999986 | 4ME 16:0 Diether DG

1,2-di-O-phytanyl-sn-glycerol


Oil

Size SKU Packaging Price
200mg 999986O-200mg 999986O-200mg 1 x 200mg $1,570.00
50mg 999986O-50mg 999986O-50mg 1 x 50mg $604.00
5mg 999986O-5mg 999986O-5mg 1 x 5mg $147.00

Chloroform

Size SKU Packaging Price
200mg 999986C-200mg 999986C-200mg 2 x 100mg 25mg/mL 4mL $1,570.00
50mg 999986C-50mg 999986C-50mg 1 x 50mg 25mg/mL 2mL $604.00
5mg 999986C-5mg 999986C-5mg 1 x 5mg 5mg/mL 1mL $147.00
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4ME 16:0 Diether DG

4ME 16:0 Diether DG

1,2-di-O-phytanyl-sn-glycerol

In biochemical signaling, diacylglycerol (DAG) functions as a second messenger signaling lipid, and is a product of the hydrolysis of the phospholipid PIP2 (phosphatidylinositolbisphosphate) by the enzyme phospholipase C (PLC) (a membrane-bound enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). Although inositol trisphosphate (IP3) diffuses into the cytosol, DAG remains within the plasma membrane due to its hydrophobic properties. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, whereas DAG is a physiological activator of protein kinase C (PKC). The production of DAG in the membrane facilitates translocation of PKC from the cytosol to the plasma membrane. (See References) Diacylglycerol mimicks the effects of the tumor-promoting compounds phorbol esters.

Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.

Storage:
Diacylglycerols are conveniently stored in chloroform solutions in glass vials with teflon-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.

Delivery to cells:
Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.

Effective concentration:
Most biological responses saturate at 20 to 250 µM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C43H88O3
Percent Composition
C 79.07%, H 13.58%, O 7.35%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
99341-19-2
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
653.157
Exact Mass
652.673
Synonyms

archaeol1,2-di-(3,7,11,15-tetramethylhexadecyl)-sn-glycerolDG(16:0(3me,7me,11me,15me)e/16:0(3me,7me,11me,15me)e)/0:0)

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PubMed ID: 12345

Lorem ipsum dolor sit amet, omnis melius gloriatur at his, veri exerci conclusionemque pro eu, simul possit ancillae an vix. Ut case iudico pro, vero necessitatibus te quo, ea sit regione appetere. Exerci persequeris pro in, usu brute iudico erroribus at. Quem posse nostro eam ei, at tale iriure admodum sed.

PubMed ID: 12345