890700 | 12:0 EPC (Cl Salt)

1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (chloride salt)

12:0 EPC (Cl Salt)

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12:0 EPC (Cl Salt)

1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (chloride salt)

O-alkyl phosphatidylcholines constitute the first chemically stable triesters of biological lipid structures and the first cationic derivatives of phospholipids consisting entirely of biological metabolites linked with ester bonds. The lipid has low toxicity and is biodegradable.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C34H69NO8PCl
Percent Composition
C 59.50%, H 10.13%, Cl 5.17%, N 2.04%, O 18.65%, P 4.51%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
474945-22-7
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
686.34
Exact Mass
685.445
Synonyms
1,2-didodecanoyl-sn-glycero-3-ethylphosphocholine (chloride salt)
References

Koynova R, Tenchov B, Wang L, Macdonald RC. Hydrophobic moiety of cationic lipids strongly modulates their transfection activity. Mol Pharm. 2009 May-Jun;6(3):951-8. doi: 10.1021/mp8002573. PMID: 19341312; PMCID: PMC3014849.

PubMed ID: 19341312

Tenchov BG, Wang L, Koynova R, MacDonald RC. Modulation of a membrane lipid lamellar-nonlamellar phase transition by cationic lipids: a measure for transfection efficiency. Biochim Biophys Acta. 2008 Oct;1778(10):2405-12. doi: 10.1016/j.bbamem.2008.07.022. Epub 2008 Aug 5. PMID: 18722340.

PubMed ID: 18722340

Koynova R, Tarahovsky YS, Wang L, MacDonald RC. Lipoplex formulation of superior efficacy exhibits high surface activity and fusogenicity, and readily releases DNA. Biochim Biophys Acta. 2007 Feb;1768(2):375-86. doi: 10.1016/j.bbamem.2006.10.016. Epub 2006 Nov 1. PMID: 17156744; PMCID: PMC1861830.

PubMed ID: 17156744

Koynova R, Wang L, MacDonald RC. Synergy in lipofection by cationic lipid mixtures: superior activity at the gel-liquid crystalline phase transition. J Phys Chem B. 2007 Jul 12;111(27):7786-95. doi: 10.1021/jp071286y. Epub 2007 Jun 16. PMID: 17571876; PMCID: PMC2532599.

PubMed ID: 17571876
Certificates of Analysis

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