Products

DChemsPC | 880346

1,2-dicholesterylhemisuccinoyl-sn-glycero-3-phosphocholine

880346P

Powder

25 mg
$180.00
200 mg
$600.00
500 mg
$1140.00
1 g
$1850.00

All Prices in US Dollars
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  • Physical/Chemical Properties
Cholesterol exchange is a major reason for the instability of liposomes in blood. The formation of a covalent hybrid between cholesterol and glycerophosphocholine preserves the bilayer-stabilizing effect of free cholesterol but prevents its transfer from the bilayer. Thus, disterolphospholipids are valuable new components for liposome formulation.
Molecular Formula
C70H116NO12P
Percent Composition
C 70.38%, H 9.79%, N 1.17%, O 16.07%, P 2.59%
Purity
>99%
Stability
1 Years
Storage
-20°C
CAS Number
1155878-69-5
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
1194.643
Exact Mass
1193.824
Synonyms
DCholPC
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Notes
GIF Graphics File. 
GIF Graphics File. 
MDL Molfile. 
CDX File. 
Flasinski, M., B. Konderla, M. Broniatowski, and P. Wydro. (2016). Sterol - phospholipid hybrids at the air/water interface - studies on properties and interactions with parent lipid molecules. Langmuir [PubMed]

Foglia, F., D.J. Barlow, F.C. Szoka, Z. Huang, S.E. Rogers, and M.J. Lawrence. (2011). Structural studies of the monolayers and bilayers formed by a novel cholesterol-phospholipid chimera. Langmuir 27:8275-81. [PubMed]

Iman, M., Z. Huang, F.C. Szoka Jr, and M.R. Jaafari. (2011). Characterization of the colloidal properties, in vitro antifungal activity, antileishmanial activity and toxicity in mice of a distigmasterylhemisuccinoyl-glycero-phosphocholine liposome-intercalated amphotericin B. Int J Pharm. [PubMed]

Huang, Z., M.R. Jaafari, and F.C. Szoka Jr. (2009). Disterolphospholipids: nonexchangeable lipids and their application to liposomal drug delivery. Angew Chem Int Ed Engl 48:4146-9. [PubMed]

Huang, Z., Szoka, F.C., Jr. (2008) Sterol-Modified Phospholipids: Cholesterol and Phospholipid Chimeras with Improved Biomembrane Properties. J Am Chem Soc 130:15702-15712. [PubMed]

A summary of the physical/chemical properties of Sterol-Modified Phospholipids is presented in a PowerPoint presentation. This information was kindly provided by Dr. Francis C. Szoka, Jr., Department of Biopharmaceutical Sciences, University of California, San Francisco, California.