860679 | C24:1 Ceramide-d7 (d18:1-d7/24:1(15Z))

N-nervonoyl-D-erythro-sphingosine (d7)


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1mg 860679P-1mg 860679P-1mg 1 x 1mg $632.84

DCM:Methanol (1:1)

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1mg 860679L-1mg 860679L-1mg 1 x 1mg $750.00
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C24:1 Ceramide-d7 (d18:1-d7/24:1(15Z))

C24:1 Ceramide-d7 (d18:1-d7/24:1(15Z))

N-nervonoyl-D-erythro-sphingosine (d7)

Monitoring the levels of the ceramides (Cer) d18:1/16:0, Cer d18:1/18:0, Cer d18:1/24:0, and Cer d18:1/24:1 and ratios thereof in human plasma empowers the prediction of fatal outcome of coronary artery disease. Avanti has now made available these 4 ceramides in a stable isotope form as a convenience for a newly described validated liquid chromatography-tandem mass spectrometry methodology for their clinical-scaled measurement.
Refer: D. Kauhanen et al. (2016). Development and validation of a high-throughput LC-MS/MS assay for routine measurement of molecular ceramides. Anal Bioanal Chem 408:3475-83
Avanti Numbers 860676, 760677, 860678 and 860679 refer.

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C42H74D7NO3
Percent Composition
C 77.00%, H 13.54%, N 2.14%, O 7.33%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
1840942-16-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
655.140
Exact Mass
654.670

Zhang T, Trauger SA, Vidoudez C, Doane KP, Pluimer BR, Peterson RT. Parallel Reaction Monitoring reveals structure-specific ceramide alterations in the zebrafish. Sci Rep. 2019 Dec 27;9(1):19939. doi: 10.1038/s41598-019-56466-z. PMID: 31882772; PMCID: PMC6934720.

PubMed ID: 3182772

Razak Hady H, Błachnio-Zabielska AU, Szczerbiński Ł, Zabielski P, Imierska M, Dadan J, Krętowski AJ. Ceramide Content in Liver Increases Along with Insulin Resistance in Obese Patients. J Clin Med. 2019 Dec 12;8(12):2197. doi: 10.3390/jcm8122197. PMID: 31842461; PMCID: PMC6947381.

PubMed ID: 31842461

Nejatian N, Trautmann S, Thomas D, Pfeilschifter J, Badenhoop K, Koch A, Penna-Martinez M. Vitamin D effects on sphingosine 1-phosphate signaling and metabolism in monocytes from type 2 diabetes patients and controls. J Steroid Biochem Mol Biol. 2019 Feb;186:130-135. doi: 10.1016/j.jsbmb.2018.10.005. Epub 2018 Oct 15.

PubMed ID: 30336275

Kauhanen D, Sysi-Aho M, Koistinen KM, Laaksonen R, Sinisalo J, Ekroos K. Development and validation of a high-throughput LC-MS/MS assay for routine measurement of molecular ceramides. Anal Bioanal Chem. 2016 May;408(13):3475-83. doi: 10.1007/s00216-016-9425-z. Epub 2016 Feb 27.

PubMed ID: 26922344