880120 | 18:0 PEG2000 PE

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)


Chloroform

Size SKU Packaging Price
25mg 880120C-25mg 880120C-25mg 1 x 25mg 10mg/mL 2.5mL $119.00
200mg 880120C-200mg 880120C-200mg 2 x 100mg 25mg/mL 4mL $252.00
500mg 880120C-500mg 880120C-500mg 1 x 500mg 25mg/mL 20mL $525.00

Powder

Size SKU Packaging Price
25mg 880120P-25mg 880120P-25mg 1 x 25mg $119.00
200mg 880120P-200mg 880120P-200mg 1 x 200mg $252.00
500mg 880120P-500mg 880120P-500mg 1 x 500mg $525.00
1g 880120P-1g 880120P-1g 1 x 1g $910.00
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18:0 PEG2000 PE

18:0 PEG2000 PE

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)

PEG-modified lipids are typically added to phospholipid vesicles used for drug delivery to provide a steric coating on the surface of the membrane to hinder clearing of the particles by the reticuloendothelial system (RES). This prolongs the circulating plasma half-life of the drug. The plasma half-life of the drug can be "tuned" from several hours to days depending on the size of the PEG and fatty acids attached to the lipid anchor.

Hygroscopic
Yes
Light Sensitive
No
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
474922-77-5
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
2805.497
Exact Mass
0.000
Synonyms
<p>DSPE-mPEG(2000)</p>

Kulkarni JA, Darjuan MM, Mercer JE, Chen S, van der Meel R, Thewalt JL, Tam YYC, Cullis PR. Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA. ACS Nano. 2018 Apr 6. doi: 10.1021/acsnano.8b01516.

PubMed ID: 29614232

Kakimoto Y, Tachihara Y, Okamoto Y, Miyazawa K, Fukuma T, Tero R. Morphology and Physical Properties of Hydrophilic-Polymer-Modified Lipids in Supported Lipid Bilayers. Langmuir. 2018 Jun 4. doi: 10.1021/acs.langmuir.8b00870. [Epub ahead of print]

PubMed ID: 29788718

Kakimoto Y, Tachihara Y, Okamoto Y, Miyazawa K, Fukuma T, Tero R. Morphology and Physical Properties of Hydrophilic-Polymer-Modified Lipids in Supported Lipid Bilayers. Langmuir. 2018 May 23. doi: 10.1021/acs.langmuir.8b00870. [Epub ahead of print]

PubMed ID: 29788718

Huiqing Lv , Zhongmin Zhang, Xiaoyu Wu , Yaoxia Wang, Chenglin Li, Weihong Gong, Liang Gui , Xin Wang Preclinical Evaluation of Liposomal C8 Ceramide as a Potent anti-Hepatocellular Carcinoma Agent. Plos One: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145195

PubMed ID: 26727592