890704 | 18:1 EPC (Cl Salt)

1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (chloride salt)


Chloroform

Size SKU Packaging Price
25mg 890704C-25mg 890704C-25mg 1 x 25mg 10mg/mL 2.5mL $152.75
100mg 890704C-100mg 890704C-100mg 1 x 100mg 25mg/mL 4mL $418.00

Powder

Size SKU Packaging Price
25mg 890704P-25mg 890704P-25mg 1 x 25mg $152.75
100mg 890704P-100mg 890704P-100mg 1 x 100mg $418.00
200mg 890704P-200mg 890704P-200mg 2 x 100mg $720.00
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18:1 EPC (Cl Salt)

18:1 EPC (Cl Salt)

1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (chloride salt)

O-alkyl phosphatidylcholines constitute the first chemically stable triesters of biological lipid structures and the first cationic derivatives of phospholipids consisting entirely of biological metabolites linked with ester bonds. The lipid has low toxicity and is biodegradable.

Hygroscopic
No
Light Sensitive
Yes
Molecular Formula
C46H89NO8PCl
Percent Composition
C 64.95%, H 10.55%, Cl 4.17%, N 1.65%, O 15.05%, P 3.64%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
474945-24-9
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
850.628
Exact Mass
849.601
Synonyms
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-ethylphosphocholine (chloride salt)
EDOPC
DOPC+

Sut TN, Jackman JA, Cho NJ. Understanding How Membrane Surface Charge Influences Lipid Bicelle Adsorption onto Oxide Surfaces. Langmuir. 2019 Jun 25;35(25):8436-8444. doi: 10.1021/acs.langmuir.9b00570. Epub 2019 Jun 10.

PubMed ID: 31141663

Ferhan AR, Yoon BK, Park S, Sut TN, Chin H, Park JH, Jackman JA, Cho NJ. Solvent-assisted preparation of supported lipid bilayers. Nat Protoc. 2019 Jul;14(7):2091-2118. doi: 10.1038/s41596-019-0174-2. Epub 2019 Jun 7.

PubMed ID: 31175346

Patel S, Ryals RC, Weller KK, Pennesi ME, Sahay G. Lipid nanoparticles for delivery of messenger RNA to the back of the eye. J Control Release. 2019 Apr 12;303:91-100. doi: 10.1016/j.jconrel.2019.04.015. [Epub ahead of print]

PubMed ID: 30986436

Shoji A, Takahashi Y, Osato S, Sugawara M. An enzyme-modified capillary as a platform for simultaneous fluorometric detection of d-glucose and l- lactate. J Pharm Biomed Anal. 2019 Jan 30;163:1-8. doi: 10.1016/j.jpba.2018.09.028. Epub 2018 Sep 19.

PubMed ID: 30268727

Evans KO, Compton DL, Kim S, Appell M. Charged phospholipid effects on AAPH oxidation assay as determined using liposomes. Chem Phys Lipids. 2019 Feb 21;220:49-56. doi: 10.1016/j.chemphyslip.2019.02.004. [Epub ahead of print]

PubMed ID: 30796887

Zhang M, Lemay SG. Interaction of anionic bulk nanobubbles with cationic liposomes: evidence for reentrant condensation. Langmuir. 2019 Feb 27. doi: 10.1021/acs.langmuir.8b03927. [Epub ahead of print]

PubMed ID: 30811209

Wang L, Biswas KH, Yoon BK, Kawakami LM, Park S, Groves JT, Li L, Huang W, Cho NJ. Membrane Reconstitution of Monoamine Oxidase Enzymes on Supported Lipid Bilayers. Langmuir. 2018 Aug 31. doi: 10.1021/acs.langmuir.8b01348. [Epub ahead of print]

PubMed ID: 30049212

Piffoux M, Silva AKA, Wilhelm C, Gazeau F, Tareste D. Modification of Extracellular Vesicles by Fusion with Liposomes for the Design of Personalized Biogenic Drug Delivery Systems. ACS Nano. 2018 Jul 10. doi: 10.1021/acsnano.8b02053. [Epub ahead of print]

PubMed ID: 29975503

Koynova, R., Tenchov, B., Wang, L., MacDonald, R.C. (2009) Hydrophobic moiety of cationic lipids strongly modulates their transfection activity. Mol Pharm. 6:951-8.

PubMed ID: 19341312

Tenchov, B.G., Wang, L., Koynova, R., MacDonald, R.C. (2008) Modulation of a membrane lipid lamellar-nonlamellar phase transition by cationic lipids: a measure for transfection efficiency. Biochim Biophys Acta. 1778:2405-12.

PubMed ID: 18722340

Koynova, R., Tarahovsky, Y.S., Wang, L., MacDonald, R.C. (2007) Lipoplex formulation of superior efficacy exhibits high surface activity and fusogenicity, and readily releases DNA. Biochim Biophys Acta. 1768:375-86.

PubMed ID: 17156744

Koynova, R., Wang, L., MacDonald, R.C. (2007) Synergy in lipofection by cationic lipid mixtures: superior activity at the gel-liquid crystalline phase transition. J Phys Chem B. 111:7786-95.

PubMed ID: 17571876

Wang, L., MacDonald, R.C. (2007) Synergistic effect between components of mixtures of cationic amphipaths in transfection of primary endothelial cells. Mol Pharm. 4:615-23.

PubMed ID: 17408283

Biswas KH, Jackman JA, Park JH, Groves JT, Cho NJ Interfacial Forces Dictate the Pathway of Phospholipid Vesicle Adsorption onto Silicon Dioxide Surfaces. Langmuir. 2018 Jan 11. doi: 10.1021/acs.langmuir.7b03799.

PubMed ID: 29281791