860677 | C18 Ceramide-d7 (d18:1-d7/18:0)

N-stearoyl-D-erythro-sphingosine (d7)


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C18 Ceramide-d7 (d18:1-d7/18:0)

C18 Ceramide-d7 (d18:1-d7/18:0)

N-stearoyl-D-erythro-sphingosine (d7)

Monitoring the levels of the ceramides (Cer) d18:1/16:0, Cer d18:1/18:0, Cer d18:1/24:0, and Cer d18:1/24:1 and ratios thereof in human plasma empowers the prediction of fatal outcome of coronary artery disease. Avanti has now made available these 4 ceramides in a stable isotope form as a convenience for a newly described validated liquid chromatography-tandem mass spectrometry methodology for their clinical-scaled measurement.
Refer: D. Kauhanen et al. (2016). Development and validation of a high-throughput LC-MS/MS assay for routine measurement of molecular ceramides. Anal Bioanal Chem 408:3475-83
Avanti Numbers 860676, 760677, 860678 and 860679 refer.

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C36H64D7NO3
Percent Composition
C 75.46%, H 13.72%, N 2.44%, O 8.38%
Purity
>99%
Stability
1 year
Storage Temperature
-20°C
CAS Number
1840942-14-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
572.997
Exact Mass
572.587

Tobias F, Pathmasiri KC, Cologna SM. Mass spectrometry imaging reveals ganglioside and ceramide localization patterns during cerebellar degeneration in the Npc1-/- mouse model. Anal Bioanal Chem. 2019 Sep;411(22):5659-5668. doi: 10.1007/s00216-019-01989-7. Epub 2019 Jun 29.

PubMed ID: 31254056

Kauhanen, D., M. Sysi-Aho, K.M. Koistinen, R. Laaksonen, J. Sinisalo, and K. Ekroos. (2016). Development and validation of a high-throughput LC-MS/MS assay for routine measurement of molecular ceramides. Anal Bioanal Chem 408:3475-83. [PubMed]

PubMed ID: 26922344