850200 | Regadenoson
2-[4-[(methylamino)carbonyl]-1H-pyrazol-1-yl]adenosine
Info
Regadenoson
2-[4-[(methylamino)carbonyl]-1H-pyrazol-1-yl]adenosine
Regadenoson (Lexiscan) is an A2A adenosine receptor agonist used as a coronary vasodilator in pharmacologic stress testing. Recently, it has been demonstrated that regadenoson can temporarily disrupt the integrity of the blood-brain barrier (BBB) by inhibiting P-glycoprotein function.
Data
No
No
C15H18N8O5
C 46.15%, H 4.65%, N 28.71%, O 20.49%
>99%
1 year
-20°C
CAS Number
313348-27-5
CAS Registry Number is a Registered Trademark of the American Chemical Society
CAS Registry Number is a Registered Trademark of the American Chemical Society
390.354
390.14
<p>LexiscanCVT-3146</p>
References
Cerqueira MD. The future of pharmacologic stress: selective A2A adenosine receptor agonists. Am J Cardiol. 2004 Jul 22;94(2A):33D-40D; discussion 40D-42D. doi: 10.1016/j.amjcard.2004.04.017. PMID: 15261132.
PubMed ID: 15261132Kim DG, Bynoe MS. A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier. J Clin Invest. 2016 May 2;126(5):1717-33. doi: 10.1172/JCI76207. Epub 2016 Apr 4. PMID: 27043281; PMCID: PMC4855938.
PubMed ID: 27043281
Certificates of Analysis
- Certificate of Analysis (Lot No. 850200P-5MG-A-010 and 5624PHA010)
- Certificate of Analysis (Lot No. 850200P-5MG-B-010 and 5624PHB010)
- Certificate of Analysis (Lot No. 850200P-5MG-C-010 and 5624PHC010)