890703 | 18:0 EPC (Cl Salt)

1,2-distearoyl-sn-glycero-3-ethylphosphocholine (chloride salt)

18:0 EPC (Cl Salt)

Chloroform

Size SKU Packaging Price
25mg 890703C-25mg 890703C-25mg 1 x 25mg 10mg/mL 2.5mL $210.00
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Powder

Size SKU Packaging Price
25mg 890703P-25mg 890703P-25mg 1 x 25mg $210.00 210
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Info

18:0 EPC (Cl Salt)

1,2-distearoyl-sn-glycero-3-ethylphosphocholine (chloride salt)

O-alkyl phosphatidylcholines constitute the first chemically stable triesters of biological lipid structures and the first cationic derivatives of phospholipids consisting entirely of biological metabolites linked with ester bonds. The lipid has low toxicity and is biodegradable.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C46H93NO8PCl
Percent Composition
C 64.65%, H 10.97%, Cl 4.15%, N 1.64%, O 14.98%, P 3.62%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
328268-13-9
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
854.659
Exact Mass
853.633
Synonyms
1,2-dioctadecanoyl-sn-glycero-3-ethylphosphocholine (chloride salt)
References

Patel S, Ryals RC, Weller KK, Pennesi ME, Sahay G. Lipid nanoparticles for delivery of messenger RNA to the back of the eye. J Control Release. 2019 Apr 12;303:91-100. doi: 10.1016/j.jconrel.2019.04.015. [Epub ahead of print]

PubMed ID: 30986436

Koynova, R., Tenchov, B., Wang, L., MacDonald, R.C. (2009) Hydrophobic moiety of cationic lipids strongly modulates their transfection activity. Mol Pharm. 6:951-8.

PubMed ID: 19341312

Tenchov, B.G., Wang, L., Koynova, R., MacDonald, R.C. (2008) Modulation of a membrane lipid lamellar-nonlamellar phase transition by cationic lipids: a measure for transfection efficiency. Biochim Biophys Acta. 1778:2405-12.

PubMed ID: 18722340

Koynova, R., Tarahovsky, Y.S., Wang, L., MacDonald, R.C. (2007) Lipoplex formulation of superior efficacy exhibits high surface activity and fusogenicity, and readily releases DNA. Biochim Biophys Acta. 1768:375-86.

PubMed ID: 17156744

Wang, L., MacDonald, R.C. (2007) Synergistic effect between components of mixtures of cationic amphipaths in transfection of primary endothelial cells. Mol Pharm. 4:615-23.

PubMed ID: 17408283

Gillissen JJJ, Tabaei SR, Jackman JA, Cho NJ Effect of Glucose on the Mobility of Membrane-Adhering Liposomes Langmuir. 2017 Dec 19. doi: 10.1021/acs.langmuir.7b03364.

PubMed ID: 29200303
Certificates of Analysis

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