880135 | DSPE-PEG(2000) Carboxylic Acid

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000] (sodium salt)


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10mg 880135P-10mg 880135P-10mg 1 x 10mg $120.50
25mg 880135P-25mg 880135P-25mg 1 x 25mg $175.50
50mg 880135P-50mg 880135P-50mg 1 x 50mg $248.50
100mg 880135P-100mg 880135P-100mg 1 x 100mg $435.00
500mg 880135P-500mg 880135P-500mg 1 x 500mg $1,680.00
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DSPE-PEG(2000) Carboxylic Acid

DSPE-PEG(2000) Carboxylic Acid

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000] (sodium salt)

Representative Structure

The molecular weight and exact mass are averages based on the polydispersity of PEG. 

Hygroscopic
Yes
Light Sensitive
No
Molecular Formula
C131H257NNaO55P (average MW due to polydispersity of PEG)
Percent Composition

C 56.59%, H 9.32%, N 0.50%, Na 0.83%, O 31.65%, P 1.11%

Purity
>99%
Stability
1 Year
Storage Temperature
-20C
CAS Number
1403744-37-5
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
2780.380
Exact Mass
2778.700

Mashreghi M, Zamani P, Moosavian SA, Jaafari MR. Anti-Epcam Aptamer (Syl3c)-Functionalized Liposome for Targeted Delivery Of Doxorubicin: In Vitro And In Vivo Antitumor Studies in Mice Bearing C26 Colon Carcinoma. Nanoscale Res Lett. 2020 May 7;15(1):101. doi: 10.1186/s11671-020-03334-9. PMID: 32383027; PMCID: PMC7206479.

PubMed ID: 32383027

Kong L, Li XT, Ni YN, Xiao HH, Yao YJ, Wang YY, Ju RJ, Li HY, Liu JJ, Fu M, Wu YT, Yang JX, Cheng L. Transferrin-Modified Osthole PEGylated Liposomes Travel the Blood-Brain Barrier and Mitigate Alzheimer's Disease-Related Pathology in APP/PS-1 Mice. Int J Nanomedicine. 2020 Apr 23;15:2841-2858. doi: 10.2147/IJN.S239608. PMID: 32425521; PMCID: PMC7186891.

PubMed ID: 32425521

An J, Forchheimer D, Sävmarker J, Brülls M, Frenning G. Nanoscale characterization of PEGylated phospholipid coatings formed by spray drying on silica microparticles. J Colloid Interface Sci. 2020 May 21;577:92-100. doi: 10.1016/j.jcis.2020.05.045. Epub ahead of print. PMID: 32473480.

PubMed ID: 32473480

Kuo YC, Lou YI, Rajesh R. Dual functional liposomes carrying antioxidants against tau hyperphosphorylation and apoptosis of neurons. J Drug Target. 2020 May 12:1-12. doi: 10.1080/1061186X.2020.1761819. Epub ahead of print. PMID: 32338078.

PubMed ID: 32338078

Benne N, Martins Cardoso R, Boyle AL, Kros A, Jiskoot W, Kuiper J, Bouwstra J, Van Eck M, Slütter B. Complement Receptor Targeted Liposomes Encapsulating the Liver X Receptor Agonist GW3965 Accumulate in and Stabilize Atherosclerotic Plaques. Adv Healthc Mater. 2020 May;9(10):e2000043. doi: 10.1002/adhm.202000043. Epub 2020 Apr 24. PMID: 32329226.

PubMed ID: 32329226

Wei Y, Liu S, Pan C, Yang Z, Liu Y, Yong J, Quan L. Molecular Antenna-Sensitized Upconversion Nanoparticle for Temperature Monitored Precision Photothermal Therapy. Int J Nanomedicine. 2020 Mar 2;15:1409-1420. doi: 10.2147/IJN.S236371. PMID: 32184595; PMCID: PMC7060035.

PubMed ID: 32184595

Lee SWL, Campisi M, Osaki T, Possenti L, Mattu C, Adriani G, Kamm RD, Chiono V. Modeling Nanocarrier Transport across a 3D In Vitro Human Blood-Brain-Barrier Microvasculature. Adv Healthc Mater. 2020 Apr;9(7):e1901486. doi: 10.1002/adhm.201901486. Epub 2020 Mar 3. PMID: 32125776.

PubMed ID: 32125776

Ye S , Liu Y , Lu Y , Ji Y , Mei L , Yang M , Gong X , Gu Q , Li D , Yang F , Li CJ . Cyclic RGD functionalized liposomes targeted to activated platelets for thrombosis dual-mode magnetic resonance imaging. J Mater Chem B. 2020 Jan 22;8(3):447-453. doi: 10.1039/c9tb01834d. PMID: 31833530.

PubMed ID: 31833530

Ramesh A , Kumar S , Nguyen A , Brouillard A , Kulkarni A . Lipid-based phagocytosis nanoenhancer for macrophage immunotherapy. Nanoscale. 2020 Jan 23;12(3):1875-1885. doi: 10.1039/c9nr08670f. PMID: 31903467.

PubMed ID: 31903467

Yang F, Medik Y, Li L, Tian X, Fu D, Brouwer KLR, Wagner K, Sun B, Sendi H, Mi Y, Wang AZ. Nanoparticle Drug Delivery Can Reduce the Hepatotoxicity of Therapeutic Cargo. Small. 2020 Jan 23:e1906360. doi: 10.1002/smll.201906360. Epub ahead of print. PMID: 31972070.

PubMed ID: 31972070

Kim K, Jo EJ, Lee KJ, Park J, Jung GY, Shin YB, Lee LP, Kim MG. Gold nanocap-supported upconversion nanoparticles for fabrication of a solid-phase aptasensor to detect ochratoxin A. Biosens Bioelectron. 2019 Nov 14:111885. doi: 10.1016/j.bios.2019.111885. [Epub ahead of print]

PubMed ID: 31759762

Jie Zhang, Qi G, Xu C, Jin Y. Enzymatic Preparation of Plasmonic-Fluorescent Quantum Dot-Gold Hybrid Nanoprobes for Sensitive Detection of Glucose and Alkaline Phosphatase and Dual-Modality Cell Imaging. Anal Chem. 2019 Nov 5;91(21):14074-14079. doi: 10.1021/acs.analchem.9b03818. Epub 2019 Oct 18.

PubMed ID: 31592647

Guo P, Huang J, Moses-Gardner A, Smith ER, Moses MA. Quantitative Analysis of Different Cell Entry Routes of Actively Targeted Nanomedicines Using Imaging Flow Cytometry. Cytometry A. 2019 Aug;95(8):843-853. doi: 10.1002/cyto.a.23848. Epub 2019 Jul 11.

PubMed ID: 31294926

Meng L, Chu X, Xing H, Liu X, Xin X, Chen L, Jin M, Guan Y, Huang W, Gao Z. Improving glioblastoma therapeutic outcomes via doxorubicin-loaded nanomicelles modified with borneol. Int J Pharm. 2019 Aug 15;567:118485. doi: 10.1016/j.ijpharm.2019.118485. Epub 2019 Jun 29.

PubMed ID: 31260781

Yung-Chih Kuo, Rajendiran Rajesh, Jyh-Ping Hsu. Electrophoretic mobility of neuron-like cells regenerated from iPSCs with induction of retinoic acid- and nerve growth factor-loaded solid lipid nanoparticles. Journal of the Taiwan Institute of Chemical Engineers. 2019 October;103:167-176. doi: 10.1016/j.jtice.2019.07.010


Wang Y, Fu M, Liu J, Yang Y, Yu Y, Li J, Pan W, Fan L, Li G, Li X, Wang X. Inhibition of tumor metastasis by targeted daunorubicin and dioscin codelivery liposomes modified with PFV for the treatment of non-small-cell lung cancer. Int J Nanomedicine. 2019 May 31;14:4071-4090. doi: 10.2147/IJN.S194304. eCollection 2019.

PubMed ID: 31239668

Qin Zeng, Yunxia Wu, and Tao Zhang. Photoacoustic nanoprobe for β-galactosidase activity detection and imaging in vivo. Journal of Innovative Optical Health Sciences. 27 February 2019. Vol. 12, No. 03, 1941001. doi: 10.1142/S1793545819410013


Lusi V, Moore TL, Laurino F, Coclite A, Perreira R, Ferreira M, Rizzuti I, Palomba R, Zunino P, Duocastella M, Mizrahy S, Peer D, Decuzzi P. A tissue chamber chip for assessing nanoparticle mobility in the extravascular space. Biomed Microdevices. 2019 Apr 6;21(2):41. doi: 10.1007/s10544-019-0398-5.

PubMed ID: 30955101

Guo P, Moses-Gardner A, Huang J, Smith ER, Moses MA. ITGA2 as a potential nanotherapeutic target for glioblastoma. Sci Rep. 2019 Apr 17;9(1):6195. doi: 10.1038/s41598-019-42643-7.

PubMed ID: 30996239

Hua S, Vaughan B. In vitro comparison of liposomal drug delivery systems targeting the oxytocin receptor: a potential novel treatment for obstetric complications. Int J Nanomedicine. 2019 Mar 27;14:2191-2206. doi: 10.2147/IJN.S198116. eCollection 2019.

PubMed ID: 30988616

Guo P, Yang J, Liu D, Huang L, Fell G, Huang J, Moses MA, Auguste DT. Dual complementary liposomes inhibit triple-negative breast tumor progression and metastasis. Sci Adv. 2019 Mar 20;5(3):eaav5010. doi: 10.1126/sciadv.aav5010. eCollection 2019 Mar.

PubMed ID: 30906868

Getachew Tedla, Jesse Plotkin, Anthony Dellinger, and Christopher Kepley. Design and Testing of Dual-Targeted Gd3N@C80-Containing Glioblastoma Theranostics. Journal of Nanomaterials, Vol. 2019, Article ID 1242930, 13 pages, 2019. https://doi.org/10.1155/2019/1242930.


Kim B, Pena CD, Auguste DT. Targeted Lipid Nanoemulsions Encapsulating Epigenetic Drugs Exhibit Selective Cytotoxicity on CDH1-/FOXM1+ Triple Negative Breast Cancer Cells. Mol Pharm. 2019 Mar 29. doi: 10.1021/acs.molpharmaceut.8b01065. [Epub ahead of print]

PubMed ID: 30883132

Shim G, Kim D, Lee S, Chang RS, Byun J, Oh YK. Staphylococcus aureus-mimetic control of antibody orientation on nanoparticles. Nanomedicine. 2019 Feb;16:267-277. doi: 10.1016/j.nano.2018.09.007. Epub 2018 Oct 24.

PubMed ID: 30368001

Rao J, Mei L, Liu J, Tang X, Yin S, Xia C, Wei J, Wan D, Wang X, Wang Y, Li M, Zhang Z, He Q. Size-adjustable micelles co-loaded with a chemotherapeutic agent and an autophagy inhibitor for enhancing cancer treatment via increased tumor retention. Acta Biomater. 2019 Apr 15;89:300-312. doi: 10.1016/j.actbio.2019.03.022. Epub 2019 Mar 14.

PubMed ID: 30878446

Fan CH, Wang TW, Hsieh YK, Wang CF, Gao Z, Kim A, Nagasaki Y, Yeh CK. Enhancing Boron Uptake in Brain Glioma by a Boron-Polymer/Microbubble Complex with Focused Ultrasound. ACS Appl Mater Interfaces. 2019 Mar 27;11(12):11144-11156. doi: 10.1021/acsami.8b22468. Epub 2019 Mar 18.

PubMed ID: 30883079

Kuo YC, Chang YH, Rajesh R. Targeted delivery of etoposide, carmustine and doxorubicin to human glioblastoma cells using methoxy poly(ethylene glycol)‑poly(ε‑caprolactone) nanoparticles conjugated with wheat germ agglutinin and folic acid. Mater Sci Eng C Mater Biol Appl. 2019 Mar;96:114-128. doi: 10.1016/j.msec.2018.10.094. Epub 2018 Nov 4.

PubMed ID: 30606517

Zhang X, Kang Y, Liu GT, Li DD, Zhang JY, Gu ZP, Wu J. Poly(cystine-PCL) based pH/redox dual-responsive nanocarriers for enhanced tumor therapy. Biomater Sci. 2019 Feb 27. doi: 10.1039/c9bm00009g. [Epub ahead of print]

PubMed ID: 30810135

Jen-Tsung Yang, Yung-Chih Kuo, I-Yin Chen, Rajendiran Rajesh, Yung-I Lou, and Jyh-Ping Hsu. Protection against Neurodegeneration in the Hippocampus Using Sialic Acid- and 5-HT-Moduline-Conjugated Lipopolymer Nanoparticles. ACS Biomater. Sci. Eng., Article ASAP


Fan CH, Lin YT, Ho YJ, Yeh CK. Spatial-Temporal Cellular Bioeffects from Acoustic Droplet Vaporization. Theranostics. 2018 Nov 10;8(20):5731-5743. doi: 10.7150/thno.28782. eCollection 2018.

PubMed ID: 30555577