Miscibility of Phospholipid Binary Mixtures

Component 1 Component 2 Delta Tc Miscibility
Phosphatidylcholine:Phosphatidylcholine Mixtures
12:0 PC 16:0 PC 43 L
12:0 PC 18:0 PC 57 VL
14:0 PC 16:0 PC 17 H
14:0 PC 18:0 PC 31 L-M
14:0 PC 20:0 PC 42 VL
16:0 PC 18:0 PC 14 H
18:1cdelta9PC 14:0 PC 40 VL
18:1cdelta9PC 16:0 PC 57 VL
18:1cdelta9PC 18:0 PC 71 VL
18:1cdelta9PC 22:0 PC 91 VL
18:1tdelta9PC 14:0 PC 11 L-M
18:1tdelta9PC 16:0 PC 28 L-M
18:1tdelta9PC 18:0 PC 42 L
16:0/18:1cdelta9PC 16:0 PC 44 VL
16:0/18:1cdelta9PC 16:0 PC 35 VL
16:0/22:6cccccc PC 16:0 PC ~70 VL
Phosphatidylcholine:Phosphatidylglycerol Mixtures
12:0 PC 12:0 PG•Na ~0 P
12:0 PC 12:0 PG•½Ca ~75 H
12:0 PC 14:0 PG•Na 25 M-H
12:0 PC 14:0 PG•½Ca ~87 M
12:0 PC 16:0 PG•Na 43 M
12:0 PC 16:0 PG•½Ca ~93 L
14:0 PC 14:0 PG•Na 0 H-P
14:0 PC 14:0 PG•½Mg ~51 H
14:0 PC 14:0 PG•½Ca ~61 H
14:0 PC 16:0 PG•Na 17 H
14:0 PC 16:0 PG•½Ca ~67 L-M
16:0 PC 14:0 PG•Na 18 H
16:0 PC 14:0 PG•½Ca 44 H
16:0 PC 16:0 PG•Na 0 P
16:0 PC 16:0 PG•½Ca ~50 H
18:0 PC 14:0 PG•Na 32 M
18:0 PC 16:0 PG•Na 14 H
18:0 PC 18:1cdelta9PG•½Ca ~70 VL
18:0 PC 18:1tdelta9PG•Na 45 L,complex
18:1cdelta9PC 16:0 PG•Na 59 VL
18:1cdelta9PC 16:0 PG•½Ca 107 VL
18:1cdelta9PC 18:1cdelta9PG•Na ~0 P
18:1cdelta9PC 18:1cdelta9PG•½Ca ~0 H
Phosphatidylcholine:Phosphatidylethanolamine Mixtures
14:0 PC 14:0 PE 24 M
14:0 PC 16:0 PE ~39 M
14:0 PC 16:1cdelta9PE 60 VL
14:0 PC 18:1cdelta9PE 38 VL
16:0 PC 16:0 PE 22 H
16:0 PC 16:1cdelta9PE 78 VL
16:0 PC 18:1cdelta9PE 57 VL
18:0 PC 14:0 PE 6 M-H
16:1cdelta9PC 14:0 PE 84 VL
18:1cdelta9PC 14:0 PE 65 VL
18:1cdelta9PC 16:0 PE 79 VL
18:1tdelta9PC 16:0 PE 50 VL(Fluid immiscibility)
Phosphatidylcholine:Phosphatidic Acid Mixtures
14:0 PC 14:0 PA•NaH 26 M
14:0 PC 14:0 PA•Ca L-M
16:0 PC 16:0 PA•NaH 25 M
16:0 PC 16:0 PA•Ca,ph 6 No transition <70°
16:0 PC 16:0 PA•Ca,ph 8 VL-L
16:0 PC 16:0 PA:H2 21 M-H
Phosphatidylcholine:Phosphatidylserine Mixtures
14:0 PC 14:0 PS•Na 15 L
14:0 PC 14:0 PS•Ca L
14:0 PC 16:0 PS•Na 29 M-H;complex
14:0 PC 18:1cdelta9PS•Na ~35 L-M
14:0 PC 18:1cdelta9PS•Ca VL
18:0 PC 18:1cdelta9PS•Na 65 VL
18:1cdelta9PC 14:0 PS•Na 58 VL
Miscellaneous Phospholipid Mixtures
16:0 PE 18:1cdelta9PE 76 VL
14:0 PG•Na 16:0 PG•Na 18 H
16:0 PE 18:1tdelta9PG•Na 51 L
18:1cdelta9PE 16:0 PG•Na 63 L-M,complex
18:1cdelta9PE 14:0 PS•Na 53 L
18:1tdelta9PE 18:1cdelta9PS•Na 45 L

MISCIBILITY KEY

P = Perfect. Ideal mixing and no broadening of the phase transition in the mixture.

H = High. Mixing ideal or very nearly so; phase transitions of mixture are markedly broader than those of the pure components.

M = Moderate. Phase diagram deviates markedly from ideal behavior, but the solidus curve is not flat over any significant range of compositions.

L = Low. Solidus curve in phase diagram is essentially flat over some range of compositions encompassing a region 20-50% wide over the XB-axis.

VL = Very Low. Solidus curve is essentially flat over most of the range of compositions (along >50% of the XB-axis).

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REFERENCES

  • Thermotropic Phase Transitions of Pure Lipids in Model Membranes and Their Modifications by Membrane Proteins, Dr. John R. Silvius. Lipid-Protein Interactions. John Wiley & Sons, Inc., New York, 1982. Reprinted with permission from John Wiley & Sons, Inc.