890890 | 18:1 TAP (DOTAP)

1,2-dioleoyl-3-trimethylammonium-propane (chloride salt)

Powder

Size SKU Packaging Price
25mg 890890P-25mg 890890P-25mg 1 x 25mg $207.00
200mg 890890P-200mg 890890P-200mg 2 x 100mg $432.00
500mg 890890P-500mg 890890P-500mg 5 x 100mg $885.00
1g 890890P-1g 890890P-1g 1 x 1g $1,621.62

Chloroform

Size SKU Packaging Price
25mg 890890C-25mg 890890C-25mg 1 x 25mg 10mg/mL 2.5mL $207.00
200mg 890890C-200mg 890890C-200mg 2 x 100mg 25mg/mL 4mL $432.00
500mg 890890C-500mg 890890C-500mg 5 x 100mg 25mg/mL 4mL $885.00
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18:1 TAP (DOTAP)

18:1 TAP (DOTAP)

1,2-dioleoyl-3-trimethylammonium-propane (chloride salt)

DOTAP is one of the most widely used cationic lipids for gene transfection applications. DOTAP is proven to be efficient for in vitro and in vivo transfection applications. Various analogues of TAP are available for structure-activity relationship studies.

Simberg D, Weisman S, Talmon Y, Barenholz Y. DOTAP (and other cationic lipids): chemistry, biophysics, and transfection. Crit Rev Ther Drug Carrier Syst. 2004;21(4):257-317. doi: 10.1615/critrevtherdrugcarriersyst.v21.i4.10. PMID: 15638468.

Hygroscopic
No
Light Sensitive
Yes
Molecular Formula
C42H80NO4Cl
Percent Composition
C 72.22%, H 11.54%, Cl 5.08%, N 2.01%, O 9.16%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
132172-61-3
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
698.542
Exact Mass
697.578
Synonyms
1,2-di-(9Z-octadecenoyl)-3-trimethylammonium-propane (chloride salt)
DOTAP

Lu Z, Pang T, Yin X, Cui H, Fang G, Xue X, Luo T. Delivery of TSPAN1 siRNA by Novel Th17 Targeted Cationic Liposomes for Gastric Cancer Intervention. J Pharm Sci. 2020 Jun 1:S0022-3549(20)30267-7. doi: 10.1016/j.xphs.2020.05.018. Epub ahead of print. PMID: 32497593.

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Kolyvushko O, Latzke J, Dahmani I, Osterrieder N, Chiantia S, Azab W. Differentially-Charged Liposomes Interact with Alphaherpesviruses and Interfere with Virus Entry. Pathogens. 2020 May 8;9(5):359. doi: 10.3390/pathogens9050359. PMID: 32397270; PMCID: PMC7281745.

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Arora S, Sharma D, Singh J. GLUT-1: An Effective Target To Deliver Brain-Derived Neurotrophic Factor Gene Across the Blood Brain Barrier. ACS Chem Neurosci. 2020 Jun 3;11(11):1620-1633. doi: 10.1021/acschemneuro.0c00076. Epub 2020 May 12. PMID: 32352752.

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Nobeyama T, Shigyou K, Nakatsuji H, Sugiyama H, Komura N, Ando H, Hamada T, Murakami T. Control of Lipid Bilayer Phases of Cell-Sized Liposomes by Surface-Engineered Plasmonic Nanoparticles. Langmuir. 2020 Jun 19. doi: 10.1021/acs.langmuir.0c00049. Epub ahead of print. PMID: 32502354.

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Van Hoecke L, Verbeke R, De Vlieger D, Dewitte H, Roose K, Van Nevel S, Krysko O, Bachert C, Schepens B, Lentacker I, Saelens X. mRNA Encoding a Bispecific Single Domain Antibody Construct Protects against Influenza A Virus Infection in Mice. Mol Ther Nucleic Acids. 2020 Jun 5;20:777-787. doi: 10.1016/j.omtn.2020.04.015. Epub 2020 May 1. PMID: 32438313; PMCID: PMC7240188.

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Hubert M, Larsson E, Vegesna NVG, Ahnlund M, Johansson AI, Moodie LW, Lundmark R. Lipid accumulation controls the balance between surface connection and scission of caveolae. Elife. 2020 May 4;9:e55038. doi: 10.7554/eLife.55038. PMID: 32364496; PMCID: PMC7239661.

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Hoffmann M, Hersch N, Gerlach S, Dreissen G, Springer R, Merkel R, Csiszár A, Hoffmann B. Complex Size and Surface Charge Determine Nucleic Acid Transfer by Fusogenic Liposomes. Int J Mol Sci. 2020 Mar 24;21(6):2244. doi: 10.3390/ijms21062244. PMID: 32213928; PMCID: PMC7139958.

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Webb C, Forbes N, Roces CB, Anderluzzi G, Lou G, Abraham S, Ingalls L, Marshall K, Leaver TJ, Watts JA, Aylott JW, Perrie Y. Using microfluidics for scalable manufacturing of nanomedicines from bench to GMP: A case study using protein-loaded liposomes. Int J Pharm. 2020 May 30;582:119266. doi: 10.1016/j.ijpharm.2020.119266. Epub 2020 Apr 3. PMID: 32251694.

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Yoshikawa N, Fumoto S, Yoshikawa K, Hu D, Okami K, Kato R, Nakashima M, Miyamoto H, Nishida K. Interaction of Lipoplex with Albumin Enhances Gene Expression in Hepatitis Mice. Pharmaceutics. 2020 Apr 10;12(4):E341. doi: 10.3390/pharmaceutics12040341. PMID: 32290201.

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Chen Q, Guan G, Deng F, Yang D, Wu P, Kang S, Sun R, Wang X, Zhou D, Dai W, Wang X, Zhang H, He B, Chen D, Zhang Q. Anisotropic active ligandations in siRNA-Loaded hybrid nanodiscs lead to distinct carcinostatic outcomes by regulating nano-bio interactions. Biomaterials. 2020 Apr 3;251:120008. doi: 10.1016/j.biomaterials.2020.120008. Epub ahead of print. PMID: 32388031.

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Van de Vyver T, Bogaert B, De Backer L, Joris F, Guagliardo R, Van Hoeck J, Merckx P, Van Calenbergh S, Ramishetti S, Peer D, Remaut K, De Smedt SC, Raemdonck K. Cationic Amphiphilic Drugs Boost the Lysosomal Escape of Small Nucleic Acid Therapeutics in a Nanocarrier-Dependent Manner. ACS Nano. 2020 Apr 28;14(4):4774-4791. doi: 10.1021/acsnano.0c00666. Epub 2020 Apr 14. PMID: 32250113.

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Liu HY, Pappa AM, Pavia A, Pitsalidis C, Thiburce Q, Salleo A, Owens RM, Daniel S. Self-Assembly of Mammalian-Cell Membranes on Bioelectronic Devices with Functional Transmembrane Proteins. Langmuir. 2020 Jun 22. doi: 10.1021/acs.langmuir.0c00804. Epub ahead of print. PMID: 32388991.

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Cheng Q, Wei T, Farbiak L, Johnson LT, Dilliard SA, Siegwart DJ. Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR-Cas gene editing. Nat Nanotechnol. 2020 Apr;15(4):313-320. doi: 10.1038/s41565-020-0669-6. Epub 2020 Apr 6. PMID: 32251383.

 PubMed ID: 32251383

Wang L, Liang TT. CD59 receptor targeted delivery of miRNA-1284 and cisplatin-loaded liposomes for effective therapeutic efficacy against cervical cancer cells. AMB Express. 2020 Mar 17;10(1):54. doi: 10.1186/s13568-020-00990-z. PMID: 32185543; PMCID: PMC7078418.

 PubMed ID: 32185543

Kim D, Han J, Park SY, Kim H, Park JH, Lee HJ. Antitumor Efficacy of Focused Ultrasound-MFL Nanoparticles Combination Therapy in Mouse Breast Cancer Xenografts. Materials (Basel). 2020 Mar 2;13(5):1099. doi: 10.3390/ma13051099. PMID: 32121631; PMCID: PMC7084991.

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Sheshachala S, Grösche M, Scherr T, Hu Y, Sun P, Bartschat A, Mikut R, Niemeyer CM. Segregation of Dispersed Silica Nanoparticles in Microfluidic Water-in-Oil Droplets: A Kinetic Study. Chemphyschem. 2020 Mar 6. doi: 10.1002/cphc.201901151. Epub ahead of print. PMID: 32142187.

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Parvathaneni V, Kulkarni NS, Shukla SK, Farrales PT, Kunda NK, Muth A, Gupta V. Systematic Development and Optimization of Inhalable Pirfenidone Liposomes for Non-Small Cell Lung Cancer Treatment. Pharmaceutics. 2020 Feb 28;12(3):206. doi: 10.3390/pharmaceutics12030206. PMID: 32121070; PMCID: PMC7150896.

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Li C, Li Q, Wang Z, Han X. Phospholipid Self-Assemblies Shaped Like Ancient Chinese Coins for Artificial Organelles. Anal Chem. 2020 Apr 21;92(8):6060-6064. doi: 10.1021/acs.analchem.0c00430. Epub 2020 Apr 1. PMID: 32207619.

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Sethuraman SN, Singh MP, Patil G, Li S, Fiering S, Hoopes PJ, Guha C, Malayer J, Ranjan A. Novel calreticulin-nanoparticle in combination with focused ultrasound induces immunogenic cell death in melanoma to enhance antitumor immunity. Theranostics. 2020 Feb 10;10(8):3397-3412. doi: 10.7150/thno.42243. PMID: 32206098; PMCID: PMC7069083.

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Mlynarczyk DT, Piskorz J, Popenda L, Stolarska M, Szczolko W, Konopka K, Jurga S, Sobotta L, Mielcarek J, Düzgüneş N, Goslinski T. S-seco-porphyrazine as a new member of the seco-porphyrazine family - Synthesis, characterization and photocytotoxicity against cancer cells. Bioorg Chem. 2020 Mar;96:103634. doi: 10.1016/j.bioorg.2020.103634. Epub 2020 Jan 30. PMID: 32044518.

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Quagliarini E, Di Santo R, Palchetti S, Ferri G, Cardarelli F, Pozzi D, Caracciolo G. Effect of Protein Corona on The Transfection Efficiency of Lipid-Coated Graphene Oxide-Based Cell Transfection Reagents. Pharmaceutics. 2020 Jan 30;12(2):113. doi: 10.3390/pharmaceutics12020113. PMID: 32019150; PMCID: PMC7076454.

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Leonard F, Curtis LT, Hamed AR, Zhang C, Chau E, Sieving D, Godin B, Frieboes HB. Nonlinear response to cancer nanotherapy due to macrophage interactions revealed by mathematical modeling and evaluated in a murine model via CRISPR-modulated macrophage polarization. Cancer Immunol Immunother. 2020 Feb 8. doi: 10.1007/s00262-020-02504-z. Epub ahead of print. PMID: 32036448.

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Salloum E, Henry-Amar M, Caillou B, Friedman S, Pico JL, Bayle C, Hayat M. Lymphoblastic lymphoma in adults: a clinicopathological study of 34 cases treated at the Institut Gustave-Roussy. Eur J Cancer Clin Oncol. 1988 Oct;24(10):1609-16. doi: 10.1016/0277-5379(88)90053-3. PMID: 3208805.

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Yang K, Mesquita B, Horvatovich P, Salvati A. Tuning liposome composition to modulate corona formation in human serum and cellular uptake. Acta Biomater. 2020 Apr 1;106:314-327. doi: 10.1016/j.actbio.2020.02.018. Epub 2020 Feb 17. PMID: 32081780.

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Huang Y, Chen Y, Zhou S, Chen L, Wang J, Pei Y, Xu M, Feng J, Jiang T, Liang K, Liu S, Song Q, Jiang G, Gu X, Zhang Q, Gao X, Chen J. Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors. Nat Commun. 2020 Jan 30;11(1):622. doi: 10.1038/s41467-020-14425-7. PMID: 32001695; PMCID: PMC6992734.

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Huang Y, Chen Y, Zhou S, Chen L, Wang J, Pei Y, Xu M, Feng J, Jiang T, Liang K, Liu S, Song Q, Jiang G, Gu X, Zhang Q, Gao X, Chen J. Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors. Nat Commun. 2020 Jan 30;11(1):622. doi: 10.1038/s41467-020-14425-7. PMID: 32001695; PMCID: PMC6992734.

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Zhen S, Liu Y, Lu J, Tuo X, Yang X, Chen H, Chen W, Li X. Human Papillomavirus Oncogene Manipulation Using Clustered Regularly Interspersed Short Palindromic Repeats/Cas9 Delivered by pH-Sensitive Cationic Liposomes. Hum Gene Ther. 2020 Feb 19:10.1089/hum.2019.312. doi: 10.1089/hum.2019.312. Epub ahead of print. PMID: 31973584.

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Nakamura T, Kawai M, Sato Y, Maeki M, Tokeshi M, Harashima H. The Effect of Size and Charge of Lipid Nanoparticles Prepared by Microfluidic Mixing on Their Lymph Node Transitivity and Distribution. Mol Pharm. 2020 Feb 5:10.1021/acs.molpharmaceut.9b01182. doi: 10.1021/acs.molpharmaceut.9b01182. Epub ahead of print. PMID: 31990567.

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Tada R, Ohshima A, Tanazawa Y, Ohmi A, Takahashi S, Kiyono H, Kunisawa J, Aramaki Y, Negishi Y. Essential Role of Host Double-Stranded DNA Released from Dying Cells by Cationic Liposomes for Mucosal Adjuvanticity. Vaccines (Basel). 2019 Dec 27;8(1):E8. doi: 10.3390/vaccines8010008. PMID: 31892192.

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Zhu H, Liu Q, Miao L, Musetti S, Huo M, Huang L. Remodeling the fibrotic tumor microenvironment of desmoplastic melanoma to facilitate vaccine immunotherapy. Nanoscale. 2020 Feb 7;12(5):3400-3410. doi: 10.1039/c9nr09610h. Epub 2020 Jan 28. PMID: 31989142.

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Huang KW, Hsu FF, Qiu JT, Chern GJ, Lee YA, Chang CC, Huang YT, Sung YC, Chiang CC, Huang RL, Lin CC, Dinh TK, Huang HC, Shih YC, Alson D, Lin CY, Lin YC, Chang PC, Lin SY, Chen Y. Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer. Sci Adv. 2020 Jan 15;6(3):eaax5032. doi: 10.1126/sciadv.aax5032. PMID: 31998834; PMCID: PMC6962042.

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Otosu T, Yamaguchi S. Effect of electrostatic interaction on the leaflet-specific diffusion in a supported lipid bilayer revealed by fluorescence lifetime correlation analysis. Phys Chem Chem Phys. 2020 Jan 21;22(3):1242-1249. doi: 10.1039/c9cp05833h. Epub 2019 Dec 18. PMID: 31850441.

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Palchetti S, Digiacomo L, Giulimondi F, Pozzi D, Peruzzi G, Ferri G, Amenitsch H, Cardarelli F, Mahmoudi M, Caracciolo G. A mechanistic explanation of the inhibitory role of the protein corona on liposomal gene expression. Biochim Biophys Acta Biomembr. 2020 Mar 1;1862(3):183159. doi: 10.1016/j.bbamem.2019.183159. Epub 2019 Dec 16. PMID: 31857070.

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Hussain MT, Forbes N, Perrie Y, Malik KP, Duru C, Matejtschuk P. Freeze-drying cycle optimization for the rapid preservation of protein-loaded liposomal formulations. Int J Pharm. 2020 Jan 5;573:118722. doi: 10.1016/j.ijpharm.2019.118722. Epub 2019 Nov 6. PMID: 31705976.

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Webb C, Khadke S, Schmidt ST, Roces CB, Forbes N, Berrie G, Perrie Y. The Impact of Solvent Selection: Strategies to Guide the Manufacturing of Liposomes Using Microfluidics. Pharmaceutics. 2019 Dec 4;11(12):653. doi: 10.3390/pharmaceutics11120653. PMID: 31817217; PMCID: PMC6955969.

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Gusti-Ngurah-Putu EP, Huang L, Hsu YC. Effective Combined Photodynamic Therapy with Lipid Platinum Chloride Nanoparticles Therapies of Oral Squamous Carcinoma Tumor Inhibition. J Clin Med. 2019 Dec 2;8(12):2112. doi: 10.3390/jcm8122112. PMID: 31810241; PMCID: PMC6947167.

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Fisher C, Obaid G, Niu C, Foltz W, Goldstein A, Hasan T, Lilge L. Liposomal Lapatinib in Combination with Low-Dose Photodynamic Therapy for the Treatment of Glioma. J Clin Med. 2019 Dec 14;8(12):2214. doi: 10.3390/jcm8122214. PMID: 31847378; PMCID: PMC6947404.

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Hu M, Zhou X, Wang Y, Guan K, Huang L. Relaxin-FOLFOX-IL-12 triple combination therapy engages memory response and achieves long-term survival in colorectal cancer liver metastasis. J Control Release. 2019 Dec 31;319:213-221. doi: 10.1016/j.jconrel.2019.12.053. [Epub ahead of print]. PMID: 31899270.

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Steffes VM, Zhang Z, MacDonald S, Crowe J, Ewert KK, Carragher B, Potter CS, Safinya CR. PEGylation of Paclitaxel-Loaded Cationic Liposomes Drives Steric Stabilization of Bicelles and Vesicles thereby Enhancing Delivery and Cytotoxicity to Human Cancer Cells. ACS Appl Mater Interfaces. 2020 Jan 8;12(1):151-162. doi: 10.1021/acsami.9b16150. Epub 2019 Dec 24. PMID: 31820904.

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Maoyafikuddin M, Pundir M, Thaokar R. Starch aided synthesis of giant unilamellar vesicles. Chem Phys Lipids. 2020 Jan;226:104834. doi: 10.1016/j.chemphyslip.2019.104834. Epub 2019 Nov 26.

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Ma X, Zhang J, Zhang Y, Liu J. Adsorption Promoted Aggregation-Induced Emission Showing Strong Dye Lateral Interactions. Langmuir. 2019 Dec 10;35(49):16304-16311. doi: 10.1021/acs.langmuir.9b02823. Epub 2019 Nov 21.

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Bellefroid C, Lechanteur A, Evrard B, Mottet D, Debacq-Chainiaux F, Piel G. In vitro skin penetration enhancement techniques: A combined approach of ethosomes and microneedles. Int J Pharm. 2019 Dec 15;572:118793. doi: 10.1016/j.ijpharm.2019.118793. Epub 2019 Nov 9.

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Xiao W, Zhang W, Huang H, Xie Y, Zhang Y, Guo X, Jin C, Liao X, Yao S, Chen G, Song X. Cancer Targeted Gene Therapy for Inhibition of Melanoma Lung Metastasis with eIF3i shRNA Loaded Liposomes. Mol Pharm. 2020 Jan 6;17(1):229-238. doi: 10.1021/acs.molpharmaceut.9b00943. Epub 2019 Dec 10.

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Handumrongkul C, Ye AL, Chmura SA, Soroceanu L, Mack M, Ice RJ, Thistle R, Myers M, Ursu SJ, Liu Y, Kashani-Sabet M, Heath TD, Liggitt D, Lewis DB, Debs R. Durable multitransgene expression in vivo using systemic, nonviral DNA delivery. Sci Adv. 2019 Nov 27;5(11):eaax0217. doi: 10.1126/sciadv.aax0217. eCollection 2019 Nov.

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Grippin AJ, Wummer B, Wildes T, Dyson K, Trivedi V, Yang C, Sebastian M, Mendez-Gomez HR, Padala S, Grubb M, Fillingim M, Monsalve A, Sayour EJ, Dobson J, Mitchell DA. Dendritic Cell-Activating Magnetic Nanoparticles Enable Early Prediction of Antitumor Response with Magnetic Resonance Imaging. ACS Nano. 2019 Dec 24;13(12):13884-13898. doi: 10.1021/acsnano.9b05037. Epub 2019 Dec 2.

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André EM, Delcroix GJ, Kandalam S, Sindji L, Montero-Menei CN. A Combinatorial Cell and Drug Delivery Strategy for Huntington's Disease Using Pharmacologically Active Microcarriers and RNAi Neuronally-Committed Mesenchymal Stromal Cells. Pharmaceutics. 2019 Oct 12;11(10). pii: E526. doi: 10.3390/pharmaceutics11100526.

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Giorgia La Barbera, Anna Laura Capriotti, Giulio Caracciolo, Chiara Cavaliere, Andrea Cerrato, Carmela Maria Montone, Susy Piovesana, Daniela Pozzi, Erica Quagliarini, Aldo Laganà. A comprehensive analysis of liposomal biomolecular corona upon human plasma incubation: The evolution towards the lipid corona. Talanta. 2019 Oct 22. doi: 10.1016/j.talanta.2019.120487

Wiedenhoeft T, Tarantini S, Nyúl-Tóth Á, Yabluchanskiy A, Csipo T, Balasubramanian P, Lipecz A, Kiss T, Csiszar A, Csiszar A, Ungvari Z. Fusogenic liposomes effectively deliver resveratrol to the cerebral microcirculation and improve endothelium-dependent neurovascular coupling responses in aged mice. Geroscience. 2019 Oct 25. doi: 10.1007/s11357-019-00102-1. [Epub ahead of print]

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Luan J, Chen W, Fan J, Wang S, Zhang X, Zai W, Jin X, Wang Y, Feng Z, Zhang J, Liu ML, Ju D. GSDMD membrane pore is critical for IL-1β release and antagonizing IL-1β by hepatocyte-specific nanobiologics is a promising therapeutics for murine alcoholic steatohepatitis. Biomaterials. 2020 Jan;227:119570. doi: 10.1016/j.biomaterials.2019.119570. Epub 2019 Oct 21.

 PubMed ID: 31670032

Wheat W, Chow L, Kuzmik A, Soontararak S, Kurihara J, Lappin M, Dow S. Local immune and microbiological responses to mucosal administration of a Liposome-TLR agonist immunotherapeutic in dogs. BMC Vet Res. 2019 Sep 13;15(1):330. doi: 10.1186/s12917-019-2073-8.

 PubMed ID: 31519215

Wheat W, Chow L, Kuzmik A, Soontararak S, Kurihara J, Lappin M, Dow S. Local immune and microbiological responses to mucosal administration of a Liposome-TLR agonist immunotherapeutic in dogs. BMC Vet Res. 2019 Sep 13;15(1):330. doi: 10.1186/s12917-019-2073-8.

 PubMed ID: 31519215

Hibbitts A, Lucía A, Serrano-Sevilla I, De Matteis L, McArthur M, de la Fuente JM, Aínsa JA, Navarro F. Co-delivery of free vancomycin and transcription factor decoy-nanostructured lipid carriers can enhance inhibition of methicillin resistant Staphylococcus aureus (MRSA). PLoS One. 2019 Sep 3;14(9):e0220684. doi: 10.1371/journal.pone.0220684. eCollection 2019.

 PubMed ID: 31479462

Ravi V, Madhankumar AB, Abraham T, Slagle-Webb B, Connor JR. Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms. PLoS One. 2019 Sep 6;14(9):e0221952. doi: 10.1371/journal.pone.0221952. eCollection 2019.

 PubMed ID: 31491006

Kono Y, Gogatsubo S, Ohba T, Fujita T. Enhanced macrophage delivery to the colon using magnetic lipoplexes with a magnetic field. Drug Deliv. 2019 Dec;26(1):935-943. doi: 10.1080/10717544.2019.1662515.

 PubMed ID: 31530198

O'Mary HL, Hanafy MS, Aldayel AM, Valdes SA, Alzhrani RF, Hufnagel S, Koleng JJ, Cui Z. Effect of the Ratio of Betamethasone to TNF-α siRNA Coencapsulated in Solid Lipid Nanoparticles on the Acute Proinflammatory Activity of the Nanoparticles. Mol Pharm. 2019 Sep 30. doi: 10.1021/acs.molpharmaceut.9b00629. [Epub ahead of print]

 PubMed ID: 31525980

Xu F, Yan JJ, Gan Y, Chang Y, Wang HL, He XX, Zhao Q. miR-885-5p Negatively Regulates Warburg Effect by Silencing Hexokinase 2 in Liver Cancer. Mol Ther Nucleic Acids. 2019 Sep 12;18:308-319. doi: 10.1016/j.omtn.2019.09.002. [Epub ahead of print]

 PubMed ID: 31614321

Kimura S, Khalil IA, Elewa YHA, Harashima H. Spleen selective enhancement of transfection activities of plasmid DNA driven by octaarginine and an ionizable lipid and its implications for cancer immunization. J Control Release. 2019 Sep 14. pii: S0168-3659(19)30550-4. doi: 10.1016/j.jconrel.2019.09.009. [Epub ahead of print]

 PubMed ID: 31526828

Zhang D, Baldwin P, Leal AS, Carapellucci S, Sridhar S, Liby KT. A nano-liposome formulation of the PARP inhibitor Talazoparib enhances treatment efficacy and modulates immune cell populations in mammary tumors of BRCA-deficient mice. Theranostics. 2019 Aug 14;9(21):6224-6238. doi: 10.7150/thno.36281. eCollection 2019.

 PubMed ID: 31534547

Fan Y, Stronsky SM, Xu Y, Steffens JT, van Tongeren SA, Erwin A, Cooper CL, Moon JJ. Multilamellar Vaccine Particle Elicits Potent Immune Activation with Protein Antigens and Protects Mice against Ebola Virus Infection. ACS Nano. 2019 Sep 12. doi: 10.1021/acsnano.9b03660. [Epub ahead of print]

 PubMed ID: 31497947

Hattori Y, Nakagawa Y, Onishi H. Gene delivery into hepatic cells with ternary complexes of plasmid DNA, cationic liposomes and apolipoprotein E-derived peptide. Exp Ther Med. 2019 Oct;18(4):2628-2638. doi: 10.3892/etm.2019.7863. Epub 2019 Aug 7.

 PubMed ID: 31572511

Inglut CT, Gaitan B, Najafali D, Abad Lopez I, Connolly NP, Orsila S, Perttilä R, Woodworth GF, Chen Y, Huang HC. Predictors and Limitations of the Penetration Depth of Photodynamic Effects in the Rodent Brain. Photochem Photobiol. 2019 Aug 23. doi: 10.1111/php.13155. [Epub ahead of print]

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Jõemetsa S, Spustova K, Kustanovich K, Ainla A, Schindler S, Eigler S, Lobovkina T, Lara-Avila S, Jesorka A, Gözen I. Molecular Lipid Films on Microengineering Materials. Langmuir. 2019 Aug 13;35(32):10286-10298. doi: 10.1021/acs.langmuir.9b01120. Epub 2019 Aug 1.

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Bouxsein NF, Leal C, McAllister CS, Li Y, Ewert KK, Samuel CE, Safinya CR. 3D Columnar Phase of Stacked Short DNA Organized by Coherent Membrane Undulations. Langmuir. 2019 Sep 10;35(36):11891-11901. doi: 10.1021/acs.langmuir.9b01726. Epub 2019 Aug 22.

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Li W, Yan R, Liu Y, He C, Zhang X, Lu Y, Khan MW, Xu C, Yang T, Xiang G. Co-delivery of Bmi1 small interfering RNA with ursolic acid by folate receptor-targeted cationic liposomes enhances anti-tumor activity of ursolic acid in vitro and in vivo. Drug Deliv. 2019 Dec;26(1):794-802. doi: 10.1080/10717544.2019.1645244.

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Yang H, Liu Z, Song Y, Hu C. Hyaluronic acid-functionalized bilosomes for targeted delivery of tripterine to inflamed area with enhancive therapy on arthritis. Drug Deliv. 2019 Dec;26(1):820-830. doi: 10.1080/10717544.2019.1636423.

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N'Diaye M, Vergnaud-Gauduchon J, Nicolas V, Faure V, Denis S, Abreu S, Chaminade P, Rosilio V. Mol Pharm. 2019 Sep 3;16(9):4045-4058. doi: 10.1021/acs.molpharmaceut.9b00797. Epub 2019 Aug 13. Hybrid Lipid Polymer Nanoparticles for Combined Chemo- and Photodynamic Therapy.

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Bruna dos Santos Rodrigues, Sushant Lakkadwala, Takahisa Kanekiyo, Jagdish Singh. Development and screening of brain-targeted lipid-based nanoparticles with enhanced cell penetration and gene delivery properties. International Journal of Nanomedicine; Macclesfield Vol. 14, (2019): 6497-6517. DOI:10.2147/IJN.S215941

Einhäupl P, Krook J, Svensson N, Van Acker K, Van Passel S. Eliciting stakeholder needs - An anticipatory approach assessing enhanced landfill mining. Waste Manag. 2019 Oct;98:113-125. doi: 10.1016/j.wasman.2019.08.009. Epub 2019 Aug 21.

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Takechi-Haraya Y, Goda Y, Izutsu K, Sakai-Kato K. Improved Atomic Force Microscopy Stiffness Measurements of Nanoscale Liposomes by Cantilever Tip Shape Evaluation. Anal Chem. 2019 Aug 20;91(16):10432-10440. doi: 10.1021/acs.analchem.9b00250. Epub 2019 Aug 7.

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Thanki K, van Eetvelde D, Geyer A, Fraire J, Hendrix R, Van Eygen H, Putteman E, Sami H, de Souza Carvalho-Wodarz C, Franzyk H, Nielsen HM, Braeckmans K, Lehr CM, Ogris M, Foged C. Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration. J Control Release. 2019 Sep 28;310:82-93. doi: 10.1016/j.jconrel.2019.08.004. Epub 2019 Aug 6.

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Melo M, Porter E, Zhang Y, Silva M, Li N, Dobosh B, Liguori A, Skog P, Landais E, Menis S, Sok D, Nemazee D, Schief WR, Weiss R, Irvine DJ. Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles. Mol Ther. 2019 Aug 19. pii: S1525-0016(19)30367-3. doi: 10.1016/j.ymthe.2019.08.007. [Epub ahead of print]

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Bae J, Parayath N, Ma W, Amiji M, Munshi N, Anderson K. BCMA peptide-engineered nanoparticles enhance induction and function of antigen-specific CD8+ cytotoxic T lymphocytes against multiple myeloma: clinical applications. Leukemia. 2019 Aug 19. doi: 10.1038/s41375-019-0540-7. [Epub ahead of print]

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Giulimondi F, Digiacomo L, Pozzi D, Palchetti S, Vulpis E, Capriotti AL, Chiozzi RZ, Laganà A, Amenitsch H, Masuelli L, Mahmoudi M, Screpanti I, Zingoni A, Caracciolo G. Interplay of protein corona and immune cells controls blood residency of liposomes. Nat Commun. 2019 Aug 15;10(1):3686. doi: 10.1038/s41467-019-11642-7.

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Komura F, Takahashi Y, Inoue T, Takakura Y, Nishikawa M. Development of a Nanostructured RNA/DNA Assembly as an Adjuvant Targeting Toll-Like Receptor 7/8. Nucleic Acid Ther. 2019 Jul 18. doi: 10.1089/nat.2019.0787. [Epub ahead of print]

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Ghellab SE, Mu W, Li Q, Han X. Prediction of the size of electroformed giant unilamellar vesicle using response surface methodology. Biophys Chem. 2019 Oct;253:106217. doi: 10.1016/j.bpc.2019.106217. Epub 2019 Jul 4.

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Blakney AK, McKay PF, Yus BI, Aldon Y, Shattock RJ. Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA. Gene Ther. 2019 Sep;26(9):363-372. doi: 10.1038/s41434-019-0095-2. Epub 2019 Jul 12.

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Xu H, Chen B, Gong W, Yang Z, Qu J. Nanoliposomes Co-Encapsulating Photoswitchable Probe and Photosensitizer for Super-Resolution Optical Imaging and Photodynamic Therapy. Cytometry A. 2019 Jul 16. doi: 10.1002/cyto.a.23864. [Epub ahead of print]

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Mohamed A, Pekoz AY, Ross K, Hutcheon GA, Saleem IY. Pulmonary delivery of Nanocomposite Microparticles (NCMPs) incorporating miR-146a for treatment of COPD. Int J Pharm. 2019 Oct 5;569:118524. doi: 10.1016/j.ijpharm.2019.118524. Epub 2019 Jul 15.

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Katayama T, Kinugawa S, Takada S, Furihata T, Fukushima A, Yokota T, Anzai T, Hibino M, Harashima H, Yamada Y. A mitochondrial delivery system using liposome-based nanocarriers that target myoblast cells. Mitochondrion. 2019 Jul 19;49:66-72. doi: 10.1016/j.mito.2019.07.005. [Epub ahead of print]

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Girish V, Pazzi J, Li A, Subramaniam AB. Fabrics of Diverse Chemistries Promote the Formation of Giant Vesicles from Phospholipids and Amphiphilic Block Copolymers. Langmuir. 2019 Jul 16;35(28):9264-9273. doi: 10.1021/acs.langmuir.9b01621. Epub 2019 Jul 5.

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Wang F, Sun Y, Shi J. Programmed death-ligand 1 monoclonal antibody-linked immunoliposomes for synergistic efficacy of miR-130a and oxaliplatin in gastric cancers. Nanomedicine (Lond). 2019 Jul;14(13):1729-1744. doi: 10.2217/nnm-2019-0073. Epub 2019 Jul 10.

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Villamizar O, Waters SA, Scott T, Saayman S, Grepo N, Urak R, Davis A, Jaffe A, Morris KV. Targeted Activation of Cystic Fibrosis Transmembrane Conductance Regulator. Mol Ther. 2019 Jul 15. pii: S1525-0016(19)30314-4. doi: 10.1016/j.ymthe.2019.07.002. [Epub ahead of print]

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Villamizar O, Waters SA, Scott T, Saayman S, Grepo N, Urak R, Davis A, Jaffe A, Morris KV. Targeted Activation of Cystic Fibrosis Transmembrane Conductance Regulator. Mol Ther. 2019 Jul 15. pii: S1525-0016(19)30314-4. doi: 10.1016/j.ymthe.2019.07.002. [Epub ahead of print]

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Moro M, Di Paolo D, Milione M, Centonze G, Bornaghi V, Borzi C, Gandellini P, Perri P, Pastorino U, Ponzoni M, Sozzi G, Fortunato O. Coated cationic lipid-nanoparticles entrapping miR-660 inhibit tumor growth in patient-derived xenografts lung cancer models. J Control Release. 2019 Jul 9;308:44-56. doi: 10.1016/j.jconrel.2019.07.006. [Epub ahead of print]

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Park J, Kuo Y, Li J, Huang YL, Miller EW, Weiss S. Improved Surface Functionalization and Characterization of Membrane-Targeted Semiconductor Voltage Nanosensors. J Phys Chem Lett. 2019 Jul 18;10(14):3906-3913. doi: 10.1021/acs.jpclett.9b01258. Epub 2019 Jul 1.

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Kim B, Sun S, Varner JA, Howell SB, Ruoslahti E, Sailor MJ. Securing the Payload, Finding the Cell, and Avoiding the Endosome: Peptide-Targeted, Fusogenic Porous Silicon Nanoparticles for Delivery of siRNA. Adv Mater. 2019 Jul 3:e1902952. doi: 10.1002/adma.201902952. [Epub ahead of print]

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Tunsirikongkon A, Pyo YC, Kim DH, Lee SE, Park JS. Optimization of Polyarginine-Conjugated PEG Lipid Grafted Proliposome Formulation for Enhanced Cellular Association of a Protein Drug. Pharmaceutics. 2019 Jun 11;11(6). pii: E272. doi: 10.3390/pharmaceutics11060272.

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Yoshiyuki Hattori, Kyoko Tamaki, Kei-ichi Ozaki, Kumi Kawano, Hiraku Onishi. Optimized combination of cationic lipids and neutral helper lipids in cationic liposomes for siRNA delivery into the lung by intravenous injection of siRNA lipoplexes. Journal of Drug Delivery Science and Technology. 2019 August;52:1042-1050.

Hattori Y, Hu S, Onishi H. Effects of cationic lipids in cationic liposomes and disaccharides in the freeze-drying of siRNA lipoplexes on gene silencing in cells by reverse transfection. J Liposome Res. 2019 Jul 5:1-11. doi: 10.1080/08982104.2019.1630643. [Epub ahead of print]

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Juanes M, Creese O, Fernández-Trillo P, Montenegro J. Messenger RNA delivery by hydrazone-activated polymers. Medchemcomm. 2019 Jun 18;10(7):1138-1144. doi: 10.1039/c9md00231f. eCollection 2019 Jul 1.

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Sakurai Y, Kato A, Hida Y, Hamada J, Maishi N, Hida K, Harashima H. Synergistic Enhancement of Cellular Uptake With CD44-Expressing Malignant Pleural Mesothelioma by Combining Cationic Liposome and Hyaluronic Acid-Lipid Conjugate. J Pharm Sci. 2019 Jun 21. pii: S0022-3549(19)30382-X. doi: 10.1016/j.xphs.2019.06.012. [Epub ahead of print]

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Lu Y, Zhong L, Jiang Z, Pan H, Zhang Y, Zhu G, Bai L, Tong R, Shi J, Duan X. Cationic micelle-based siRNA delivery for efficient colon cancer gene therapy. Nanoscale Res Lett. 2019 Jun 4;14(1):193. doi: 10.1186/s11671-019-2985-z.

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Mendonça MCP, Radaic A, Garcia-Fossa F, da Cruz-Höfling MA, Vinolo MAR, de Jesus MB. The in vivo toxicological profile of cationic solid lipid nanoparticles. Drug Deliv Transl Res. 2019 Jun 25. doi: 10.1007/s13346-019-00657-8. [Epub ahead of print]

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Landry MR, Rangel JL, Dao VP, MacKenzie MA, Gutierrez FL, Dowell KM, Calkins AL, Fuller AA, Stokes GY. Length and Charge of Water-Soluble Peptoids Impact Binding to Phospholipid Membranes. J Phys Chem B. 2019 Jul 11;123(27):5822-5831. doi: 10.1021/acs.jpcb.9b04641. Epub 2019 Jun 28.

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Riccardo Di Santo, Erica Quagliarini, Sara Palchetti, Daniela Pozzi, Valentina Palmieri, Giordano Perini, Massimiliano Papi, Anna Laura Capriotti, Aldo Laganà, and Giulio Caracciolo. Microfluidic-generated lipid-graphene oxide nanoparticles for gene delivery. Appl. Phys. Lett. 114, 233701 (2019). doi: 10.1063/1.5100932