880346 | DChemsPC



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25mg 880346P-25mg 880346P-25mg 1 x 25mg $266.50
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Cholesterol exchange is a major reason for the instability of liposomes in blood. The formation of a covalent hybrid between cholesterol and glycerophosphocholine preserves the bilayer-stabilizing effect of free cholesterol but prevents its transfer from the bilayer. Thus, disterolphospholipids are valuable new components for liposome formulation.

Light Sensitive
Molecular Formula
Percent Composition
C 70.38%, H 9.79%, N 1.17%, O 16.07%, P 2.59%
1 Years
Storage Temperature
CAS Number
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
Exact Mass

Flasiński M, Konderla B, Broniatowski M, Wydro P. Sterol-Phospholipid Hybrids at the Air/Water Interface: Studies on Properties and Interactions with Parent Lipid Molecules. Langmuir. 2016 Apr 26;32(16):4095-102. doi: 10.1021/acs.langmuir.5b04311. Epub 2016 Apr 13. PMID: 27046325.

PubMed ID: 27046325

Foglia F, Barlow DJ, Szoka FC, Huang Z, Rogers SE, Lawrence MJ. Structural studies of the monolayers and bilayers formed by a novel cholesterol-phospholipid chimera. Langmuir. 2011 Jul 5;27(13):8275-81. doi: 10.1021/la200739y. Epub 2011 Jun 2. PMID: 21634402.

PubMed ID: 21634402

Iman M, Huang Z, Szoka FC Jr, Jaafari MR. Characterization of the colloidal properties, in vitro antifungal activity, antileishmanial activity and toxicity in mice of a di-stigma-steryl-hemi-succinoyl-glycero-phosphocholine liposome-intercalated amphotericin B. Int J Pharm. 2011 Apr 15;408(1-2):163-72. doi: 10.1016/j.ijpharm.2011.01.044. Epub 2011 Jan 26. PMID: 21277963; PMCID: PMC3071037.

PubMed ID: 21277963

Huang Z, Szoka FC Jr. Sterol-modified phospholipids: cholesterol and phospholipid chimeras with improved biomembrane properties. J Am Chem Soc. 2008 Nov 19;130(46):15702-12. doi: 10.1021/ja8065557. Epub 2008 Oct 25. PMID: 18950160; PMCID: PMC2701441.

PubMed ID: 18950160

A summary of the physical/chemical properties of Sterol-Modified Phospholipids is presented in a PowerPoint presentation. This information was kindly provided by Dr. Francis C. Szoka, Jr., Department of Biopharmaceutical Sciences, University of California, San Francisco, California.