890880 | 18:0 TAP

1,2-stearoyl-3-trimethylammonium-propane (chloride salt)

18:0 TAP

Chloroform

Size SKU Packaging Price
25mg 890880C-25mg 890880C-25mg 1 x 25mg 10mg/mL 2.5mL $217.25
200mg 890880C-200mg 890880C-200mg 2 x 100mg 25mg/mL 4mL $454.00
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Powder

Size SKU Packaging Price
25mg 890880P-25mg 890880P-25mg 1 x 25mg $217.25 217.25
200mg 890880P-200mg 890880P-200mg 1 x 200mg $454.00 454
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Info

18:0 TAP

1,2-stearoyl-3-trimethylammonium-propane (chloride salt)

DOTAP is one of the most widely used cationic lipids for gene transfection applications. DOTAP is proven to be efficient for in vitro and in vivo transfection applications. Various analogues of TAP are available for structure-activity relationship studies.

Simberg D, Weisman S, Talmon Y, Barenholz Y. DOTAP (and other cationic lipids): chemistry, biophysics, and transfection. Crit Rev Ther Drug Carrier Syst. 2004;21(4):257-317. doi: 10.1615/critrevtherdrugcarriersyst.v21.i4.10. PMID: 15638468.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C42H84NO4Cl
Percent Composition
C 71.80%, H 12.05%, Cl 5.05%, N 1.99%, O 9.11%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
220609-41-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
702.574
Exact Mass
701.609
Synonyms
1,2-dioctadecanoyl-3-trimethylammonium-propane (chloride salt)
DSTAP
Transition Temp
62.9°C (see Regelin et al)
References

Lou G, Anderluzzi G, Tandrup Schmidt S, Woods S, Gallorini S, Brazzoli M, Giusti F, Ferlenghi I, Johnson R, Roberts CW, O'Hagan DT, Baudner BC, Perrie Y. Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection. J Control Release. 2020 Jun 30:S0168-3659(20)30362-X. doi: 10.1016/j.jconrel.2020.06.027. Epub ahead of print. PMID: 32619745.

PubMed ID: 32619745

Li X, Xu M, Lv W, Yang X. Ultrasound-targeted microbubble destruction-mediated miR-767 inhibition suppresses tumor progression of non-small cell lung cancer. Exp Ther Med. 2020 May;19(5):3391-3397. doi: 10.3892/etm.2020.8602. Epub 2020 Mar 12. PMID: 32266038; PMCID: PMC7132231.

PubMed ID: 32266038

Takechi-Haraya Y, Goda Y, Izutsu K, Sakai-Kato K. Improved Atomic Force Microscopy Stiffness Measurements of Nanoscale Liposomes by Cantilever Tip Shape Evaluation. Anal Chem. 2019 Aug 20;91(16):10432-10440. doi: 10.1021/acs.analchem.9b00250. Epub 2019 Aug 7.

PubMed ID: 31390864

Rasmus Eliasen, Thomas L. Andresen, Jannik B. Larsen. PEG‐Lipid Post Insertion into Drug Delivery Liposomes Quantified at the Single Liposome Level. Advanced Materials Interfaces. 2019 April 03. doi: 10.1002/admi.201801807


Patel S, Ryals RC, Weller KK, Pennesi ME, Sahay G. Lipid nanoparticles for delivery of messenger RNA to the back of the eye. J Control Release. 2019 Apr 12;303:91-100. doi: 10.1016/j.jconrel.2019.04.015. [Epub ahead of print]

PubMed ID: 30986436

Takechi-Haraya Y, Goda Y, Sakai-Kato K. Atomic Force Microscopy Study on the Stiffness of Nanosized Liposomes Containing Charged Lipids. Langmuir. 2018 Jun 18. doi: 10.1021/acs.langmuir.8b01121. [Epub ahead of print]

PubMed ID: 29869883

Regelin, A.E., Fankhaenel, S., Gürtesch, L., Prinz, C., von Kiedrowski, G., Massing, U. (2000) Biophysical and lipofection studies of DOTAP analogs. Biochim Biophys Acta. 1464:151-64.

PubMed ID: 10704929
Certificates of Analysis

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