870792 | D-threo-PPMP

1R,2R-(+)-1-phenyl-2-palmitoylamino-3-N-morpholine-1-propanol


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D-threo-PPMP

D-threo-PPMP

1R,2R-(+)-1-phenyl-2-palmitoylamino-3-N-morpholine-1-propanol

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C29H50N2O3
Percent Composition
C 73.37%, H 10.62%, N 5.90%, O 10.11%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
139889-53-5
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
474.719
Exact Mass
474.382
Synonyms
<p>PPMP</p>
Atilla-Gokcumen, G.E., Bedigian, A.V., Sasse, S., Eggert, U.S. (2011) Inhibition of Glycosphingolipid Biosynthesis Induces Cytokinesis Failure. J Am Chem Soc. Jun 14. [PubMed] Wu, X., Kim, Y., Sun, B.C., Moore, J.D., Shaw, W.A., Maurer, B.J. (2006) Liquid chromatography method for quantifying D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (D-threo-PPMP) in mouse plasma and liver. J Chromatogr B Analyt Technol Biomed Life Sci. 837(1-2):44-8. [PubMed] Gouazé, V., Liu, Y.Y., Prickett, C.S., Yu, J.Y., Giuliano, A.E., Cabot, M.C. (2005) Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. Cancer Res. 65(9):3861-7. [PubMed] O'Donnell, P.H., Guo, W.X., Reynolds, C.P., Maurer, B.J. (2002) N-(4-hydroxyphenyl)retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes. Leukemia. 16(5):902-10. [PubMed] Maurer, B.J., Melton, L., Billups, C., Cabot, M.C., Reynolds, C.P. (2000) Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism. J Natl Cancer Inst. 92(23):1897-909. [PubMed] de Chaves, E.I., Bussière, M., Vance, D.E., Campenot, R.B., Vance, J.E. (1997) Elevation of ceramide within distal neurites inhibits neurite growth in cultured rat sympathetic neurons. J Biol Chem. 272(5):3028-35. [PubMed]