870792 | D-threo-PPMP

1R,2R-(+)-1-phenyl-2-palmitoylamino-3-N-morpholine-1-propanol

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D-threo-PPMP

D-threo-PPMP

1R,2R-(+)-1-phenyl-2-palmitoylamino-3-N-morpholine-1-propanol

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C29H50N2O3
Percent Composition
C 73.37%, H 10.62%, N 5.90%, O 10.11%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
139889-53-5
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
474.719
Exact Mass
474.382
Synonyms
PPMP

Atilla-Gokcumen GE, Bedigian AV, Sasse S, Eggert US. Inhibition of glycosphingolipid biosynthesis induces cytokinesis failure. J Am Chem Soc. 2011 Jul 6;133(26):10010-3. doi: 10.1021/ja202804b. Epub 2011 Jun 14. PMID: 21668028; PMCID: PMC3131740.

 PubMed ID: 21668028

Wu X, Kim Y, Sun BC, Moore JD, Shaw WA, Maurer BJ. Liquid chromatography method for quantifying D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (D-threo-PPMP) in mouse plasma and liver. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jun 6;837(1-2):44-8. doi: 10.1016/j.jchromb.2006.03.060. Epub 2006 May 22. PMID: 16716770.

 PubMed ID: 16716770

Gouazé V, Liu YY, Prickett CS, Yu JY, Giuliano AE, Cabot MC. Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. Cancer Res. 2005 May 1;65(9):3861-7. doi: 10.1158/0008-5472.CAN-04-2329. PMID: 15867385.

 PubMed ID: 15867385

O'Donnell PH, Guo WX, Reynolds CP, Maurer BJ. N-(4-hydroxyphenyl)retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes. Leukemia. 2002 May;16(5):902-10. doi: 10.1038/sj.leu.2402485. PMID: 11986953.

 PubMed ID: 11986953

Maurer BJ, Melton L, Billups C, Cabot MC, Reynolds CP. Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism. J Natl Cancer Inst. 2000 Dec 6;92(23):1897-909. doi: 10.1093/jnci/92.23.1897. PMID: 11106681.

 PubMed ID: 11106681

de Chaves EI, Bussière M, Vance DE, Campenot RB, Vance JE. Elevation of ceramide within distal neurites inhibits neurite growth in cultured rat sympathetic neurons. J Biol Chem. 1997 Jan 31;272(5):3028-35. doi: 10.1074/jbc.272.5.3028. PMID: 9006952.

 PubMed ID: 9006952