880123 | DSPE-PEG(5000) Folate

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-5000] (ammonium salt)


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500µg 880123P-500ug 880123P-500ug $350.00

Chloroform/Methanol

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500µg 880123X-500ug 880123X-500ug $350.00
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DSPE-PEG(5000) Folate

DSPE-PEG(5000) Folate

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-5000] (ammonium salt)

Folate receptors are cellular surface markers for numerous solid tumors and myeloid leukemias.  Avanti now offers a derivative, DSPE-PEG-folate, which can be incorporated into liposomes as a targeting ligand.
Folate targeted drug delivery has emerged as an alternative therapy for the treatment and imaging of many cancers and inflammatory diseases. Due to its small molecular size and high binding affinity for cell surface folate receptors (FR), folate conjugates have the ability to deliver a variety of molecular complexes to pathologic cells without causing harm to normal tissues. Complexes that have been successfully delivered to FR expressing cells, to date, include protein toxins, immune stimulants, chemotherapeutic agents, liposomes, nanoparticles, and imaging agents. This review will summarize the applications of folic acid as a targeting ligand and highlight the various methods being developed for delivery of therapeutic and imaging agents to FR-expressing cells.
Hilgenbrink, A.R., Low, P.S. (2005). Folate Receptor-Mediated Drug Targeting: From Therapeutics to Diagnostics. Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 94:2135–2146.

Representative Structure

The molecular weight and exact mass are averages based on the polydispersity of PEG.

Hygroscopic
Yes
Light Sensitive
No
Molecular Formula

C287H558N11O127P (average MW due to polydispersity of PEG)

Percent Composition

C 55.36%, H 9.03%, N 2.47%, O 32.63%, P 0.50%

Purity
According to the published synthetic protocol, the product will be 80-85% gamma conjugated and contain 15-20% of the other positional isomer. This does not seem to impact the functionality.
Stability
1 Years
Storage Temperature
-20°C
CAS Number
1236288-25-7
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
6226.545
Exact Mass
6222.728

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PubMed ID: 31817179

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PubMed ID: 3163335

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PubMed ID: 31052347

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PubMed ID: 30710640

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PubMed ID: 16564596

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PubMed ID: 16564654

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PubMed ID: 15756028

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PubMed ID: 15301962

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PubMed ID: 10077479