890860 | 14:0 TAP

1,2-dimyristoyl-3-trimethylammonium-propane (chloride salt)

14:0 TAP


Size SKU Packaging Price
25mg 890860C-25mg 890860C-25mg 1 x 25mg 10mg/mL 2.5mL $217.25
200mg 890860C-200mg 890860C-200mg 2 x 100mg 25mg/mL 4mL $454.00
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Size SKU Packaging Price
200mg 890860P-200mg 890860P-200mg 1 x 200mg $454.00 454
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14:0 TAP

1,2-dimyristoyl-3-trimethylammonium-propane (chloride salt)

DOTAP is one of the most widely used cationic lipids for gene transfection applications. DOTAP is proven to be efficient for in vitro and in vivo transfection applications. Various analogues of TAP are available for structure-activity relationship studies.

Simberg D, Weisman S, Talmon Y, Barenholz Y. DOTAP (and other cationic lipids): chemistry, biophysics, and transfection. Crit Rev Ther Drug Carrier Syst. 2004;21(4):257-317. doi: 10.1615/critrevtherdrugcarriersyst.v21.i4.10. PMID: 15638468.

Light Sensitive
Molecular Formula
Percent Composition
C 69.17%, H 11.61%, Cl 6.01%, N 2.37%, O 10.84%
1 Years
Storage Temperature
CAS Number
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
Exact Mass
1,2-ditetradecanoyl-3-trimethylammonium-propane (chloride salt)
Transition Temp
39.1°C (see Regelin et al)

Lou G, Anderluzzi G, Tandrup Schmidt S, Woods S, Gallorini S, Brazzoli M, Giusti F, Ferlenghi I, Johnson R, Roberts CW, O'Hagan DT, Baudner BC, Perrie Y. Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection. J Control Release. 2020 Jun 30:S0168-3659(20)30362-X. doi: 10.1016/j.jconrel.2020.06.027. Epub ahead of print. PMID: 32619745.

PubMed ID: 32619745

Kanwa N, De SK, Maity A, Chakraborty A. Interaction of aliphatic amino acids with zwitterionic and charged lipid membranes: hydration and dehydration phenomena. Phys Chem Chem Phys. 2020 Feb 14;22(6):3234-3244. doi: 10.1039/c9cp06188f. Epub 2020 Jan 29. PMID: 31994545.

PubMed ID: 31994545

Tanaka M, Miyake H, Oka S, Maeda S, Iwasaki K, Mukai T. Effects of charged lipids on the physicochemical and biological properties of lipid-styrene maleic acid copolymer discoidal particles. Biochim Biophys Acta Biomembr. 2020 Jan 28;1862(5):183209. doi: 10.1016/j.bbamem.2020.183209. Epub ahead of print. PMID: 32004520.

PubMed ID: 32004520

Li P, Shen Y, Wang L, Lu W, Li W, Chen K, Zhou Y, Shen L, Wei F, Zheng W. The electric double layer structure modulates poly-dT25 conformation and adsorption kinetics at the cationic lipid bilayer interface. Soft Matter. 2019 Apr 23. doi: 10.1039/c9sm00321e. [Epub ahead of print]

PubMed ID: 31011740

Regelin, A.E., Fankhaenel, S., Gürtesch, L., Prinz, C., von Kiedrowski, G., Massing, U. (2000) Biophysical and lipofection studies of DOTAP analogs. Biochim Biophys Acta. 1464:151-64. [PubMed]

PubMed ID: 10704929
Bicelle Preparation

Bicelles can be integrated into standard crystallization protocols, and in contrast to micelles, bicelles maintain the protein in a more native bilayer environment allowing proteins to be captured in a more biologically relevant orientation. Reference/Protocol

Certificates of Analysis

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