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  • Physical/Chemical Properties
Sterol-modified phospholipids stabilize bilayers but do not exchange between membranes as freely as cholesterol. This new class of phospholipids provides a new tool for biophysical studies on membranes and may improve liposomal drug delivery in organs predisposed to the extraction of free cholesterol from bilayers, such as the skin, lung or blood.
Molecular Formula
Percent Composition
C 69.13%, H 10.18%, N 1.41%, O 16.15%, P 3.13%
1 Year
CAS Number
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
Exact Mass
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MDL Molfile. 
CDX File. 
Foglia, F., D.J. Barlow, F.C. Szoka, Z. Huang, S.E. Rogers, and M.J. Lawrence. (2011). Structural studies of the monolayers and bilayers formed by a novel cholesterol-phospholipid chimera. Langmuir 27:8275-81. [PubMed]Iman, M., Z. Huang, F.C. Szoka Jr, and M.R. Jaafari. (2011). Characterization of the colloidal properties, in vitro antifungal activity, antileishmanial activity and toxicity in mice of a distigmasterylhemisuccinoyl-glycero-phosphocholine liposome-intercalated amphotericin B. Int J Pharm. [PubMed]Huang, Z., M.R. Jaafari, and F.C. Szoka Jr. (2009). Disterolphospholipids: nonexchangeable lipids and their application to liposomal drug delivery. Angew Chem Int Ed Engl 48:4146-9. [PubMed]Huang, Z., Szoka, F.C., Jr. (2008) Sterol-Modified Phospholipids: Cholesterol and Phospholipid Chimeras with Improved Biomembrane Properties. J Am Chem Soc 130:15702-15712. [PubMed]
A summary of the physical/chemical properties of Sterol-Modified Phospholipids is presented in a PowerPoint presentation. This information was kindly provided by Dr. Francis C. Szoka, Jr., Department of Biopharmaceutical Sciences, University of California, San Francisco, California.