860677 | C18 Ceramide-d7 (d18:1-d7/18:0)

N-stearoyl-D-erythro-sphingosine (d7)


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C18 Ceramide-d7 (d18:1-d7/18:0)

C18 Ceramide-d7 (d18:1-d7/18:0)

N-stearoyl-D-erythro-sphingosine (d7)

Monitoring the levels of the ceramides (Cer) d18:1/16:0, Cer d18:1/18:0, Cer d18:1/24:0, and Cer d18:1/24:1 and ratios thereof in human plasma empowers the prediction of fatal outcome of coronary artery disease. Avanti has now made available these 4 ceramides in a stable isotope form as a convenience for a newly described validated liquid chromatography-tandem mass spectrometry methodology for their clinical-scaled measurement.
Refer: D. Kauhanen et al. (2016). Development and validation of a high-throughput LC-MS/MS assay for routine measurement of molecular ceramides. Anal Bioanal Chem 408:3475-83
Avanti Numbers 860676, 760677, 860678 and 860679 refer.

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C36H64D7NO3
Percent Composition
C 75.46%, H 13.72%, N 2.44%, O 8.38%
Purity
>99%
Stability
1 year
Storage Temperature
-20°C
CAS Number
1840942-14-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
572.997
Exact Mass
572.587

Zhang T, Trauger SA, Vidoudez C, Doane KP, Pluimer BR, Peterson RT. Parallel Reaction Monitoring reveals structure-specific ceramide alterations in the zebrafish. Sci Rep. 2019 Dec 27;9(1):19939. doi: 10.1038/s41598-019-56466-z. PMID: 31882772; PMCID: PMC6934720.

PubMed ID: 31882772

Zalewska A, Maciejczyk M, Szulimowska J, Imierska M, Błachnio-Zabielska A. High-Fat Diet Affects Ceramide Content, Disturbs Mitochondrial Redox Balance, and Induces Apoptosis in the Submandibular Glands of Mice. Biomolecules. 2019 Dec 15;9(12):E877. doi: 10.3390/biom9120877. PMID: 31847462.

PubMed ID: 31847462

Razak Hady H, Błachnio-Zabielska AU, Szczerbiński Ł, Zabielski P, Imierska M, Dadan J, Krętowski AJ. Ceramide Content in Liver Increases Along with Insulin Resistance in Obese Patients. J Clin Med. 2019 Dec 12;8(12):2197. doi: 10.3390/jcm8122197. PMID: 31842461; PMCID: PMC6947381.

PubMed ID: 31842461

Tobias F, Pathmasiri KC, Cologna SM. Mass spectrometry imaging reveals ganglioside and ceramide localization patterns during cerebellar degeneration in the Npc1-/- mouse model. Anal Bioanal Chem. 2019 Sep;411(22):5659-5668. doi: 10.1007/s00216-019-01989-7. Epub 2019 Jun 29.

PubMed ID: 31254056

Kauhanen, D., M. Sysi-Aho, K.M. Koistinen, R. Laaksonen, J. Sinisalo, and K. Ekroos. (2016). Development and validation of a high-throughput LC-MS/MS assay for routine measurement of molecular ceramides. Anal Bioanal Chem 408:3475-83. [PubMed]

PubMed ID: 26922344