860659 | sphingosine-1-phosphate-d7

D-erythro-sphingosine-d7-1-phosphate


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sphingosine-1-phosphate-d7

sphingosine-1-phosphate-d7

D-erythro-sphingosine-d7-1-phosphate

Sphingosine-1-phosphate (S1P), a zwitterionic sphingolipid, is an important cellular metabolite and signalling lipid in animal cells. It has also been found in insects, yeasts and plants. You can find additional information on S1P at the following link:
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C18H31D7NO5P
Percent Composition
C 55.93%, H 11.73%, N 3.62%, O 20.70%, P 8.01%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
2260670-15-1
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
386.515
Exact Mass
386.293

Richter AM, Possling A, Malysheva N, Yousef KP, Herbst S, von Kleist M, Hengge R. Local c-di-GMP Signaling in the Control of Synthesis of the E. coli Biofilm Exopolysaccharide pEtN-Cellulose. J Mol Biol. 2020 Jun 11:S0022-2836(20)30403-4. doi: 10.1016/j.jmb.2020.06.006. Epub ahead of print. PMID: 32534064.

PubMed ID: 32534064

Haimerl P, Bernhardt U, Schindela S, Henkel FD, Lechner A, Zissler UM, Pastor X, Thomas D, Cecil A, Ge Y, Haid M, Prehn C, Tokarz J, Heinig M, Adamski J, Schmidt-Weber CB, Chaker AM, Bieren JE. Inflammatory macrophage memory in NSAID-exacerbated respiratory disease. J Allergy Clin Immunol. 2020 Jun 12:S0091-6749(20)30803-4. doi: 10.1016/j.jaci.2020.04.064. Epub ahead of print. PMID: 32540397.

PubMed ID: 32540397

Zhang H, Li K, Zhao Y, Zhang Y, Sun J, Li S, Lin G. Long-term use of fluoxetine accelerates bone loss through the disruption of sphingolipids metabolism in bone marrow adipose tissue. Transl Psychiatry. 2020 May 12;10(1):138. doi: 10.1038/s41398-020-0819-5. PMID: 32398744; PMCID: PMC7217841.

PubMed ID: 32398744

Zoicas I, Schumacher F, Kleuser B, Reichel M, Gulbins E, Fejtova A, Kornhuber J, Rhein C. The Forebrain-Specific Overexpression of Acid Sphingomyelinase Induces Depressive-Like Symptoms in Mice. Cells. 2020 May 18;9(5):1244. doi: 10.3390/cells9051244. PMID: 32443534; PMCID: PMC7290754.

PubMed ID: 32443534

Kharel Y, Huang T, Salamon A, Harris TE, Santos WL, Lynch KR. Mechanism of sphingosine 1-phosphate clearance from blood. Biochem J. 2020 Mar 13;477(5):925-935. doi: 10.1042/BCJ20190730. PMID: 32065229; PMCID: PMC7059866.

PubMed ID: 32065229

Carstens H, Schumacher F, Keitsch S, Kramer M, Kühn C, Sehl C, Soddemann M, Wilker B, Herrmann D, Swaidan A, Kleuser B, Verhaegh R, Hilken G, Edwards MJ, Dubicanac M, Carpinteiro A, Wissmann A, Becker KA, Kamler M, Gulbins E. Clinical Development of Sphingosine as Anti-Bacterial Drug: Inhalation of Sphingosine in Mini Pigs has no Adverse Side Effects. Cell Physiol Biochem. 2019;53(6):1015-1028. doi: 10.33594/000000194. PMID: 31854953.

PubMed ID: 31854953

Poppe A, Moritz E, Geffken M, Schreiber J, Greiwe G, Amschler K, Wruck ML, Schwedhelm E, Daum G, Kluge S, Peine S, Winkler MS. Analyses of sphingosine-1-phosphate in the context of transfusion: how much is in stored blood products and in patient blood? Transfusion. 2019 Oct;59(10):3071-3076. doi: 10.1111/trf.15494. Epub 2019 Sep 4.

PubMed ID: 31483505

Morris MC, Kassam F, Bercz A, Beckmann N, Schumacher F, Gulbins E, Makley AT, Goodman MD. The Role of Chemoprophylactic Agents in Modulating Platelet Aggregability After Traumatic Brain Injury. J Surg Res. 2019 Jul 3;244:1-8. doi: 10.1016/j.jss.2019.06.022. [Epub ahead of print]

PubMed ID: 31279258

Salas-Perdomo A, Miró-Mur F, Gallizioli M, Brait VH, Justicia C, Meissner A, Urra X, Chamorro A, Planas AM. Role of the S1P pathway and inhibition by fingolimod in preventing hemorrhagic transformation after stroke. Sci Rep. 2019 Jun 5;9(1):8309. doi: 10.1038/s41598-019-44845-5.

PubMed ID: 31165772

Nejatian N, Trautmann S, Thomas D, Pfeilschifter J, Badenhoop K, Koch A, Penna-Martinez M. Vitamin D effects on sphingosine 1-phosphate signaling and metabolism in monocytes from type 2 diabetes patients and controls. J Steroid Biochem Mol Biol. 2019 Feb;186:130-135. doi: 10.1016/j.jsbmb.2018.10.005. Epub 2018 Oct 15.

PubMed ID: 30336275