867000 | KRN7000

α-Galactosyl Ceramide


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1mg 867000P-1mg 867000P-1mg 1 x 1mg $225.00
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KRN7000

KRN7000

α-Galactosyl Ceramide

KRN7000 is a synthetic analog of α-galactosylceramide and the marine natural product agelasphin. It is a specific ligand for human and mouse NKT cells and remains the best studied ligand of the lipid-binding MHC class I-like protein CD1d. KRN7000 protects against LPS-induced shock and displays potent antitumor activity in various in vivo models.
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C50H99NO9
Percent Composition
C 69.97%, H 11.63%, N 1.63%, O 16.78
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
158021-47-7
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
858.322
Exact Mass
857.732
Synonyms
<p>αGalCer (2S,3S,4R)-1-O-(D-galactosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol</p>
Fuji, N., Y. Ueda, H. Fujiwara, T. Toh, T. Yoshimura, and H. Yamagishi. (2000). Antitumor effect of alpha-galactosylceramide (KRN7000) on spontaneous hepatic metastases requires endogenous interleukin 12 in the liver.Clin Cancer Res 6:3380-7. [PubMed]
Formulation for dissolving KRN7000:
Using pyrogen-free water, a solution is made of sucrose (57 mg/mL), L-histidine (7.5 mg/mL), and Tween 20 (5 mg/mL). The pH is adjusted to 7.2. KRN7000 is dissolved in a 10:1 (vol:vol) mixture of THF and methanol at a concentration of 1 mg/mL. The KRN7000 solution is added dropwise to the aqueous solution with constant stirring (20 µL KRN7000 solution per mL of aqueous solution). The resulting mixture is sonicated in a bath sonicator for 10 min and filter-sterilized.