870819 | N-oleoylglycine

N-oleoylglycine


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N-oleoylglycine

N-oleoylglycine

N-oleoylglycine

N-oleoylglycine is thought to be a substrate for the peptide amidating enzyme, peptidylglycine alpha amidating monooxygenase (PAM), in the biosynthesis of oleoylamide.1 Recent evidence indicates that oleoylglycine possesses biologic activity independent of its conversion to oleamide. Also, increased availability of oleoylglycine as a potential substrate for PAM does not drive the biosynthesis of oleamide.2
1 Merkler, D.J., Merkler, K.A., Stern, W., Fleming, F.F. (1996) Fatty acid amide biosynthesis: a possible new role for peptidylglycine alpha-amidating enzyme and acyl-coenzyme A: glycine N-acyltransferase. Arch Biochem Biophys. 330:430-4.
2 Chaturvedi, S., Driscoll, W.J., Elliot, B.M., Faraday, M.M., Grunberg, N.E., Mueller, G.P. (2006) In vivo evidence that N-oleoylglycine acts independently of its conversion to oleamide. Prostaglandins Other Lipid Mediat. 81:136-49.
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C20H37NO3
Percent Composition
C 70.75%, H 10.98%, N 4.13%, O 14.14%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
2601-90-3
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
339.513
Exact Mass
339.277
Bradshaw, H.B., Rimmerman, N., Hu, S.S., Burstein, S., Walker, J.M. (2009) Novel endogenous N-acyl glycines identification and characterization. Vitam Horm. 81:191-205. [PubMed] Chaturvedi, S., Driscoll, W.J., Elliot, B.M., Faraday, M.M., Grunberg, N.E., Mueller, G.P. (2006) In vivo evidence that N-oleoylglycine acts independently of its conversion to oleamide. Prostaglandins Other Lipid Mediat.81:136-49. [PubMed] Merkler, D.J., Merkler, K.A., Stern, W., Fleming, F.F. (1996) Fatty acid amide biosynthesis: a possible new role for peptidylglycine alpha-amidating enzyme and acyl-coenzyme A: glycine N-acyltransferase. Arch Biochem Biophys. 330:430-4. [PubMed]