880151 | DMG-PEG 2000

1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000

DMG-PEG 2000

Powder

Size SKU Packaging Price
1g 880151P-1g 880151P-1g 1 x 1g $259.02
5g 880151P-5g 880151P-5g 1 x 5g $1,036.15
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Info

DMG-PEG 2000

1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000

DMG-PEG 2000, also known as 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000, is a lipid excipient designed for the preparation of lipid nanoparticles (LNPs) for RNA delivery. It is derived from dimyristoyl glycerol (DMG) and exhibits similar properties as phospholipids in the way it associates with membranes.

Applications

DMG-PEG 2000 has been used to create a lipid nanoparticle tailored for microRNA, mRNA, and short interfering RNA (siRNA) delivery. This lipid nanoparticle has been crucial in gene regulation studies and therapeutic interventions.

DMG-PEG 2000 has also found uses in liposome preparation and LNP preparation for siRNA (small interfering RNA) delivery in developing the COVID-19 vaccine. It manufactures lipid nanoparticles used in mRNA vaccines

It's had a significant impact on advanced cancer treatment research. In anticancer drug delivery studies, DMG-PEG 2000 has been used in liposome preparations to facilitate the delivery of anticancer drugs targeting hepatocellular, gastrointestinal, neuroendocrine, and adrenocortical carcinoma.

Packaging

Unlock the potential of lipid technology with DMG-PEG 2000 in 1 g and 5 g powder packaging from Avanti Research.

With over 50 years of working in the research, pharmaceutical, and diagnostic industries, Avanti Research is renowned for its dedication to lipid products that save and improve lives.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula

C122H242O50 (average MW due to polydispersity of PEG)

Percent Composition

C 58.40% H 9.72% O 31.88%

Purity
>99%
Stability
1 Year
Storage Temperature
-20
CAS Number
160743-62-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
2509.2
Exact Mass
2507.64
Synonyms
770151
Solubility in Different Solvents
Soluble in ethanol, DMSO, and Chloroform:Methanol (9:1) at 5mg/mL
References

Webb C, Forbes N, Roces CB, Anderluzzi G, Lou G, Abraham S, Ingalls L, Marshall K, Leaver TJ, Watts JA, Aylott JW, Perrie Y. Using microfluidics for scalable manufacturing of nanomedicines from bench to GMP: A case study using protein-loaded liposomes. Int J Pharm. 2020 May 30;582:119266. doi: 10.1016/j.ijpharm.2020.119266. Epub 2020 Apr 3. PMID: 32251694.

PubMed ID: 32251694

Zhao P, Hou X, Yan J, Du S, Xue Y, Li W, Xiang G, Dong Y. Long-term storage of lipid-like nanoparticles for mRNA delivery. Bioact Mater. 2020 Mar 18;5(2):358-363. doi: 10.1016/j.bioactmat.2020.03.001. PMID: 32206737; PMCID: PMC7078456.

PubMed ID: 32206737

Veiga N, Goldsmith M, Diesendruck Y, Ramishetti S, Rosenblum D, Elinav E, Behlke MA, Benhar I, Peer D. Leukocyte-specific siRNA delivery revealing IRF8 as a potential anti-inflammatory target. J Control Release. 2019 Oct 18;313:33-41. doi: 10.1016/j.jconrel.2019.10.001. [Epub ahead of print]

PubMed ID: 31634546
Certificates of Analysis

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