880120 | 18:0 PEG2000 PE

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)


Chloroform

Size SKU Packaging Price
25mg 880120C-25mg 880120C-25mg 1 x 25mg 10mg/mL 2.5mL $134.75
200mg 880120C-200mg 880120C-200mg 2 x 100mg 25mg/mL 4mL $284.00
500mg 880120C-500mg 880120C-500mg 1 x 500mg 25mg/mL 20mL $595.00

Powder

Size SKU Packaging Price
25mg 880120P-25mg 880120P-25mg 1 x 25mg $134.75
200mg 880120P-200mg 880120P-200mg 1 x 200mg $284.00
500mg 880120P-500mg 880120P-500mg 1 x 500mg $595.00
1g 880120P-1g 880120P-1g 1 x 1g $1,030.00
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18:0 PEG2000 PE

18:0 PEG2000 PE

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)

Representative Structure

The formula weight and exact mass are averages based on the polydispersity of PEG.

PEG-modified lipids are typically added to phospholipid vesicles used for drug delivery to provide a steric coating on the surface of the membrane to hinder clearing of the particles by the reticuloendothelial system (RES). This prolongs the circulating plasma half-life of the drug. The plasma half-life of the drug can be "tuned" from several hours to days depending on the size of the PEG and fatty acids attached to the lipid anchor.

Hygroscopic
Yes
Light Sensitive
No
Molecular Formula

C133H267N2O55P (average FW due to polydispersity of PEG)

Percent Composition

C 56.94%, H 9.59%, N 1.00%, O 31.36%, P 1.10%

Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
474922-77-5
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
2805.497
Exact Mass
2803.530
Synonyms
DSPE-mPEG(2000)

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PubMed ID: 32501014

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Collins GC, Jing B, Lindsey BD. High contrast power Doppler imaging in side-viewing intravascular ultrasound imaging via angular compounding. Ultrasonics. 2020 Jun 2;108:106200. doi: 10.1016/j.ultras.2020.106200. Epub ahead of print. PMID: 32521337.

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PubMed ID: 32389804

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PubMed ID: 32368056

Molska A, Nyman AKG, Sofias AM, Kristiansen KA, Hak S, Widerøe M. In vitro and in vivo evaluation of organic solvent-free injectable melatonin nanoformulations. Eur J Pharm Biopharm. 2020 Jul;152:248-256. doi: 10.1016/j.ejpb.2020.05.003. Epub 2020 May 18. PMID: 32439308.

PubMed ID: 32439308

Gaál A, Garay TM, Horváth I, Máthé D, Szöllősi D, Veres DS, Mbuotidem J, Kovács T, Tóvári J, Bergmann R, Streli C, Szakács G, Mihály J, Varga Z, Szoboszlai N. Development and In Vivo Application of a Water-Soluble Anticancer Copper Ionophore System Using a Temperature-Sensitive Liposome Formulation. Pharmaceutics. 2020 May 20;12(5):466. doi: 10.3390/pharmaceutics12050466. PMID: 32443790; PMCID: PMC7284829.

PubMed ID: 32443790

Reddy GB, Kerr DL, Spasojevic I, Tovmasyan A, Hsu DS, Brigman BE, Somarelli JA, Needham D, Eward WC. Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) shows efficacy against Osteosarcoma. Mol Cancer Ther. 2020 May 5:molcanther.0689.2019. doi: 10.1158/1535-7163.MCT-19-0689. Epub ahead of print. PMID: 32371588.

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Mozhi A, Sunil V, Zhan W, Ghode PB, Thakor NV, Wang CH. Enhanced penetration of pro-apoptotic and anti-angiogenic micellar nanoprobe in 3D multicellular spheroids for chemophototherapy. J Control Release. 2020 Jul 10;323:502-518. doi: 10.1016/j.jconrel.2020.05.005. Epub 2020 May 5. PMID: 32387550.

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Liao Y, Li B, Zhao Z, Fu Y, Tan Q, Li X, Wang W, Yin J, Shan H, Tang BZ, Huang X. Targeted Theranostics for Tuberculosis: A Rifampicin-Loaded Aggregation-Induced Emission Carrier for Granulomas Tracking and Anti-Infection. ACS Nano. 2020 Jun 15. doi: 10.1021/acsnano.0c00586. Epub ahead of print. PMID: 32401009.

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PubMed ID: 32325827

Wang YQ, Ji MY, Wang C. Endoplasmic reticulum-targeted glutathione and pH dual responsive vitamin lipid nanovesicles for tocopheryl DM1 delivery and cancer therapy. Int J Pharm. 2020 May 30;582:119331. doi: 10.1016/j.ijpharm.2020.119331. Epub 2020 Apr 11. PMID: 32289484.

PubMed ID: 32289484

Lee H, Jiang D, Pardridge WM. Lyoprotectant Optimization for the Freeze-Drying of Receptor-Targeted Trojan Horse Liposomes for Plasmid DNA Delivery. Mol Pharm. 2020 Apr 29. doi: 10.1021/acs.molpharmaceut.0c00310. Epub ahead of print. PMID: 32315188.

PubMed ID: 32315188

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PubMed ID: 32335285

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PubMed ID: 31955018

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PubMed ID: 31894806

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PubMed ID: 31989142

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PubMed ID: 31968248

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PubMed ID: 31899272

Du J, Liu S, Zhang P, Liu H, Li Y, He W, Li C, Chau JHC, Kwok RTK, Lam JWY, Cai L, Huang Y, Zhang W, Hou J, Tang BZ. Highly Stable and Bright NIR-II AIE Dots for Intraoperative Identification of Ureter. ACS Appl Mater Interfaces. 2020 Feb 4:10.1021/acsami.9b22957. doi: 10.1021/acsami.9b22957. Epub ahead of print. PMID: 31970976.

PubMed ID: 31970976

Wan WL, Tian B, Lin YJ, Korupalli C, Lu MY, Cui Q, Wan D, Chang Y, Sung HW. Photosynthesis-inspired H2 generation using a chlorophyll-loaded liposomal nanoplatform to detect and scavenge excess ROS. Nat Commun. 2020 Jan 27;11(1):534. doi: 10.1038/s41467-020-14413-x. PMID: 31988280; PMCID: PMC6985250.

PubMed ID: 31988280

Huang KW, Hsu FF, Qiu JT, Chern GJ, Lee YA, Chang CC, Huang YT, Sung YC, Chiang CC, Huang RL, Lin CC, Dinh TK, Huang HC, Shih YC, Alson D, Lin CY, Lin YC, Chang PC, Lin SY, Chen Y. Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer. Sci Adv. 2020 Jan 15;6(3):eaax5032. doi: 10.1126/sciadv.aax5032. PMID: 31998834; PMCID: PMC6962042.

PubMed ID: 31998834

Odeh F, Naffa R, Azzam H, Mahmoud IS, Alshaer W, Al Bawab A, Ismail S. Co-encapsulation of thymoquinone with docetaxel enhances the encapsulation efficiency into PEGylated liposomes and the chemosensitivity of MCF7 breast cancer cells to docetaxel. Heliyon. 2019 Nov 27;5(11):e02919. doi: 10.1016/j.heliyon.2019.e02919. PMID: 31844767; PMCID: PMC6895652.

PubMed ID: 31844767

Zhong X, Zhang M, Tian Z, Wang Q, Wang Z. The Study of Enhanced High-Intensity Focused Ultrasound Therapy by Sonodynamic N2O Microbubbles. Nanoscale Res Lett. 2019 Dec 16;14(1):381. doi: 10.1186/s11671-019-3219-0. PMID: 31845016; PMCID: PMC6915195.

PubMed ID: 31845016

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Huang Y, Nan L, Xiao C, Ji Q, Li K, Wei Q, Liu Y, Bao G. Optimum Preparation Method for Self-Assembled PEGylation Nano-Adjuvant Based on Rehmannia glutinosa Polysaccharide and Its Immunological Effect on Macrophages. Int J Nanomedicine. 2019 Nov 29;14:9361-9375. doi: 10.2147/IJN.S221398. PMID: 31819437; PMCID: PMC6890198.

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Samaddar S, Mazur J, Boehm D, Thompson DH. Development And In Vitro Characterization Of Bladder Tumor Cell Targeted Lipid-Coated Polyplex For Dual Delivery Of Plasmids And Small Molecules. Int J Nanomedicine. 2019 Dec 4;14:9547-9561. doi: 10.2147/IJN.S225172. PMID: 31824150; PMCID: PMC6900316.

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Lee JY, Shin DH, Kim JS. Anticancer Effect of Metformin in Herceptin-Conjugated Liposome for Breast Cancer. Pharmaceutics. 2019 Dec 20;12(1):E11. doi: 10.3390/pharmaceutics12010011. PMID: 31877620.

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Gusti-Ngurah-Putu EP, Huang L, Hsu YC. Effective Combined Photodynamic Therapy with Lipid Platinum Chloride Nanoparticles Therapies of Oral Squamous Carcinoma Tumor Inhibition. J Clin Med. 2019 Dec 2;8(12):2112. doi: 10.3390/jcm8122112. PMID: 31810241; PMCID: PMC6947167.

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Fisher C, Obaid G, Niu C, Foltz W, Goldstein A, Hasan T, Lilge L. Liposomal Lapatinib in Combination with Low-Dose Photodynamic Therapy for the Treatment of Glioma. J Clin Med. 2019 Dec 14;8(12):2214. doi: 10.3390/jcm8122214. PMID: 31847378; PMCID: PMC6947404.

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Cho C, Jang J, Kang Y, Watanabe H, Uchihashi T, Kim SJ, Kato K, Lee JY, Song JJ. Structural basis of nucleosome assembly by the Abo1 AAA+ ATPase histone chaperone. Nat Commun. 2019 Dec 17;10(1):5764. doi: 10.1038/s41467-019-13743-9.

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Ye L, Hu R, Liu L, Liu J, Liu J, Chen H, Hu Y, Liu Y, Liu X, Liu C, Tng DJH, Meng Y, Qu J, Swihart MT, Yong KT. Comparing Semiconductor Nanocrystal Toxicity in Pregnant Mice and Non-Human Primates. Nanotheranostics. 2019 Jan 1;3(1):54-65. doi: 10.7150/ntno.27452. eCollection 2019.

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Melnikov PA, Valikhov MP, Kuznetsov II, Grinenko NF, Sukhinich KK, Simbirtsev AS, Kekelidze ZI, Chekhonin VP. Analysis of the Effect of IL-1β on Blood-Brain Barrier Permeability in M6 Glioma Mouse Model Using Intravital Microscopy. Bull Exp Biol Med. 2019 Nov 22. doi: 10.1007/s10517-019-04661-3. [Epub ahead of print]

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Wu M, Song Z, Zhang S, Dan Q, Tang C, Peng C, Liang Y, Zhang L, Wang H, Li Y. Local Tumor Ischemia-Reperfusion Mediated By Ultrasound-Targeted Microbubble Destruction Enhances The Anti-Tumor Efficacy Of Doxorubicin Chemotherapy. Cancer Manag Res. 2019 Nov 5;11:9387-9395. doi: 10.2147/CMAR.S225607. eCollection 2019.

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Cullion K, Petishnok LC, Ji T, Zurakowski D, Kohane DS. The Duration of Nerve Block from Local Anesthetic Formulations in Male and Female Rats. Pharm Res. 2019 Nov 8;36(12):179. doi: 10.1007/s11095-019-2715-3.

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Gallez A, Palazzo C, Blacher S, Tskitishvili E, Noël A, Foidart JM, Evrard B, Pequeux C, Piel G. Liposomes and drug-in-cyclodextrin-in-liposomes formulations encapsulating 17β-estradiol: An innovative drug delivery system that prevents the activation of the membrane-initiated steroid signaling (MISS) of estrogen receptor α. Int J Pharm. 2020 Jan 5;573:118861. doi: 10.1016/j.ijpharm.2019.118861. Epub 2019 Nov 22.

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Peng PC, Hong RL, Tsai T, Chen CT. Co-Encapsulation of Chlorin e6 and Chemotherapeutic Drugs in a PEGylated Liposome Enhance the Efficacy of Tumor Treatment: Pharmacokinetics and Therapeutic Efficacy. Pharmaceutics. 2019 Nov 17;11(11). pii: E617. doi: 10.3390/pharmaceutics11110617.

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Kulkarni JA, Witzigmann D, Leung J, Tam YYC, Cullis PR. On the role of helper lipids in lipid nanoparticle formulations of siRNA. Nanoscale. 2019 Nov 21;11(45):21733-21739. doi: 10.1039/c9nr09347h.

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Beguin E, Gray MD, Logan KA, Nesbitt H, Sheng Y, Kamila S, Barnsley LC, Bau L, McHale AP, Callan JF, Stride E. Magnetic microbubble mediated chemo-sonodynamic therapy using a combined magnetic-acoustic device. J Control Release. 2019 Nov 13;317:23-33. doi: 10.1016/j.jconrel.2019.11.013. [Epub ahead of print]

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Veiga N, Goldsmith M, Diesendruck Y, Ramishetti S, Rosenblum D, Elinav E, Behlke MA, Benhar I, Peer D. Leukocyte-specific siRNA delivery revealing IRF8 as a potential anti-inflammatory target. J Control Release. 2019 Oct 18;313:33-41. doi: 10.1016/j.jconrel.2019.10.001. [Epub ahead of print]

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Zheng Z, Ji H, Zong W, Ran Q, Wang X, Yang X, Zhao Z, Yang C, Xiao Y. Construction and characterization of immunoliposomes targeting fibroblast growth factor receptor 3. AMB Express. 2019 Sep 18;9(1):150. doi: 10.1186/s13568-019-0875-5.

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Chung CHY, Cui B, Song R, Liu X, Xu X, Yao S. Scalable Production of Monodisperse Functional Microspheres by Multilayer Parallelization of High Aspect Ratio Microfluidic Channels. Micromachines (Basel). 2019 Sep 10;10(9). pii: E592. doi: 10.3390/mi10090592.

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Guidi F, Supponen O, Upadhyay A, Vos HJ, Borden MA, Tortoli P. Microbubble radiation force-induced translation in plane-wave versus focused transmission modes. IEEE Trans Ultrason Ferroelectr Freq Control. 2019 Aug 23. doi: 10.1109/TUFFC.2019.2937158. [Epub ahead of print]

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Zhang X, Lin C, Chan W, Liu K, Lu A, Lin G, Hu R, Shi H, Zhang H, Yang Z. Dual-Functional Liposomes with Carbonic Anhydrase IX Antibody and BR2 Peptide Modification Effectively Improve Intracellular Delivery of Cantharidin to Treat Orthotopic Hepatocellular Carcinoma Mice. Molecules. 2019 Sep 12;24(18). pii: E3332. doi: 10.3390/molecules24183332.

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Shang H, Wu B, Liang X, Sun Y, Han X, Zhang L, Wang Q, Cheng W. Evaluation of therapeutic effect of targeting nanobubbles conjugated with NET-1 siRNA by shear wave elastography: an in vivo study of hepatocellular carcinoma bearing mice model. Drug Deliv. 2019 Dec;26(1):944-951. doi: 10.1080/10717544.2019.1667450.

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Abdurakman E, Bencsik M, Cave GWV, Hoad CL, McGowan S, Fairhurst DJ, Major G, Gowland PA, Bowtell R. Design and testing of microbubble-based MRI contrast agents for gastric pressure measurement. Magn Reson Med. 2019 Sep 16. doi: 10.1002/mrm.27992. [Epub ahead of print]

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Liu Y, Chen S, Sun J, Zhu S, Chen C, Xie W, Zheng J, Zhu Y, Xiao L, Hao L, Wang Z, Chang S. Folate-Targeted and Oxygen/Indocyanine Green-Loaded Lipid Nanoparticles for Dual-Mode Imaging and Photo-sonodynamic/Photothermal Therapy of Ovarian Cancer in Vitro and in Vivo. Mol Pharm. 2019 Oct 7;16(10):4104-4120. doi: 10.1021/acs.molpharmaceut.9b00339. Epub 2019 Sep 13.

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Kozlovskaya V, Liu F, Yang Y, Ingle K, Qian S, Halade GV, Urban VS, Kharlampieva E. Temperature-Responsive Polymersomes of Poly(3-methyl-N-vinylcaprolactam)-block-poly(N-vinylpyrrolidone) To Decrease Doxorubicin-Induced Cardiotoxicity. Biomacromolecules. 2019 Oct 14;20(10):3989-4000. doi: 10.1021/acs.biomac.9b01026. Epub 2019 Sep 24.

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Choi B, Soh M, Manandhar Y, Kim D, Han SI, Baik S, Shin K, Koo S, Kwon HJ, Ko G, Oh J, Hwang H, Hyeon T, Lee SJ. Highly selective microglial uptake of ceria-zirconia nanoparticles for enhanced analgesic treatment of neuropathic pain. Nanoscale. 2019 Sep 2. doi: 10.1039/c9nr02648g. [Epub ahead of print]

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Zhang D, Baldwin P, Leal AS, Carapellucci S, Sridhar S, Liby KT. A nano-liposome formulation of the PARP inhibitor Talazoparib enhances treatment efficacy and modulates immune cell populations in mammary tumors of BRCA-deficient mice. Theranostics. 2019 Aug 14;9(21):6224-6238. doi: 10.7150/thno.36281. eCollection 2019.

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Guevara ML, Jilesen Z, Stojdl D, Persano S. Codelivery of mRNA with α-Galactosylceramide Using a New Lipopolyplex Formulation Induces a Strong Antitumor Response upon Intravenous Administration. ACS Omega. 2019 Aug 7;4(8):13015-13026. doi: 10.1021/acsomega.9b00489. eCollection 2019 Aug 20.

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DeBoer MD. Assessing and Managing the Metabolic Syndrome in Children and Adolescents. Nutrients. 2019 Aug 2;11(8). pii: E1788. doi: 10.3390/nu11081788.

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Wang Z, Zhao K, Zhang Y, Duan X, Zhao Y. Anti-GPC3 Antibody Tagged Cationic Switchable Lipid-Based Nanoparticles for the Co-Delivery of Anti-miRNA27a And Sorafenib in Liver Cancers. Pharm Res. 2019 Aug 8;36(10):145. doi: 10.1007/s11095-019-2669-5.

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Fabio Vischio, Elisabetta Fanizza, Vito De Bellis, Teresa Sibillano, Chiara Ingrosso, Cinzia Giannini, Valentino Laquintana, Nunzio Denora, Angela Agostiano, Marinella Striccoli, M. Lucia Curri, and Nicoletta Depalo. Near-Infrared Absorbing Solid Lipid Nanoparticles Encapsulating Plasmonic Copper Sulfide Nanocrystals. J. Phys. Chem. C 2019, 123, 23205−23213


Zhou Q, Wang K, Dou J, Cao F, Liu F, Yuan H, Mu M, Xu J, Zhang D, Li X, Tian J, Yu J, Liang P. Theranostic liposomes as nanodelivered chemotherapeutics enhanced the microwave ablation of hepatocellular carcinoma. Nanomedicine (Lond). 2019 Aug;14(16):2151-2167. doi: 10.2217/nnm-2018-0424. Epub 2019 Aug 14.

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Ahmed G, Mackenzie GG, Egan J, Amiji MM. DHA-SBT-1214 Taxoid Nanoemulsion and Anti-PD-L1 Antibody Combination Therapy Enhances Anti-Tumor Efficacy in a Syngeneic Pancreatic Adenocarcinoma Model. Mol Cancer Ther. 2019 Aug 22. pii: molcanther.1046.2018. doi: 10.1158/1535-7163.MCT-18-1046. [Epub ahead of print]

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Shi D, Mi G, Shen Y, Webster TJ. Glioma-targeted dual functionalized thermosensitive Ferri-liposomes for drug delivery through an in vitro blood-brain barrier. Nanoscale. 2019 Aug 15;11(32):15057-15071. doi: 10.1039/c9nr03931g.

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Melo M, Porter E, Zhang Y, Silva M, Li N, Dobosh B, Liguori A, Skog P, Landais E, Menis S, Sok D, Nemazee D, Schief WR, Weiss R, Irvine DJ. Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles. Mol Ther. 2019 Aug 19. pii: S1525-0016(19)30367-3. doi: 10.1016/j.ymthe.2019.08.007. [Epub ahead of print]

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Da Silva CG, Camps MGM, Li TMWY, Chan AB, Ossendorp F, Cruz LJ. Co-delivery of immunomodulators in biodegradable nanoparticles improves therapeutic efficacy of cancer vaccines. Biomaterials. 2019 Nov;220:119417. doi: 10.1016/j.biomaterials.2019.119417. Epub 2019 Aug 7.

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Binderup T, Duivenvoorden R, Fay F, van Leent MMT, Malkus J, Baxter S, Ishino S, Zhao Y, Sanchez-Gaytan B, Teunissen AJP, Frederico YCA, Tang J, Carlucci G, Lyashchenko S, Calcagno C, Karakatsanis N, Soultanidis G, Senders ML, Robson PM, Mani V, Ramachandran S, Lobatto ME, Hutten BA, Granada JF, Reiner T, Swirski FK, Nahrendorf M, Kjaer A, Fisher EA, Fayad ZA, Pérez-Medina C, Mulder WJM. Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species. Sci Transl Med. 2019 Aug 21;11(506). pii: eaaw7736. doi: 10.1126/scitranslmed.aaw7736.

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Ibaraki H, Kanazawa T, Kurano T, Oogi C, Takashima Y, Seta Y. Anti-RelA siRNA-Encapsulated Flexible Liposome with Tight Junction-Opening Peptide as a Non-invasive Topical Therapeutic for Atopic Dermatitis. Biol Pharm Bull. 2019;42(7):1216-1225. doi: 10.1248/bpb.b19-00259.

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