Research Spotlight: New Technologies Shed Light on Caveolae
Exciting new functions for the small (50-100 nm) cellular invaginations, known as caveolae, are being understood!
Exciting new functions for the small (50-100 nm) cellular invaginations, known as caveolae, are being understood!
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Paul Baker Joins Avanti as Director of the Analytical Division
Spotlight: Ceramide Delivery System
In addition to its role in cellular structure, the bioactive sphingolipid, ceramide, has been shown to be important for the regulation of a host of cellular functions including cell growth, proliferation, differentiation, senescence, necrosis, and apoptosis...
Spotlight: Ceramide Synthase (CerS) Assay Kit
Ceramide synthases (CerSs) acylate sphingoid long-chain bases to form (dihydro)ceramides [1]. Mammals contain six distinct CerSs, each of which uses a specific subset of fatty acyl-coenzyme As to produce various subspecies of (dihydro)ceramides...
Spotlight: pacFA Ceramide
Dr. Erhard Bieberich's laboratory at Georgia Reagents University is interested in proteins that mediate the regulation of cilia and flagella by ceramide. Flagella and cilia are sensory and motor cellular organelle responsible for moving extracellular fluids and particles and propelling cells and unicellular organisms...
Biophysical Society Meeting: February 27- March 2, 2016
On February 27- March 2, 2016, The Avanti Roadshow will be at the 60th Annual Biophysical Society Meeting in Los Angeles, CA! Year after year, the Biophysical Society Meeting is a great place that brings together some of the leading scientists from around the world. With over 7,000 attendees and 500 speakers, Avanti loves this meeting because it still maintains the “small meeting” feel. It is a great place for learning and networking.
140th Edition-The Lipid Lowdown
The proatherogenic properties of the cholesterol 5,6-secosterols (atheronal-A and atheronal-B), recently discovered in atherosclerotic arteries, have been investigated in terms of their effects on monocyte/macrophage function. A fluorescent analogue of atheronal-B, when cultured in either aqueous buffer or in media containing fetal calf serum, is rapidly taken-up into cultured macrophage cells and accumulates at perinuclear sites...
Spotlight: MVL5/GMO Delivery System for siRNA/DNA
The therapeutic promise of gene therapy in treating and altering disease states has provided significant motivation in developing improved methods to deliver genes to cells [1,2]. Currently, two major classes of gene delivery vectors exist: viral and synthetic...
Product Spotlight: Fluorescent Endocannabinoids
Avanti’s new Fluorescent Endocannabinoids may be used to map the impact of various treatments and inhibitors on endocannabinoid uptake and distribution in living cells.
The Lipid Lowdown-Potential To Treat Type II Diabetes
PAHSA levels correlate highly with insulin sensitivity and are reduced in adipose tissue and serum of insulin-resistant humans. In adipocytes, PAHSAs signal through GPR120 to enhance insulin-stimulated glucose uptake. Thus, FAHFAs are endogenous lipids with the potential to treat type 2 diabetes.
Nanomedicines Symposium: Advances in Materials, Manufacturing & Therapeutic Applications
Precision Nanosystems' engineers and scientists will be available to demonstrate the full NanoAssemblr product suite.
Lipids for Liposomes: Selection, Preparation and Application Video
Dr. Di Bush gave a presentation at CRS in Seattle, Washington. Her presentation covered the selection, preparation and application of liposomes. To see her full presentation click the link below.
NEW products this week: 9/19/2016
14:0 Sphingomyelin. This adds to the list of 19 Natural and Synthetic SM’s and derivatives currently available.
NEW products this week: 10/03/2016
This adds to the list of 13 Functionalized PEG Lipids currently available.
147th Edition of the Avanti Newsletter
Whether you are looking for phospholipids, sphingolipids, sterols, or any other of our numerous product offerings, Avanti’s research products are the highest purity lipids on the market and give you the best possibility for success.
NEW products this week: 10/17/2017
Deuterated Hydroxy Phytosphingosine (S & R), Deuterated Hydroxy Ceramide (S & R), Deuterated Hydroxy Sphinganine (S & R), Deuterated Phytosphingosine. Deuterated Hydroxy Sphingosine...
New products this week: 10/31/2016
These new derivatives gives the researcher a choice of 19 Deuterated Ceramides from which to choose CER7-2’R,6R(d9) CER7-2’S,6R(d9)
This week in research: March 29, 2017
Researchers from Northwest University (Xi’an, Shaanxi, China) used numerous lipid analytical standards from Avanti in a serum lipidomic analysis using UPLC-QTOF/HDMS to study lipid metabolism in chronic kidney disease (CKD). This interesting work identifies profound changes in lipid metabolites in individuals with CKD...
This week in research: April 5, 2017
People do Amazing Things with Our Lipids! Researchers from the National Center for Global Health and Medicine (Tokyo, Japan) are studying the role of PAF signaling in neuropathic pain, a chronic pain condition resulting from injury of the peripheral or central nervous systems. PAF, as well as, ATP and lyophosphatidic acid are thought to be central mediators of neuropathic pain.