Products

MVL5 | 890000

N1-[2-((1S)-1-[(3-aminopropyl)amino]-4-[di(3-amino-propyl)amino]butylcarboxamido)ethyl]-3,4-di[oleyloxy]-benzamide

890000P

Powder

1 mg
$185.00

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New Multivalent Cationic Lipid for siRNA Delivery
• Improved total gene silencing
• Lower non-specific gene silencing
• Lower toxicity
These attributes establish the multivalent MVL5 as a superior transfection vector for siRNAs, and have implications for the optimal use of cationic lipids in therapeutic applications.
 
Now available as a pre-mixed kit, MVL5 and GMO ready to use.
Avanti Number 640009
Molecular Formula
C59H116Cl5N7O4
Percent Composition
C 60.83%, H 10.04%, Cl 15.22%, N 8.42%, O 5.49%
Purity
>99%
Stability
6 Months
Storage
-20°C
CAS Number
464926-03-2
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
1164.862
Exact Mass
1161.754
Synonyms
N1,N1,N4-tris(3-ammoniopropyl)-5-((2-(3,4-bis((Z)-octadec-9-en-1-yloxy)benzamido)ethyl)amino)-5-oxopentane-1,4-diaminium chloride
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Notes
GIF Graphics File. 
GIF Graphics File. 
MDL Molfile. 
CDX File. 
Chan, C.L., K.K. Ewert, R.N. Majzoub, Y.K. Hwu, K.S. Liang, C. Leal, and C.R. Safinya. (2014). Optimizing cationic and neutral lipids for efficient gene delivery at high serum content. J Gene Med 16:84-96. [PubMed]

Leal, C., K.K. Ewert, R.S. Shirazi, N.F. Bouxsein, and C.R. Safinya. (2011). Nanogyroids incorporating multivalent lipids: enhanced membrane charge density and pore forming ability for gene silencing. Langmuir 27:7691-7. [PubMed]

Bouxsein, N.F., C.S. McAllister, K.K. Ewert, C.E. Samuel, and C.R. Safinya. (2007). Structure and gene silencing activities of monovalent and pentavalent cationic lipid vectors complexed with siRNA. Biochemistry 46:4785-92. [PubMed]

Ewert, K., A. Ahmad, H.M. Evans, H.W. Schmidt, and C.R. Safinya. (2002). Efficient synthesis and cell-transfection properties of a new multivalent cationic lipid for nonviral gene delivery.

J Med Chem 45:5023-9. [PubMed]