860533 | C16 Ceramide-1-Phosphate (d18:1/16:0)

N-palmitoyl-ceramide-1-phosphate (ammonium salt)


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C16 Ceramide-1-Phosphate (d18:1/16:0)

C16 Ceramide-1-Phosphate (d18:1/16:0)

N-palmitoyl-ceramide-1-phosphate (ammonium salt)

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C34H71N2O6P
Percent Composition
C 64.32%, H 11.27%, N 4.41%, O 15.12%, P 4.88%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
1246303-22-9
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
634.911
Exact Mass
634.505
Synonyms
N-(hexadecanoyl)-sphing-4-enine-1-phosphate
CerP(d18:1/16:0)
110754

Presa N, Dominguez-Herrera A, van der Veen JN, Vance DE, Gómez-Muñoz A. Implication of phosphatidylethanolamine N-methyltransferase in adipocyte differentiation. Biochim Biophys Acta Mol Basis Dis. 2020 Jun 2;1866(10):165853. doi: 10.1016/j.bbadis.2020.165853. Epub ahead of print. PMID: 32502648.

PubMed ID: 32502648

Hori M, Gokita M, Yasue M, Honda T, Kohama T, Mashimo M, Nakamura H, Murayama T. Down-regulation of ceramide kinase via proteasome and lysosome pathways in PC12 cells by serum withdrawal: Its protection by nerve growth factor and role in exocytosis. Biochim Biophys Acta Mol Cell Res. 2020 Apr 1;1867(7):118714. doi: 10.1016/j.bbamcr.2020.118714. Epub ahead of print. PMID: 32246947.

PubMed ID: 32246947

Mallela SK, Mitrofanova A, Merscher S, Fornoni A. Regulation of the amount of ceramide-1-phosphate synthesized in differentiated human podocytes. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Sep 2;1864(12):158517. doi: 10.1016/j.bbalip.2019.158517. [Epub ahead of print]

PubMed ID: 31487557

Mena HA, Zubiry PR, Dizier B, Mignon V, Parborell F, Schattner M, Boisson-Vidal C, Negrotto S. Ceramide 1-Phosphate Protects Endothelial Colony-Forming Cells From Apoptosis and Increases Vasculogenesis In Vitro and In Vivo. Arterioscler Thromb Vasc Biol. 2019 Oct;39(10):e219-e232. doi: 10.1161/ATVBAHA.119.312766. Epub 2019 Aug 22.

PubMed ID: 31434496

Mitrofanova A, Mallela SK, Ducasa GM, Yoo TH, Rosenfeld-Gur E, Zelnik ID, Molina J, Varona Santos J, Ge M, Sloan A, Kim JJ, Pedigo C, Bryn J, Volosenco I, Faul C, Zeidan YH, Garcia Hernandez C, Mendez AJ, Leibiger I, Burke GW, Futerman AH, Barisoni L, Ishimoto Y, Inagi R, Merscher S, Fornoni A. SMPDL3b modulates insulin receptor signaling in diabetic kidney disease. Nat Commun. 2019 Jun 19;10(1):2692. doi: 10.1038/s41467-019-10584-4.

PubMed ID: 31217420

Gómez-Muñoz, A., Kong, J.Y., Salh, B., Steinbrecher, U.P. (2004). Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages. J Lipid Res 45:99-105. [PubMed]

PubMed ID: 14523050

Hinkovska Galcheva, V.T., Boxer, L.A.,Mansfield, P.J., Harsh, D.,Blackwood, A., Shayman, J.A.. (1998). The formation of ceramide-1-phosphate during neutrophil phagocytosis and its role in liposome fusion. J Biol Chem 273:50,33203. [PubMed]

PubMed ID: 9837889

Gómez-Muñoz, A.,Duffy, P.A., Martin, A., O’Brien, L., Byun, H.S., Bittman, R., Brindley, D.N. (1995). Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: antagonism by cell-permeable ceramides. Mol Pharmacol 47:833-9. [PubMed]

PubMed ID: 7746276