860823 | 24:0(2R-OH) Ceramide

N-(2'-(R)-hydroxylignoceroyl)-D-erythro-sphingosine


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24:0(2R-OH) Ceramide

24:0(2R-OH) Ceramide

N-(2'-(R)-hydroxylignoceroyl)-D-erythro-sphingosine

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C42H83NO4
Percent Composition
C 75.73%, H 12.56%, N 2.10%, O 9.61%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
64655-47-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
666.113
Exact Mass
665.632
Synonyms
110983

Peñalva DA, Oresti GM, Dupuy F, Antollini SS, Maggio B, Aveldaño MI, Fanani ML. Atypical surface behavior of ceramides with nonhydroxy and 2-hydroxy very long-chain (C28-C32) PUFAs. Biochim Biophys Acta. 2014 Mar;1838(3):731-8. doi: 10.1016/j.bbamem.2013.11.018. Epub 2013 Dec 5.

PubMed ID: 24315999

Szulc, Z. M., A. Bai, J. Bielawski, N. Mayroo, D. E. Miller, H. Gracz, Y. A. Hannun, and A. Bielawska. Synthesis, NMR Characterization and Divergent Biological Actions of 2'-Hydroxy-Ceramide/Dihydroceramide Stereoisomers in MCF7 Cells. Bioorg Med Chem 18, no. 21 (2010): 7565-79.

PubMed ID: 20851613

Hama, H. (2010) Fatty acid 2-Hydroxylation in mammalian sphingolipid biology. Biochim Biophys Acta. 1801:405-14.

PubMed ID: 20026285

Alderson, N.L., Hama, H. (2009) Fatty acid 2-hydroxylase regulates cAMP-induced cell cycle exit in D6P2T schwannoma cells. J Lipid Res. 50:1203-8

PubMed ID: 19171550

Herrero, A.B., Astudillo, A.M., Balboa, M.A., Cuevas, C., Balsinde, J., Moreno, S. (2008) Levels of SCS7/FA2H-mediated fatty acid 2-hydroxylation determine the sensitivity of cells to antitumor PM02734. Cancer Res. 68:9779-87.

PubMed ID: 19047157

Andrej Kováčik, Michaela Šilarová, Petra Pullmannová, Jaroslav Maixner, and Kateřina Vávrová. Effects of 6-Hydroxyceramides on the Thermotropic Phase Behavior and Permeability of Model Skin Lipid Membranes. Langmuir, Article ASAP

PubMed ID: 28230380