DChemsPC | 880346
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- Physical/Chemical Properties
- Cholesterol exchange is a major reason for the instability of liposomes in blood. The formation of a covalent hybrid between cholesterol and glycerophosphocholine preserves the bilayer-stabilizing effect of free cholesterol but prevents its transfer from the bilayer. Thus, disterolphospholipids are valuable new components for liposome formulation.
- Molecular Formula
- Percent Composition
- C 70.38%, H 9.79%, N 1.17%, O 16.07%, P 2.59%
- 1 Years
- CAS Number
CAS Registry Number is a Registered Trademark of the American Chemical Society
- Molecular Weight
- Exact Mass
Foglia, F., D.J. Barlow, F.C. Szoka, Z. Huang, S.E. Rogers, and M.J. Lawrence. (2011). Structural studies of the monolayers and bilayers formed by a novel cholesterol-phospholipid chimera. Langmuir 27:8275-81. [PubMed]
Iman, M., Z. Huang, F.C. Szoka Jr, and M.R. Jaafari. (2011). Characterization of the colloidal properties, in vitro antifungal activity, antileishmanial activity and toxicity in mice of a distigmasterylhemisuccinoyl-glycero-phosphocholine liposome-intercalated amphotericin B. Int J Pharm. [PubMed]
Huang, Z., M.R. Jaafari, and F.C. Szoka Jr. (2009). Disterolphospholipids: nonexchangeable lipids and their application to liposomal drug delivery. Angew Chem Int Ed Engl 48:4146-9. [PubMed]
Huang, Z., Szoka, F.C., Jr. (2008) Sterol-Modified Phospholipids: Cholesterol and Phospholipid Chimeras with Improved Biomembrane Properties. J Am Chem Soc 130:15702-15712. [PubMed]