890808 | 22:0 Trehalose

D-(+)-trehalose 6,6'-dibehenate


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25mg 890808P-25mg 890808P-25mg $1,008.00
5mg 890808P-5mg 890808P-5mg $252.00
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22:0 Trehalose

22:0 Trehalose

D-(+)-trehalose 6,6'-dibehenate

Incorporation of the glycolipid trehalose 6,6'-dibehenate (TDB) into cationic liposomes composed of the quaternary ammonium compound dimethyldioctadecylammonium (DDA) produce an adjuvant system which induces a powerful cell-mediated immune response and a strong antibody response, desirable for a high number of disease targets.
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C56H106O13
Percent Composition
C 68.12%, H 10.82%, O 21.06%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
66758-35-8
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
987.433
Exact Mass
986.763
Synonyms
TDB6,6'-didocosanoyl-α,α'-trehalose
Fomsgaard, A., Karlsson, I., Gram, G., Schou, C., Tang, S., Bang, P., Kromann, I., Andersen, P., Andreasen, L.V. (2011) Development and preclinical safety evaluation of a new therapeutic HIV-1 vaccine based on 18 T-cell minimal epitope peptides applying a novel cationic adjuvant CAF01. Vaccine. 29:7067-74. Nordly, P., Agger, E.M., Andersen, P., Nielsen, H.M., Foged, C. (2011) Incorporation of the TLR4 agonist monophosphoryl lipid A into the bilayer of DDA/TDB liposomes: physico-chemical characterization and induction of CD8+ T-cell responses in vivo. Pharm Res. 28:553-62. Gram, G.J., Karlsson, I., Agger, E.M., Andersen, P., Fomsgaard, A. (2009) A novel liposome-based adjuvant CAF01 for induction of CD8(+) cytotoxic T-lymphocytes (CTL) to HIV-1 minimal CTL peptides in HLA-A*0201 transgenic mice. PLoS One. 4:e6950. Davidsen, J., Rosenkrands, I., Christensen, D., Vangala, A., Kirby, D., Perrie, Y., Agger, E.M., Andersen, P. (2005) Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6'-dibehenate)-a novel adjuvant inducing both strong CMI and antibody responses. Biochim Biophys Acta. 1718:22-31.