890890 | 18:1 TAP (DOTAP)
1,2-dioleoyl-3-trimethylammonium-propane (chloride salt)
18:1 TAP (DOTAP)
1,2-dioleoyl-3-trimethylammonium-propane (chloride salt)
DOTAP is one of the most widely used cationic lipids for gene transfection applications. DOTAP is proven to be efficient for in vitro and in vivo transfection applications. Various analogues of TAP are available for structure-activity relationship studies.
Simberg D, Weisman S, Talmon Y, Barenholz Y. DOTAP (and other cationic lipids): chemistry, biophysics, and transfection. Crit Rev Ther Drug Carrier Syst. 2004;21(4):257-317. doi: 10.1615/critrevtherdrugcarriersyst.v21.i4.10. PMID: 15638468.
CAS Registry Number is a Registered Trademark of the American Chemical Society
DOTAP
Lu Z, Pang T, Yin X, Cui H, Fang G, Xue X, Luo T. Delivery of TSPAN1 siRNA by Novel Th17 Targeted Cationic Liposomes for Gastric Cancer Intervention. J Pharm Sci. 2020 Jun 1:S0022-3549(20)30267-7. doi: 10.1016/j.xphs.2020.05.018. Epub ahead of print. PMID: 32497593.
PubMed ID: 32497593Mai Y, Guo J, Zhao Y, Ma S, Hou Y, Yang J. Intranasal delivery of cationic liposome-protamine complex mRNA vaccine elicits effective anti-tumor immunity. Cell Immunol. 2020 Aug;354:104143. doi: 10.1016/j.cellimm.2020.104143. Epub 2020 Jun 4. PMID: 32563850.
PubMed ID: 32563850Farid M, Faber T, Dietrich D, Lamprecht A. Cell membrane fusing liposomes for cytoplasmic delivery in brain endothelial cells. Colloids Surf B Biointerfaces. 2020 Jun 24;194:111193. doi: 10.1016/j.colsurfb.2020.111193. Epub ahead of print. PMID: 32592944.
PubMed ID: 32592944Vicente-Pascual M, Gómez-Aguado I, Rodríguez-Castejón J, Rodríguez-Gascón A, Muntoni E, Battaglia L, Del Pozo-Rodríguez A, Solinís Aspiazu MÁ. Topical Administration of SLN-Based Gene Therapy for the Treatment of Corneal Inflammation by De Novo IL-10 Production. Pharmaceutics. 2020 Jun 23;12(6):E584. doi: 10.3390/pharmaceutics12060584. PMID: 32586018.
PubMed ID: 32586018Lou G, Anderluzzi G, Tandrup Schmidt S, Woods S, Gallorini S, Brazzoli M, Giusti F, Ferlenghi I, Johnson R, Roberts CW, O'Hagan DT, Baudner BC, Perrie Y. Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection. J Control Release. 2020 Jun 30:S0168-3659(20)30362-X. doi: 10.1016/j.jconrel.2020.06.027. Epub ahead of print. PMID: 32619745.
PubMed ID: 32619745Caviglia C, Garbarino F, Canali C, Melander F, Raiteri R, Ferrari G, Sampietro M, Heiskanen A, Andresen TL, Zór K, Emnéus J. Monitoring cell endocytosis of liposomes by real-time electrical impedance spectroscopy. Anal Bioanal Chem. 2020 May 25. doi: 10.1007/s00216-020-02592-x. Epub ahead of print. PMID: 32451643.
PubMed ID: 32451643Kolyvushko O, Latzke J, Dahmani I, Osterrieder N, Chiantia S, Azab W. Differentially-Charged Liposomes Interact with Alphaherpesviruses and Interfere with Virus Entry. Pathogens. 2020 May 8;9(5):359. doi: 10.3390/pathogens9050359. PMID: 32397270; PMCID: PMC7281745.
PubMed ID: 32397270Arora S, Sharma D, Singh J. GLUT-1: An Effective Target To Deliver Brain-Derived Neurotrophic Factor Gene Across the Blood Brain Barrier. ACS Chem Neurosci. 2020 Jun 3;11(11):1620-1633. doi: 10.1021/acschemneuro.0c00076. Epub 2020 May 12. PMID: 32352752.
PubMed ID: 32352752Nobeyama T, Shigyou K, Nakatsuji H, Sugiyama H, Komura N, Ando H, Hamada T, Murakami T. Control of Lipid Bilayer Phases of Cell-Sized Liposomes by Surface-Engineered Plasmonic Nanoparticles. Langmuir. 2020 Jun 19. doi: 10.1021/acs.langmuir.0c00049. Epub ahead of print. PMID: 32502354.
PubMed ID: 32502354Van Hoecke L, Verbeke R, De Vlieger D, Dewitte H, Roose K, Van Nevel S, Krysko O, Bachert C, Schepens B, Lentacker I, Saelens X. mRNA Encoding a Bispecific Single Domain Antibody Construct Protects against Influenza A Virus Infection in Mice. Mol Ther Nucleic Acids. 2020 Jun 5;20:777-787. doi: 10.1016/j.omtn.2020.04.015. Epub 2020 May 1. PMID: 32438313; PMCID: PMC7240188.
PubMed ID: 32438313Hubert M, Larsson E, Vegesna NVG, Ahnlund M, Johansson AI, Moodie LW, Lundmark R. Lipid accumulation controls the balance between surface connection and scission of caveolae. Elife. 2020 May 4;9:e55038. doi: 10.7554/eLife.55038. PMID: 32364496; PMCID: PMC7239661.
PubMed ID: 32364496Hoffmann M, Hersch N, Gerlach S, Dreissen G, Springer R, Merkel R, Csiszár A, Hoffmann B. Complex Size and Surface Charge Determine Nucleic Acid Transfer by Fusogenic Liposomes. Int J Mol Sci. 2020 Mar 24;21(6):2244. doi: 10.3390/ijms21062244. PMID: 32213928; PMCID: PMC7139958.
PubMed ID: 32213928Webb C, Forbes N, Roces CB, Anderluzzi G, Lou G, Abraham S, Ingalls L, Marshall K, Leaver TJ, Watts JA, Aylott JW, Perrie Y. Using microfluidics for scalable manufacturing of nanomedicines from bench to GMP: A case study using protein-loaded liposomes. Int J Pharm. 2020 May 30;582:119266. doi: 10.1016/j.ijpharm.2020.119266. Epub 2020 Apr 3. PMID: 32251694.
PubMed ID: 32251694Yoshikawa N, Fumoto S, Yoshikawa K, Hu D, Okami K, Kato R, Nakashima M, Miyamoto H, Nishida K. Interaction of Lipoplex with Albumin Enhances Gene Expression in Hepatitis Mice. Pharmaceutics. 2020 Apr 10;12(4):E341. doi: 10.3390/pharmaceutics12040341. PMID: 32290201.
PubMed ID: 32290201Chen Q, Guan G, Deng F, Yang D, Wu P, Kang S, Sun R, Wang X, Zhou D, Dai W, Wang X, Zhang H, He B, Chen D, Zhang Q. Anisotropic active ligandations in siRNA-Loaded hybrid nanodiscs lead to distinct carcinostatic outcomes by regulating nano-bio interactions. Biomaterials. 2020 Apr 3;251:120008. doi: 10.1016/j.biomaterials.2020.120008. Epub ahead of print. PMID: 32388031.
PubMed ID: 32388031Van de Vyver T, Bogaert B, De Backer L, Joris F, Guagliardo R, Van Hoeck J, Merckx P, Van Calenbergh S, Ramishetti S, Peer D, Remaut K, De Smedt SC, Raemdonck K. Cationic Amphiphilic Drugs Boost the Lysosomal Escape of Small Nucleic Acid Therapeutics in a Nanocarrier-Dependent Manner. ACS Nano. 2020 Apr 28;14(4):4774-4791. doi: 10.1021/acsnano.0c00666. Epub 2020 Apr 14. PMID: 32250113.
PubMed ID: 32250113Liu HY, Pappa AM, Pavia A, Pitsalidis C, Thiburce Q, Salleo A, Owens RM, Daniel S. Self-Assembly of Mammalian-Cell Membranes on Bioelectronic Devices with Functional Transmembrane Proteins. Langmuir. 2020 Jun 22. doi: 10.1021/acs.langmuir.0c00804. Epub ahead of print. PMID: 32388991.
PubMed ID: 32388991Cheng Q, Wei T, Farbiak L, Johnson LT, Dilliard SA, Siegwart DJ. Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR-Cas gene editing. Nat Nanotechnol. 2020 Apr;15(4):313-320. doi: 10.1038/s41565-020-0669-6. Epub 2020 Apr 6. PMID: 32251383.
PubMed ID: 32251383Wang L, Liang TT. CD59 receptor targeted delivery of miRNA-1284 and cisplatin-loaded liposomes for effective therapeutic efficacy against cervical cancer cells. AMB Express. 2020 Mar 17;10(1):54. doi: 10.1186/s13568-020-00990-z. PMID: 32185543; PMCID: PMC7078418.
PubMed ID: 32185543Kim D, Han J, Park SY, Kim H, Park JH, Lee HJ. Antitumor Efficacy of Focused Ultrasound-MFL Nanoparticles Combination Therapy in Mouse Breast Cancer Xenografts. Materials (Basel). 2020 Mar 2;13(5):1099. doi: 10.3390/ma13051099. PMID: 32121631; PMCID: PMC7084991.
PubMed ID: 32121631Sheshachala S, Grösche M, Scherr T, Hu Y, Sun P, Bartschat A, Mikut R, Niemeyer CM. Segregation of Dispersed Silica Nanoparticles in Microfluidic Water-in-Oil Droplets: A Kinetic Study. Chemphyschem. 2020 Mar 6. doi: 10.1002/cphc.201901151. Epub ahead of print. PMID: 32142187.
PubMed ID: 32142187Parvathaneni V, Kulkarni NS, Shukla SK, Farrales PT, Kunda NK, Muth A, Gupta V. Systematic Development and Optimization of Inhalable Pirfenidone Liposomes for Non-Small Cell Lung Cancer Treatment. Pharmaceutics. 2020 Feb 28;12(3):206. doi: 10.3390/pharmaceutics12030206. PMID: 32121070; PMCID: PMC7150896.
PubMed ID: 32121070Li C, Li Q, Wang Z, Han X. Phospholipid Self-Assemblies Shaped Like Ancient Chinese Coins for Artificial Organelles. Anal Chem. 2020 Apr 21;92(8):6060-6064. doi: 10.1021/acs.analchem.0c00430. Epub 2020 Apr 1. PMID: 32207619.
PubMed ID: 32207619Sethuraman SN, Singh MP, Patil G, Li S, Fiering S, Hoopes PJ, Guha C, Malayer J, Ranjan A. Novel calreticulin-nanoparticle in combination with focused ultrasound induces immunogenic cell death in melanoma to enhance antitumor immunity. Theranostics. 2020 Feb 10;10(8):3397-3412. doi: 10.7150/thno.42243. PMID: 32206098; PMCID: PMC7069083.
PubMed ID: 32206098Mlynarczyk DT, Piskorz J, Popenda L, Stolarska M, Szczolko W, Konopka K, Jurga S, Sobotta L, Mielcarek J, Düzgüneş N, Goslinski T. S-seco-porphyrazine as a new member of the seco-porphyrazine family - Synthesis, characterization and photocytotoxicity against cancer cells. Bioorg Chem. 2020 Mar;96:103634. doi: 10.1016/j.bioorg.2020.103634. Epub 2020 Jan 30. PMID: 32044518.
PubMed ID: 32044518Quagliarini E, Di Santo R, Palchetti S, Ferri G, Cardarelli F, Pozzi D, Caracciolo G. Effect of Protein Corona on The Transfection Efficiency of Lipid-Coated Graphene Oxide-Based Cell Transfection Reagents. Pharmaceutics. 2020 Jan 30;12(2):113. doi: 10.3390/pharmaceutics12020113. PMID: 32019150; PMCID: PMC7076454.
PubMed ID: 32019150Leonard F, Curtis LT, Hamed AR, Zhang C, Chau E, Sieving D, Godin B, Frieboes HB. Nonlinear response to cancer nanotherapy due to macrophage interactions revealed by mathematical modeling and evaluated in a murine model via CRISPR-modulated macrophage polarization. Cancer Immunol Immunother. 2020 Feb 8. doi: 10.1007/s00262-020-02504-z. Epub ahead of print. PMID: 32036448.
PubMed ID: 32036448Salloum E, Henry-Amar M, Caillou B, Friedman S, Pico JL, Bayle C, Hayat M. Lymphoblastic lymphoma in adults: a clinicopathological study of 34 cases treated at the Institut Gustave-Roussy. Eur J Cancer Clin Oncol. 1988 Oct;24(10):1609-16. doi: 10.1016/0277-5379(88)90053-3. PMID: 3208805.
PubMed ID: 3208805Yang K, Mesquita B, Horvatovich P, Salvati A. Tuning liposome composition to modulate corona formation in human serum and cellular uptake. Acta Biomater. 2020 Apr 1;106:314-327. doi: 10.1016/j.actbio.2020.02.018. Epub 2020 Feb 17. PMID: 32081780.
PubMed ID: 32081780Huang Y, Chen Y, Zhou S, Chen L, Wang J, Pei Y, Xu M, Feng J, Jiang T, Liang K, Liu S, Song Q, Jiang G, Gu X, Zhang Q, Gao X, Chen J. Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors. Nat Commun. 2020 Jan 30;11(1):622. doi: 10.1038/s41467-020-14425-7. PMID: 32001695; PMCID: PMC6992734.
PubMed ID: 32001695Huang Y, Chen Y, Zhou S, Chen L, Wang J, Pei Y, Xu M, Feng J, Jiang T, Liang K, Liu S, Song Q, Jiang G, Gu X, Zhang Q, Gao X, Chen J. Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors. Nat Commun. 2020 Jan 30;11(1):622. doi: 10.1038/s41467-020-14425-7. PMID: 32001695; PMCID: PMC6992734.
PubMed ID: 32001695Zhen S, Liu Y, Lu J, Tuo X, Yang X, Chen H, Chen W, Li X. Human Papillomavirus Oncogene Manipulation Using Clustered Regularly Interspersed Short Palindromic Repeats/Cas9 Delivered by pH-Sensitive Cationic Liposomes. Hum Gene Ther. 2020 Feb 19:10.1089/hum.2019.312. doi: 10.1089/hum.2019.312. Epub ahead of print. PMID: 31973584.
PubMed ID: 31973584Nakamura T, Kawai M, Sato Y, Maeki M, Tokeshi M, Harashima H. The Effect of Size and Charge of Lipid Nanoparticles Prepared by Microfluidic Mixing on Their Lymph Node Transitivity and Distribution. Mol Pharm. 2020 Feb 5:10.1021/acs.molpharmaceut.9b01182. doi: 10.1021/acs.molpharmaceut.9b01182. Epub ahead of print. PMID: 31990567.
PubMed ID: 31990567Tada R, Ohshima A, Tanazawa Y, Ohmi A, Takahashi S, Kiyono H, Kunisawa J, Aramaki Y, Negishi Y. Essential Role of Host Double-Stranded DNA Released from Dying Cells by Cationic Liposomes for Mucosal Adjuvanticity. Vaccines (Basel). 2019 Dec 27;8(1):E8. doi: 10.3390/vaccines8010008. PMID: 31892192.
PubMed ID: 31892192Zhu H, Liu Q, Miao L, Musetti S, Huo M, Huang L. Remodeling the fibrotic tumor microenvironment of desmoplastic melanoma to facilitate vaccine immunotherapy. Nanoscale. 2020 Feb 7;12(5):3400-3410. doi: 10.1039/c9nr09610h. Epub 2020 Jan 28. PMID: 31989142.
PubMed ID: 31989142Huang KW, Hsu FF, Qiu JT, Chern GJ, Lee YA, Chang CC, Huang YT, Sung YC, Chiang CC, Huang RL, Lin CC, Dinh TK, Huang HC, Shih YC, Alson D, Lin CY, Lin YC, Chang PC, Lin SY, Chen Y. Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer. Sci Adv. 2020 Jan 15;6(3):eaax5032. doi: 10.1126/sciadv.aax5032. PMID: 31998834; PMCID: PMC6962042.
PubMed ID: 31998834Otosu T, Yamaguchi S. Effect of electrostatic interaction on the leaflet-specific diffusion in a supported lipid bilayer revealed by fluorescence lifetime correlation analysis. Phys Chem Chem Phys. 2020 Jan 21;22(3):1242-1249. doi: 10.1039/c9cp05833h. Epub 2019 Dec 18. PMID: 31850441.
PubMed ID: 3185441Palchetti S, Digiacomo L, Giulimondi F, Pozzi D, Peruzzi G, Ferri G, Amenitsch H, Cardarelli F, Mahmoudi M, Caracciolo G. A mechanistic explanation of the inhibitory role of the protein corona on liposomal gene expression. Biochim Biophys Acta Biomembr. 2020 Mar 1;1862(3):183159. doi: 10.1016/j.bbamem.2019.183159. Epub 2019 Dec 16. PMID: 31857070.
PubMed ID: 31857070Hussain MT, Forbes N, Perrie Y, Malik KP, Duru C, Matejtschuk P. Freeze-drying cycle optimization for the rapid preservation of protein-loaded liposomal formulations. Int J Pharm. 2020 Jan 5;573:118722. doi: 10.1016/j.ijpharm.2019.118722. Epub 2019 Nov 6. PMID: 31705976.
PubMed ID: 31705976Webb C, Khadke S, Schmidt ST, Roces CB, Forbes N, Berrie G, Perrie Y. The Impact of Solvent Selection: Strategies to Guide the Manufacturing of Liposomes Using Microfluidics. Pharmaceutics. 2019 Dec 4;11(12):653. doi: 10.3390/pharmaceutics11120653. PMID: 31817217; PMCID: PMC6955969.
PubMed ID: 31817217Gusti-Ngurah-Putu EP, Huang L, Hsu YC. Effective Combined Photodynamic Therapy with Lipid Platinum Chloride Nanoparticles Therapies of Oral Squamous Carcinoma Tumor Inhibition. J Clin Med. 2019 Dec 2;8(12):2112. doi: 10.3390/jcm8122112. PMID: 31810241; PMCID: PMC6947167.
PubMed ID: 31810241Fisher C, Obaid G, Niu C, Foltz W, Goldstein A, Hasan T, Lilge L. Liposomal Lapatinib in Combination with Low-Dose Photodynamic Therapy for the Treatment of Glioma. J Clin Med. 2019 Dec 14;8(12):2214. doi: 10.3390/jcm8122214. PMID: 31847378; PMCID: PMC6947404.
PubMed ID: 31847378Hu M, Zhou X, Wang Y, Guan K, Huang L. Relaxin-FOLFOX-IL-12 triple combination therapy engages memory response and achieves long-term survival in colorectal cancer liver metastasis. J Control Release. 2019 Dec 31;319:213-221. doi: 10.1016/j.jconrel.2019.12.053. [Epub ahead of print]. PMID: 31899270.
PubMed ID: 31899270Steffes VM, Zhang Z, MacDonald S, Crowe J, Ewert KK, Carragher B, Potter CS, Safinya CR. PEGylation of Paclitaxel-Loaded Cationic Liposomes Drives Steric Stabilization of Bicelles and Vesicles thereby Enhancing Delivery and Cytotoxicity to Human Cancer Cells. ACS Appl Mater Interfaces. 2020 Jan 8;12(1):151-162. doi: 10.1021/acsami.9b16150. Epub 2019 Dec 24. PMID: 31820904.
PubMed ID: 31820904Maoyafikuddin M, Pundir M, Thaokar R. Starch aided synthesis of giant unilamellar vesicles. Chem Phys Lipids. 2020 Jan;226:104834. doi: 10.1016/j.chemphyslip.2019.104834. Epub 2019 Nov 26.
PubMed ID: 31778665Ma X, Zhang J, Zhang Y, Liu J. Adsorption Promoted Aggregation-Induced Emission Showing Strong Dye Lateral Interactions. Langmuir. 2019 Dec 10;35(49):16304-16311. doi: 10.1021/acs.langmuir.9b02823. Epub 2019 Nov 21.
PubMed ID: 31702160Bellefroid C, Lechanteur A, Evrard B, Mottet D, Debacq-Chainiaux F, Piel G. In vitro skin penetration enhancement techniques: A combined approach of ethosomes and microneedles. Int J Pharm. 2019 Dec 15;572:118793. doi: 10.1016/j.ijpharm.2019.118793. Epub 2019 Nov 9.
PubMed ID: 31715350Xiao W, Zhang W, Huang H, Xie Y, Zhang Y, Guo X, Jin C, Liao X, Yao S, Chen G, Song X. Cancer Targeted Gene Therapy for Inhibition of Melanoma Lung Metastasis with eIF3i shRNA Loaded Liposomes. Mol Pharm. 2020 Jan 6;17(1):229-238. doi: 10.1021/acs.molpharmaceut.9b00943. Epub 2019 Dec 10.
PubMed ID: 31765158Handumrongkul C, Ye AL, Chmura SA, Soroceanu L, Mack M, Ice RJ, Thistle R, Myers M, Ursu SJ, Liu Y, Kashani-Sabet M, Heath TD, Liggitt D, Lewis DB, Debs R. Durable multitransgene expression in vivo using systemic, nonviral DNA delivery. Sci Adv. 2019 Nov 27;5(11):eaax0217. doi: 10.1126/sciadv.aax0217. eCollection 2019 Nov.
PubMed ID: 31807699Grippin AJ, Wummer B, Wildes T, Dyson K, Trivedi V, Yang C, Sebastian M, Mendez-Gomez HR, Padala S, Grubb M, Fillingim M, Monsalve A, Sayour EJ, Dobson J, Mitchell DA. Dendritic Cell-Activating Magnetic Nanoparticles Enable Early Prediction of Antitumor Response with Magnetic Resonance Imaging. ACS Nano. 2019 Dec 24;13(12):13884-13898. doi: 10.1021/acsnano.9b05037. Epub 2019 Dec 2.
PubMed ID: 31730332André EM, Delcroix GJ, Kandalam S, Sindji L, Montero-Menei CN. A Combinatorial Cell and Drug Delivery Strategy for Huntington's Disease Using Pharmacologically Active Microcarriers and RNAi Neuronally-Committed Mesenchymal Stromal Cells. Pharmaceutics. 2019 Oct 12;11(10). pii: E526. doi: 10.3390/pharmaceutics11100526.
PubMed ID: 31614758Giorgia La Barbera, Anna Laura Capriotti, Giulio Caracciolo, Chiara Cavaliere, Andrea Cerrato, Carmela Maria Montone, Susy Piovesana, Daniela Pozzi, Erica Quagliarini, Aldo Laganà. A comprehensive analysis of liposomal biomolecular corona upon human plasma incubation: The evolution towards the lipid corona. Talanta. 2019 Oct 22. doi: 10.1016/j.talanta.2019.120487
Wiedenhoeft T, Tarantini S, Nyúl-Tóth Á, Yabluchanskiy A, Csipo T, Balasubramanian P, Lipecz A, Kiss T, Csiszar A, Csiszar A, Ungvari Z. Fusogenic liposomes effectively deliver resveratrol to the cerebral microcirculation and improve endothelium-dependent neurovascular coupling responses in aged mice. Geroscience. 2019 Oct 25. doi: 10.1007/s11357-019-00102-1. [Epub ahead of print]
PubMed ID: 31654270Luan J, Chen W, Fan J, Wang S, Zhang X, Zai W, Jin X, Wang Y, Feng Z, Zhang J, Liu ML, Ju D. GSDMD membrane pore is critical for IL-1β release and antagonizing IL-1β by hepatocyte-specific nanobiologics is a promising therapeutics for murine alcoholic steatohepatitis. Biomaterials. 2020 Jan;227:119570. doi: 10.1016/j.biomaterials.2019.119570. Epub 2019 Oct 21.
PubMed ID: 31670032Wheat W, Chow L, Kuzmik A, Soontararak S, Kurihara J, Lappin M, Dow S. Local immune and microbiological responses to mucosal administration of a Liposome-TLR agonist immunotherapeutic in dogs. BMC Vet Res. 2019 Sep 13;15(1):330. doi: 10.1186/s12917-019-2073-8.
PubMed ID: 31519215Wheat W, Chow L, Kuzmik A, Soontararak S, Kurihara J, Lappin M, Dow S. Local immune and microbiological responses to mucosal administration of a Liposome-TLR agonist immunotherapeutic in dogs. BMC Vet Res. 2019 Sep 13;15(1):330. doi: 10.1186/s12917-019-2073-8.
PubMed ID: 31519215Hibbitts A, Lucía A, Serrano-Sevilla I, De Matteis L, McArthur M, de la Fuente JM, Aínsa JA, Navarro F. Co-delivery of free vancomycin and transcription factor decoy-nanostructured lipid carriers can enhance inhibition of methicillin resistant Staphylococcus aureus (MRSA). PLoS One. 2019 Sep 3;14(9):e0220684. doi: 10.1371/journal.pone.0220684. eCollection 2019.
PubMed ID: 31479462Ravi V, Madhankumar AB, Abraham T, Slagle-Webb B, Connor JR. Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms. PLoS One. 2019 Sep 6;14(9):e0221952. doi: 10.1371/journal.pone.0221952. eCollection 2019.
PubMed ID: 31491006Kono Y, Gogatsubo S, Ohba T, Fujita T. Enhanced macrophage delivery to the colon using magnetic lipoplexes with a magnetic field. Drug Deliv. 2019 Dec;26(1):935-943. doi: 10.1080/10717544.2019.1662515.
PubMed ID: 31530198O'Mary HL, Hanafy MS, Aldayel AM, Valdes SA, Alzhrani RF, Hufnagel S, Koleng JJ, Cui Z. Effect of the Ratio of Betamethasone to TNF-α siRNA Coencapsulated in Solid Lipid Nanoparticles on the Acute Proinflammatory Activity of the Nanoparticles. Mol Pharm. 2019 Sep 30. doi: 10.1021/acs.molpharmaceut.9b00629. [Epub ahead of print]
PubMed ID: 31525980Xu F, Yan JJ, Gan Y, Chang Y, Wang HL, He XX, Zhao Q. miR-885-5p Negatively Regulates Warburg Effect by Silencing Hexokinase 2 in Liver Cancer. Mol Ther Nucleic Acids. 2019 Sep 12;18:308-319. doi: 10.1016/j.omtn.2019.09.002. [Epub ahead of print]
PubMed ID: 31614321Kimura S, Khalil IA, Elewa YHA, Harashima H. Spleen selective enhancement of transfection activities of plasmid DNA driven by octaarginine and an ionizable lipid and its implications for cancer immunization. J Control Release. 2019 Sep 14. pii: S0168-3659(19)30550-4. doi: 10.1016/j.jconrel.2019.09.009. [Epub ahead of print]
PubMed ID: 31526828Zhang D, Baldwin P, Leal AS, Carapellucci S, Sridhar S, Liby KT. A nano-liposome formulation of the PARP inhibitor Talazoparib enhances treatment efficacy and modulates immune cell populations in mammary tumors of BRCA-deficient mice. Theranostics. 2019 Aug 14;9(21):6224-6238. doi: 10.7150/thno.36281. eCollection 2019.
PubMed ID: 31534547Fan Y, Stronsky SM, Xu Y, Steffens JT, van Tongeren SA, Erwin A, Cooper CL, Moon JJ. Multilamellar Vaccine Particle Elicits Potent Immune Activation with Protein Antigens and Protects Mice against Ebola Virus Infection. ACS Nano. 2019 Sep 12. doi: 10.1021/acsnano.9b03660. [Epub ahead of print]
PubMed ID: 31497947Hattori Y, Nakagawa Y, Onishi H. Gene delivery into hepatic cells with ternary complexes of plasmid DNA, cationic liposomes and apolipoprotein E-derived peptide. Exp Ther Med. 2019 Oct;18(4):2628-2638. doi: 10.3892/etm.2019.7863. Epub 2019 Aug 7.
PubMed ID: 31572511Inglut CT, Gaitan B, Najafali D, Abad Lopez I, Connolly NP, Orsila S, Perttilä R, Woodworth GF, Chen Y, Huang HC. Predictors and Limitations of the Penetration Depth of Photodynamic Effects in the Rodent Brain. Photochem Photobiol. 2019 Aug 23. doi: 10.1111/php.13155. [Epub ahead of print]
PubMed ID: 31441057Jõemetsa S, Spustova K, Kustanovich K, Ainla A, Schindler S, Eigler S, Lobovkina T, Lara-Avila S, Jesorka A, Gözen I. Molecular Lipid Films on Microengineering Materials. Langmuir. 2019 Aug 13;35(32):10286-10298. doi: 10.1021/acs.langmuir.9b01120. Epub 2019 Aug 1.
PubMed ID: 31369272Bouxsein NF, Leal C, McAllister CS, Li Y, Ewert KK, Samuel CE, Safinya CR. 3D Columnar Phase of Stacked Short DNA Organized by Coherent Membrane Undulations. Langmuir. 2019 Sep 10;35(36):11891-11901. doi: 10.1021/acs.langmuir.9b01726. Epub 2019 Aug 22.
PubMed ID: 31408350Li W, Yan R, Liu Y, He C, Zhang X, Lu Y, Khan MW, Xu C, Yang T, Xiang G. Co-delivery of Bmi1 small interfering RNA with ursolic acid by folate receptor-targeted cationic liposomes enhances anti-tumor activity of ursolic acid in vitro and in vivo. Drug Deliv. 2019 Dec;26(1):794-802. doi: 10.1080/10717544.2019.1645244.
PubMed ID: 31366257Yang H, Liu Z, Song Y, Hu C. Hyaluronic acid-functionalized bilosomes for targeted delivery of tripterine to inflamed area with enhancive therapy on arthritis. Drug Deliv. 2019 Dec;26(1):820-830. doi: 10.1080/10717544.2019.1636423.
PubMed ID: 31389248N'Diaye M, Vergnaud-Gauduchon J, Nicolas V, Faure V, Denis S, Abreu S, Chaminade P, Rosilio V. Mol Pharm. 2019 Sep 3;16(9):4045-4058. doi: 10.1021/acs.molpharmaceut.9b00797. Epub 2019 Aug 13. Hybrid Lipid Polymer Nanoparticles for Combined Chemo- and Photodynamic Therapy.
PubMed ID: 31361499Bruna dos Santos Rodrigues, Sushant Lakkadwala, Takahisa Kanekiyo, Jagdish Singh. Development and screening of brain-targeted lipid-based nanoparticles with enhanced cell penetration and gene delivery properties. International Journal of Nanomedicine; Macclesfield Vol. 14, (2019): 6497-6517. DOI:10.2147/IJN.S215941
Einhäupl P, Krook J, Svensson N, Van Acker K, Van Passel S. Eliciting stakeholder needs - An anticipatory approach assessing enhanced landfill mining. Waste Manag. 2019 Oct;98:113-125. doi: 10.1016/j.wasman.2019.08.009. Epub 2019 Aug 21.
PubMed ID: 31445456Takechi-Haraya Y, Goda Y, Izutsu K, Sakai-Kato K. Improved Atomic Force Microscopy Stiffness Measurements of Nanoscale Liposomes by Cantilever Tip Shape Evaluation. Anal Chem. 2019 Aug 20;91(16):10432-10440. doi: 10.1021/acs.analchem.9b00250. Epub 2019 Aug 7.
PubMed ID: 31390864Thanki K, van Eetvelde D, Geyer A, Fraire J, Hendrix R, Van Eygen H, Putteman E, Sami H, de Souza Carvalho-Wodarz C, Franzyk H, Nielsen HM, Braeckmans K, Lehr CM, Ogris M, Foged C. Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration. J Control Release. 2019 Sep 28;310:82-93. doi: 10.1016/j.jconrel.2019.08.004. Epub 2019 Aug 6.
PubMed ID: 31398360Melo M, Porter E, Zhang Y, Silva M, Li N, Dobosh B, Liguori A, Skog P, Landais E, Menis S, Sok D, Nemazee D, Schief WR, Weiss R, Irvine DJ. Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles. Mol Ther. 2019 Aug 19. pii: S1525-0016(19)30367-3. doi: 10.1016/j.ymthe.2019.08.007. [Epub ahead of print]
Bae J, Parayath N, Ma W, Amiji M, Munshi N, Anderson K. BCMA peptide-engineered nanoparticles enhance induction and function of antigen-specific CD8+ cytotoxic T lymphocytes against multiple myeloma: clinical applications. Leukemia. 2019 Aug 19. doi: 10.1038/s41375-019-0540-7. [Epub ahead of print]
PubMed ID: 31427721Giulimondi F, Digiacomo L, Pozzi D, Palchetti S, Vulpis E, Capriotti AL, Chiozzi RZ, Laganà A, Amenitsch H, Masuelli L, Mahmoudi M, Screpanti I, Zingoni A, Caracciolo G. Interplay of protein corona and immune cells controls blood residency of liposomes. Nat Commun. 2019 Aug 15;10(1):3686. doi: 10.1038/s41467-019-11642-7.
PubMed ID: 31417080Komura F, Takahashi Y, Inoue T, Takakura Y, Nishikawa M. Development of a Nanostructured RNA/DNA Assembly as an Adjuvant Targeting Toll-Like Receptor 7/8. Nucleic Acid Ther. 2019 Jul 18. doi: 10.1089/nat.2019.0787. [Epub ahead of print]
PubMed ID: 31329033Ghellab SE, Mu W, Li Q, Han X. Prediction of the size of electroformed giant unilamellar vesicle using response surface methodology. Biophys Chem. 2019 Oct;253:106217. doi: 10.1016/j.bpc.2019.106217. Epub 2019 Jul 4.
PubMed ID: 31306917Blakney AK, McKay PF, Yus BI, Aldon Y, Shattock RJ. Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA. Gene Ther. 2019 Sep;26(9):363-372. doi: 10.1038/s41434-019-0095-2. Epub 2019 Jul 12.
PubMed ID: 31300730Xu H, Chen B, Gong W, Yang Z, Qu J. Nanoliposomes Co-Encapsulating Photoswitchable Probe and Photosensitizer for Super-Resolution Optical Imaging and Photodynamic Therapy. Cytometry A. 2019 Jul 16. doi: 10.1002/cyto.a.23864. [Epub ahead of print]
PubMed ID: 31313510Mohamed A, Pekoz AY, Ross K, Hutcheon GA, Saleem IY. Pulmonary delivery of Nanocomposite Microparticles (NCMPs) incorporating miR-146a for treatment of COPD. Int J Pharm. 2019 Oct 5;569:118524. doi: 10.1016/j.ijpharm.2019.118524. Epub 2019 Jul 15.
PubMed ID: 31319144Katayama T, Kinugawa S, Takada S, Furihata T, Fukushima A, Yokota T, Anzai T, Hibino M, Harashima H, Yamada Y. A mitochondrial delivery system using liposome-based nanocarriers that target myoblast cells. Mitochondrion. 2019 Jul 19;49:66-72. doi: 10.1016/j.mito.2019.07.005. [Epub ahead of print]
PubMed ID: 31326598Girish V, Pazzi J, Li A, Subramaniam AB. Fabrics of Diverse Chemistries Promote the Formation of Giant Vesicles from Phospholipids and Amphiphilic Block Copolymers. Langmuir. 2019 Jul 16;35(28):9264-9273. doi: 10.1021/acs.langmuir.9b01621. Epub 2019 Jul 5.
PubMed ID: 31276413Wang F, Sun Y, Shi J. Programmed death-ligand 1 monoclonal antibody-linked immunoliposomes for synergistic efficacy of miR-130a and oxaliplatin in gastric cancers. Nanomedicine (Lond). 2019 Jul;14(13):1729-1744. doi: 10.2217/nnm-2019-0073. Epub 2019 Jul 10.
PubMed ID: 31290727Villamizar O, Waters SA, Scott T, Saayman S, Grepo N, Urak R, Davis A, Jaffe A, Morris KV. Targeted Activation of Cystic Fibrosis Transmembrane Conductance Regulator. Mol Ther. 2019 Jul 15. pii: S1525-0016(19)30314-4. doi: 10.1016/j.ymthe.2019.07.002. [Epub ahead of print]
PubMed ID: 31383454Villamizar O, Waters SA, Scott T, Saayman S, Grepo N, Urak R, Davis A, Jaffe A, Morris KV. Targeted Activation of Cystic Fibrosis Transmembrane Conductance Regulator. Mol Ther. 2019 Jul 15. pii: S1525-0016(19)30314-4. doi: 10.1016/j.ymthe.2019.07.002. [Epub ahead of print]
PubMed ID: 31383454Moro M, Di Paolo D, Milione M, Centonze G, Bornaghi V, Borzi C, Gandellini P, Perri P, Pastorino U, Ponzoni M, Sozzi G, Fortunato O. Coated cationic lipid-nanoparticles entrapping miR-660 inhibit tumor growth in patient-derived xenografts lung cancer models. J Control Release. 2019 Jul 9;308:44-56. doi: 10.1016/j.jconrel.2019.07.006. [Epub ahead of print]
PubMed ID: 31299263Park J, Kuo Y, Li J, Huang YL, Miller EW, Weiss S. Improved Surface Functionalization and Characterization of Membrane-Targeted Semiconductor Voltage Nanosensors. J Phys Chem Lett. 2019 Jul 18;10(14):3906-3913. doi: 10.1021/acs.jpclett.9b01258. Epub 2019 Jul 1.
PubMed ID: 31241960Kim B, Sun S, Varner JA, Howell SB, Ruoslahti E, Sailor MJ. Securing the Payload, Finding the Cell, and Avoiding the Endosome: Peptide-Targeted, Fusogenic Porous Silicon Nanoparticles for Delivery of siRNA. Adv Mater. 2019 Jul 3:e1902952. doi: 10.1002/adma.201902952. [Epub ahead of print]
PubMed ID: 31267590Tunsirikongkon A, Pyo YC, Kim DH, Lee SE, Park JS. Optimization of Polyarginine-Conjugated PEG Lipid Grafted Proliposome Formulation for Enhanced Cellular Association of a Protein Drug. Pharmaceutics. 2019 Jun 11;11(6). pii: E272. doi: 10.3390/pharmaceutics11060272.
PubMed ID: 31212607Yoshiyuki Hattori, Kyoko Tamaki, Kei-ichi Ozaki, Kumi Kawano, Hiraku Onishi. Optimized combination of cationic lipids and neutral helper lipids in cationic liposomes for siRNA delivery into the lung by intravenous injection of siRNA lipoplexes. Journal of Drug Delivery Science and Technology. 2019 August;52:1042-1050.
Hattori Y, Hu S, Onishi H. Effects of cationic lipids in cationic liposomes and disaccharides in the freeze-drying of siRNA lipoplexes on gene silencing in cells by reverse transfection. J Liposome Res. 2019 Jul 5:1-11. doi: 10.1080/08982104.2019.1630643. [Epub ahead of print]
PubMed ID: 31185779Juanes M, Creese O, Fernández-Trillo P, Montenegro J. Messenger RNA delivery by hydrazone-activated polymers. Medchemcomm. 2019 Jun 18;10(7):1138-1144. doi: 10.1039/c9md00231f. eCollection 2019 Jul 1.
PubMed ID: 31391886Sakurai Y, Kato A, Hida Y, Hamada J, Maishi N, Hida K, Harashima H. Synergistic Enhancement of Cellular Uptake With CD44-Expressing Malignant Pleural Mesothelioma by Combining Cationic Liposome and Hyaluronic Acid-Lipid Conjugate. J Pharm Sci. 2019 Jun 21. pii: S0022-3549(19)30382-X. doi: 10.1016/j.xphs.2019.06.012. [Epub ahead of print]
PubMed ID: 31229434Lu Y, Zhong L, Jiang Z, Pan H, Zhang Y, Zhu G, Bai L, Tong R, Shi J, Duan X. Cationic micelle-based siRNA delivery for efficient colon cancer gene therapy. Nanoscale Res Lett. 2019 Jun 4;14(1):193. doi: 10.1186/s11671-019-2985-z.
PubMed ID: 31165329Mendonça MCP, Radaic A, Garcia-Fossa F, da Cruz-Höfling MA, Vinolo MAR, de Jesus MB. The in vivo toxicological profile of cationic solid lipid nanoparticles. Drug Deliv Transl Res. 2019 Jun 25. doi: 10.1007/s13346-019-00657-8. [Epub ahead of print]
PubMed ID: 31240624Landry MR, Rangel JL, Dao VP, MacKenzie MA, Gutierrez FL, Dowell KM, Calkins AL, Fuller AA, Stokes GY. Length and Charge of Water-Soluble Peptoids Impact Binding to Phospholipid Membranes. J Phys Chem B. 2019 Jul 11;123(27):5822-5831. doi: 10.1021/acs.jpcb.9b04641. Epub 2019 Jun 28.
PubMed ID: 31251622Riccardo Di Santo, Erica Quagliarini, Sara Palchetti, Daniela Pozzi, Valentina Palmieri, Giordano Perini, Massimiliano Papi, Anna Laura Capriotti, Aldo Laganà, and Giulio Caracciolo. Microfluidic-generated lipid-graphene oxide nanoparticles for gene delivery. Appl. Phys. Lett. 114, 233701 (2019). doi: 10.1063/1.5100932
Dos Santos Rodrigues B, Banerjee A, Kanekiyo T, Singh J. Functionalized liposomal nanoparticles for efficient gene delivery system to neuronal cell transfection. Int J Pharm. 2019 Jul 20;566:717-730. doi: 10.1016/j.ijpharm.2019.06.026. Epub 2019 Jun 13.
PubMed ID: 31202901Kim SS, Harford JB, Moghe M, Slaughter T, Doherty C, Chang EH. A tumor-targeting nanomedicine carrying the p53 gene crosses the blood-brain barrier and enhances anti-PD-1 immunotherapy in mouse models of glioblastoma. Int J Cancer. 2019 Jun 26. doi: 10.1002/ijc.32531. [Epub ahead of print]
PubMed ID: 31241175Han WB, Kang DH, Na JH, Yu YG, Kim TS. Enhancement of membrane protein reconstitution on 3D free-standing lipid bilayer array in a microfluidic channel. Biosens Bioelectron. 2019 Jun 6;141:111404. doi: 10.1016/j.bios.2019.111404. [Epub ahead of print]
PubMed ID: 31202186Lakkadwala S, Dos Santos Rodrigues B, Sun C, Singh J. Dual functionalized liposomes for efficient co-delivery of anti-cancer chemotherapeutics for the treatment of glioblastoma. J Control Release. 2019 Jun 26;307:247-260. doi: 10.1016/j.jconrel.2019.06.033. [Epub ahead of print]
PubMed ID: 31252036Baldwin P, Ohman AW, Medina JE, McCarthy ET, Dinulescu DM, Sridhar S. Nanoformulation of Talazoparib Delays Tumor Progression and Ascites Formation in a Late Stage Cancer Model. Front Oncol. 2019 May 10;9:353. doi: 10.3389/fonc.2019.00353. eCollection 2019.
PubMed ID: 31134152Won Il Choi, Abhishek Sahu, Frederik R. Wurm, and Seong-Min Jo. Magnetoliposomes with size controllable insertion of magnetic nanoparticles for efficient targeting of cancer cells. (Paper) RSC Adv., 2019, 9, 15053-15060. doi: 10.1039/C9RA02529D
Zhang M, Wang Q, Wan KW, Ahmed W, Phoenix DA, Zhang Z, Elrayess MA, Elhissi A, Sun X. Liposome mediated-CYP1A1 gene silencing nanomedicine prepared using lipid film-coated proliposomes as a potential treatment strategy of lung cancer. Int J Pharm. 2019 Jul 20;566:185-193. doi: 10.1016/j.ijpharm.2019.04.078. Epub 2019 Apr 30.
PubMed ID: 31051230Velasco-Olmo A, Ormaetxea Gisasola J, Martinez Galvez JM, Vera Lillo J, Shnyrova AV. Combining patch-clamping and fluorescence microscopy for quantitative reconstitution of cellular membrane processes with Giant Suspended Bilayers. Sci Rep. 2019 May 10;9(1):7255. doi: 10.1038/s41598-019-43561-4.
PubMed ID: 31076583Wang X, Hua Y, Xu G, Deng S, Yang D, Gao X. Targeting EZH2 for glioma therapy with a novel nanoparticle-siRNA complex. Int J Nanomedicine. 2019 Apr 15;14:2637-2653. doi: 10.2147/IJN.S189871. eCollection 2019.
PubMed ID: 31043779Zhang X, Men K, Zhang Y, Zhang R, Yang L, Duan X. Local and systemic delivery of mRNA encoding survivin-T34A by lipoplex for efficient colon cancer gene therapy. Int J Nanomedicine. 2019 Apr 23;14:2733-2751. doi: 10.2147/IJN.S198747. eCollection 2019.
PubMed ID: 31118608Giannakou C, Aimonen K, Bloois LV, Catalán J, Geertsma RE, Gremmer ER, de Jong WH, Keizers PH, Schwillens PL, Vandebriel RJ, Park MV. Sensitive method for endotoxin determination in nanomedicinal product samples. Nanomedicine (Lond). 2019 May;14(10):1231-1246. doi: 10.2217/nnm-2018-0339.
PubMed ID: 31050581Baglo Y, Liang BJ, Robey RW, Ambudkar SV, Gottesman MM, Huang HC. Porphyrin-lipid assemblies and nanovesicles overcome ABC transporter-mediated photodynamic therapy resistance in cancer cells. Cancer Lett. 2019 Aug 10;457:110-118. doi: 10.1016/j.canlet.2019.04.037. Epub 2019 May 6.
PubMed ID: 31071369Armin Tahmasbi Rad, Shipra Malik, Lin Yang, Tripat Kaur Oberoi-Khanuja, Mu-Ping Nieh, and Raman Bahal. A universal discoidal nanoplatform for the intracellular delivery of PNAs. Nanoscale, 2019, Advance Article. doi: 10.1039/C9NR03667A
Li M, Xie H, Liu Y, Xia C, Cun X, Long Y, Chen X, Deng M, Guo R, Zhang Z, He Q. Knockdown of hypoxia-inducible factor-1 alpha by tumor targeted delivery of CRISPR/Cas9 system suppressed the metastasis of pancreatic cancer. J Control Release. 2019 May 14;304:204-215. doi: 10.1016/j.jconrel.2019.05.019. [Epub ahead of print]
PubMed ID: 31100311Blakney AK, McKay PF, Ibarzo Yus B, Hunter JE, Dex EA, Shattock RJ. The Skin You Are In: Design-of-Experiments Optimization of Lipid Nanoparticle Self-Amplifying RNA Formulations in Human Skin Explants. ACS Nano. 2019 May 28;13(5):5920-5930. doi: 10.1021/acsnano.9b01774. Epub 2019 May 3.
PubMed ID: 31046232Kurimoto S, Yoshinaga N, Igarashi K, Matsumoto Y, Cabral H, Uchida S. PEG-OligoRNA Hybridization of mRNA for Developing Sterically Stable Lipid Nanoparticles toward In Vivo Administration. Molecules. 2019 Apr 3;24(7). pii: E1303. doi: 10.3390/molecules24071303.
PubMed ID: 30987102Fang Y, Vadlamudi M, Huang Y, Guo X. Lipid-Coated, pH-Sensitive Magnesium Phosphate Particles for Intracellular Protein Delivery. Pharm Res. 2019 Apr 11;36(6):81. doi: 10.1007/s11095-019-2607-6.
PubMed ID: 30976936Torrecilla J, Gómez-Aguado I, Vicente-Pascual M, Del Pozo-Rodríguez A, Solinís MÁ, Rodríguez-Gascón A. MMP-9 Downregulation with Lipid Nanoparticles for Inhibiting Corneal Neovascularization by Gene Silencing. Nanomaterials (Basel). 2019 Apr 18;9(4). pii: E631. doi: 10.3390/nano9040631.
PubMed ID: 31003493Gholamian Dehkordi N, Elahian F, Khosravian P, Mirzaei SA. Intelligent TAT-coupled anti-HER2 immunoliposomes knock downed MDR1 to produce chemosensitize phenotype of multidrug resistant carcinoma. J Cell Physiol. 2019 Apr 18. doi: 10.1002/jcp.28683. [Epub ahead of print]
PubMed ID: 31001890Rasmus Eliasen, Thomas L. Andresen, Jannik B. Larsen. PEG‐Lipid Post Insertion into Drug Delivery Liposomes Quantified at the Single Liposome Level. Advanced Materials Interfaces. 2019 April 03. doi: 10.1002/admi.201801807
Yao Y, Wang T, Liu Y, Zhang N. Co-delivery of sorafenib and VEGF-siRNA via pH-sensitive liposomes for the synergistic treatment of hepatocellular carcinoma. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1374-1383. doi: 10.1080/21691401.2019.1596943.
PubMed ID: 30977418Patel S, Ryals RC, Weller KK, Pennesi ME, Sahay G. Lipid nanoparticles for delivery of messenger RNA to the back of the eye. J Control Release. 2019 Apr 12;303:91-100. doi: 10.1016/j.jconrel.2019.04.015. [Epub ahead of print]
PubMed ID: 30986436Blakney AK, McKay PF, Ibarzo Yus B, Hunter JE, Dex EA, Shattock RJ. The Skin You're In: Design of Experiments Optimization of Lipid Nanoparticle Self-Amplifying RNA Formulations in Human Skin Explants. ACS Nano. 2019 May 2. doi: 10.1021/acsnano.9b01774. [Epub ahead of print]
PubMed ID: 31046232Dewitte H, Roovers S, De Smedt SC, Lentacker I. Enhancing Nucleic Acid Delivery with Ultrasound and Microbubbles. Methods Mol Biol. 2019;1943:241-251. doi: 10.1007/978-1-4939-9092-4_16.
PubMed ID: 30838621Kommineni N, Mahira S, Domb AJ, Khan W. Cabazitaxel-Loaded Nanocarriers for Cancer Therapy with Reduced Side Effects. Pharmaceutics. 2019 Mar 25;11(3). pii: E141. doi: 10.3390/pharmaceutics11030141.
PubMed ID: 30934535Barzegari Firouzabadi F, Oryan SH, Sheikhha MH, Kalantar SM, Javed A. Preparation and Evaluation of A Novel Liposomal Nano-Formulation in Metastatic Cancer Treatment Studies. Cell J. 2019 Jul;21(2):135-142. doi: 10.22074/cellj.2019.6008. Epub 2019 Feb 20.
PubMed ID: 30825286Walunj M, Doppalapudi S, Bulbake U, Khan W. Preparation, characterization, and in vivo evaluation of cyclosporine cationic liposomes for the treatment of psoriasis. J Liposome Res. 2019 Mar 21:1-12. doi: 10.1080/08982104.2019.1593449. [Epub ahead of print]
PubMed ID: 30897993Höfer CT, Di Lella S, Dahmani I, Jungnick N, Bordag N, Bobone S, Huang Q, Keller S, Herrmann A, Chiantia S. Structural determinants of the interaction between influenza A virus matrix protein M1 and lipid membranes. Biochim Biophys Acta Biomembr. 2019 Mar 20;1861(6):1123-1134. doi: 10.1016/j.bbamem.2019.03.013. [Epub ahead of print]
PubMed ID: 30902626Maqbool F, Moyle PM, Thurecht KJ, Falconer JR. Dispersibility of phospholipids and their optimization for the efficient production of liposomes using supercritical fluid technology. Int J Pharm. 2019 Mar 30;563:174-183. doi: 10.1016/j.ijpharm.2019.03.053. [Epub ahead of print]
PubMed ID: 30940503Bilan Wang, Daoke Yang, Yangmei Shen. Anti-colon cancer effect of matrix protein gene therapy with nanoparticles. Polymer. 2019 April 29;170:148-156. doi: 10.1016/j.polymer.2019.03.023
Holm A, Kunz L, Riscoe AR, Kao KC, Cargnello M, Frank CW. General Self-Assembly Method for Deposition of Graphene Oxide into Uniform Close-Packed Monolayer Films. Langmuir. 2019 Apr 2;35(13):4460-4470. doi: 10.1021/acs.langmuir.8b03994. Epub 2019 Mar 19.
PubMed ID: 30836748Hasan M, Hama S, Kogure K. Low Electric Treatment activates Rho GTPase via Heat Shock Protein 90 and Protein Kinase C for Intracellular Delivery of siRNA. Sci Rep. 2019 Mar 11;9(1):4114. doi: 10.1038/s41598-019-40904-z.
PubMed ID: 30858501Jacobs D, Hoogerheide DP, Rovini A, Jiang Z, Lee JC, Rostovtseva TK, Bezrukov SM. Probing Membrane Association of α-Synuclein Domains with VDAC Nanopore Reveals Unexpected Binding Pattern. Sci Rep. 2019 Mar 14;9(1):4580. doi: 10.1038/s41598-019-40979-8.
PubMed ID: 30872688Tan X, Fang Y, Ren Y, Li Y, Wu P, Yang X, Liu W. D-α-tocopherol polyethylene glycol 1000 succinate-modified liposomes with an siRNA corona confer enhanced cellular uptake and targeted delivery of doxorubicin via tumor priming. Int J Nanomedicine. 2019 Feb 18;14:1255-1268. doi: 10.2147/IJN.S191858. eCollection 2019.
PubMed ID: 30863058Lu X, Liu J, Gou L, Li J, Yuan B, Yang K, Ma Y. Designing Melittin-Graphene Hybrid Complexes for Enhanced Antibacterial Activity. Adv Healthc Mater. 2019 Mar 13:e1801521. doi: 10.1002/adhm.201801521. [Epub ahead of print]
PubMed ID: 30866165Andey T, Bora-Singhal N, Chellappan SP, Singh M. Cationic lipoplexes for treatment of cancer stem cell-derived murine lung tumors. Nanomedicine. 2019 Mar 1;18:31-43. doi: 10.1016/j.nano.2019.02.007. [Epub ahead of print]
PubMed ID: 30831275Zhu D, Hu C, Fan F, Qin Y, Huang C, Zhang Z, Lu L, Wang H, Sun H, Leng X, Wang C, Kong D, Zhang L. Co-delivery of antigen and dual agonists by programmed mannose-targeted cationic lipid-hybrid polymersomes for enhanced vaccination. Biomaterials. 2019 Mar 20;206:25-40. doi: 10.1016/j.biomaterials.2019.03.012. [Epub ahead of print]
PubMed ID: 30925286Xu H, Ohulchanskyy TY, Yakovliev A, Zinyuk R, Song J, Liu L, Qu J, Yuan Z. Nanoliposomes Co-Encapsulating CT Imaging Contrast Agent and Photosensitizer for Enhanced, Imaging Guided Photodynamic Therapy of Cancer. Theranostics. 2019 Feb 12;9(5):1323-1335. doi: 10.7150/thno.31079. eCollection 2019.
PubMed ID: 30867833Lukasz Sobotta, Sebastian Lijewski, Jolanta Dlugaszewska, Joanna Nowicka, Jadwiga Mielcarek, Tomasz Goslinski. Photodynamic inactivation of Enterococcus faecalis by conjugates of zinc(II) phthalocyanines with thymol and carvacrol loaded into lipid vesicles. Inorganica Chimica Acta. 2019 April 1;489:180-189. doi: 10.1016/j.ica.2019.02.031
Wheat W, Chow L, Coy J, Contreras E, Lappin M, Dow S. Activation of upper respiratory tract mucosal innate immune responses in cats by liposomal toll-like receptor ligand complexes delivered topically. J Vet Intern Med. 2019 Mar;33(2):838-845. doi: 10.1111/jvim.15426. Epub 2019 Feb 15.
PubMed ID: 30770582Lukasz Sobotta, Jolanta Dlugaszewska, Daniel Ziental, Wojciech Szczolko, Tomasz Koczorowski, Tomasz Goslinski, Jadwiga Mielcarek. Optical properties of a series of pyrrolyl-substituted porphyrazines and their photoinactivation potential against Enterococcus faecalis after incorporation into liposomes. Journal of Photochemistry and Photobiology A: Chemistry. 2019 January 1;368:104-109. doi: 10.1016/j.jphotochem.2018.09.015
Wui SR, Kim KS, Ryu JI, Ko A, Do HTT, Lee YJ, Kim HJ, Lim SJ, Park SA, Cho YJ, Kim CG, Lee NG. Efficient induction of cell-mediated immunity to varicella-zoster virus glycoprotein E co-lyophilized with a cationic liposome-based adjuvant in mice. Vaccine. 2019 Apr 3;37(15):2131-2141. doi: 10.1016/j.vaccine.2019.02.048. Epub 2019 Feb 28.
PubMed ID: 30827737Gomes FO, Maia LB, Loureiro JA, Pereira MC, Delerue-Matos C, Moura I, Moura JJG, Morais S. Biosensor for direct bioelectrocatalysis detection of nitric oxide using nitric oxide reductase incorporated in carboxylated single-walled carbon nanotubes/lipidic 3 bilayer nanocomposite. Bioelectrochemistry. 2019 Feb 5;127:76-86. doi: 10.1016/j.bioelechem.2019.01.010. [Epub ahead of print]
PubMed ID: 30745281Sakai-Kato K, Yoshida K, Izutsu KI. Effect of surface charge on the size-dependent cellular internalization of liposomes. Chem Phys Lipids. 2019 Jan 17. pii: S0009-3084(18)30137-3. doi: 10.1016/j.chemphyslip.2019.01.004. [Epub ahead of print]
PubMed ID: 30660745Hillyer LM, Woodward B. Acutely malnourished weanling mice administered Flt3 ligand can support a cell-mediated inflammatory response. Cytokine. 2019 Jan;113:39-49. doi: 10.1016/j.cyto.2018.06.004. Epub 2018 Jul 7.
PubMed ID: 30539781Lira RB, Robinson T, Dimova R, Riske KA. Highly Efficient Protein-free Membrane Fusion: A Giant Vesicle Study. Biophys J. 2019 Jan 8;116(1):79-91. doi: 10.1016/j.bpj.2018.11.3128. Epub 2018 Dec 1.
PubMed ID: 30579564Lakkadwala S, Singh J. Co-delivery of doxorubicin and erlotinib through liposomal nanoparticles for glioblastoma tumor regression using an in vitro brain tumor model. Colloids Surf B Biointerfaces. 2019 Jan 1;173:27-35. doi: 10.1016/j.colsurfb.2018.09.047. Epub 2018 Sep 21.
PubMed ID: 30261346Kumagai A, Dupuy FG, Arsov Z, Elhady Y, Moody D, Ernst RK, Deslouches B, Montelaro RC, Peter Di Y, Tristram-Nagle S. Elastic behavior of model membranes with antimicrobial peptides depends on lipid specificity and d-enantiomers. Soft Matter. 2019 Feb 20;15(8):1860-1868. doi: 10.1039/c8sm02180e.
PubMed ID: 30702120Zhang Y, Bush X, Yan B, Chen JA. Gemcitabine nanoparticles promote antitumor immunity against melanoma. Biomaterials. 2019 Jan;189:48-59. doi: 10.1016/j.biomaterials.2018.10.022. Epub 2018 Oct 20.
PubMed ID: 30388589Amdursky N, Lin Y, Aho N, Groenhof G. Exploring fast proton transfer events associated with lateral proton diffusion on the surface of membranes. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2443-2451. doi: 10.1073/pnas.1812351116. Epub 2019 Jan 24.
PubMed ID: 30679274Guan S, Munder A, Hedtfeld S, Braubach P, Glage S, Zhang L, Lienenklaus S, Schultze A, Hasenpusch G, Garrels W, Stanke F, Miskey C, Johler SM, Kumar Y, Tümmler B, Rudolph C, Ivics Z, Rosenecker J. Self-assembled peptide-poloxamine nanoparticles enable in vitro and in vivo genome restoration for cystic fibrosis. Nat Nanotechnol. 2019 Mar;14(3):287-297. doi: 10.1038/s41565-018-0358-x. Epub 2019 Jan 28.
PubMed ID: 30692673Loria R, Giliberti C, Bedini A, Palomba R, Caracciolo G, Ceci P, Falvo E, Marconi R, Falcioni R, Bossi G, Strigari L. Very low intensity ultrasounds as a new strategy to improve selective delivery of nanoparticles-complexes in cancer cells. J Exp Clin Cancer Res. 2019 Jan 3;38(1):1. doi: 10.1186/s13046-018-1018-6.
PubMed ID: 30606223Song X, Yan G, Quan S, Jin E, Quan J, Jin G. MRI-visible liposome-polyethylenimine complexes for DNA delivery: preparation and evaluation. Biosci Biotechnol Biochem. 2019 Apr;83(4):622-632. doi: 10.1080/09168451.2018.1562875. Epub 2018 Dec 25.
PubMed ID: 30585119Thanki K, Papai S, Lokras A, Rose F, Falkenberg E, Franzyk H, Foged C. Application of a Quality-By-Design Approach to Optimise Lipid-Polymer Hybrid Nanoparticles Loaded with a Splice-Correction Antisense Oligonucleotide: Maximising Loading and Intracellular Delivery. Pharm Res. 2019 Jan 9;36(3):37. doi: 10.1007/s11095-018-2566-3.
PubMed ID: 30623253Habibulla Imran, Palinci Nagarajan Manikandan, Venkataraman Dharuman. Ultra-sensitive and selective label free electrochemical DNA detection at layer-by-layer self-assembled graphene oxide and vesicle liposome nano-architecture. Journal of Electroanalytical Chemistry. 2019 February 15;835:10-21. doi: 10.1016/j.jelechem.2019.01.011.
Mohamed A, Kunda NK, Ross K, Hutcheon GA, Saleem IY. Polymeric nanoparticles for the delivery of miRNA to treat Chronic Obstructive Pulmonary Disease (COPD). Eur J Pharm Biopharm. 2019 Mar;136:1-8. doi: 10.1016/j.ejpb.2019.01.002. Epub 2019 Jan 4.
PubMed ID: 30615927Mohamed A, Kunda NK, Ross K, Hutcheon GA, Saleem IY. Polymeric nanoparticles for the delivery of miRNA to treat Chronic Obstructive Pulmonary Disease (COPD). Eur J Pharm Biopharm. 2019 Mar;136:1-8. doi: 10.1016/j.ejpb.2019.01.002. Epub 2019 Jan 4.
PubMed ID: 30615927Di Santo R, Digiacomo L, Palchetti S, Palmieri V, Perini G, Pozzi D, Papi M, Caracciolo G. Microfluidic manufacturing of surface-functionalized graphene oxide nanoflakes for gene delivery. Nanoscale. 2019 Feb 7;11(6):2733-2741. doi: 10.1039/c8nr09245a.
PubMed ID: 30672541Chen M, Song F, Liu Y, Tian J, Liu C, Li R, Zhang Q. A dual pH-sensitive liposomal system with charge-reversal and NO generation for overcoming multidrug resistance in cancer. Nanoscale. 2019 Mar 7;11(9):3814-3826. doi: 10.1039/c8nr06218h. Epub 2019 Jan 2.
PubMed ID: 30600823Ewins E, Lira RB, Zhang W, Yuan J, Antonietti M, Robinson T, Dimova R. Poly(Ionic Liquid) Nanoparticles Selectively Disrupt Biomembranes. Adv Sci (Weinh). 2018 Dec 17;6(4):1801602. doi: 10.1002/advs.201801602. eCollection 2019 Feb 2019
PubMed ID: 30828532Xiang J, Liu X, Zhou Z, Zhu D, Zhou Q, Piao Y, Jiang L, Tang J, Liu X, Shen Y. Reactive Oxygen Species (ROS)-Responsive Charge-Switchable Nanocarriers for Gene Therapy of Metastatic Cancer. ACS Appl Mater Interfaces. 2018 Dec 19;10(50):43352-43362. doi: 10.1021/acsami.8b13291. Epub 2018 Dec 4.
PubMed ID: 30465424Maroof H, Islam F, Dong L, Ajjikuttira P, Gopalan V, McMillan NAJ, Lam AK. Liposomal Delivery of miR-34b-5p Induced Cancer Cell Death in Thyroid Carcinoma Cells. 2018 Dec 11;7(12). pii: E265. doi: 10.3390/cells7120265.
PubMed ID: 30544959Faneca H, Düzgüneş N, Pedroso de Lima MC. Suicide Gene Therapy for Oral Squamous Cell Carcinoma. Methods Mol Biol. 2019;1895:43-55. doi: 10.1007/978-1-4939-8922-5_4.
PubMed ID: 30539528Sathyanarayanan G, Haapala M, Sikanen T. Interfacing Digital Microfluidics with Ambient Mass Spectrometry Using SU-8 as Dielectric Layer. Micromachines (Basel). 2018 Dec 8;9(12). pii: E649. doi: 10.3390/mi9120649.
PubMed ID: 30544772Angmo S, Rana S, Yadav K, Sandhir R, Singhal NK. Novel Liposome Eencapsulated Guanosine Di Phosphate based Therapeutic Target against Anemia of Inflammation. Sci Rep. 2018 Dec 6;8(1):17684. doi: 10.1038/s41598-018-35992-2.
PubMed ID: 30523271Baldwin P, Ohman AW, Tangutoori S, Dinulescu DM, Sridhar S. Intraperitoneal delivery of NanoOlaparib for disseminated late-stage cancer treatment. Int J Nanomedicine. 2018 Nov 29;13:8063-8074. doi: 10.2147/IJN.S186881. eCollection 2018.
PubMed ID: 30555227Das M, Shen L, Liu Q, Goodwin TJ, Huang L. Nanoparticle Delivery of RIG-I Agonist Enables Effective and Safe Adjuvant Therapy in Pancreatic Cancer. Mol Ther. 2018 Nov 17. pii: S1525-0016(18)30548-3. doi: 10.1016/j.ymthe.2018.11.012. [Epub ahead of print].
PubMed ID: 30545600Mukai H, Hatanaka K, Yagi N, Warashina S, Zouda M, Takahashi M, Narushima K, Yabuuchi H, Iwano J, Kuboyama T, Enokizono J, Wada Y, Watanabe Y. Pharmacokinetic evaluation of liposomal nanoparticle-encapsulated nucleic acid drug: A combined study of dynamic PET imaging and LC/MS/MS analysis. J Control Release. 2019 Jan 28;294:185-194. doi: 10.1016/j.jconrel.2018.12.006. Epub 2018 Dec 7.
PubMed ID: 30529725Lira RB, Robinson T, Dimova R, Riske KA. Highly Efficient Protein-free Membrane Fusion: A Giant Vesicle Study. Biophys J. 2019 Jan 8;116(1):79-91. doi: 10.1016/j.bpj.2018.11.3128. Epub 2018 Dec 1.
PubMed ID: 30579564Amadei F, Fröhlich B, Stremmel W, Tanaka M. Non-Classical Interactions of Phosphatidylcholine with Mucin Protect Intestinal Surfaces: A Microinterferometry Study. Langmuir. 2018 Oct 25. doi: 10.1021/acs.langmuir.8b03035. [Epub ahead of print]
PubMed ID: 30359036Eric H. Hill, Jingang Li, Linhan Lin, Yaoran Liu, and Yuebing Zheng. Opto-Thermophoretic Attraction, Trapping, and Dynamic Manipulation of Lipid Vesicles. Langmuir, Just Accepted Manuscript. DOI: 10.1021/acs.langmuir.8b01979. Publication Date (Web): October 11, 2018
PubMed ID: 30350700Chung PJ, Hwang HL, Dasbiswas K, Leong A, Lee KYC. Osmotic shock-triggered assembly of highly-charged, nanoparticle-supported membranes. Langmuir. 2018 Oct 10. doi: 10.1021/acs.langmuir.8b03026. [Epub ahead of print]
PubMed ID: 30303390Khmelinskaia A, Mücksch J, Petrov EP, Franquelim HG, Schwille P. Control of membrane binding and diffusion of cholesteryl-modified DNA origami nanostructures by DNA spacers. Langmuir. 2018 Sep 25. doi: 10.1021/acs.langmuir.8b01850. [Epub ahead of print]
PubMed ID: 30253101Sayour EJ, Grippin A, De Leon G, Stover B, Rahman M, Karachi A, Wummer B, Moore G, Castillo-Caro P, Fredenburg K, Sarkisian MR, Huang J, Deleyrolle LP, Sahay B, Carrera-Justiz S, Mendez-Gomez HR, Mitchell DA. Personalized Tumor RNA Loaded Lipid-Nanoparticles Prime the Systemic and Intratumoral Milieu for Response to Cancer Immunotherapy. Nano Lett. 2018 Sep 27. doi: 10.1021/acs.nanolett.8b02179. [Epub ahead of print]
PubMed ID: 30259750Kim H, Sung J, Chang Y, Alfeche A, Leal C. Microfluidics Synthesis of Gene Silencing Cubosomes. ACS Nano. 2018 Aug 15. doi: 10.1021/acsnano.8b03770. [Epub ahead of print]
PubMed ID: 30081623Bi H, Wang X, Han X, Voitchovsky K. Impact of Electric Fields on the Nanoscale Behavior of Lipid Monolayers at the Surface of Graphite in Solution. Langmuir. 2018 Jul 20. doi: 10.1021/acs.langmuir.8b01631. [Epub ahead of print]
PubMed ID: 30028144Movsesian N, Tittensor M, Dianat G, Gupta M, Malmstadt N. Giant Lipid Vesicle Formation Using Vapor-Deposited Charged Porous Polymers. Langmuir. 2018 Jul 17. doi: 10.1021/acs.langmuir.8b00736. [Epub ahead of print]
PubMed ID: 29961336Movsesian N, Tittensor M, Dianat G, Gupta M, Malmstadt N. Giant Lipid Vesicle Formation Using Vapor-Deposited Charged Porous Polymers. Langmuir. 2018 Jul 2. doi: 10.1021/acs.langmuir.8b00736. [Epub ahead of print]
PubMed ID: 29961336Takechi-Haraya Y, Goda Y, Sakai-Kato K. Atomic Force Microscopy Study on the Stiffness of Nanosized Liposomes Containing Charged Lipids. Langmuir. 2018 Jun 18. doi: 10.1021/acs.langmuir.8b01121. [Epub ahead of print]
PubMed ID: 29869883Xu, J., J.C. Luft, X. Yi, S. Tian, G. Owens, J. Wang, A. Johnson, P. Berglund, J. Smith, M.E. Napier, and J.M. Desimone. (2013). RNA Replicon Delivery via Lipid-Complexed PRINT Protein Particles. Mol Pharm [PubMed]
PubMed ID: 23924216Regelin, A.E., Fankhaenel, S., Gürtesch, L., Prinz, C., von Kiedrowski, G., Massing, U. (2000) Biophysical and lipofection studies of DOTAP analogs. Biochim Biophys Acta. 1464:151-64. [PubMed]
PubMed ID: 10704929Effects of Surface Charges on the Bactericide Activity of CdTe/ZnS Quantum Dots: A Cell Membrane Disruption Perspective, Lu Lai*† , Sheng-Jin Li†, Jing Feng†, Ping Mei†, Zhao-Hua Ren†, Yan-Ling Chang†, and Yi Liu*‡ † College of Chemistry and Environmental Engineering, Yangtze University, Jingzhou, Hubei 434023, P. R. China, ‡ State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecule Sciences, Wuhan University, Wuhan 430072, P. R. China Langmuir, Article ASAP, DOI: 10.1021/acs.langmuir.7b00173[PubMed]
PubMed ID: 28178781Blaschke BM, Böhm P, Drieschner S, Nickel B, Garrido JA. Lipid monolayer formation and lipid exchange monitored by a graphene field-effect transistor. Langmuir. 2018 Mar 15. doi: 10.1021/acs.langmuir.8b00162. [Epub ahead of print]
PubMed ID: 29542929- Certificate of Analysis (Lot No. 890890C-1G-A-163 and 6361CQA163)
- Certificate of Analysis (Lot No. 890890C-200MG-A-163 and 6361CNA163)
- Certificate of Analysis (Lot No. 890890C-25MG-A-163 and 6361CJA163)
- Certificate of Analysis (Lot No. 890890C-500MG-A-163 and 6361CPA163)
- Certificate of Analysis (Lot No. 890890P-1G-A-163 and 6361PQA163)
- Certificate of Analysis (Lot No. 890890P-200MG-A-163 and 6361PNA163)
- Certificate of Analysis (Lot No. 890890P-25MG-A-163 and 6361PJA163)
- Certificate of Analysis (Lot No. 890890P-500MG-A-163 and 6361PPA163)
- Certificate of Analysis (Lot No. 890890C-200MG-A-164 and 6361CNA164)
- Certificate of Analysis (Lot No. 890890P-1G-A-164 and 6361PQA164)
- Certificate of Analysis (Lot No. 890890P-200MG-A-164 and 6361PNA164)
- Certificate of Analysis (Lot No. 890890P-200MG-B-163 and 6361PNB163)
- Certificate of Analysis (Lot No. 890890P-500MG-A-164 and 6361PPA164)
- Certificate of Analysis (Lot No. 890890C-500MG-B-163 and 6361CPB163)
- Certificate of Analysis (Lot No. 890890P-25MG-B-164 and 6361PJB164)
- Certificate of Analysis (Lot No. 890890P-1G-B-164 and 6361PQB164)
- Certificate of Analysis (Lot No. 890890P-500MG-B-164 and 6361PPB164)
- Certificate of Analysis (Lot No. 890890P-200MG-A-165 and 6361PNA165)
- Certificate of Analysis (Lot No. 890890P-500MG-A-165 and 6361PPA165)
- Certificate of Analysis (Lot No. 890890C-25MG-A-165 and 6361CJA165)
- Certificate of Analysis (Lot No. 890890C-200MG-A-165 and 6361CNA165)
- Certificate of Analysis (Lot No. 890890P-25MG-A-165 and 6361PJA165)
- Certificate of Analysis (Lot No. 890890C-25MG-B-165 and 6361CJB165)
- Certificate of Analysis (Lot No. 890890P-25MG-B-165 and 6361PJB165)
- Certificate of Analysis (Lot No. 890890P-500MG-B-165 and 6361PPB165)
- Certificate of Analysis (Lot No. 890890P-200MG-C-165 and 6361PNC165)
- Certificate of Analysis (Lot No. 890890C-25MG-C-165 and 6361CJC165)
- Certificate of Analysis (Lot No. 890890C-500MG-C-163 and 6361CPC163)
- Certificate of Analysis (Lot No. 890890P-25MG-C-165 and 6361PJC165)
- Certificate of Analysis (Lot No. 890890P-200MG-D-165 and 6361PND165)
- Certificate of Analysis (Lot No. 890890P-500MG-C-165 and 6361PPC165)
- Certificate of Analysis (Lot No. 890890C-200MG-B-165 and 6361CNB165)
- Certificate of Analysis (Lot No. 890890P-500MG-D-165 and 6361PPD165)
- Certificate of Analysis (Lot No. 890890P-500MG-E-165 and 6361PPE165)
- Certificate of Analysis (Lot No. 890890P-200MG-A-169 and 6361PNA169)
- Certificate of Analysis (Lot No. 890890P-1G-A-169 and 6361PQA169)
- Certificate of Analysis (Lot No. 890890C-200MG-A-169 and 6361CNA165)
- Certificate of Analysis (Lot No. 890890P-500MG-A-169 and 6361PPA169)
- Certificate of Analysis (Lot No. 890890C-500MG-A-169 and 6361CPA169)
- Certificate of Analysis (Lot No. 890890P-1G-A-170 and 6361PQA170)
- Certificate of Analysis (Lot No. 890890P-200MG-A-170 and 6361PNA170)
- Certificate of Analysis (Lot No. 890890C-200MG-B-169 and 6361CNB165)
- Certificate of Analysis (Lot No. 890890C-500MG-A-170 and 6361CPA170)
- Certificate of Analysis (Lot No. 890890C-200MG-A-170 and 6361CNA170)
- Certificate of Analysis (Lot No. 890890C-25MG-A-170 and 6361CJA170)
- Certificate of Analysis (Lot No. 890890P-500MG-A-170 and 6361PPA170)
- Certificate of Analysis (Lot No. 890890P-25MG-A-170 and 6361PJA170)
- Certificate of Analysis (Lot No. 890890C-200MG-B-170 and 6361CNB170)
- Certificate of Analysis (Lot No. 890890P-200MG-B-170 and 6361PNB170)
- Certificate of Analysis (Lot No. 890890P-200MG-C-170 and 6361PNC170)
- Certificate of Analysis (Lot No. 890890P-25MG-B-170 and 6361PJB170)
- Certificate of Analysis (Lot No. 890890P-500MG-B-170 and 6361PPB170)
- Certificate of Analysis (Lot No. 890890P-200MG-D-170 and 6361PND170)
- Certificate of Analysis (Lot No. 890890P-1G-B-170 and 6361PQB170)
- Certificate of Analysis (Lot No. 890890P-500MG-A-171 and 6361PPA171)
- Certificate of Analysis (Lot No. 890890C-500MG-A-171 and 6361CPA171)
- Certificate of Analysis (Lot No. 890890P-25MG-A-171 and 6361PJA171)
- Certificate of Analysis (Lot No. 890890P-1G-A-171 and 6361PQA171)
- Certificate of Analysis (Lot No. 890890P-200MG-A-171 and 6361PNA171)
- Certificate of Analysis (Lot No. 890890C-200MG-A-173 and 6361CNA173)
- Certificate of Analysis (Lot No. 890890P-500MG-A-173 and 6361PPA173)
- Certificate of Analysis (Lot No. 890890P-200MG-A-173 and 6362PNA173)
- Certificate of Analysis (Lot No. 890890P-1G-A-173 and 6361PQA173)
- Certificate of Analysis (Lot No. 890890C-25MG-A-173 and 6361CJA173)
- Certificate of Analysis (Lot No. 890890P-500MG-B-173 and 6361PPB173)
- Certificate of Analysis (Lot No. 890890P-200MG-B-173 and 6362PNB173)
- Certificate of Analysis (Lot No. 890890P-200MG-B-171 and 6361PNB171)
- Certificate of Analysis (Lot No. 890890P-1G-B-173 and 6361PQB173)
- Certificate of Analysis (Lot No. 890890C-200MG-A-171 and 6361CNA171)
- Certificate of Analysis (Lot No. 890890P-1G-A-174 and 6361PQA174)
- Certificate of Analysis (Lot No. 890890P-500MG-A-174 and 6361PPA174)
- Certificate of Analysis (Lot No. 890890P-200MG-A-174 and 6361PNA174)
- Certificate of Analysis (Lot No. 890890C-500MG-A-174 and 6361CPA174)
- Certificate of Analysis (Lot No. 890890C-200MG-A-174 and 6361CNA174)
- Certificate of Analysis (Lot No. 890890C-25MG-A-174 and 6361CJA174)
- Certificate of Analysis (Lot No. 890890P-500MG-B-174 and 6361PPB174)
- Certificate of Analysis (Lot No. 890890P-1G-B-174 and 6361PQB174)
- Certificate of Analysis (Lot No. 890890P-500MG-C-174 and 6361PPC174)
- Certificate of Analysis (Lot No. 890890P-200MG-D-174 and 6361PND174)
- Certificate of Analysis (Lot No. 890890C-25MG-B-174 and 6361CJB174)
- Certificate of Analysis (Lot No. 890890P-500MG-A-177 and 6361PPA177)
- Certificate of Analysis (Lot No. 890890C-500MG-A-177 and 6361CPA177)
- Certificate of Analysis (Lot No. 890890C-200MG-B-177 and 6361CNB177)
- Certificate of Analysis (Lot No. 890890C-200MG-A-177 and 6361CNA177)
- Certificate of Analysis (Lot No. 890890C-25MG-A-177 and 6361CJA177)
- Certificate of Analysis (Lot No. 890890P-25MG-A-177 and 6361PJA177)
- Certificate of Analysis (Lot No. 890890P-25MG-A-179 and 6361PJA179)
- Certificate of Analysis (Lot No. 890890P-500MG-B-177 and 6361PPB177)
- Certificate of Analysis (Lot No. 890890P-200MG-C-175 and 6361PNC175)
- Certificate of Analysis (Lot No. 890890P-200MG-A-179 and 6361PNA179)
- Certificate of Analysis (Lot No. 890890P-500MG-B-179 and 6361PPB179)
- Certificate of Analysis (Lot No. 890890P-200MG-B-179 and 6361PNB179)
- Certificate of Analysis (Lot No. 890890P-500MG-D-179 and 6361PPD179)
- Certificate of Analysis (Lot No. 890890P-1G-C-179 and 6361PQC179)
- Certificate of Analysis (Lot No. 890890P-500MG-C-179 and 6361PPC179)
- Certificate of Analysis (Lot No. 890890P-200MG-C-179 and 6361PNC179)
- Certificate of Analysis (Lot No. 890890P-25MG-B-179 and 6361PJB179)
- Certificate of Analysis (Lot No. 890890P-1G-B-179 and 6361PQB179)
- Certificate of Analysis (Lot No. 890890P-200MG-A-179 and 6361PNA179)
- Certificate of Analysis (Lot No. 890890P-500MG-E-179 and 6361PPE179)
- Certificate of Analysis (Lot No. 890890C-500MG-B-179 and 6361CPB179)
- Certificate of Analysis (Lot No. 890890C-200MG-A-179 and 6361CNA179)
- Certificate of Analysis (Lot No. 890890P-200MG-D-179 and 6361PND179)
- Certificate of Analysis (Lot No. 890890C-200MG-B-179 and 6361CNB179)
- Certificate of Analysis (Lot No. 890890P-500MG-F-179 and 6361PPF179)