890890 | 18:1 TAP (DOTAP)
1,2-dioleoyl-3-trimethylammonium-propane (chloride salt)

18:1 TAP (DOTAP)
1,2-dioleoyl-3-trimethylammonium-propane (chloride salt)
DOTAP is one of the most widely used cationic lipids for gene transfection applications. DOTAP is proven to be efficient for in vitro and in vivo transfection applications. Various analogues of TAP are available for structure-activity relationship studies.
Simberg D, Weisman S, Talmon Y, Barenholz Y. DOTAP (and other cationic lipids): chemistry, biophysics, and transfection. Crit Rev Ther Drug Carrier Syst. 2004;21(4):257-317. doi: 10.1615/critrevtherdrugcarriersyst.v21.i4.10. PMID: 15638468.
CAS Registry Number is a Registered Trademark of the American Chemical Society
DOTAP
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- 3D Structure
- Structure
- Safety Data Sheet
- Safety Data Sheet
- Certificate of Analysis (Lot No. 890890C-1G-A-163 and 6361CQA163)
- Certificate of Analysis (Lot No. 890890C-200MG-A-163 and 6361CNA163)
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- Certificate of Analysis (Lot No. 890890P-200MG-A-163 and 6361PNA163)
- Certificate of Analysis (Lot No. 890890P-25MG-A-163 and 6361PJA163)
- Certificate of Analysis (Lot No. 890890P-500MG-A-163 and 6361PPA163)
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- Certificate of Analysis (Lot No. 890890P-1G-A-164 and 6361PQA164)
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- Certificate of Analysis (Lot No. 890890P-1G-B-164 and 6361PQB164)
- Certificate of Analysis (Lot No. 890890P-500MG-B-164 and 6361PPB164)
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- Certificate of Analysis (Lot No. 890890P-500MG-A-165 and 6361PPA165)
- Certificate of Analysis (Lot No. 890890C-25MG-A-165 and 6361CJA165)
- Certificate of Analysis (Lot No. 890890C-200MG-A-165 and 6361CNA165)
- Certificate of Analysis (Lot No. 890890P-25MG-A-165 and 6361PJA165)
- Certificate of Analysis (Lot No. 890890C-25MG-B-165 and 6361CJB165)
- Certificate of Analysis (Lot No. 890890P-25MG-B-165 and 6361PJB165)
- Certificate of Analysis (Lot No. 890890P-500MG-B-165 and 6361PPB165)
- Certificate of Analysis (Lot No. 890890P-200MG-C-165 and 6361PNC165)
- Certificate of Analysis (Lot No. 890890C-25MG-C-165 and 6361CJC165)
- Certificate of Analysis (Lot No. 890890C-500MG-C-163 and 6361CPC163)
- Certificate of Analysis (Lot No. 890890P-25MG-C-165 and 6361PJC165)
- Certificate of Analysis (Lot No. 890890P-200MG-D-165 and 6361PND165)
- Certificate of Analysis (Lot No. 890890P-500MG-C-165 and 6361PPC165)
- Certificate of Analysis (Lot No. 890890C-200MG-B-165 and 6361CNB165)
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- Certificate of Analysis (Lot No. 890890C-200MG-A-169 and 6361CNA165)
- Certificate of Analysis (Lot No. 890890P-500MG-A-169 and 6361PPA169)
- Certificate of Analysis (Lot No. 890890C-500MG-A-169 and 6361CPA169)
- Certificate of Analysis (Lot No. 890890P-1G-A-170 and 6361PQA170)
- Certificate of Analysis (Lot No. 890890P-200MG-A-170 and 6361PNA170)
- Certificate of Analysis (Lot No. 890890C-200MG-B-169 and 6361CNB165)
- Certificate of Analysis (Lot No. 890890C-500MG-A-170 and 6361CPA170)
- Certificate of Analysis (Lot No. 890890C-200MG-A-170 and 6361CNA170)
- Certificate of Analysis (Lot No. 890890C-25MG-A-170 and 6361CJA170)
- Certificate of Analysis (Lot No. 890890P-500MG-A-170 and 6361PPA170)
- Certificate of Analysis (Lot No. 890890P-25MG-A-170 and 6361PJA170)
- Certificate of Analysis (Lot No. 890890C-200MG-B-170 and 6361CNB170)
- Certificate of Analysis (Lot No. 890890P-200MG-B-170 and 6361PNB170)
- Certificate of Analysis (Lot No. 890890P-200MG-C-170 and 6361PNC170)
- Certificate of Analysis (Lot No. 890890P-25MG-B-170 and 6361PJB170)
- Certificate of Analysis (Lot No. 890890P-500MG-B-170 and 6361PPB170)
- Certificate of Analysis (Lot No. 890890P-200MG-D-170 and 6361PND170)
- Certificate of Analysis (Lot No. 890890P-1G-B-170 and 6361PQB170)
- Certificate of Analysis (Lot No. 890890P-500MG-A-171 and 6361PPA171)
- Certificate of Analysis (Lot No. 890890C-500MG-A-171 and 6361CPA171)
- Certificate of Analysis (Lot No. 890890P-25MG-A-171 and 6361PJA171)
- Certificate of Analysis (Lot No. 890890P-1G-A-171 and 6361PQA171)
- Certificate of Analysis (Lot No. 890890P-200MG-A-171 and 6361PNA171)
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- Certificate of Analysis (Lot No. 890890P-500MG-A-173 and 6361PPA173)
- Certificate of Analysis (Lot No. 890890P-200MG-A-173 and 6362PNA173)
- Certificate of Analysis (Lot No. 890890P-1G-A-173 and 6361PQA173)
- Certificate of Analysis (Lot No. 890890C-25MG-A-173 and 6361CJA173)
- Certificate of Analysis (Lot No. 890890P-500MG-B-173 and 6361PPB173)
- Certificate of Analysis (Lot No. 890890P-200MG-B-173 and 6362PNB173)
- Certificate of Analysis (Lot No. 890890P-200MG-B-171 and 6361PNB171)
- Certificate of Analysis (Lot No. 890890P-1G-B-173 and 6361PQB173)
- Certificate of Analysis (Lot No. 890890C-200MG-A-171 and 6361CNA171)
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- Certificate of Analysis (Lot No. 890890P-200MG-A-174 and 6361PNA174)
- Certificate of Analysis (Lot No. 890890C-500MG-A-174 and 6361CPA174)
- Certificate of Analysis (Lot No. 890890C-200MG-A-174 and 6361CNA174)
- Certificate of Analysis (Lot No. 890890C-25MG-A-174 and 6361CJA174)
- Certificate of Analysis (Lot No. 890890P-500MG-B-174 and 6361PPB174)
- Certificate of Analysis (Lot No. 890890P-1G-B-174 and 6361PQB174)
- Certificate of Analysis (Lot No. 890890P-500MG-C-174 and 6361PPC174)
- Certificate of Analysis (Lot No. 890890P-200MG-D-174 and 6361PND174)
- Certificate of Analysis (Lot No. 890890C-25MG-B-174 and 6361CJB174)
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PubMed ID: 31715350Xiao W, Zhang W, Huang H, Xie Y, Zhang Y, Guo X, Jin C, Liao X, Yao S, Chen G, Song X. Cancer Targeted Gene Therapy for Inhibition of Melanoma Lung Metastasis with eIF3i shRNA Loaded Liposomes. Mol Pharm. 2020 Jan 6;17(1):229-238. doi: 10.1021/acs.molpharmaceut.9b00943. Epub 2019 Dec 10.
PubMed ID: 31765158Handumrongkul C, Ye AL, Chmura SA, Soroceanu L, Mack M, Ice RJ, Thistle R, Myers M, Ursu SJ, Liu Y, Kashani-Sabet M, Heath TD, Liggitt D, Lewis DB, Debs R. Durable multitransgene expression in vivo using systemic, nonviral DNA delivery. Sci Adv. 2019 Nov 27;5(11):eaax0217. doi: 10.1126/sciadv.aax0217. eCollection 2019 Nov.
PubMed ID: 31807699Grippin AJ, Wummer B, Wildes T, Dyson K, Trivedi V, Yang C, Sebastian M, Mendez-Gomez HR, Padala S, Grubb M, Fillingim M, Monsalve A, Sayour EJ, Dobson J, Mitchell DA. Dendritic Cell-Activating Magnetic Nanoparticles Enable Early Prediction of Antitumor Response with Magnetic Resonance Imaging. ACS Nano. 2019 Dec 24;13(12):13884-13898. doi: 10.1021/acsnano.9b05037. Epub 2019 Dec 2.
PubMed ID: 31730332André EM, Delcroix GJ, Kandalam S, Sindji L, Montero-Menei CN. A Combinatorial Cell and Drug Delivery Strategy for Huntington's Disease Using Pharmacologically Active Microcarriers and RNAi Neuronally-Committed Mesenchymal Stromal Cells. Pharmaceutics. 2019 Oct 12;11(10). pii: E526. doi: 10.3390/pharmaceutics11100526.
PubMed ID: 31614758Giorgia La Barbera, Anna Laura Capriotti, Giulio Caracciolo, Chiara Cavaliere, Andrea Cerrato, Carmela Maria Montone, Susy Piovesana, Daniela Pozzi, Erica Quagliarini, Aldo Laganà. A comprehensive analysis of liposomal biomolecular corona upon human plasma incubation: The evolution towards the lipid corona. Talanta. 2019 Oct 22. doi: 10.1016/j.talanta.2019.120487
Wiedenhoeft T, Tarantini S, Nyúl-Tóth Á, Yabluchanskiy A, Csipo T, Balasubramanian P, Lipecz A, Kiss T, Csiszar A, Csiszar A, Ungvari Z. Fusogenic liposomes effectively deliver resveratrol to the cerebral microcirculation and improve endothelium-dependent neurovascular coupling responses in aged mice. Geroscience. 2019 Oct 25. doi: 10.1007/s11357-019-00102-1. [Epub ahead of print]
PubMed ID: 31654270Luan J, Chen W, Fan J, Wang S, Zhang X, Zai W, Jin X, Wang Y, Feng Z, Zhang J, Liu ML, Ju D. GSDMD membrane pore is critical for IL-1β release and antagonizing IL-1β by hepatocyte-specific nanobiologics is a promising therapeutics for murine alcoholic steatohepatitis. Biomaterials. 2020 Jan;227:119570. doi: 10.1016/j.biomaterials.2019.119570. Epub 2019 Oct 21.
PubMed ID: 31670032Wheat W, Chow L, Kuzmik A, Soontararak S, Kurihara J, Lappin M, Dow S. Local immune and microbiological responses to mucosal administration of a Liposome-TLR agonist immunotherapeutic in dogs. BMC Vet Res. 2019 Sep 13;15(1):330. doi: 10.1186/s12917-019-2073-8.
PubMed ID: 31519215Wheat W, Chow L, Kuzmik A, Soontararak S, Kurihara J, Lappin M, Dow S. Local immune and microbiological responses to mucosal administration of a Liposome-TLR agonist immunotherapeutic in dogs. BMC Vet Res. 2019 Sep 13;15(1):330. doi: 10.1186/s12917-019-2073-8.
PubMed ID: 31519215Hibbitts A, Lucía A, Serrano-Sevilla I, De Matteis L, McArthur M, de la Fuente JM, Aínsa JA, Navarro F. Co-delivery of free vancomycin and transcription factor decoy-nanostructured lipid carriers can enhance inhibition of methicillin resistant Staphylococcus aureus (MRSA). PLoS One. 2019 Sep 3;14(9):e0220684. doi: 10.1371/journal.pone.0220684. eCollection 2019.
PubMed ID: 31479462Ravi V, Madhankumar AB, Abraham T, Slagle-Webb B, Connor JR. Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms. PLoS One. 2019 Sep 6;14(9):e0221952. doi: 10.1371/journal.pone.0221952. eCollection 2019.
PubMed ID: 31491006Kono Y, Gogatsubo S, Ohba T, Fujita T. Enhanced macrophage delivery to the colon using magnetic lipoplexes with a magnetic field. Drug Deliv. 2019 Dec;26(1):935-943. doi: 10.1080/10717544.2019.1662515.
PubMed ID: 31530198O'Mary HL, Hanafy MS, Aldayel AM, Valdes SA, Alzhrani RF, Hufnagel S, Koleng JJ, Cui Z. Effect of the Ratio of Betamethasone to TNF-α siRNA Coencapsulated in Solid Lipid Nanoparticles on the Acute Proinflammatory Activity of the Nanoparticles. Mol Pharm. 2019 Sep 30. doi: 10.1021/acs.molpharmaceut.9b00629. [Epub ahead of print]
PubMed ID: 31525980Xu F, Yan JJ, Gan Y, Chang Y, Wang HL, He XX, Zhao Q. miR-885-5p Negatively Regulates Warburg Effect by Silencing Hexokinase 2 in Liver Cancer. Mol Ther Nucleic Acids. 2019 Sep 12;18:308-319. doi: 10.1016/j.omtn.2019.09.002. [Epub ahead of print]
PubMed ID: 31614321Kimura S, Khalil IA, Elewa YHA, Harashima H. Spleen selective enhancement of transfection activities of plasmid DNA driven by octaarginine and an ionizable lipid and its implications for cancer immunization. J Control Release. 2019 Sep 14. pii: S0168-3659(19)30550-4. doi: 10.1016/j.jconrel.2019.09.009. [Epub ahead of print]
PubMed ID: 31526828Zhang D, Baldwin P, Leal AS, Carapellucci S, Sridhar S, Liby KT. A nano-liposome formulation of the PARP inhibitor Talazoparib enhances treatment efficacy and modulates immune cell populations in mammary tumors of BRCA-deficient mice. Theranostics. 2019 Aug 14;9(21):6224-6238. doi: 10.7150/thno.36281. eCollection 2019.
PubMed ID: 31534547Fan Y, Stronsky SM, Xu Y, Steffens JT, van Tongeren SA, Erwin A, Cooper CL, Moon JJ. Multilamellar Vaccine Particle Elicits Potent Immune Activation with Protein Antigens and Protects Mice against Ebola Virus Infection. ACS Nano. 2019 Sep 12. doi: 10.1021/acsnano.9b03660. [Epub ahead of print]
PubMed ID: 31497947Hattori Y, Nakagawa Y, Onishi H. Gene delivery into hepatic cells with ternary complexes of plasmid DNA, cationic liposomes and apolipoprotein E-derived peptide. Exp Ther Med. 2019 Oct;18(4):2628-2638. doi: 10.3892/etm.2019.7863. Epub 2019 Aug 7.
PubMed ID: 31572511Inglut CT, Gaitan B, Najafali D, Abad Lopez I, Connolly NP, Orsila S, Perttilä R, Woodworth GF, Chen Y, Huang HC. Predictors and Limitations of the Penetration Depth of Photodynamic Effects in the Rodent Brain. Photochem Photobiol. 2019 Aug 23. doi: 10.1111/php.13155. [Epub ahead of print]
PubMed ID: 31441057Jõemetsa S, Spustova K, Kustanovich K, Ainla A, Schindler S, Eigler S, Lobovkina T, Lara-Avila S, Jesorka A, Gözen I. Molecular Lipid Films on Microengineering Materials. Langmuir. 2019 Aug 13;35(32):10286-10298. doi: 10.1021/acs.langmuir.9b01120. Epub 2019 Aug 1.
PubMed ID: 31369272Bouxsein NF, Leal C, McAllister CS, Li Y, Ewert KK, Samuel CE, Safinya CR. 3D Columnar Phase of Stacked Short DNA Organized by Coherent Membrane Undulations. Langmuir. 2019 Sep 10;35(36):11891-11901. doi: 10.1021/acs.langmuir.9b01726. Epub 2019 Aug 22.
PubMed ID: 31408350Li W, Yan R, Liu Y, He C, Zhang X, Lu Y, Khan MW, Xu C, Yang T, Xiang G. Co-delivery of Bmi1 small interfering RNA with ursolic acid by folate receptor-targeted cationic liposomes enhances anti-tumor activity of ursolic acid in vitro and in vivo. Drug Deliv. 2019 Dec;26(1):794-802. doi: 10.1080/10717544.2019.1645244.
PubMed ID: 31366257Yang H, Liu Z, Song Y, Hu C. Hyaluronic acid-functionalized bilosomes for targeted delivery of tripterine to inflamed area with enhancive therapy on arthritis. Drug Deliv. 2019 Dec;26(1):820-830. doi: 10.1080/10717544.2019.1636423.
PubMed ID: 31389248N'Diaye M, Vergnaud-Gauduchon J, Nicolas V, Faure V, Denis S, Abreu S, Chaminade P, Rosilio V. Mol Pharm. 2019 Sep 3;16(9):4045-4058. doi: 10.1021/acs.molpharmaceut.9b00797. Epub 2019 Aug 13. Hybrid Lipid Polymer Nanoparticles for Combined Chemo- and Photodynamic Therapy.
PubMed ID: 31361499Bruna dos Santos Rodrigues, Sushant Lakkadwala, Takahisa Kanekiyo, Jagdish Singh. Development and screening of brain-targeted lipid-based nanoparticles with enhanced cell penetration and gene delivery properties. International Journal of Nanomedicine; Macclesfield Vol. 14, (2019): 6497-6517. DOI:10.2147/IJN.S215941
Einhäupl P, Krook J, Svensson N, Van Acker K, Van Passel S. Eliciting stakeholder needs - An anticipatory approach assessing enhanced landfill mining. Waste Manag. 2019 Oct;98:113-125. doi: 10.1016/j.wasman.2019.08.009. Epub 2019 Aug 21.
PubMed ID: 31445456Takechi-Haraya Y, Goda Y, Izutsu K, Sakai-Kato K. Improved Atomic Force Microscopy Stiffness Measurements of Nanoscale Liposomes by Cantilever Tip Shape Evaluation. Anal Chem. 2019 Aug 20;91(16):10432-10440. doi: 10.1021/acs.analchem.9b00250. Epub 2019 Aug 7.
PubMed ID: 31390864Thanki K, van Eetvelde D, Geyer A, Fraire J, Hendrix R, Van Eygen H, Putteman E, Sami H, de Souza Carvalho-Wodarz C, Franzyk H, Nielsen HM, Braeckmans K, Lehr CM, Ogris M, Foged C. Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration. J Control Release. 2019 Sep 28;310:82-93. doi: 10.1016/j.jconrel.2019.08.004. Epub 2019 Aug 6.
PubMed ID: 31398360Melo M, Porter E, Zhang Y, Silva M, Li N, Dobosh B, Liguori A, Skog P, Landais E, Menis S, Sok D, Nemazee D, Schief WR, Weiss R, Irvine DJ. Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles. Mol Ther. 2019 Aug 19. pii: S1525-0016(19)30367-3. doi: 10.1016/j.ymthe.2019.08.007. [Epub ahead of print]
Bae J, Parayath N, Ma W, Amiji M, Munshi N, Anderson K. BCMA peptide-engineered nanoparticles enhance induction and function of antigen-specific CD8+ cytotoxic T lymphocytes against multiple myeloma: clinical applications. Leukemia. 2019 Aug 19. doi: 10.1038/s41375-019-0540-7. [Epub ahead of print]
PubMed ID: 31427721Giulimondi F, Digiacomo L, Pozzi D, Palchetti S, Vulpis E, Capriotti AL, Chiozzi RZ, Laganà A, Amenitsch H, Masuelli L, Mahmoudi M, Screpanti I, Zingoni A, Caracciolo G. Interplay of protein corona and immune cells controls blood residency of liposomes. Nat Commun. 2019 Aug 15;10(1):3686. doi: 10.1038/s41467-019-11642-7.
PubMed ID: 31417080Komura F, Takahashi Y, Inoue T, Takakura Y, Nishikawa M. Development of a Nanostructured RNA/DNA Assembly as an Adjuvant Targeting Toll-Like Receptor 7/8. Nucleic Acid Ther. 2019 Jul 18. doi: 10.1089/nat.2019.0787. [Epub ahead of print]
PubMed ID: 31329033Ghellab SE, Mu W, Li Q, Han X. Prediction of the size of electroformed giant unilamellar vesicle using response surface methodology. Biophys Chem. 2019 Oct;253:106217. doi: 10.1016/j.bpc.2019.106217. Epub 2019 Jul 4.
PubMed ID: 31306917Blakney AK, McKay PF, Yus BI, Aldon Y, Shattock RJ. Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA. Gene Ther. 2019 Sep;26(9):363-372. doi: 10.1038/s41434-019-0095-2. Epub 2019 Jul 12.
PubMed ID: 31300730Xu H, Chen B, Gong W, Yang Z, Qu J. Nanoliposomes Co-Encapsulating Photoswitchable Probe and Photosensitizer for Super-Resolution Optical Imaging and Photodynamic Therapy. Cytometry A. 2019 Jul 16. doi: 10.1002/cyto.a.23864. [Epub ahead of print]
PubMed ID: 31313510Mohamed A, Pekoz AY, Ross K, Hutcheon GA, Saleem IY. Pulmonary delivery of Nanocomposite Microparticles (NCMPs) incorporating miR-146a for treatment of COPD. Int J Pharm. 2019 Oct 5;569:118524. doi: 10.1016/j.ijpharm.2019.118524. Epub 2019 Jul 15.
PubMed ID: 31319144Katayama T, Kinugawa S, Takada S, Furihata T, Fukushima A, Yokota T, Anzai T, Hibino M, Harashima H, Yamada Y. A mitochondrial delivery system using liposome-based nanocarriers that target myoblast cells. Mitochondrion. 2019 Jul 19;49:66-72. doi: 10.1016/j.mito.2019.07.005. [Epub ahead of print]
PubMed ID: 31326598Girish V, Pazzi J, Li A, Subramaniam AB. Fabrics of Diverse Chemistries Promote the Formation of Giant Vesicles from Phospholipids and Amphiphilic Block Copolymers. Langmuir. 2019 Jul 16;35(28):9264-9273. doi: 10.1021/acs.langmuir.9b01621. Epub 2019 Jul 5.
PubMed ID: 31276413Wang F, Sun Y, Shi J. Programmed death-ligand 1 monoclonal antibody-linked immunoliposomes for synergistic efficacy of miR-130a and oxaliplatin in gastric cancers. Nanomedicine (Lond). 2019 Jul;14(13):1729-1744. doi: 10.2217/nnm-2019-0073. Epub 2019 Jul 10.
PubMed ID: 31290727Villamizar O, Waters SA, Scott T, Saayman S, Grepo N, Urak R, Davis A, Jaffe A, Morris KV. Targeted Activation of Cystic Fibrosis Transmembrane Conductance Regulator. Mol Ther. 2019 Jul 15. pii: S1525-0016(19)30314-4. doi: 10.1016/j.ymthe.2019.07.002. [Epub ahead of print]
PubMed ID: 31383454Villamizar O, Waters SA, Scott T, Saayman S, Grepo N, Urak R, Davis A, Jaffe A, Morris KV. Targeted Activation of Cystic Fibrosis Transmembrane Conductance Regulator. Mol Ther. 2019 Jul 15. pii: S1525-0016(19)30314-4. doi: 10.1016/j.ymthe.2019.07.002. [Epub ahead of print]
PubMed ID: 31383454Moro M, Di Paolo D, Milione M, Centonze G, Bornaghi V, Borzi C, Gandellini P, Perri P, Pastorino U, Ponzoni M, Sozzi G, Fortunato O. Coated cationic lipid-nanoparticles entrapping miR-660 inhibit tumor growth in patient-derived xenografts lung cancer models. J Control Release. 2019 Jul 9;308:44-56. doi: 10.1016/j.jconrel.2019.07.006. [Epub ahead of print]
PubMed ID: 31299263Park J, Kuo Y, Li J, Huang YL, Miller EW, Weiss S. Improved Surface Functionalization and Characterization of Membrane-Targeted Semiconductor Voltage Nanosensors. J Phys Chem Lett. 2019 Jul 18;10(14):3906-3913. doi: 10.1021/acs.jpclett.9b01258. Epub 2019 Jul 1.
PubMed ID: 31241960Kim B, Sun S, Varner JA, Howell SB, Ruoslahti E, Sailor MJ. Securing the Payload, Finding the Cell, and Avoiding the Endosome: Peptide-Targeted, Fusogenic Porous Silicon Nanoparticles for Delivery of siRNA. Adv Mater. 2019 Jul 3:e1902952. doi: 10.1002/adma.201902952. [Epub ahead of print]
PubMed ID: 31267590Tunsirikongkon A, Pyo YC, Kim DH, Lee SE, Park JS. Optimization of Polyarginine-Conjugated PEG Lipid Grafted Proliposome Formulation for Enhanced Cellular Association of a Protein Drug. Pharmaceutics. 2019 Jun 11;11(6). pii: E272. doi: 10.3390/pharmaceutics11060272.
PubMed ID: 31212607Yoshiyuki Hattori, Kyoko Tamaki, Kei-ichi Ozaki, Kumi Kawano, Hiraku Onishi. Optimized combination of cationic lipids and neutral helper lipids in cationic liposomes for siRNA delivery into the lung by intravenous injection of siRNA lipoplexes. Journal of Drug Delivery Science and Technology. 2019 August;52:1042-1050.
Hattori Y, Hu S, Onishi H. Effects of cationic lipids in cationic liposomes and disaccharides in the freeze-drying of siRNA lipoplexes on gene silencing in cells by reverse transfection. J Liposome Res. 2019 Jul 5:1-11. doi: 10.1080/08982104.2019.1630643. [Epub ahead of print]
PubMed ID: 31185779Juanes M, Creese O, Fernández-Trillo P, Montenegro J. Messenger RNA delivery by hydrazone-activated polymers. Medchemcomm. 2019 Jun 18;10(7):1138-1144. doi: 10.1039/c9md00231f. eCollection 2019 Jul 1.
PubMed ID: 31391886Sakurai Y, Kato A, Hida Y, Hamada J, Maishi N, Hida K, Harashima H. Synergistic Enhancement of Cellular Uptake With CD44-Expressing Malignant Pleural Mesothelioma by Combining Cationic Liposome and Hyaluronic Acid-Lipid Conjugate. J Pharm Sci. 2019 Jun 21. pii: S0022-3549(19)30382-X. doi: 10.1016/j.xphs.2019.06.012. [Epub ahead of print]
PubMed ID: 31229434Lu Y, Zhong L, Jiang Z, Pan H, Zhang Y, Zhu G, Bai L, Tong R, Shi J, Duan X. Cationic micelle-based siRNA delivery for efficient colon cancer gene therapy. Nanoscale Res Lett. 2019 Jun 4;14(1):193. doi: 10.1186/s11671-019-2985-z.
PubMed ID: 31165329Mendonça MCP, Radaic A, Garcia-Fossa F, da Cruz-Höfling MA, Vinolo MAR, de Jesus MB. The in vivo toxicological profile of cationic solid lipid nanoparticles. Drug Deliv Transl Res. 2019 Jun 25. doi: 10.1007/s13346-019-00657-8. [Epub ahead of print]
PubMed ID: 31240624Landry MR, Rangel JL, Dao VP, MacKenzie MA, Gutierrez FL, Dowell KM, Calkins AL, Fuller AA, Stokes GY. Length and Charge of Water-Soluble Peptoids Impact Binding to Phospholipid Membranes. J Phys Chem B. 2019 Jul 11;123(27):5822-5831. doi: 10.1021/acs.jpcb.9b04641. Epub 2019 Jun 28.
PubMed ID: 31251622Riccardo Di Santo, Erica Quagliarini, Sara Palchetti, Daniela Pozzi, Valentina Palmieri, Giordano Perini, Massimiliano Papi, Anna Laura Capriotti, Aldo Laganà, and Giulio Caracciolo. Microfluidic-generated lipid-graphene oxide nanoparticles for gene delivery. Appl. Phys. Lett. 114, 233701 (2019). doi: 10.1063/1.5100932