870621 | 18:0-PhoDAG

1-stearoyl-2-[(E)-4-(4-((4-butylphenyl)diazenyl)phenyl)butanoyl]-sn-glycerol


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25mg 870621P-25mg 870621P-25mg 1 x 25mg $1,689.50
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18:0-PhoDAG

18:0-PhoDAG

1-stearoyl-2-[(E)-4-(4-((4-butylphenyl)diazenyl)phenyl)butanoyl]-sn-glycerol

Diacylglycerols (DAG) play a key role in transient receptor potential (TRP) channels. TRP channels are linked to a wide variety of biological processes including the body's ability to sense and process pain, temperature, tastes, pressure, and vision.  18:0 PhoDAG is embedded with a photoswitchable azobenzene moiety that allows rapid photoactivation of these DAG-sensitive TRP channels. The photoswitchable DAG allows for the further exploration of the physiological relevance of these TRP channels in the body’s homeostasis process.

Leinders-Zufall, T., Storch, U., Bleymehl, K.; et. al. PhoDAGs Enable Optical Control of Diacylglycerol-Sensitive Transient Receptor Potential Channels. Cell Chem. Bio. 2020 Dec 21; 2(25): 215-223. https://doi.org/10.1016/j.chem...

Hygroscopic
No
Light Sensitive
Yes
Molecular Formula

C41H64N2O5

Percent Composition

C 74.06% H 9.70% N 4.21% O 12.03% 

Purity
>99%
Stability
One Year
Storage Temperature
-20°C
CAS Number
1985595-31-0
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
664.970
Exact Mass
664.480

Zhang X, Barraza KM, Upton KT, Beauchamp JL. Subtle Changes in Lipid Environment Have Profound Effects on Membrane Oxidation Chemistry. J Am Chem Soc. 2018 Nov 21. doi: 10.1021/jacs.8b08610. [Epub ahead of print]

PubMed ID: 30461271