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KRN7000 | 867000

α-Galactosyl Ceramide



1 mg

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KRN7000 is a synthetic analog of α-galactosylceramide and the marine natural product agelasphin. It is a specific ligand for human and mouse NKT cells and remains the best studied ligand of the lipid-binding MHC class I-like protein CD1d. KRN7000 protects against LPS-induced shock and displays potent antitumor activity in various in vivo models.
Molecular Formula
Percent Composition
C 69.97%, H 11.63%, N 1.63%, O 16.78
1 Years
CAS Number
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
Exact Mass
GIF Graphics File. 
GIF Graphics File. 
MDL Molfile. 
CDX File. 
Fuji, N., Y. Ueda, H. Fujiwara, T. Toh, T. Yoshimura, and H. Yamagishi. (2000). Antitumor effect of alpha-galactosylceramide (KRN7000) on spontaneous hepatic metastases requires endogenous interleukin 12 in the liver.Clin Cancer Res 6:3380-7. [PubMed]
Formulation for dissolving KRN7000:
Using pyrogen-free water, a solution is made of sucrose (57 mg/mL), L-histidine (7.5 mg/mL), and Tween 20 (5 mg/mL). The pH is adjusted to 7.2. KRN7000 is dissolved in a 10:1 (vol:vol) mixture of THF and methanol at a concentration of 1 mg/mL.  The KRN7000 solution is added dropwise to the aqueous solution with constant stirring (20 µL KRN7000 solution per mL of aqueous solution).  The resulting mixture is sonicated in a bath sonicator for 10 min and filter-sterilized.