870606 | POVPC

1-palmitoyl-2-(5'-oxo-valeroyl)-sn-glycero-3-phosphocholine


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POVPC

POVPC

1-palmitoyl-2-(5'-oxo-valeroyl)-sn-glycero-3-phosphocholine

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C29H56NO9P
Percent Composition
C 58.67%, H 9.51%, N 2.36%, O 24.25%, P 5.22%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
121324-31-0
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
593.730
Exact Mass
593.369
Synonyms
<p>POVPC</p>

Thiagarajan D, Fiskesund R, Frostegård A, Steen J, Rahman M, Vikström M, Lundström S, Frostegård J. Immunoglobulin G1 Antibodies Against Phosphorylcholine Are Associated With Protection in Systemic Lupus Erythematosus and Atherosclerosis: Potential Underlying Mechanisms. ACR Open Rheumatol. 2020 Jun;2(6):344-356. doi: 10.1002/acr2.11127. Epub 2020 May 11. PMID: 32392632; PMCID: PMC7301871.

PubMed ID: 32392632

Dong Y, Arif AA, Guo J, Ha Z, Lee-Sayer SSM, Poon GFT, Dosanjh M, Roskelley CD, Huan T, Johnson P. CD44 Loss Disrupts Lung Lipid Surfactant Homeostasis and Exacerbates Oxidized Lipid-Induced Lung Inflammation. Front Immunol. 2020 Jan 30;11:29. doi: 10.3389/fimmu.2020.00029. PMID: 32082314; PMCID: PMC7002364.

PubMed ID: 32082314

Di Gioia M, Spreafico R, Springstead JR, Mendelson MM, Joehanes R, Levy D, Zanoni I.Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation. Nat Immunol. 2020 Jan;21(1):42-53. doi: 10.1038/s41590-019-0539-2. Epub 2019 Nov 25.

PubMed ID: 31768073

Ouchi Y, Unoura K, Nabika H. Role of Oxidized Lipids in Permeation of H2O2 Through a Lipid Membrane: Molecular Mechanism of an Inhibitor to Promoter Switch. Sci Rep. 2019 Aug 29;9(1):12497. doi: 10.1038/s41598-019-48954-z.

PubMed ID: 31467337

Ye Y, Wu T, Zhang T, Han J, Habazi D, Saxena R, Mohan C. Elevated oxidized lipids, anti-lipid autoantibodies and oxidized lipid immune complexes in active SLE. Clin Immunol. 2019 May 7;205:43-48. doi: 10.1016/j.clim.2019.05.004. [Epub ahead of print]

PubMed ID: 31075396

Karki P, Meliton A, Shah A, Tian Y, Ohmura T, Sarich N, Birukova AA, Birukov KG. Role of truncated oxidized phospholipids in acute endothelial barrier dysfunction caused by particulate matter. PLoS One. 2018 Nov 12;13(11):e0206251. doi: 10.1371/journal.pone.0206251. eCollection 2018.

PubMed ID: 30419037

Beranova, L., Cwiklik, L., Jurkiewicz, P., Hof, M., Jungwirth, P. (2010) Oxidation changes physical properties of phospholipid bilayers: fluorescence spectroscopy and molecular simulations. Langmuir 26:6140-4.


Turner, W.W., K. Hartvigsen, A. Boullier, E.N. Montano, J.L. Witztum, and M.S. VanNieuwenhze. (2012). Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors. J Med Chem 55:8178-82.

PubMed ID: 22934615

Moumtzi, A., M. Trenker, K. Flicker, E. Zenzmaier, R. Saf, and A. Hermetter. (2007). Import and fate of fluorescent analogs of oxidized phospholipids in vascular smooth muscle cells. J Lipid Res 48:565-82.

PubMed ID: 17135656

Ke Y, Karki P, Kim J, Son S, Berdyshev E, Bochkov VN, Birukova AA, Birukov KG. Elevated truncated oxidized phospholipids as a factor exacerbating ALI in the aging lungs. FASEB J. 2018 Dec 6:fj201800981R. doi: 10.1096/fj.201800981R. [Epub ahead of print].

PubMed ID: 30521374