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900410 | 5-PAHSA

5-(palmitoyloxy)octadecanoic acid

5-PAHSA

Chloroform

Size SKU Packaging Price
1mg 900410C-1mg 900410C-1mg 1 x 1mg 1mg/mL 1mL $100.09
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Info

5-PAHSA

5-(palmitoyloxy)octadecanoic acid

PAHSA levels correlate highly with insulin sensitivity and are reduced in adipose tissue and serum of insulin-resistant humans. In adipocytes, PAHSAs signal through GPR120 to enhance insulin-stimulated glucose uptake. Thus, FAHFAs are endogenous lipids with the potential to treat type 2 diabetes.

Avanti has obtained a license from the patent holder to manufacture these products for research use.
Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C34H66O4
Percent Composition
C 75.78%, H 12.34%, O 11.88%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
1481636-41-2
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
538.885
Exact Mass
538.496
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References

Pham TH, Vidal NP, Manful CF, Fillier TA, Pumphrey RP, Doody KM, Thomas RH. Moose and Caribou as Novel Sources of Functional Lipids: Fatty Acid Esters of Hydroxy Fatty Acids, Diglycerides and Monoacetyldiglycerides. Molecules. 2019 Jan 10;24(2). pii: E232. doi: 10.3390/molecules24020232.

 PubMed ID: 30634564

Kolar, M.J., S.S. Kamat, W.H. Parsons, E.A. Homan, T. Maher, O.D. Peroni, I. Syed, K. Fjeld, A. Molven, B.B. Kahn, B.F. Cravatt, and A. Saghatelian. (2016). Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. Biochemistry 55:4636-41.

 PubMed ID: 27509211

Yore, M.M., I. Syed, P.M. Moraes-Vieira, T. Zhang, M.A. Herman, E.A. Homan, R.T. Patel, J. Lee, S. Chen, O.D. Peroni, A.S. Dhaneshwar, A. Hammarstedt, U. Smith, T.E. McGraw, A. Saghatelian, and B.B. Kahn. (2014). Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell 159:318-32.

 PubMed ID: 25303528
Certificates of Analysis

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