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Miscibility of Phospholipid Binary Mixtures

Component 1
Component 2
Delta Tc
Miscibility
Phosphatidylcholine:Phosphatidylcholine Mixtures
12:0 PC
16:0 PC
43
L
12:0 PC
18:0 PC
57
VL
14:0 PC
16:0 PC
17
H
14:0 PC
18:0 PC
31
L-M
14:0 PC
20:0 PC
42
VL
16:0 PC
18:0 PC
14
H
18:1cdelta9PC
14:0 PC
40
VL
18:1cdelta9PC
16:0 PC
57
VL
18:1cdelta9PC
18:0 PC
71
VL
18:1cdelta9PC
22:0 PC
91
VL
18:1tdelta9PC
14:0 PC
11
L-M
18:1tdelta9PC
16:0 PC
28
L-M
18:1tdelta9PC
18:0 PC
42
L
16:0/18:1cdelta9PC
16:0 PC
44
VL
16:0/18:1cdelta9PC
16:0 PC
35
VL
16:0/22:6cccccc PC
16:0 PC
~70
VL
Phosphatidylcholine:Phosphatidylglycerol Mixtures
12:0 PC
12:0 PG•Na
~0
P
12:0 PC
12:0 PG•½Ca
~75
H
12:0 PC
14:0 PG•Na
25
M-H
12:0 PC
14:0 PG•½Ca
~87
M
12:0 PC
16:0 PG•Na
43
M
12:0 PC
16:0 PG•½Ca
~93
L
14:0 PC
14:0 PG•Na
0
H-P
14:0 PC
14:0 PG•½Mg
~51
H
14:0 PC
14:0 PG•½Ca
~61
H
14:0 PC
16:0 PG•Na
17
H
14:0 PC
16:0 PG•½Ca
~67
L-M
16:0 PC
14:0 PG•Na
18
H
16:0 PC
14:0 PG•½Ca
44
H
16:0 PC
16:0 PG•Na
0
P
16:0 PC
16:0 PG•½Ca
~50
H
18:0 PC
14:0 PG•Na
32
M
18:0 PC
16:0 PG•Na
14
H
18:0 PC
18:1cdelta9PG•½Ca
~70
VL
18:0 PC
18:1tdelta9PG•Na
45
L,complex
18:1cdelta9PC
16:0 PG•Na
59
VL
18:1cdelta9PC
16:0 PG•½Ca
107
VL
18:1cdelta9PC
18:1cdelta9PG•Na
~0
P
18:1cdelta9PC
18:1cdelta9PG•½Ca
~0
H
Phosphatidylcholine:Phosphatidylethanolamine Mixtures
14:0 PC
14:0 PE
24
M
14:0 PC
16:0 PE
~39
M
14:0 PC
16:1cdelta9PE
60
VL
14:0 PC
18:1cdelta9PE
38
VL
16:0 PC
16:0 PE
22
H
16:0 PC
16:1cdelta9PE
78
VL
16:0 PC
18:1cdelta9PE
57
VL
18:0 PC
14:0 PE
6
M-H
16:1cdelta9PC
14:0 PE
84
VL
18:1cdelta9PC
14:0 PE
65
VL
18:1cdelta9PC
16:0 PE
79
VL
18:1tdelta9PC
16:0 PE
50
VL(Fluid immiscibility)
Phosphatidylcholine:Phosphatidic Acid Mixtures
14:0 PC
14:0 PA•NaH
26
M
14:0 PC
14:0 PA•Ca
L-M
16:0 PC
16:0 PA•NaH
25
M
16:0 PC
16:0 PA•Ca,ph
6
No transition <70°
16:0 PC
16:0 PA•Ca,ph
8
VL-L
16:0 PC
16:0 PA:H2
21
M-H
Phosphatidylcholine:Phosphatidylserine Mixtures
14:0 PC
14:0 PS•Na
15
L
14:0 PC
14:0 PS•Ca
L
14:0 PC
16:0 PS•Na
29
M-H;complex
14:0 PC
18:1cdelta9PS•Na
~35
L-M
14:0 PC
18:1cdelta9PS•Ca
VL
18:0 PC
18:1cdelta9PS•Na
65
VL
18:1cdelta9PC
14:0 PS•Na
58
VL
Miscellaneous Phospholipid Mixtures
16:0 PE
18:1cdelta9PE
76
VL
14:0 PG•Na
16:0 PG•Na
18
H
16:0 PE
18:1tdelta9PG•Na
51
L
18:1cdelta9PE
16:0 PG•Na
63
L-M,complex
18:1cdelta9PE
14:0 PS•Na
53
L
18:1tdelta9PE
18:1cdelta9PS•Na
45
L

Miscibility Key

P = Perfect. Ideal mixing and no broadening of the phase transition in the mixture.

H = High. Mixing ideal or very nearly so; phase transitions of mixture are markedly broader than those of the pure components.

M = Moderate. Phase diagram deviates markedly from ideal behavior, but the solidus curve is not flat over any significant range of compositions.

L = Low. Solidus curve in phase diagram is essentially flat over some range of compositions encompassing a region 20-50% wide over the XB-axis.

VL = Very Low. Solidus curve is essentially flat over most of the range of compositions (along >50% of the XB-axis).

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References

  • Thermotropic Phase Transitions of Pure Lipids in Model Membranes and Their Modifications by Membrane Proteins, Dr. John R. Silvius. Lipid-Protein Interactions. John Wiley & Sons, Inc., New York, 1982. Reprinted with permission from John Wiley & Sons, Inc.