890000 | MVL5

N1-[2-((1S)-1-[(3-aminopropyl)amino]-4-[di(3-amino-propyl)amino]butylcarboxamido)ethyl]-3,4-di[oleyloxy]-benzamide


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1mg 890000P-1mg 890000P-1mg 1 x 1mg $194.00
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MVL5

MVL5

N1-[2-((1S)-1-[(3-aminopropyl)amino]-4-[di(3-amino-propyl)amino]butylcarboxamido)ethyl]-3,4-di[oleyloxy]-benzamide

New Multivalent Cationic Lipid for siRNA Delivery
• Improved total gene silencing • Lower non-specific gene silencing • Lower toxicity
These attributes establish the multivalent MVL5 as a superior transfection vector for siRNAs, and have implications for the optimal use of cationic lipids in therapeutic applications.
Now available as a pre-mixed kit, MVL5 and GMO ready to use. Avanti Number 640009
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C59H116Cl5N7O4
Percent Composition
C 60.83%, H 10.04%, Cl 15.22%, N 8.42%, O 5.49%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
464926-03-2
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
1164.862
Exact Mass
1161.754
Synonyms

N1,N1,N4-tris(3-ammoniopropyl)-5-((2-(3,4-bis((Z)-octadec-9-en-1-yloxy)benzamido)ethyl)amino)-5-oxopentane-1,4-diaminium chloride

Chan, C.L., K.K. Ewert, R.N. Majzoub, Y.K. Hwu, K.S. Liang, C. Leal, and C.R. Safinya. (2014). Optimizing cationic and neutral lipids for efficient gene delivery at high serum content. J Gene Med 16:84-96. [PubMed] Leal, C., K.K. Ewert, R.S. Shirazi, N.F. Bouxsein, and C.R. Safinya. (2011). Nanogyroids incorporating multivalent lipids: enhanced membrane charge density and pore forming ability for gene silencing. Langmuir 27:7691-7. [PubMed] Bouxsein, N.F., C.S. McAllister, K.K. Ewert, C.E. Samuel, and C.R. Safinya. (2007). Structure and gene silencing activities of monovalent and pentavalent cationic lipid vectors complexed with siRNA. Biochemistry 46:4785-92. [PubMed] Ewert, K., A. Ahmad, H.M. Evans, H.W. Schmidt, and C.R. Safinya. (2002). Efficient synthesis and cell-transfection properties of a new multivalent cationic lipid for nonviral gene delivery. J Med Chem 45:5023-9. [PubMed]