Products

18:0 PEG2000 PE | 880120

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)

880120P

Powder

880120P-
25 mg
$119.00
880120P-
200 mg
$252.00
880120P-
500 mg
$525.00
880120P-
1 g
$910.00

880120C

Chloroform

880120C-
25 mg
$119.00
880120C-
200 mg
$252.00
880120C-
500 mg
$525.00
880120C-
1 g
$910.00

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PEG-modified lipids are typically added to phospholipid vesicles used for drug delivery to provide a steric coating on the surface of the membrane to hinder clearing of the particles by the reticuloendothelial system (RES). This prolongs the circulating plasma half-life of the drug. The plasma half-life of the drug can be "tuned" from several hours to days depending on the size of the PEG and fatty acids attached to the lipid anchor.
Purity
>99%
Stability
1 Years
Storage
-20°C
CAS Number
474922-77-5
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
2805.497 (average MW due to polydispersity of PEG)
Transition Temp
12.8°C (melting transition in micelles)
Synonyms
DSPE-mPEG(2000)
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Notes
GIF Graphics File. 
GIF Graphics File. 
MDL Molfile. 
CDX File. 
Huiqing Lv ,  Zhongmin Zhang, Xiaoyu Wu , Yaoxia Wang, Chenglin Li, Weihong Gong, Liang Gui , Xin Wang Preclinical Evaluation of Liposomal C8 Ceramide as a Potent anti-Hepatocellular Carcinoma Agent.   [PubMed]Plos One: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145195