880343 | PChemsPC

1-palmitoyl-2-cholesterylhemisuccinoyl-sn-glycero-3-phosphocholine


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PChemsPC

PChemsPC

1-palmitoyl-2-cholesterylhemisuccinoyl-sn-glycero-3-phosphocholine

Sterol-modified phospholipids stabilize bilayers but do not exchange between membranes as freely as cholesterol. This new class of phospholipids provides a new tool for biophysical studies on membranes and may improve liposomal drug delivery in organs predisposed to the extraction of free cholesterol from bilayers, such as the skin, lung or blood.
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C55H98NO10P
Percent Composition
C 68.50%, H 10.24%, N 1.45%, O 16.59%, P 3.21%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
155401-40-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
964.341
Exact Mass
963.693
Synonyms
PCholPC
Flasinski, M., B. Konderla, M. Broniatowski, and P. Wydro. (2016). Sterol - phospholipid hybrids at the air/water interface - studies on properties and interactions with parent lipid molecules. Langmuir [PubMed] Foglia, F., D.J. Barlow, F.C. Szoka, Z. Huang, S.E. Rogers, and M.J. Lawrence. (2011). Structural studies of the monolayers and bilayers formed by a novel cholesterol-phospholipid chimera. Langmuir 27:8275-81. [PubMed] Iman, M., Z. Huang, F.C. Szoka Jr, and M.R. Jaafari. (2011). Characterization of the colloidal properties, in vitro antifungal activity, antileishmanial activity and toxicity in mice of a distigmasterylhemisuccinoyl-glycero-phosphocholine liposome-intercalated amphotericin B. Int J Pharm. [PubMed] Huang, Z., M.R. Jaafari, and F.C. Szoka Jr. (2009). Disterolphospholipids: nonexchangeable lipids and their application to liposomal drug delivery. Angew Chem Int Ed Engl 48:4146-9. [PubMed] Huang, Z., Szoka, F.C., Jr. (2008) Sterol-Modified Phospholipids: Cholesterol and Phospholipid Chimeras with Improved Biomembrane Properties. J Am Chem Soc 130:15702-15712. [PubMed]
A summary of the physical/chemical properties of Sterol-Modified Phospholipids is presented in a PowerPoint presentation. This information was kindly provided by Dr. Francis C. Szoka, Jr., Department of Biopharmaceutical Sciences, University of California, San Francisco, California.