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880134 | PMA

Polymethacrylate Copolymer (N−C4−52−6.9)

PMA

Powder

Size SKU Packaging Price
500mg 880134P-500mg 880134P-500mg 1 x 500mg $355.00
1g 880134P-1g 880134P-1g 1 x 1g $675.00
5g 880134P-5g 880134P-5g 1 x 5g $2,350.00
Info

PMA

Polymethacrylate Copolymer (N−C4−52−6.9)

Perform Structure and Functional Studies on a Variety of Membrane Proteins

Advantages of PMA Based Lipid Nanodiscs:

PMA is more stable than SMA at lower pH and in the presence of divalent metal ions

PMA has a mild effect on lipid acyl chains

Spontaneously Forms Lipid Nanodiscs through Fragmentation of the Lipid Bilayer

Amenable to Biophysical Characterization using CD, UV/vis, and Fluorescence Spectroscopy

Ability to Product Nanodiscs of Various Sizes

Larger PMA Polymer Nanodiscs can be aligned in a magnetic field allowing for solid-state NMR studies on membrane proteins or peptides


Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula

C21H40NO6S+

Percent Composition

Fraction of Butyl Methacrylate (BMA) in Copolymer: ~0.52

Fraction of Methyl Acryoloxy Choline (MAC) in Copolymer: ~0.48

Degree of Polymerization (DP): ~39.00

Purity
>99%
Storage Temperature
-20°C
CAS Number
2315261-99-3
CAS Registry Number is a Registered Trademark of the American Chemical Society
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References

Yasuhara K, Arakida J, Ravula T, Ramadugu SK, Sahoo B, Kikuchi JI, Ramamoorthy A. Spontaneous Lipid Nanodisc Fomation by Amphiphilic Polymethacrylate Copolymers. J Am Chem Soc. 2017 Dec 27;139(51):18657-18663. doi: 10.1021/jacs.7b10591. Epub 2017 Dec 5.

 PubMed ID: 29171274
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