999986 | 4ME 16:0 Diether DG



Size SKU Packaging Price
5mg 999986O-5mg 999986O-5mg 1 x 5mg $166.10
50mg 999986O-50mg 999986O-50mg 1 x 50mg $682.50


Size SKU Packaging Price
5mg 999986C-5mg 999986C-5mg 1 x 5mg 5mg/mL 1mL $166.10
Base Price: ${originalprice|money}
Custom Packaging: (${concentration} @$4.00/ea. + $100) ${custompackagingtotal|money}
Packaging: ${concentration}
Item Total: ${totalprice|money}
(Sales Tax may apply)
Please select an option above.
${sku} - ${concentration}

4ME 16:0 Diether DG

4ME 16:0 Diether DG


In biochemical signaling, diacylglycerol (DAG) functions as a second messenger signaling lipid, and is a product of the hydrolysis of the phospholipid PIP2 (phosphatidylinositolbisphosphate) by the enzyme phospholipase C (PLC) (a membrane-bound enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). Although inositol trisphosphate (IP3) diffuses into the cytosol, DAG remains within the plasma membrane due to its hydrophobic properties. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, whereas DAG is a physiological activator of protein kinase C (PKC). The production of DAG in the membrane facilitates translocation of PKC from the cytosol to the plasma membrane. (See References) Diacylglycerol mimicks the effects of the tumor-promoting compounds phorbol esters.

Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.

Diacylglycerols are conveniently stored in chloroform solutions in glass vials with teflon-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.

Delivery to cells:
Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.

Effective concentration:
Most biological responses saturate at 20 to 250 µM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.

Light Sensitive
Molecular Formula
Percent Composition
C 79.07%, H 13.58%, O 7.35%
1 Years
Storage Temperature
CAS Number
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
Exact Mass

Iaea DB, Spahr ZR, Singh RK, Chan RB, Zhou B, Bareja R, Elemento O, Di Paolo G, Zhang X, Maxfield FR. Stable reduction of STARD4 alters cholesterol regulation and lipid homeostasis. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Apr;1865(4):158609. doi: 10.1016/j.bbalip.2020.158609. Epub 2020 Jan 7. PMID: 31917335; PMCID: PMC6996790.

PubMed ID: 31917335

Meyer S, Thiel V, Joergensen RG, Sundrum A. Relationships between feeding and microbial faeces indices in dairy cows at different milk yield levels. PLoS One. 2019 Aug 20;14(8):e0221266. doi: 10.1371/journal.pone.0221266. eCollection 2019.

PubMed ID: 31430322

Lorem ipsum dolor sit amet, omnis melius gloriatur at his, veri exerci conclusionemque pro eu, simul possit ancillae an vix. Ut case iudico pro, vero necessitatibus te quo, ea sit regione appetere. Exerci persequeris pro in, usu brute iudico erroribus at. Quem posse nostro eam ei, at tale iriure admodum sed.