880150 | 14:0 PEG2000 PE

1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)

14:0 PEG2000 PE

Powder

Size SKU Packaging Price
25mg 880150P-25mg 880150P-25mg 1 x 25mg $186.75
200mg 880150P-200mg 880150P-200mg 1 x 200mg $396.00
500mg 880150P-500mg 880150P-500mg 1 x 500mg $845.00
1g 880150P-1g 880150P-1g 1 x 1g $1,453.84
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Info

14:0 PEG2000 PE

1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)

14:0 PEG2000 PE

14:0 PEG2000 PE, also known as 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt), is a polyethylene glycol (PEG)-phospholipid conjugate in the polymerizable lipid category. It plays a pivotal role in vesicle formulation by preventing aggregation from peptide addition, which ensures stable and functional vesicles.

Application

14:0 PEG2000 PE is instrumental in the preparation and formation of giant vesicles, enabling researchers to explore cellular processes and membrane dynamics precisely and accurately. Additionally, incorporating 14:0 PEG2000 PE in lipid nanoparticle formulations enhances stability and efficacy, facilitating advanced drug delivery systems.

It has also been used to prepare unilamellar liposomes for small-angle X-ray scattering (SAXS) experiments, helping investigate molecular structures and interactions with greater clarity and detail.

Solubility

Soluble in ethanol, DMSO, and chloroform-methanol at 5mg/mL.

Packaging

Avanti Research offers 14:0 PEG2000 PE in 25 mg, 200 mg, 500 mg, and 1 g powder packaging options. With over 50 years in business, Avanti Research is the trusted leader in lipid-based products that save and improve lives. We are the premier choice for polymerizable lipids for research and development purposes.

Data
Hygroscopic
Yes
Light Sensitive
No
Molecular Formula

C125H251N2O55P (average MW due to polydispersity of PEG)

Percent Composition

C 55.74%, H 9.39%, N 1.04%, O 32.67%, P 1.15%

Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
474922-82-2
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
2693.32
Exact Mass
2691.66
Synonyms
1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[carbonyl-methoxy(polyethylene glycol)-2000] (ammonium salt)
730150
Solubility in Different Solvents
Soluble in ethanol, DMSO, and Chloroform:Methanol (85:15) at 5mg/mL
References

Lou G, Anderluzzi G, Tandrup Schmidt S, Woods S, Gallorini S, Brazzoli M, Giusti F, Ferlenghi I, Johnson R, Roberts CW, O'Hagan DT, Baudner BC, Perrie Y. Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection. J Control Release. 2020 Jun 30:S0168-3659(20)30362-X. doi: 10.1016/j.jconrel.2020.06.027. Epub ahead of print. PMID: 32619745.

PubMed ID: 32619745

Leboeuf D, Abakumova T, Prikazchikova T, Rhym L, Anderson DG, Zatsepin TS, Piatkov KI. Downregulation of the Arg/N-degron Pathway Sensitizes Cancer Cells to Chemotherapy In Vivo. Mol Ther. 2020 Jan 21:S1525-0016(20)30053-8. doi: 10.1016/j.ymthe.2020.01.021. Epub ahead of print. PMID: 32087767.

PubMed ID: 32087767

Lone A, Thomsen TT, Nielsen JE, Thulstrup PW, Klitgaard RN, Løbner-Olesen A, Lund R, Jenssen H, Hansen PR. Structure-Activity Study of an All-d Antimicrobial Octapeptide D2D. Molecules. 2019 Dec 13;24(24):4571. doi: 10.3390/molecules24244571. PMID: 31847173; PMCID: PMC6943423.

PubMed ID: 31847173

Chen X, Mangala LS, Mooberry L, Bayraktar E, Dasari SK, Ma S, Ivan C, Court KA, Rodriguez-Aguayo C, Bayraktar R, Raut S, Sabnis N, Kong X, Yang X, Lopez-Berestein G, Lacko AG, Sood AK. Identifying and targeting angiogenesis-related microRNAs in ovarian cancer. Oncogene. 2019 Aug;38(33):6095-6108. doi: 10.1038/s41388-019-0862-y. Epub 2019 Jul 9.

PubMed ID: 31289363

Nielsen JE, Lind TK, Lone A, Gerelli Y, Hansen PR, Jenssen H, Cárdenas M, Lund R. A biophysical study of the interactions between the antimicrobial peptide indolicidin and lipid model systems. Biochim Biophys Acta Biomembr. 2019 Apr 9;1861(7):1355-1364. doi: 10.1016/j.bbamem.2019.04.003. [Epub ahead of print]

PubMed ID: 30978313

Callegari E, Domenicali M, Shankaraiah RC, D'Abundo L, Guerriero P, Giannone F, Baldassarre M, Bassi C, Elamin BK, Zagatti B, Ferracin M, Fornari F, Altavilla G, Blandamura S, Silini EM, Gramantieri L, Sabbioni S, Negrini M. MicroRNA-Based Prophylaxis in a Mouse Model of Cirrhosis and Liver Cancer. Mol Ther Nucleic Acids. 2019 Mar 1;14:239-250. doi: 10.1016/j.omtn.2018.11.018. Epub 2018 Dec 6.

PubMed ID: 30641476
Certificates of Analysis

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