860679 | C24:1 Ceramide-d7 (d18:1-d7/24:1(15Z))

N-nervonoyl-D-erythro-sphingosine (d7)

C24:1 Ceramide-d7 (d18:1-d7/24:1(15Z))

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1mg 860679P-1mg 860679P-1mg 1 x 1mg $870.31
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DCM:Methanol (1:1)

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1mg 860679L-1mg 860679L-1mg 1 x 1mg $1,050.55 1050.55
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Info

C24:1 Ceramide-d7 (d18:1-d7/24:1(15Z))

N-nervonoyl-D-erythro-sphingosine (d7)

Monitoring the levels of the ceramides (Cer) d18:1/16:0, Cer d18:1/18:0, Cer d18:1/24:0, and Cer d18:1/24:1 and ratios thereof in human plasma empowers the prediction of fatal outcome of coronary artery disease. Avanti has now made available these 4 ceramides in a stable isotope form as a convenience for a newly described validated liquid chromatography-tandem mass spectrometry methodology for their clinical-scaled measurement.
Refer: D. Kauhanen et al. (2016). Development and validation of a high-throughput LC-MS/MS assay for routine measurement of molecular ceramides. Anal Bioanal Chem 408:3475-83
Avanti Numbers 860676, 760677, 860678 and 860679 refer.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C42H74D7NO3
Percent Composition
C 77.00%, H 13.54%, N 2.14%, O 7.33%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
1840942-16-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
655.14
Exact Mass
654.67
References

Zhang T, Trauger SA, Vidoudez C, Doane KP, Pluimer BR, Peterson RT. Parallel Reaction Monitoring reveals structure-specific ceramide alterations in the zebrafish. Sci Rep. 2019 Dec 27;9(1):19939. doi: 10.1038/s41598-019-56466-z. PMID: 31882772; PMCID: PMC6934720.

PubMed ID: 3182772

Razak Hady H, Błachnio-Zabielska AU, Szczerbiński Ł, Zabielski P, Imierska M, Dadan J, Krętowski AJ. Ceramide Content in Liver Increases Along with Insulin Resistance in Obese Patients. J Clin Med. 2019 Dec 12;8(12):2197. doi: 10.3390/jcm8122197. PMID: 31842461; PMCID: PMC6947381.

PubMed ID: 31842461

Nejatian N, Trautmann S, Thomas D, Pfeilschifter J, Badenhoop K, Koch A, Penna-Martinez M. Vitamin D effects on sphingosine 1-phosphate signaling and metabolism in monocytes from type 2 diabetes patients and controls. J Steroid Biochem Mol Biol. 2019 Feb;186:130-135. doi: 10.1016/j.jsbmb.2018.10.005. Epub 2018 Oct 15.

PubMed ID: 30336275

Kauhanen D, Sysi-Aho M, Koistinen KM, Laaksonen R, Sinisalo J, Ekroos K. Development and validation of a high-throughput LC-MS/MS assay for routine measurement of molecular ceramides. Anal Bioanal Chem. 2016 May;408(13):3475-83. doi: 10.1007/s00216-016-9425-z. Epub 2016 Feb 27.

PubMed ID: 26922344
Certificates of Analysis

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