880345 | PChcPC



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25mg 880345P-25mg 880345P-25mg 1 x 25mg $266.50
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Sterol-modified phospholipids stabilize bilayers but do not exchange between membranes as freely as cholesterol. This new class of phospholipids provides a new tool for biophysical studies on membranes and may improve liposomal drug delivery in organs predisposed to the extraction of free cholesterol from bilayers, such as the skin, lung or blood.

Light Sensitive
Molecular Formula
Percent Composition
C 68.76%, H 10.43%, N 1.54%, O 15.85%, P 3.41%
1 Years
Storage Temperature
CAS Number
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
Exact Mass

Foglia F, Barlow DJ, Szoka FC, Huang Z, Rogers SE, Lawrence MJ. Structural studies of the monolayers and bilayers formed by a novel cholesterol-phospholipid chimera. Langmuir. 2011 Jul 5;27(13):8275-81. doi: 10.1021/la200739y. Epub 2011 Jun 2. PMID: 21634402.

PubMed ID: 21634402

Iman M, Huang Z, Szoka FC Jr, Jaafari MR. Characterization of the colloidal properties, in vitro antifungal activity, antileishmanial activity and toxicity in mice of a di-stigma-steryl-hemi-succinoyl-glycero-phosphocholine liposome-intercalated amphotericin B. Int J Pharm. 2011 Apr 15;408(1-2):163-72. doi: 10.1016/j.ijpharm.2011.01.044. Epub 2011 Jan 26. PMID: 21277963; PMCID: PMC3071037.

PubMed ID: 21277963

Huang Z, Jaafari MR, Szoka FC Jr. Disterolphospholipids: nonexchangeable lipids and their application to liposomal drug delivery. Angew Chem Int Ed Engl. 2009;48(23):4146-9. doi: 10.1002/anie.200900111. PMID: 19425026; PMCID: PMC2773798.

PubMed ID: 19425026

Huang Z, Szoka FC Jr. Sterol-modified phospholipids: cholesterol and phospholipid chimeras with improved biomembrane properties. J Am Chem Soc. 2008 Nov 19;130(46):15702-12. doi: 10.1021/ja8065557. Epub 2008 Oct 25. PMID: 18950160; PMCID: PMC2701441.

PubMed ID: 18950160

A summary of the physical/chemical properties of Sterol-Modified Phospholipids is presented in a PowerPoint presentation. This information was kindly provided by Dr. Francis C. Szoka, Jr., Department of Biopharmaceutical Sciences, University of California, San Francisco, California.