today is Earth Day so, we decided to post our next sustainability seconds article a little early! In honor of Earth Day 2022, we wanted to make this sustainability seconds blog a little different than usual. This time, let us look at a few statistics regarding sustainability, goals that have been set, and progress made towards accomplishing those goals.
Our Lipid Leader Research Spotlight Series highlights recent research conducted by leaders in the field. This month, Dr. Ayyalusamy Ramamoorthy was kind enough to join us as our Lipid Leader. Dr. Rams works to develop new polymer lipid-nanodiscs and uses these nanodiscs to investigate biochemical and biophysical properties of membrane proteins and amyloidogenic proteins. Check out this spotlight to learn more about why they are developing new polymers for these nanodiscs and how they are using them to better understand neurodegenerative disease such as Alzheimer's Disease!
The Oscar winning film “Lorenzo’s Oil” garnering two Academy Awards, the olive oil sitting on your kitchen counter, Avanti Polar Lipids, and Croda – what do these all have in common? Find out the answer in this month's METLIN Molecule of the Month!
The Conversations with Lipid Leaders Interview Series brings forward insights and experiences from the community's most influential and upcoming scientists. In this interview, Dr. Ayyalusamy Ramamoorthy discusses his research to develop polymers for lipid-nanodiscs and their applications in studying membrane proteins. Keep reading to find out what he had to say!
Headlines across the globe have largely been dominated by the COVID-19 pandemic for the last two-plus years – and rightly so. But infectious diseases such as COVID-19 are not the only public health crises that we face. Heart disease, cancer, and diabetes affect millions of lives every day, and we hear about the research being done to combat them regularly. In this research spotlight, let’s take a look at a public health crisis that we don’t focus on as much – the opioid addiction crisis.
Avanti is proud to be part of Croda International Plc, and their commitment to securing investment in the development of lipid systems! Keep reading to learn more!
Vaccine research has been rapidly increasing since the early 1990s. Between 1993 and 1997, less than 20,000 papers and patents were published related to vaccines. Fast forward twenty years, between 2013 and 2017, nearly 90,000 papers and patents were published related to vaccines (Global Science and Technology Trends Report, CAS, n.d.). And with the recent COVID-19 pandemic and subsequent race to find a vaccine, these numbers are sure to soar even higher between 2018 and 2022. Avanti's primary role in the pandemic has been as a supplier of lipids for the lipid nanoparticle delivery system, but our lipid-based adjuvant systems are also being investigated for COVID-19 vaccines, as well as cancer treatments and rare virus vaccines. Read the full story by clicking the link!
Water usage accounts for 6% of all carbon dioxide emissions in the UK. And annually, U.S. residents produce 320 million tons of CO2 from the energy needed to move, treat, and use water. That's why our most recent Sustainability Seconds blog reviews an article titled "The Hidden Impact of Your Daily Water Use." Keep reading to learn what habits lead to a larger impact on our environment, and what you can do to fix it!
Since the early 2000s, lipidomic analysis has become an increasingly hot research topic. The development of newer, better mass spectrometry technologies and standardized lipids and lipid mixtures continues to allow the lipidomics research community to get closer and closer to their goal – clinical translation of lipidomic research for the development of diagnostic and therapeutic tools. Avanti is a leader in the development of standardized lipids and lipid mixtures used in lipidomics research. We continue to develop our offerings to align with the needs of the research community. Federico Torta, a dear customer and leader in the lipidomic analysis community, recently published research linking visit-to-visit variability of certain lipid classes to the burden of coronary atherosclerosis in humans.
Federico Torta is an assistant professor at the National University of Singapore and is part of the Singapore Lipidomics Incubator (SLING). His research is focused on automation, high-throughput technologies for the assessment of the lipidome and sphingolipidome. Dr. Torta took the time to answer a few questions for us related to his research and the path he took to become one of the leaders in lipidomic analysis research.
We all know that cooling is energy expensive, especially air conditioning in warm climates. So, it should come as no shock to learn that the cooling industry is responsible for 10% of global CO2 emissions. For comparison, aviation and shipping combined produce about one-third this amount. This is really a double-edged sword, too: the more refrigeration that occurs, the greater the impact on global warming making refrigerants more and more necessary as the climate warms up. So, the sooner we make positive changes to our refrigeration and cooling habits, the better chance we have of reducing their negative impacts.
mRNA therapeutics are being investigated for various diseases such as cancer immunotherapy, protein replacement, and infectious diseases. One of the key benefits of using mRNA compared to non-viral DNA or adeno-associated virus (AAV) gene delivery systems is that mRNA does not have to gain access to the nucleus to undergo transcription. This usually means that protein production is more robust and much faster. mRNA therapy also has a lower risk of mutagenesis and thus has a safer genotoxic profile. Many of our previous articles have described the challenges associated with protecting mRNA in extracellular environments. Lipids have emerged as a highly attractive delivery vehicle for mRNA.
Triple negative breast cancer (TNBC) accounts for 10-15% of all breast cancers. TNBC is a particularly dangerous type of cancer due to its rapid growth and spreading, but also because of limited treatment options currently available. TNBC lacks estrogen and progesterone receptors which means that hormone therapy is not a viable treatment option. And the absence of high levels of HER2 protein means that HER2 targeted drugs are not a treatment option either. Thus, the “triple negative” designation for this cancer, and the reason that treatment options are currently limited to mainly chemotherapies. Finding a better treatment option for TNBC is imperative.
Cholesterol is the sterol that gets most of the attention in human biology, however desmosterol is an underappreciated cousin. For example, desmosterol is the immediate precursor to cholesterol in one of two cholesterol biosynthesis pathways - the Bloch pathway of cholesterol biosynthesis. As the immediate precursor to cholesterol, desmosterol is structurally very similar to cholesterol with the only difference being a double bond located on the side chain between C24 and C25. Despite the similar structures of these two molecules, they have surprisingly different physiological roles, desmosterol demonstrating itself as a master regulator of lipid metabolism.
Recently, Dr. William Griffiths along with his co-worker Dr. Yuqin Wang published a fascinating review of cholesterol metabolism in immunology. Keep reading to learn what has led to recent advancements and the role that oxysterols play in the immune system!
Messenger RNA (mRNA) isn’t the only type of RNA that Avanti lipids can encapsulate! Check out this research article that investigated the effect of cationic lipid type in liposomal delivery of small interfering RNA (siRNA) into the liver!
Since 1975, worldwide obesity has nearly tripled. As of 2016, almost 2 billion adults are overweight, and about one-third of those are obese. Even children under the age of five are becoming obese at an alarming rate. At least 2.8 million people die every year as a result of being overweight or obese. How can we discover biomarkers for obesity? Keep reading to learn what our February Lipid Leader, Dr. Maria Fedorova, and her team at TU-Dresden uncovered!
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Maria Fedorova!
How many clothing items did you buy last year? The fashion industry accounts for nearly 10% of total carbon emissions around the world. If that doesn’t sound like much, this is more than the global aviation and shipping carbon emission totals combined. Keep reading to learn more about how we can change our habits to be more sustainable fashionistas!
Our first METLIN Molecule of the Month is N,N-dimethylsphingosine (DMS), a lipid with multiple physiological activities. DMS and its relationship to neuropathic pain was first released in Nature Chemical Biology 2012 using an approach now called “activity metabolomics”. In 2017, DMS was also shown to have therapeutic impact on chronic Chagas disease cardiomyopathy, a disease caused by the parasite Trypanasoma cruzi.
CRISPR/Cas9 is a simple, two-component system that is faster, cheaper, more efficient, and more accurate than its genome editing predecessors. It allows genetic material to be added, removed, or altered at targeted locations in the genome. Keep reading to how Avanti products are being used to aid this gene editing technique!
Are lipids important in neurotransmission? Dr. Robert Ahrends and his team of researchers are striving to better understand how lipids and proteins interact during this signal transduction using a multiomics extraction and analysis workflow. Keep reading to learn more!
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Robert Ahrends!
We are in the middle of winter in the US and staying warm is a challenge for many. Heating usually requires energy - a lot of it. In the United States, nearly 40% of greenhouse gas emissions come from heating and cooling residential housing. Another 15% comes from heating water. So, heating is by far one of the most carbon intensive daily needs that we have. Why do our heating needs have such a high carbon footprint, and how can we address it? Keep reading to learn more!
We love to read research results published by our valued customers, and we love to share those results with you! Toshihide Kobayashi, National Center for Scientific Research/University of Strasbourg, said this about our lipids “We cannot publish these results without Avanti lipids. Thank you very much for the high-quality lipids.” Thank you, Toshihide, for being a loyal Avanti customer! Okay, let’s dive into the fantastic research that Toshihide has been doing! Keep reading to learn more!
“Am I doing enough?” That is a question that most people ask themselves daily. Am I doing enough for my significant other? Am I doing enough for my children? Am I doing enough for my employer? Am I doing enough for the planet, and the millions, and billions, of people that will live after me? Okay, we may not ask ourselves that last one every day, but we should! Every action that we take every single day has an impact on the future. And the small actions that we take as individuals to protect our planet can add up to an enormous positive impact on the quality of life for future generations. Keep reading to learn more!
If you’re trying to package, protect, and deliver genetic material to the inside of a cell, it is now common practice to use a lipid nanoparticle (LNP) delivery system. And who better to trust with your lipid delivery systems research than Avanti? With a quality standard that accepts nothing less than the best, Avanti’s lipid products are the best choice for preparing lipid delivery systems used in vaccine research. Keep reading to learn more!
Dr. Schwarz provided fantastic detail of his research interests and his relationship with the Avanti team. In this Lipid Leader Research Spotlight, let’s look at the research that sparked the relationship between Richard Schwarz and Avanti’s Research and Development Team! Keep reading to learn more!
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Richard Schwarz!
Avanti has you covered when it comes to lipid-based adjuvants. As you’ve seen in our research spotlights, our PHAD adjuvants can be used individually or in combination with other adjuvants to elicit stronger immune responses when compared to vaccines relying on an antigen alone. Regardless of which type of adjuvant(s) you choose for your vaccine research, you can rest assured that when you choose Avanti and Croda, you’re choosing safe and effective adjuvants. Let’s take a quick look at some of our lipid-based adjuvant products in the PHAD line.
3D-PHAD… sounds cool, right? Well, there’s more to this Avanti Lipid product than a cool name. Avanti’s PHAD is the first fully synthetic monophosphoryl lipid A (MPLA) available for use in human vaccines. But what does the 3D stand for? 3D means that this PHAD product is a 3-deacylated form of MPLA. Avanti’s PHAD products are great adjuvants for human vaccine applications due to their ability to elicit a strong immune response while also exhibiting a lower pyrogenic profile than the naturally occurring bacterial agent. Enough about this product’s name, keep reading to learn how it’s being used!
Not that we don't remember and appreciate what our veterans have done for us every day, but today is a special day to honor and remember those who have served in our Armed Forces! November 11th is a day to honor our veterans as a day that marks the ending of World War I. Join us in celebrating all of Avanti's veterans today! Keep reading to learn more about what Avanti team member, Roddie Thurman, had to say about his military service!
To kill cancer cells, short-tumor-derived peptides (8-10 amino acids in length) must be recognized by the CD8+ T cell receptors. This promising method for killing cancer cells has not produced the desired results in clinical studies. Keep reading to learn how researchers at the University of Buffalo are working to improve this method!
Adjuvants. You’ve seen them on our website. You’ve seen them featured in our blog articles. Now we want to show you how Avanti’ & Croda-Denmark can enhance your vaccine adjuvant research! Keep reading to learn more!
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Jon Lovell!
Adjuvants are a promising component in new vaccine technologies. Adjuvants improve our immune response to antigens via several mechanisms. Many times the full mechanism of action is not understood and rather difficult to elucidate. Check out the infographic for a simplified explanation of the mechanisms by which adjuvants amplify our immune response when added to vaccines!
Globally, tuberculosis, a treatable and preventable disease, kills 1.6 million people every year. A latent form of tuberculosis, Mycobacterium tuberculosis (Mtb), is estimated to infect nearly a quarter of the world’s total population. It is imperative that we as a scientific community find alternatives to the current TB vaccines being used today. Keep reading to learn more about a research team doing just that!
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Susan Baldwin!
Azobenzenes are prototypical molecular “switches” that exist in two distinct states – cis and trans. These states have different physical properties. The trans isomer is energetically preferred in solution but adding a source of energy can cause the azobenzene moiety to “switch” from trans to cis resulting in an on-and-off molecular switch. Keep reading to learn more about one such product from Avanti!
Lipid droplets are biologically important balls of fat; however, much about their formation remains unknown. The Avanti Lipids EBSA Award Winner, Elina Ikonen and her research team at the University of Helsinki, are working to understand this process. Keep reading to learn more!
We would like to congratulate Dr. Elina Ikonen on being the recipient of the 2021 European Biophysical Societies' Association (EBSA) Avanti Lipids Award! We caught up with Dr. Ikonen to find out more about her research and what winning the EBSA Avanti Lipids Award means to her! Keep reading to find out what she had to say!
Hopefully, you’ve had the opportunity to read our interview with Dr. Dennis Voelker. If you haven’t, SPOILER ALERT! In the interview, Dr. Voelker describes the significance that a recently developed fluorescence assay has in future diagnostic and therapeutic research. He says “The field of lipid biochemistry is ripe for expansion into the realm of screening for- and identifying- novel inhibitors of essential enzymes for application as new drugs for treating all types of microbial infections, including viruses, bacteria and fungi.” Keep reading to learn more about this highly selective fluorescence assay for measuring phosphatidylserine decarboxylase activity!
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Dennis Voelker!
This week’s research spotlight focuses on an important discovery from our September Lipid Leader’s lab! Keep reading to learn why lipid asymmetry may be so important!
Britt Pietruszewski, Senior HR Business Partner, took time to chat with us and provide insight into the employee-centric world of Avanti's Human Resources department! Keep reading to learn more!
Detergent-less solubilization of proteins is the new trend in protein research, and Avanti has you covered with a unique polymer solution. Avanti exclusively offers polymethacrylate (PMA) copolymer for the production of PMA-lipid nanoparticle (NP) nanodiscs. PMA offers many advantages to the commonly used SMA polymer. Keep reading to learn more!
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Bruno Antonny!
Thank you to Dr. Kari Basso, University of Florida, for submitting this recent research article! The research article explains their recent progress towards a MS/MS-based method for GSL analysis. Keep reading to learn more!
Cancer is a leading cause of death worldwide. Our Lipid Leader for this month, Dr. Yusuf Hannun, and his group of medical researchers at Stony Brook University are one of the groups providing insight into therapeutics for colorectal cancer. Keep reading to learn more about this exciting research!
Avanti is at the forefront of lipid-based delivery systems technology and our lipids are being used in research for various theranostic approaches. Keep reading to find out what types of diseases our lipids are being used to diagnose and treat!
We are delighted to share another Lipid Nanoparticle (LNP) Technology highlight! In this week's article, we take a look a closer look at microfluidics! Keep reading to learn more!
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Yusuf Hannun!
Jennifer Mayo, Customer Service Manager, took time to chat with us and provide insight into the friendly representatives that interact with our customers in Avanti's Customer Service Department! Keep reading to learn more!
We are delighted to share another Lipid Nanoparticle (LNP) Technology highlight! In this week's article, we take a look at research that might help you decide the best way to manufacture you lipid nanoparticles! Keep reading to learn more!
Continuing on our theme of Lipid Nanoparticle (LNP) Technology, did you know that cationic liposomes are being evaluated in theranostic applications? That is exactly what researchers at the Technical University of Denmark and the University of Copenhagen have been investigating. Keep reading to learn more!
This month's blog theme is Lipid Nanoparticle (LNP) Technology, and we’re going to kick it off with an article showing the effectiveness of LNPs in theranostics! Keep reading to learn more about this exciting field!
World Brain Day is July 22, 2021! Keep reading to learn about research, from one of our former lipid leaders, aimed at identifying metabolites that contribute to neurodegeneration resulting from Cerebrotendinous xanthomatosis (CTX)!
We hope you had a chance to read our most recent Lipid Leaders Interview with Dr. Fumio Sakane. To follow that great interview, we wanted to share one of his recent publications investigating the importance of lipid composition on the regulation of serotonin levels and how this contributes to the pathophysiology/therapeutics of various psychiatric disorders such as OCD, depression, autism, and schizophrenia. Keep reading to learn more!
This month's Product Spotlight is all about oxidized lipids! Keep reading to learn more about research from Yamagata University that takes advantage of several of the oxidized lipids that Avanti offers!
The Conversations with Lipid Leaders Interview Series brings forward insights and experience from the communities most influential and upcoming scientists to stay connected to current colleagues and inspire the next generation of Lipid Leaders! Keep reading for our interview with Dr. Fumio Sakane!
Becky Miller, Shipping Manager, took time to chat with us and provide insight into the busy world of Avanti's Shipping Department! Keep reading to learn more!
Nuclear receptor steroidogenic factor-1 (SF-1, NR5A1) specifically binds the signaling phosphoinositides, PI(4,5)P2 and PI(3,4,5)P3. Research has previously shown how the headgroups of these PIP lipids interact with and regulate SF-1 function. But what role do the acyl chains of these PIPs play in this interaction? Keep reading to see what researchers at Vanderbilt University School of Medicine found out.
Current events reinforce the importance of lipid-based delivery systems, and Avanti products are perfect for lipid-based particle formulations. Keep reading to learn about a special class of particles, Giant Unilamellar Vesicles (GUVs) and their interesting applications!
At Avanti, we are incredibly proud of our women engineers. In order to celebrate International Women in Engineering Day on June 23rd, we spoke to a couple of our own women engineers to find out about their current projects and what inspired them to choose this rewarding career path! Keep reading to learn more!
Hopefully, you’ve had time to read our interview with Dr. Miriam Greenberg, but if you haven’t it’s a MUST read! If you’re wondering what type of research she has been engaged in recently, keep reading this review of an article she published in 2019 titled “Cardiolipin-Induced Activation of Pyruvate Dehydrogenase Links Mitochondrial Lipid Biosynthesis to TCA Cycle Function”
Dr. Shengrong Li, Executive Director of Research Operations, took time to chat with us and provide insight into what the chemists of Avanti's Research Products Divison have been working on! Keep reading to learn more!
