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890890 | 18:1 TAP (DOTAP)

1,2-dioleoyl-3-trimethylammonium-propane (chloride salt)

18:1 TAP (DOTAP)

Powder

Size SKU Packaging Price
25mg 890890P-25mg 890890P-25mg 1 x 25mg $217.25
200mg 890890P-200mg 890890P-200mg 2 x 100mg $454.00
500mg 890890P-500mg 890890P-500mg 5 x 100mg $930.00
1g 890890P-1g 890890P-1g 1 x 1g $1,700.00
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Chloroform

Size SKU Packaging Price
25mg 890890C-25mg 890890C-25mg 1 x 25mg 10mg/mL 2.5mL $217.25 217.25
200mg 890890C-200mg 890890C-200mg 2 x 100mg 25mg/mL 4mL $454.00 454
500mg 890890C-500mg 890890C-500mg 5 x 100mg 25mg/mL 4mL $930.00 930
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Info

18:1 TAP (DOTAP)

1,2-dioleoyl-3-trimethylammonium-propane (chloride salt)

DOTAP is one of the most widely used cationic lipids for gene transfection applications. DOTAP is proven to be efficient for in vitro and in vivo transfection applications. Various analogues of TAP are available for structure-activity relationship studies.

Simberg D, Weisman S, Talmon Y, Barenholz Y. DOTAP (and other cationic lipids): chemistry, biophysics, and transfection. Crit Rev Ther Drug Carrier Syst. 2004;21(4):257-317. doi: 10.1615/critrevtherdrugcarriersyst.v21.i4.10. PMID: 15638468.

Data
Hygroscopic
No
Light Sensitive
Yes
Molecular Formula
C42H80NO4Cl
Percent Composition
C 72.22%, H 11.54%, Cl 5.08%, N 2.01%, O 9.16%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
132172-61-3
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
698.542
Exact Mass
697.578
Synonyms
1,2-di-(9Z-octadecenoyl)-3-trimethylammonium-propane (chloride salt)
DOTAP
Transition Temp
<5°C (see Regelin et al)
Solubility in Different Solvents
Soluble in ethanol at 5mg/mL, soluble in DMSO at 5mg/mL, soluble in Chloroform:Methanol:Water (65:25:4) at 5mg/mL
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References

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Wheat W, Chow L, Kuzmik A, Soontararak S, Kurihara J, Lappin M, Dow S. Local immune and microbiological responses to mucosal administration of a Liposome-TLR agonist immunotherapeutic in dogs. BMC Vet Res. 2019 Sep 13;15(1):330. doi: 10.1186/s12917-019-2073-8.

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Hibbitts A, Lucía A, Serrano-Sevilla I, De Matteis L, McArthur M, de la Fuente JM, Aínsa JA, Navarro F. Co-delivery of free vancomycin and transcription factor decoy-nanostructured lipid carriers can enhance inhibition of methicillin resistant Staphylococcus aureus (MRSA). PLoS One. 2019 Sep 3;14(9):e0220684. doi: 10.1371/journal.pone.0220684. eCollection 2019.

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Ravi V, Madhankumar AB, Abraham T, Slagle-Webb B, Connor JR. Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms. PLoS One. 2019 Sep 6;14(9):e0221952. doi: 10.1371/journal.pone.0221952. eCollection 2019.

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Kono Y, Gogatsubo S, Ohba T, Fujita T. Enhanced macrophage delivery to the colon using magnetic lipoplexes with a magnetic field. Drug Deliv. 2019 Dec;26(1):935-943. doi: 10.1080/10717544.2019.1662515.

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O'Mary HL, Hanafy MS, Aldayel AM, Valdes SA, Alzhrani RF, Hufnagel S, Koleng JJ, Cui Z. Effect of the Ratio of Betamethasone to TNF-α siRNA Coencapsulated in Solid Lipid Nanoparticles on the Acute Proinflammatory Activity of the Nanoparticles. Mol Pharm. 2019 Sep 30. doi: 10.1021/acs.molpharmaceut.9b00629. [Epub ahead of print]

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Xu F, Yan JJ, Gan Y, Chang Y, Wang HL, He XX, Zhao Q. miR-885-5p Negatively Regulates Warburg Effect by Silencing Hexokinase 2 in Liver Cancer. Mol Ther Nucleic Acids. 2019 Sep 12;18:308-319. doi: 10.1016/j.omtn.2019.09.002. [Epub ahead of print]

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Kimura S, Khalil IA, Elewa YHA, Harashima H. Spleen selective enhancement of transfection activities of plasmid DNA driven by octaarginine and an ionizable lipid and its implications for cancer immunization. J Control Release. 2019 Sep 14. pii: S0168-3659(19)30550-4. doi: 10.1016/j.jconrel.2019.09.009. [Epub ahead of print]

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Zhang D, Baldwin P, Leal AS, Carapellucci S, Sridhar S, Liby KT. A nano-liposome formulation of the PARP inhibitor Talazoparib enhances treatment efficacy and modulates immune cell populations in mammary tumors of BRCA-deficient mice. Theranostics. 2019 Aug 14;9(21):6224-6238. doi: 10.7150/thno.36281. eCollection 2019.

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Fan Y, Stronsky SM, Xu Y, Steffens JT, van Tongeren SA, Erwin A, Cooper CL, Moon JJ. Multilamellar Vaccine Particle Elicits Potent Immune Activation with Protein Antigens and Protects Mice against Ebola Virus Infection. ACS Nano. 2019 Sep 12. doi: 10.1021/acsnano.9b03660. [Epub ahead of print]

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Hattori Y, Nakagawa Y, Onishi H. Gene delivery into hepatic cells with ternary complexes of plasmid DNA, cationic liposomes and apolipoprotein E-derived peptide. Exp Ther Med. 2019 Oct;18(4):2628-2638. doi: 10.3892/etm.2019.7863. Epub 2019 Aug 7.

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Jõemetsa S, Spustova K, Kustanovich K, Ainla A, Schindler S, Eigler S, Lobovkina T, Lara-Avila S, Jesorka A, Gözen I. Molecular Lipid Films on Microengineering Materials. Langmuir. 2019 Aug 13;35(32):10286-10298. doi: 10.1021/acs.langmuir.9b01120. Epub 2019 Aug 1.

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Bouxsein NF, Leal C, McAllister CS, Li Y, Ewert KK, Samuel CE, Safinya CR. 3D Columnar Phase of Stacked Short DNA Organized by Coherent Membrane Undulations. Langmuir. 2019 Sep 10;35(36):11891-11901. doi: 10.1021/acs.langmuir.9b01726. Epub 2019 Aug 22.

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Li W, Yan R, Liu Y, He C, Zhang X, Lu Y, Khan MW, Xu C, Yang T, Xiang G. Co-delivery of Bmi1 small interfering RNA with ursolic acid by folate receptor-targeted cationic liposomes enhances anti-tumor activity of ursolic acid in vitro and in vivo. Drug Deliv. 2019 Dec;26(1):794-802. doi: 10.1080/10717544.2019.1645244.

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Yang H, Liu Z, Song Y, Hu C. Hyaluronic acid-functionalized bilosomes for targeted delivery of tripterine to inflamed area with enhancive therapy on arthritis. Drug Deliv. 2019 Dec;26(1):820-830. doi: 10.1080/10717544.2019.1636423.

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N'Diaye M, Vergnaud-Gauduchon J, Nicolas V, Faure V, Denis S, Abreu S, Chaminade P, Rosilio V. Mol Pharm. 2019 Sep 3;16(9):4045-4058. doi: 10.1021/acs.molpharmaceut.9b00797. Epub 2019 Aug 13. Hybrid Lipid Polymer Nanoparticles for Combined Chemo- and Photodynamic Therapy.

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Bruna dos Santos Rodrigues, Sushant Lakkadwala, Takahisa Kanekiyo, Jagdish Singh. Development and screening of brain-targeted lipid-based nanoparticles with enhanced cell penetration and gene delivery properties. International Journal of Nanomedicine; Macclesfield Vol. 14, (2019): 6497-6517. DOI:10.2147/IJN.S215941

Einhäupl P, Krook J, Svensson N, Van Acker K, Van Passel S. Eliciting stakeholder needs - An anticipatory approach assessing enhanced landfill mining. Waste Manag. 2019 Oct;98:113-125. doi: 10.1016/j.wasman.2019.08.009. Epub 2019 Aug 21.

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Takechi-Haraya Y, Goda Y, Izutsu K, Sakai-Kato K. Improved Atomic Force Microscopy Stiffness Measurements of Nanoscale Liposomes by Cantilever Tip Shape Evaluation. Anal Chem. 2019 Aug 20;91(16):10432-10440. doi: 10.1021/acs.analchem.9b00250. Epub 2019 Aug 7.

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Thanki K, van Eetvelde D, Geyer A, Fraire J, Hendrix R, Van Eygen H, Putteman E, Sami H, de Souza Carvalho-Wodarz C, Franzyk H, Nielsen HM, Braeckmans K, Lehr CM, Ogris M, Foged C. Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration. J Control Release. 2019 Sep 28;310:82-93. doi: 10.1016/j.jconrel.2019.08.004. Epub 2019 Aug 6.

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Melo M, Porter E, Zhang Y, Silva M, Li N, Dobosh B, Liguori A, Skog P, Landais E, Menis S, Sok D, Nemazee D, Schief WR, Weiss R, Irvine DJ. Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles. Mol Ther. 2019 Aug 19. pii: S1525-0016(19)30367-3. doi: 10.1016/j.ymthe.2019.08.007. [Epub ahead of print]

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Bae J, Parayath N, Ma W, Amiji M, Munshi N, Anderson K. BCMA peptide-engineered nanoparticles enhance induction and function of antigen-specific CD8+ cytotoxic T lymphocytes against multiple myeloma: clinical applications. Leukemia. 2019 Aug 19. doi: 10.1038/s41375-019-0540-7. [Epub ahead of print]

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Giulimondi F, Digiacomo L, Pozzi D, Palchetti S, Vulpis E, Capriotti AL, Chiozzi RZ, Laganà A, Amenitsch H, Masuelli L, Mahmoudi M, Screpanti I, Zingoni A, Caracciolo G. Interplay of protein corona and immune cells controls blood residency of liposomes. Nat Commun. 2019 Aug 15;10(1):3686. doi: 10.1038/s41467-019-11642-7.

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Komura F, Takahashi Y, Inoue T, Takakura Y, Nishikawa M. Development of a Nanostructured RNA/DNA Assembly as an Adjuvant Targeting Toll-Like Receptor 7/8. Nucleic Acid Ther. 2019 Jul 18. doi: 10.1089/nat.2019.0787. [Epub ahead of print]

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Ghellab SE, Mu W, Li Q, Han X. Prediction of the size of electroformed giant unilamellar vesicle using response surface methodology. Biophys Chem. 2019 Oct;253:106217. doi: 10.1016/j.bpc.2019.106217. Epub 2019 Jul 4.

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Blakney AK, McKay PF, Yus BI, Aldon Y, Shattock RJ. Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA. Gene Ther. 2019 Sep;26(9):363-372. doi: 10.1038/s41434-019-0095-2. Epub 2019 Jul 12.

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Xu H, Chen B, Gong W, Yang Z, Qu J. Nanoliposomes Co-Encapsulating Photoswitchable Probe and Photosensitizer for Super-Resolution Optical Imaging and Photodynamic Therapy. Cytometry A. 2019 Jul 16. doi: 10.1002/cyto.a.23864. [Epub ahead of print]

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Mohamed A, Pekoz AY, Ross K, Hutcheon GA, Saleem IY. Pulmonary delivery of Nanocomposite Microparticles (NCMPs) incorporating miR-146a for treatment of COPD. Int J Pharm. 2019 Oct 5;569:118524. doi: 10.1016/j.ijpharm.2019.118524. Epub 2019 Jul 15.

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Katayama T, Kinugawa S, Takada S, Furihata T, Fukushima A, Yokota T, Anzai T, Hibino M, Harashima H, Yamada Y. A mitochondrial delivery system using liposome-based nanocarriers that target myoblast cells. Mitochondrion. 2019 Jul 19;49:66-72. doi: 10.1016/j.mito.2019.07.005. [Epub ahead of print]

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Girish V, Pazzi J, Li A, Subramaniam AB. Fabrics of Diverse Chemistries Promote the Formation of Giant Vesicles from Phospholipids and Amphiphilic Block Copolymers. Langmuir. 2019 Jul 16;35(28):9264-9273. doi: 10.1021/acs.langmuir.9b01621. Epub 2019 Jul 5.

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Wang F, Sun Y, Shi J. Programmed death-ligand 1 monoclonal antibody-linked immunoliposomes for synergistic efficacy of miR-130a and oxaliplatin in gastric cancers. Nanomedicine (Lond). 2019 Jul;14(13):1729-1744. doi: 10.2217/nnm-2019-0073. Epub 2019 Jul 10.

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Villamizar O, Waters SA, Scott T, Saayman S, Grepo N, Urak R, Davis A, Jaffe A, Morris KV. Targeted Activation of Cystic Fibrosis Transmembrane Conductance Regulator. Mol Ther. 2019 Jul 15. pii: S1525-0016(19)30314-4. doi: 10.1016/j.ymthe.2019.07.002. [Epub ahead of print]

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Villamizar O, Waters SA, Scott T, Saayman S, Grepo N, Urak R, Davis A, Jaffe A, Morris KV. Targeted Activation of Cystic Fibrosis Transmembrane Conductance Regulator. Mol Ther. 2019 Jul 15. pii: S1525-0016(19)30314-4. doi: 10.1016/j.ymthe.2019.07.002. [Epub ahead of print]

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Moro M, Di Paolo D, Milione M, Centonze G, Bornaghi V, Borzi C, Gandellini P, Perri P, Pastorino U, Ponzoni M, Sozzi G, Fortunato O. Coated cationic lipid-nanoparticles entrapping miR-660 inhibit tumor growth in patient-derived xenografts lung cancer models. J Control Release. 2019 Jul 9;308:44-56. doi: 10.1016/j.jconrel.2019.07.006. [Epub ahead of print]

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Park J, Kuo Y, Li J, Huang YL, Miller EW, Weiss S. Improved Surface Functionalization and Characterization of Membrane-Targeted Semiconductor Voltage Nanosensors. J Phys Chem Lett. 2019 Jul 18;10(14):3906-3913. doi: 10.1021/acs.jpclett.9b01258. Epub 2019 Jul 1.

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Kim B, Sun S, Varner JA, Howell SB, Ruoslahti E, Sailor MJ. Securing the Payload, Finding the Cell, and Avoiding the Endosome: Peptide-Targeted, Fusogenic Porous Silicon Nanoparticles for Delivery of siRNA. Adv Mater. 2019 Jul 3:e1902952. doi: 10.1002/adma.201902952. [Epub ahead of print]

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Tunsirikongkon A, Pyo YC, Kim DH, Lee SE, Park JS. Optimization of Polyarginine-Conjugated PEG Lipid Grafted Proliposome Formulation for Enhanced Cellular Association of a Protein Drug. Pharmaceutics. 2019 Jun 11;11(6). pii: E272. doi: 10.3390/pharmaceutics11060272.

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Yoshiyuki Hattori, Kyoko Tamaki, Kei-ichi Ozaki, Kumi Kawano, Hiraku Onishi. Optimized combination of cationic lipids and neutral helper lipids in cationic liposomes for siRNA delivery into the lung by intravenous injection of siRNA lipoplexes. Journal of Drug Delivery Science and Technology. 2019 August;52:1042-1050.

Hattori Y, Hu S, Onishi H. Effects of cationic lipids in cationic liposomes and disaccharides in the freeze-drying of siRNA lipoplexes on gene silencing in cells by reverse transfection. J Liposome Res. 2019 Jul 5:1-11. doi: 10.1080/08982104.2019.1630643. [Epub ahead of print]

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Juanes M, Creese O, Fernández-Trillo P, Montenegro J. Messenger RNA delivery by hydrazone-activated polymers. Medchemcomm. 2019 Jun 18;10(7):1138-1144. doi: 10.1039/c9md00231f. eCollection 2019 Jul 1.

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Sakurai Y, Kato A, Hida Y, Hamada J, Maishi N, Hida K, Harashima H. Synergistic Enhancement of Cellular Uptake With CD44-Expressing Malignant Pleural Mesothelioma by Combining Cationic Liposome and Hyaluronic Acid-Lipid Conjugate. J Pharm Sci. 2019 Jun 21. pii: S0022-3549(19)30382-X. doi: 10.1016/j.xphs.2019.06.012. [Epub ahead of print]

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Lu Y, Zhong L, Jiang Z, Pan H, Zhang Y, Zhu G, Bai L, Tong R, Shi J, Duan X. Cationic micelle-based siRNA delivery for efficient colon cancer gene therapy. Nanoscale Res Lett. 2019 Jun 4;14(1):193. doi: 10.1186/s11671-019-2985-z.

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Mendonça MCP, Radaic A, Garcia-Fossa F, da Cruz-Höfling MA, Vinolo MAR, de Jesus MB. The in vivo toxicological profile of cationic solid lipid nanoparticles. Drug Deliv Transl Res. 2019 Jun 25. doi: 10.1007/s13346-019-00657-8. [Epub ahead of print]

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Landry MR, Rangel JL, Dao VP, MacKenzie MA, Gutierrez FL, Dowell KM, Calkins AL, Fuller AA, Stokes GY. Length and Charge of Water-Soluble Peptoids Impact Binding to Phospholipid Membranes. J Phys Chem B. 2019 Jul 11;123(27):5822-5831. doi: 10.1021/acs.jpcb.9b04641. Epub 2019 Jun 28.

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Riccardo Di Santo, Erica Quagliarini, Sara Palchetti, Daniela Pozzi, Valentina Palmieri, Giordano Perini, Massimiliano Papi, Anna Laura Capriotti, Aldo Laganà, and Giulio Caracciolo. Microfluidic-generated lipid-graphene oxide nanoparticles for gene delivery. Appl. Phys. Lett. 114, 233701 (2019). doi: 10.1063/1.5100932

Dos Santos Rodrigues B, Banerjee A, Kanekiyo T, Singh J. Functionalized liposomal nanoparticles for efficient gene delivery system to neuronal cell transfection. Int J Pharm. 2019 Jul 20;566:717-730. doi: 10.1016/j.ijpharm.2019.06.026. Epub 2019 Jun 13.

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Kim SS, Harford JB, Moghe M, Slaughter T, Doherty C, Chang EH. A tumor-targeting nanomedicine carrying the p53 gene crosses the blood-brain barrier and enhances anti-PD-1 immunotherapy in mouse models of glioblastoma. Int J Cancer. 2019 Jun 26. doi: 10.1002/ijc.32531. [Epub ahead of print]

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Han WB, Kang DH, Na JH, Yu YG, Kim TS. Enhancement of membrane protein reconstitution on 3D free-standing lipid bilayer array in a microfluidic channel. Biosens Bioelectron. 2019 Jun 6;141:111404. doi: 10.1016/j.bios.2019.111404. [Epub ahead of print]

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Lakkadwala S, Dos Santos Rodrigues B, Sun C, Singh J. Dual functionalized liposomes for efficient co-delivery of anti-cancer chemotherapeutics for the treatment of glioblastoma. J Control Release. 2019 Jun 26;307:247-260. doi: 10.1016/j.jconrel.2019.06.033. [Epub ahead of print]

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Baldwin P, Ohman AW, Medina JE, McCarthy ET, Dinulescu DM, Sridhar S. Nanoformulation of Talazoparib Delays Tumor Progression and Ascites Formation in a Late Stage Cancer Model. Front Oncol. 2019 May 10;9:353. doi: 10.3389/fonc.2019.00353. eCollection 2019.

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Won Il Choi, Abhishek Sahu, Frederik R. Wurm, and Seong-Min Jo. Magnetoliposomes with size controllable insertion of magnetic nanoparticles for efficient targeting of cancer cells. (Paper) RSC Adv., 2019, 9, 15053-15060. doi: 10.1039/C9RA02529D

Zhang M, Wang Q, Wan KW, Ahmed W, Phoenix DA, Zhang Z, Elrayess MA, Elhissi A, Sun X. Liposome mediated-CYP1A1 gene silencing nanomedicine prepared using lipid film-coated proliposomes as a potential treatment strategy of lung cancer. Int J Pharm. 2019 Jul 20;566:185-193. doi: 10.1016/j.ijpharm.2019.04.078. Epub 2019 Apr 30.

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Velasco-Olmo A, Ormaetxea Gisasola J, Martinez Galvez JM, Vera Lillo J, Shnyrova AV. Combining patch-clamping and fluorescence microscopy for quantitative reconstitution of cellular membrane processes with Giant Suspended Bilayers. Sci Rep. 2019 May 10;9(1):7255. doi: 10.1038/s41598-019-43561-4.

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Wang X, Hua Y, Xu G, Deng S, Yang D, Gao X. Targeting EZH2 for glioma therapy with a novel nanoparticle-siRNA complex. Int J Nanomedicine. 2019 Apr 15;14:2637-2653. doi: 10.2147/IJN.S189871. eCollection 2019.

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Zhang X, Men K, Zhang Y, Zhang R, Yang L, Duan X. Local and systemic delivery of mRNA encoding survivin-T34A by lipoplex for efficient colon cancer gene therapy. Int J Nanomedicine. 2019 Apr 23;14:2733-2751. doi: 10.2147/IJN.S198747. eCollection 2019.

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Giannakou C, Aimonen K, Bloois LV, Catalán J, Geertsma RE, Gremmer ER, de Jong WH, Keizers PH, Schwillens PL, Vandebriel RJ, Park MV. Sensitive method for endotoxin determination in nanomedicinal product samples. Nanomedicine (Lond). 2019 May;14(10):1231-1246. doi: 10.2217/nnm-2018-0339.

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Baglo Y, Liang BJ, Robey RW, Ambudkar SV, Gottesman MM, Huang HC. Porphyrin-lipid assemblies and nanovesicles overcome ABC transporter-mediated photodynamic therapy resistance in cancer cells. Cancer Lett. 2019 Aug 10;457:110-118. doi: 10.1016/j.canlet.2019.04.037. Epub 2019 May 6.

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Armin Tahmasbi Rad, Shipra Malik, Lin Yang, Tripat Kaur Oberoi-Khanuja, Mu-Ping Nieh, and Raman Bahal. A universal discoidal nanoplatform for the intracellular delivery of PNAs. Nanoscale, 2019, Advance Article. doi: 10.1039/C9NR03667A

Li M, Xie H, Liu Y, Xia C, Cun X, Long Y, Chen X, Deng M, Guo R, Zhang Z, He Q. Knockdown of hypoxia-inducible factor-1 alpha by tumor targeted delivery of CRISPR/Cas9 system suppressed the metastasis of pancreatic cancer. J Control Release. 2019 May 14;304:204-215. doi: 10.1016/j.jconrel.2019.05.019. [Epub ahead of print]

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Blakney AK, McKay PF, Ibarzo Yus B, Hunter JE, Dex EA, Shattock RJ. The Skin You Are In: Design-of-Experiments Optimization of Lipid Nanoparticle Self-Amplifying RNA Formulations in Human Skin Explants. ACS Nano. 2019 May 28;13(5):5920-5930. doi: 10.1021/acsnano.9b01774. Epub 2019 May 3.

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Kurimoto S, Yoshinaga N, Igarashi K, Matsumoto Y, Cabral H, Uchida S. PEG-OligoRNA Hybridization of mRNA for Developing Sterically Stable Lipid Nanoparticles toward In Vivo Administration. Molecules. 2019 Apr 3;24(7). pii: E1303. doi: 10.3390/molecules24071303.

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Fang Y, Vadlamudi M, Huang Y, Guo X. Lipid-Coated, pH-Sensitive Magnesium Phosphate Particles for Intracellular Protein Delivery. Pharm Res. 2019 Apr 11;36(6):81. doi: 10.1007/s11095-019-2607-6.

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Torrecilla J, Gómez-Aguado I, Vicente-Pascual M, Del Pozo-Rodríguez A, Solinís MÁ, Rodríguez-Gascón A. MMP-9 Downregulation with Lipid Nanoparticles for Inhibiting Corneal Neovascularization by Gene Silencing. Nanomaterials (Basel). 2019 Apr 18;9(4). pii: E631. doi: 10.3390/nano9040631.

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Gholamian Dehkordi N, Elahian F, Khosravian P, Mirzaei SA. Intelligent TAT-coupled anti-HER2 immunoliposomes knock downed MDR1 to produce chemosensitize phenotype of multidrug resistant carcinoma. J Cell Physiol. 2019 Apr 18. doi: 10.1002/jcp.28683. [Epub ahead of print]

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Rasmus Eliasen, Thomas L. Andresen, Jannik B. Larsen. PEG‐Lipid Post Insertion into Drug Delivery Liposomes Quantified at the Single Liposome Level. Advanced Materials Interfaces. 2019 April 03. doi: 10.1002/admi.201801807

Yao Y, Wang T, Liu Y, Zhang N. Co-delivery of sorafenib and VEGF-siRNA via pH-sensitive liposomes for the synergistic treatment of hepatocellular carcinoma. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1374-1383. doi: 10.1080/21691401.2019.1596943.

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Patel S, Ryals RC, Weller KK, Pennesi ME, Sahay G. Lipid nanoparticles for delivery of messenger RNA to the back of the eye. J Control Release. 2019 Apr 12;303:91-100. doi: 10.1016/j.jconrel.2019.04.015. [Epub ahead of print]

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Blakney AK, McKay PF, Ibarzo Yus B, Hunter JE, Dex EA, Shattock RJ. The Skin You're In: Design of Experiments Optimization of Lipid Nanoparticle Self-Amplifying RNA Formulations in Human Skin Explants. ACS Nano. 2019 May 2. doi: 10.1021/acsnano.9b01774. [Epub ahead of print]

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Dewitte H, Roovers S, De Smedt SC, Lentacker I. Enhancing Nucleic Acid Delivery with Ultrasound and Microbubbles. Methods Mol Biol. 2019;1943:241-251. doi: 10.1007/978-1-4939-9092-4_16.

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Kommineni N, Mahira S, Domb AJ, Khan W. Cabazitaxel-Loaded Nanocarriers for Cancer Therapy with Reduced Side Effects. Pharmaceutics. 2019 Mar 25;11(3). pii: E141. doi: 10.3390/pharmaceutics11030141.

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Barzegari Firouzabadi F, Oryan SH, Sheikhha MH, Kalantar SM, Javed A. Preparation and Evaluation of A Novel Liposomal Nano-Formulation in Metastatic Cancer Treatment Studies. Cell J. 2019 Jul;21(2):135-142. doi: 10.22074/cellj.2019.6008. Epub 2019 Feb 20.

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Walunj M, Doppalapudi S, Bulbake U, Khan W. Preparation, characterization, and in vivo evaluation of cyclosporine cationic liposomes for the treatment of psoriasis. J Liposome Res. 2019 Mar 21:1-12. doi: 10.1080/08982104.2019.1593449. [Epub ahead of print]

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Höfer CT, Di Lella S, Dahmani I, Jungnick N, Bordag N, Bobone S, Huang Q, Keller S, Herrmann A, Chiantia S. Structural determinants of the interaction between influenza A virus matrix protein M1 and lipid membranes. Biochim Biophys Acta Biomembr. 2019 Mar 20;1861(6):1123-1134. doi: 10.1016/j.bbamem.2019.03.013. [Epub ahead of print]

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Maqbool F, Moyle PM, Thurecht KJ, Falconer JR. Dispersibility of phospholipids and their optimization for the efficient production of liposomes using supercritical fluid technology. Int J Pharm. 2019 Mar 30;563:174-183. doi: 10.1016/j.ijpharm.2019.03.053. [Epub ahead of print]

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Bilan Wang, Daoke Yang, Yangmei Shen. Anti-colon cancer effect of matrix protein gene therapy with nanoparticles. Polymer. 2019 April 29;170:148-156. doi: 10.1016/j.polymer.2019.03.023

Holm A, Kunz L, Riscoe AR, Kao KC, Cargnello M, Frank CW. General Self-Assembly Method for Deposition of Graphene Oxide into Uniform Close-Packed Monolayer Films. Langmuir. 2019 Apr 2;35(13):4460-4470. doi: 10.1021/acs.langmuir.8b03994. Epub 2019 Mar 19.

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Hasan M, Hama S, Kogure K. Low Electric Treatment activates Rho GTPase via Heat Shock Protein 90 and Protein Kinase C for Intracellular Delivery of siRNA. Sci Rep. 2019 Mar 11;9(1):4114. doi: 10.1038/s41598-019-40904-z.

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Jacobs D, Hoogerheide DP, Rovini A, Jiang Z, Lee JC, Rostovtseva TK, Bezrukov SM. Probing Membrane Association of α-Synuclein Domains with VDAC Nanopore Reveals Unexpected Binding Pattern. Sci Rep. 2019 Mar 14;9(1):4580. doi: 10.1038/s41598-019-40979-8.

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Tan X, Fang Y, Ren Y, Li Y, Wu P, Yang X, Liu W. D-α-tocopherol polyethylene glycol 1000 succinate-modified liposomes with an siRNA corona confer enhanced cellular uptake and targeted delivery of doxorubicin via tumor priming. Int J Nanomedicine. 2019 Feb 18;14:1255-1268. doi: 10.2147/IJN.S191858. eCollection 2019.

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Lu X, Liu J, Gou L, Li J, Yuan B, Yang K, Ma Y. Designing Melittin-Graphene Hybrid Complexes for Enhanced Antibacterial Activity. Adv Healthc Mater. 2019 Mar 13:e1801521. doi: 10.1002/adhm.201801521. [Epub ahead of print]

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Andey T, Bora-Singhal N, Chellappan SP, Singh M. Cationic lipoplexes for treatment of cancer stem cell-derived murine lung tumors. Nanomedicine. 2019 Mar 1;18:31-43. doi: 10.1016/j.nano.2019.02.007. [Epub ahead of print]

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Zhu D, Hu C, Fan F, Qin Y, Huang C, Zhang Z, Lu L, Wang H, Sun H, Leng X, Wang C, Kong D, Zhang L. Co-delivery of antigen and dual agonists by programmed mannose-targeted cationic lipid-hybrid polymersomes for enhanced vaccination. Biomaterials. 2019 Mar 20;206:25-40. doi: 10.1016/j.biomaterials.2019.03.012. [Epub ahead of print]

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Xu H, Ohulchanskyy TY, Yakovliev A, Zinyuk R, Song J, Liu L, Qu J, Yuan Z. Nanoliposomes Co-Encapsulating CT Imaging Contrast Agent and Photosensitizer for Enhanced, Imaging Guided Photodynamic Therapy of Cancer. Theranostics. 2019 Feb 12;9(5):1323-1335. doi: 10.7150/thno.31079. eCollection 2019.

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Lukasz Sobotta, Sebastian Lijewski, Jolanta Dlugaszewska, Joanna Nowicka, Jadwiga Mielcarek, Tomasz Goslinski. Photodynamic inactivation of Enterococcus faecalis by conjugates of zinc(II) phthalocyanines with thymol and carvacrol loaded into lipid vesicles. Inorganica Chimica Acta. 2019 April 1;489:180-189. doi: 10.1016/j.ica.2019.02.031

Wheat W, Chow L, Coy J, Contreras E, Lappin M, Dow S. Activation of upper respiratory tract mucosal innate immune responses in cats by liposomal toll-like receptor ligand complexes delivered topically. J Vet Intern Med. 2019 Mar;33(2):838-845. doi: 10.1111/jvim.15426. Epub 2019 Feb 15.

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Lukasz Sobotta, Jolanta Dlugaszewska, Daniel Ziental, Wojciech Szczolko, Tomasz Koczorowski, Tomasz Goslinski, Jadwiga Mielcarek. Optical properties of a series of pyrrolyl-substituted porphyrazines and their photoinactivation potential against Enterococcus faecalis after incorporation into liposomes. Journal of Photochemistry and Photobiology A: Chemistry. 2019 January 1;368:104-109. doi: 10.1016/j.jphotochem.2018.09.015

Wui SR, Kim KS, Ryu JI, Ko A, Do HTT, Lee YJ, Kim HJ, Lim SJ, Park SA, Cho YJ, Kim CG, Lee NG. Efficient induction of cell-mediated immunity to varicella-zoster virus glycoprotein E co-lyophilized with a cationic liposome-based adjuvant in mice. Vaccine. 2019 Apr 3;37(15):2131-2141. doi: 10.1016/j.vaccine.2019.02.048. Epub 2019 Feb 28.

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Gomes FO, Maia LB, Loureiro JA, Pereira MC, Delerue-Matos C, Moura I, Moura JJG, Morais S. Biosensor for direct bioelectrocatalysis detection of nitric oxide using nitric oxide reductase incorporated in carboxylated single-walled carbon nanotubes/lipidic 3 bilayer nanocomposite. Bioelectrochemistry. 2019 Feb 5;127:76-86. doi: 10.1016/j.bioelechem.2019.01.010. [Epub ahead of print]

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Sakai-Kato K, Yoshida K, Izutsu KI. Effect of surface charge on the size-dependent cellular internalization of liposomes. Chem Phys Lipids. 2019 Jan 17. pii: S0009-3084(18)30137-3. doi: 10.1016/j.chemphyslip.2019.01.004. [Epub ahead of print]

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Hillyer LM, Woodward B. Acutely malnourished weanling mice administered Flt3 ligand can support a cell-mediated inflammatory response. Cytokine. 2019 Jan;113:39-49. doi: 10.1016/j.cyto.2018.06.004. Epub 2018 Jul 7.

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Lira RB, Robinson T, Dimova R, Riske KA. Highly Efficient Protein-free Membrane Fusion: A Giant Vesicle Study. Biophys J. 2019 Jan 8;116(1):79-91. doi: 10.1016/j.bpj.2018.11.3128. Epub 2018 Dec 1.

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Lakkadwala S, Singh J. Co-delivery of doxorubicin and erlotinib through liposomal nanoparticles for glioblastoma tumor regression using an in vitro brain tumor model. Colloids Surf B Biointerfaces. 2019 Jan 1;173:27-35. doi: 10.1016/j.colsurfb.2018.09.047. Epub 2018 Sep 21.

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Kumagai A, Dupuy FG, Arsov Z, Elhady Y, Moody D, Ernst RK, Deslouches B, Montelaro RC, Peter Di Y, Tristram-Nagle S. Elastic behavior of model membranes with antimicrobial peptides depends on lipid specificity and d-enantiomers. Soft Matter. 2019 Feb 20;15(8):1860-1868. doi: 10.1039/c8sm02180e.

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Zhang Y, Bush X, Yan B, Chen JA. Gemcitabine nanoparticles promote antitumor immunity against melanoma. Biomaterials. 2019 Jan;189:48-59. doi: 10.1016/j.biomaterials.2018.10.022. Epub 2018 Oct 20.

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Amdursky N, Lin Y, Aho N, Groenhof G. Exploring fast proton transfer events associated with lateral proton diffusion on the surface of membranes. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2443-2451. doi: 10.1073/pnas.1812351116. Epub 2019 Jan 24.

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Guan S, Munder A, Hedtfeld S, Braubach P, Glage S, Zhang L, Lienenklaus S, Schultze A, Hasenpusch G, Garrels W, Stanke F, Miskey C, Johler SM, Kumar Y, Tümmler B, Rudolph C, Ivics Z, Rosenecker J. Self-assembled peptide-poloxamine nanoparticles enable in vitro and in vivo genome restoration for cystic fibrosis. Nat Nanotechnol. 2019 Mar;14(3):287-297. doi: 10.1038/s41565-018-0358-x. Epub 2019 Jan 28.

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Loria R, Giliberti C, Bedini A, Palomba R, Caracciolo G, Ceci P, Falvo E, Marconi R, Falcioni R, Bossi G, Strigari L. Very low intensity ultrasounds as a new strategy to improve selective delivery of nanoparticles-complexes in cancer cells. J Exp Clin Cancer Res. 2019 Jan 3;38(1):1. doi: 10.1186/s13046-018-1018-6.

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Song X, Yan G, Quan S, Jin E, Quan J, Jin G. MRI-visible liposome-polyethylenimine complexes for DNA delivery: preparation and evaluation. Biosci Biotechnol Biochem. 2019 Apr;83(4):622-632. doi: 10.1080/09168451.2018.1562875. Epub 2018 Dec 25.

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Thanki K, Papai S, Lokras A, Rose F, Falkenberg E, Franzyk H, Foged C. Application of a Quality-By-Design Approach to Optimise Lipid-Polymer Hybrid Nanoparticles Loaded with a Splice-Correction Antisense Oligonucleotide: Maximising Loading and Intracellular Delivery. Pharm Res. 2019 Jan 9;36(3):37. doi: 10.1007/s11095-018-2566-3.

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Habibulla Imran, Palinci Nagarajan Manikandan, Venkataraman Dharuman. Ultra-sensitive and selective label free electrochemical DNA detection at layer-by-layer self-assembled graphene oxide and vesicle liposome nano-architecture. Journal of Electroanalytical Chemistry. 2019 February 15;835:10-21. doi: 10.1016/j.jelechem.2019.01.011.

Mohamed A, Kunda NK, Ross K, Hutcheon GA, Saleem IY. Polymeric nanoparticles for the delivery of miRNA to treat Chronic Obstructive Pulmonary Disease (COPD). Eur J Pharm Biopharm. 2019 Mar;136:1-8. doi: 10.1016/j.ejpb.2019.01.002. Epub 2019 Jan 4.

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Mohamed A, Kunda NK, Ross K, Hutcheon GA, Saleem IY. Polymeric nanoparticles for the delivery of miRNA to treat Chronic Obstructive Pulmonary Disease (COPD). Eur J Pharm Biopharm. 2019 Mar;136:1-8. doi: 10.1016/j.ejpb.2019.01.002. Epub 2019 Jan 4.

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Di Santo R, Digiacomo L, Palchetti S, Palmieri V, Perini G, Pozzi D, Papi M, Caracciolo G. Microfluidic manufacturing of surface-functionalized graphene oxide nanoflakes for gene delivery. Nanoscale. 2019 Feb 7;11(6):2733-2741. doi: 10.1039/c8nr09245a.

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Chen M, Song F, Liu Y, Tian J, Liu C, Li R, Zhang Q. A dual pH-sensitive liposomal system with charge-reversal and NO generation for overcoming multidrug resistance in cancer. Nanoscale. 2019 Mar 7;11(9):3814-3826. doi: 10.1039/c8nr06218h. Epub 2019 Jan 2.

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Ewins E, Lira RB, Zhang W, Yuan J, Antonietti M, Robinson T, Dimova R. Poly(Ionic Liquid) Nanoparticles Selectively Disrupt Biomembranes. Adv Sci (Weinh). 2018 Dec 17;6(4):1801602. doi: 10.1002/advs.201801602. eCollection 2019 Feb 2019

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Xiang J, Liu X, Zhou Z, Zhu D, Zhou Q, Piao Y, Jiang L, Tang J, Liu X, Shen Y. Reactive Oxygen Species (ROS)-Responsive Charge-Switchable Nanocarriers for Gene Therapy of Metastatic Cancer. ACS Appl Mater Interfaces. 2018 Dec 19;10(50):43352-43362. doi: 10.1021/acsami.8b13291. Epub 2018 Dec 4.

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Maroof H, Islam F, Dong L, Ajjikuttira P, Gopalan V, McMillan NAJ, Lam AK. Liposomal Delivery of miR-34b-5p Induced Cancer Cell Death in Thyroid Carcinoma Cells. 2018 Dec 11;7(12). pii: E265. doi: 10.3390/cells7120265.

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Faneca H, Düzgüneş N, Pedroso de Lima MC. Suicide Gene Therapy for Oral Squamous Cell Carcinoma. Methods Mol Biol. 2019;1895:43-55. doi: 10.1007/978-1-4939-8922-5_4.

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Sathyanarayanan G, Haapala M, Sikanen T. Interfacing Digital Microfluidics with Ambient Mass Spectrometry Using SU-8 as Dielectric Layer. Micromachines (Basel). 2018 Dec 8;9(12). pii: E649. doi: 10.3390/mi9120649.

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Angmo S, Rana S, Yadav K, Sandhir R, Singhal NK. Novel Liposome Eencapsulated Guanosine Di Phosphate based Therapeutic Target against Anemia of Inflammation. Sci Rep. 2018 Dec 6;8(1):17684. doi: 10.1038/s41598-018-35992-2.

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Baldwin P, Ohman AW, Tangutoori S, Dinulescu DM, Sridhar S. Intraperitoneal delivery of NanoOlaparib for disseminated late-stage cancer treatment. Int J Nanomedicine. 2018 Nov 29;13:8063-8074. doi: 10.2147/IJN.S186881. eCollection 2018.

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Das M, Shen L, Liu Q, Goodwin TJ, Huang L. Nanoparticle Delivery of RIG-I Agonist Enables Effective and Safe Adjuvant Therapy in Pancreatic Cancer. Mol Ther. 2018 Nov 17. pii: S1525-0016(18)30548-3. doi: 10.1016/j.ymthe.2018.11.012. [Epub ahead of print].

PubMed ID: 30545600

Mukai H, Hatanaka K, Yagi N, Warashina S, Zouda M, Takahashi M, Narushima K, Yabuuchi H, Iwano J, Kuboyama T, Enokizono J, Wada Y, Watanabe Y. Pharmacokinetic evaluation of liposomal nanoparticle-encapsulated nucleic acid drug: A combined study of dynamic PET imaging and LC/MS/MS analysis. J Control Release. 2019 Jan 28;294:185-194. doi: 10.1016/j.jconrel.2018.12.006. Epub 2018 Dec 7.

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Lira RB, Robinson T, Dimova R, Riske KA. Highly Efficient Protein-free Membrane Fusion: A Giant Vesicle Study. Biophys J. 2019 Jan 8;116(1):79-91. doi: 10.1016/j.bpj.2018.11.3128. Epub 2018 Dec 1.

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Amadei F, Fröhlich B, Stremmel W, Tanaka M. Non-Classical Interactions of Phosphatidylcholine with Mucin Protect Intestinal Surfaces: A Microinterferometry Study. Langmuir. 2018 Oct 25. doi: 10.1021/acs.langmuir.8b03035. [Epub ahead of print]

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Eric H. Hill, Jingang Li, Linhan Lin, Yaoran Liu, and Yuebing Zheng. Opto-Thermophoretic Attraction, Trapping, and Dynamic Manipulation of Lipid Vesicles. Langmuir, Just Accepted Manuscript. DOI: 10.1021/acs.langmuir.8b01979. Publication Date (Web): October 11, 2018

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Chung PJ, Hwang HL, Dasbiswas K, Leong A, Lee KYC. Osmotic shock-triggered assembly of highly-charged, nanoparticle-supported membranes. Langmuir. 2018 Oct 10. doi: 10.1021/acs.langmuir.8b03026. [Epub ahead of print]

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Khmelinskaia A, Mücksch J, Petrov EP, Franquelim HG, Schwille P. Control of membrane binding and diffusion of cholesteryl-modified DNA origami nanostructures by DNA spacers. Langmuir. 2018 Sep 25. doi: 10.1021/acs.langmuir.8b01850. [Epub ahead of print]

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Sayour EJ, Grippin A, De Leon G, Stover B, Rahman M, Karachi A, Wummer B, Moore G, Castillo-Caro P, Fredenburg K, Sarkisian MR, Huang J, Deleyrolle LP, Sahay B, Carrera-Justiz S, Mendez-Gomez HR, Mitchell DA. Personalized Tumor RNA Loaded Lipid-Nanoparticles Prime the Systemic and Intratumoral Milieu for Response to Cancer Immunotherapy. Nano Lett. 2018 Sep 27. doi: 10.1021/acs.nanolett.8b02179. [Epub ahead of print]

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Kim H, Sung J, Chang Y, Alfeche A, Leal C. Microfluidics Synthesis of Gene Silencing Cubosomes. ACS Nano. 2018 Aug 15. doi: 10.1021/acsnano.8b03770. [Epub ahead of print]

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Bi H, Wang X, Han X, Voitchovsky K. Impact of Electric Fields on the Nanoscale Behavior of Lipid Monolayers at the Surface of Graphite in Solution. Langmuir. 2018 Jul 20. doi: 10.1021/acs.langmuir.8b01631. [Epub ahead of print]

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Movsesian N, Tittensor M, Dianat G, Gupta M, Malmstadt N. Giant Lipid Vesicle Formation Using Vapor-Deposited Charged Porous Polymers. Langmuir. 2018 Jul 17. doi: 10.1021/acs.langmuir.8b00736. [Epub ahead of print]

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Movsesian N, Tittensor M, Dianat G, Gupta M, Malmstadt N. Giant Lipid Vesicle Formation Using Vapor-Deposited Charged Porous Polymers. Langmuir. 2018 Jul 2. doi: 10.1021/acs.langmuir.8b00736. [Epub ahead of print]

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Takechi-Haraya Y, Goda Y, Sakai-Kato K. Atomic Force Microscopy Study on the Stiffness of Nanosized Liposomes Containing Charged Lipids. Langmuir. 2018 Jun 18. doi: 10.1021/acs.langmuir.8b01121. [Epub ahead of print]

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Effects of Surface Charges on the Bactericide Activity of CdTe/ZnS Quantum Dots: A Cell Membrane Disruption Perspective, Lu Lai*† , Sheng-Jin Li†, Jing Feng†, Ping Mei†, Zhao-Hua Ren†, Yan-Ling Chang†, and Yi Liu*‡ † College of Chemistry and Environmental Engineering, Yangtze University, Jingzhou, Hubei 434023, P. R. China, ‡ State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecule Sciences, Wuhan University, Wuhan 430072, P. R. China Langmuir, Article ASAP, DOI: 10.1021/acs.langmuir.7b00173[PubMed]

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Blaschke BM, Böhm P, Drieschner S, Nickel B, Garrido JA. Lipid monolayer formation and lipid exchange monitored by a graphene field-effect transistor. Langmuir. 2018 Mar 15. doi: 10.1021/acs.langmuir.8b00162. [Epub ahead of print]

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