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Phase Transition Temperatures for Glycerophospholipids

Phosphatidylcholine
Phosphatidylglycerol (Sodium Salt)
Product
Tm (°C)
Product
Tm (°C)
12:0 PC (DLPC)
-2
12:0 PG (DLPG)
-3
13:0 PC
14
14:0 PG (DMPG)
23
14:0 PC (DMPC)
24
16:0 PG (DPPG)
41
15:0 PC
35
18:0 PG (DSPG)
55
16:0 PC (DPPC)
41
18:1 PG (DOPG)
-18
17:0 PC
50
16:0-18:1 PG (POPG)
-2
18:0 PC (DSPC)
55
Phosphatidylserine (Sodium Salt)
19:0 PC
62
14:0 PS (DMPS)
35
20:0 PC
66
16:0 PS (DPPS)
54
21:0 PC
71
18:0 PS (DSPS)
68
22:0 PC
75
18:1 PS (DOPS)
-11
23:0 PC
79.5
16:0-18:1 PS (POPS)
14
24:0 PC
80.3
Phosphatidic Acid (Sodium Salt)
16:1 PC
-36
12:0 PA (DLPA)
31
18:1c9 PC (DOPC)
-17
14:0 PA (DMPA)
52
18:1t9 PC
12
16:0 PA (DPPA)
65
18:1c6 PC
1
18:0 PA (DSPA)
75
22:1c13 PC 13 18:1 PA (DOPA) -4
18:2 PC
-57
16:0-18:1 PA (POPA)
28
18:3 PC
-60
Cardiolipin
14:0 CL
47
16:0 CL
62.2
20:4 PC
-69
Phosphatidylethanolamine
14:0-16:0 PC
35
Tm (°C)
Th (°C)
14:0-18:0 PC
40
12:0 PE (DLPE)
29
16:0-14:0 PC
27
14:0 PE (DMPE)
50
16:0-18:0 PC
49
16:0 PE (DPPE)
63
118
16:0-18:1 PC (POPC)
-2
18:0 PE(DSPE)
74
100
16:0-22:6 PC
-27
20:0 PE
83
96
18:0-14:0 PC
30
18:1c9 PE (DOPE)
-16
10
18:0-16:0 PC
44
18:1t9 PE
38
64
18:0-18:1 PC
6
18:2 PE
-40
-15
18:1-16:0 PC
-9
18:3 PE
-30
18:1-18:0 PC
9
16:0-18:1 PE (POPE)
25
71

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Phase Transition Temperatures for Saturated Diacyl Phospholipids

Phase Transition in Lipid Bilayer

References

  • Thermotropic Phase Transitions of Pure Lipids in Model Membranes and Their Modifications by Membrane Proteins, Dr. John R. Silvius, Lipid-Protein Interactions, John Wiley & Sons, Inc., New York, 1982. Reprinted with permission from John Wiley & Sons, Inc.
  • Lipid Thermotropic Phase Transition Database (LIPIDAT) – NIST Standard Reference Database 34