860517 | C17 Ceramide (d18:1/17:0)


C17 Ceramide (d18:1/17:0)


Size SKU Packaging Price
5mg 860517P-5mg 860517P-5mg 1 x 5mg $94.45
10mg 860517P-10mg 860517P-10mg 1 x 10mg $177.70
25mg 860517P-25mg 860517P-25mg 1 x 25mg $371.25
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C17 Ceramide (d18:1/17:0)


Light Sensitive
Molecular Formula
Percent Composition
C 76.17%, H 12.60%, N 2.54%, O 8.70%
1 Years
Storage Temperature
CAS Number
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
Exact Mass

Richter AM, Possling A, Malysheva N, Yousef KP, Herbst S, von Kleist M, Hengge R. Local c-di-GMP Signaling in the Control of Synthesis of the E. coli Biofilm Exopolysaccharide pEtN-Cellulose. J Mol Biol. 2020 Jun 11:S0022-2836(20)30403-4. doi: 10.1016/j.jmb.2020.06.006. Epub ahead of print. PMID: 32534064.

PubMed ID: 32534064

Bouillet B, Gautier T, Denimal D, Samson M, Masson D, Pais de Barros JP, Maquart G, Xolin M, Grosfeld A, Dalle H, Vergès B, Moldes M, Fève B. Glucocorticoids impair HDL-mediated cholesterol efflux besides increased HDL cholesterol concentration - a proof of concept. Eur J Endocrinol. 2020 Jun 1:EJE-20-0477. doi: 10.1530/EJE-20-0477. Epub ahead of print. PMID: 32570209.

PubMed ID: 32570209

Haimerl P, Bernhardt U, Schindela S, Henkel FD, Lechner A, Zissler UM, Pastor X, Thomas D, Cecil A, Ge Y, Haid M, Prehn C, Tokarz J, Heinig M, Adamski J, Schmidt-Weber CB, Chaker AM, Bieren JE. Inflammatory macrophage memory in NSAID-exacerbated respiratory disease. J Allergy Clin Immunol. 2020 Jun 12:S0091-6749(20)30803-4. doi: 10.1016/j.jaci.2020.04.064. Epub ahead of print. PMID: 32540397.

PubMed ID: 32540397

Sakai E, Kurano M, Morita Y, Aoki J, Yatomi Y. Establishment of a Measurement System for Sphingolipids in the Cerebrospinal Fluid Based on Liquid Chromatography-Tandem Mass Spectrometry, and Its Application in the Diagnosis of Carcinomatous Meningitis. J Appl Lab Med. 2020 May 14:jfaa022. doi: 10.1093/jalm/jfaa022. Epub ahead of print. PMID: 32407524.

PubMed ID: 32407524

Narduzzi L, Dervilly G, Marchand A, Audran M, Le Bizec B, Buisson C. Applying metabolomics to detect growth hormone administration in athletes: Proof of concept. Drug Test Anal. 2020 Apr 4. doi: 10.1002/dta.2798. Epub ahead of print. PMID: 32246894.

PubMed ID: 32246894

Bianco M, Calvano CD, Losito I, Palmisano F, Cataldi TRI. Targeted analysis of ceramides and cerebrosides in yellow lupin seeds by reversed-phase liquid chromatography coupled to electrospray ionization and multistage mass spectrometry. Food Chem. 2020 Sep 15;324:126878. doi: 10.1016/j.foodchem.2020.126878. Epub 2020 Apr 21. PMID: 32344348.

PubMed ID: 32344348

da Costa E, Ricardo F, Melo T, Mamede R, Abreu MH, Domingues P, Domingues MR, Calado R. Site-Specific Lipidomic Signatures of Sea Lettuce (Ulva spp., Chlorophyta) Hold the Potential to Trace Their Geographic Origin. Biomolecules. 2020 Mar 23;10(3):E489. doi: 10.3390/biom10030489. PMID: 32210093.

PubMed ID: 32210093

Petrocelli JJ, McKenzie AI, Mahmassani ZS, Reidy PT, Stoddard GJ, Poss AM, Holland WL, Summers SA, Drummond MJ. Ceramide biomarkers predictive of cardiovascular disease risk increase in healthy older adults after bed rest. J Gerontol A Biol Sci Med Sci. 2020 Mar 26:glaa072. doi: 10.1093/gerona/glaa072. Epub ahead of print. PMID: 32215553.

PubMed ID: 32215553

Yukawa T, Nakahata T, Okamoto R, Ishichi Y, Miyamoto Y, Nishimura S, Oikawa T, Kubo K, Adachi R, Satomi Y, Nakakariya M, Amano N, Kamaura M, Matsunaga N. Discovery of 1,8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor. Bioorg Med Chem. 2020 Apr 1;28(7):115376. doi: 10.1016/j.bmc.2020.115376. Epub 2020 Feb 12. PMID: 32088125.

PubMed ID: 32088125

McKenzie AI, Reidy PT, Nelson DS, Mulvey JL, Yonemura NM, Petrocelli JJ, Mahmassani ZS, Tippetts TS, Summers SA, Funai K, Drummond MJ. Pharmacological inhibition of TLR4 ameliorates muscle and liver ceramide content after disuse in previously physically active mice. Am J Physiol Regul Integr Comp Physiol. 2020 Mar 1;318(3):R503-R511. doi: 10.1152/ajpregu.00330.2019. Epub 2020 Jan 29. PMID: 31994900.

PubMed ID: 31994900

Lee HS, Park HY, Kwon SP, Kim B, Lee Y, Kim S, Shin KO, Park K. NADPH Oxidase-Mediated Activation of Neutral Sphingomyelinase Is Responsible for Diesel Particulate Extract-Induced Keratinocyte Apoptosis. Int J Mol Sci. 2020 Feb 3;21(3):1001. doi: 10.3390/ijms21031001. PMID: 32028642; PMCID: PMC7037446.

PubMed ID: 32028642

Noto D, Di Gaudio F, Altieri IG, Cefalù AB, Indelicato S, Fayer F, Spina R, Scrimali C, Giammanco A, Mattina A, Indelicato S, Greco M, Bongiorno D, Averna M. Automated untargeted stable isotope assisted lipidomics of liver cells on high glucose shows alteration of sphingolipid kinetics. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Jun;1865(6):158656. doi: 10.1016/j.bbalip.2020.158656. Epub 2020 Feb 8. PMID: 32045699.

PubMed ID: 32045699

Xie Y, Wu B, Wu Z, Tu X, Xu S, Lv X, Yin H, Xiang J, Chen H, Wei F. Ultrasound-assisted one-phase solvent extraction coupled with liquid chromatography-quadrupole time-of-flight mass spectrometry for efficient profiling of egg yolk lipids. Food Chem. 2020 Mar 2;319:126547. doi: 10.1016/j.foodchem.2020.126547. Epub ahead of print. PMID: 32182541.

PubMed ID: 32182541

Hou B, Zhao Y, He P, Xu C, Ma P, Lam SM, Li B, Gil V, Shui G, Qiang G, Liew CW, Du G. Targeted lipidomics and transcriptomics profiling reveal the heterogeneity of visceral and subcutaneous white adipose tissue. Life Sci. 2020 Jan 29;245:117352. doi: 10.1016/j.lfs.2020.117352. Epub ahead of print. PMID: 32006527.

PubMed ID: 32006527

Zhang T, Trauger SA, Vidoudez C, Doane KP, Pluimer BR, Peterson RT. Parallel Reaction Monitoring reveals structure-specific ceramide alterations in the zebrafish. Sci Rep. 2019 Dec 27;9(1):19939. doi: 10.1038/s41598-019-56466-z. PMID: 31882772; PMCID: PMC6934720.

PubMed ID: 31882772

Iaea DB, Spahr ZR, Singh RK, Chan RB, Zhou B, Bareja R, Elemento O, Di Paolo G, Zhang X, Maxfield FR. Stable reduction of STARD4 alters cholesterol regulation and lipid homeostasis. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Apr;1865(4):158609. doi: 10.1016/j.bbalip.2020.158609. Epub 2020 Jan 7. PMID: 31917335; PMCID: PMC6996790.

PubMed ID: 31917335

Boretti FS, Burla B, Deuel J, Gao L, Wenk MR, Liesegang A, Sieber-Ruckstuhl NS. Serum lipidome analysis of healthy beagle dogs receiving different diets. Metabolomics. 2019 Dec 3;16(1):1. doi: 10.1007/s11306-019-1621-3. PMID: 31797205; PMCID: PMC6890591.

PubMed ID: 31797205

Murase Y, Takeichi T, Kawamoto A, Tanahashi K, Okuno Y, Takama H, Shimizu E, Ishikawa J, Ogi T, Akiyama M. Reduced stratum corneum acylceramides in autosomal recessive congenital ichthyosis with a NIPAL4 mutation. J Dermatol Sci. 2019 Dec 4;S0923-1811(19)30369-X. doi: 10.1016/j.jdermsci.2019.12.001. [Epub ahead of print]. PMID: 31836270.

PubMed ID: 31836270

Beckmann N, Becker KA, Kadow S, Schumacher F, Kramer M, Kühn C, Schulz-Schaeffer WJ, Edwards MJ, Kleuser B, Gulbins E, Carpinteiro A. Acid Sphingomyelinase Deficiency Ameliorates Farber Disease. Int J Mol Sci. 2019 Dec 11;20(24):6253. doi: 10.3390/ijms20246253. PMID: 31835809; PMCID: PMC6941101.

PubMed ID: 31835809

Gaggini M, Carli F, Rosso C, Younes R, D'Aurizio R, Bugianesi E, Gastaldelli A. Altered Metabolic Profile and Adipocyte Insulin Resistance Mark Severe Liver Fibrosis in Patients with Chronic Liver Disease. Int J Mol Sci. 2019 Dec 16;20(24):6333. doi: 10.3390/ijms20246333. PMID: 31888144; PMCID: PMC6940758.

PubMed ID: 31888144

Li H, Song Y, Zhang H, Wang X, Cong P, Xu J, Xue C. Comparative lipid profile of four edible shellfishes by UPLC-Triple TOF-MS/MS. Food Chem. 2020 Apr 25;310:125947. doi: 10.1016/j.foodchem.2019.125947. Epub 2019 Dec 4. PMID: 31841939.

PubMed ID: 31841939

Yan B, Zou Z, Chu H, Chan G, Tsang JO, Lai PM, Yuan S, Yip CC, Yin F, Kao RY, Sze KH, Lau SK, Chan JF, Yuen KY. Lipidomic Profiling Reveals Significant Perturbations of Intracellular Lipid Homeostasis in Enterovirus-Infected Cells. Int J Mol Sci. 2019 Nov 26;20(23). pii: E5952. doi: 10.3390/ijms20235952.

PubMed ID: 31779252

Kim YR, Lee EJ, Shin KO, Kim MH, Pewzner-Jung Y, Lee YM, Park JW, Futerman AH, Park WJ. Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases. Exp Mol Med. 2019 Nov 1;51(11):129. doi: 10.1038/s12276-019-0340-1.

PubMed ID: 31676768

Triebl A, Burla B, Selvalatchmanan J, Oh J, Tan SH, Chan MY, Mellet NA, Meikle PJ, Torta F, Wenk MR. Shared reference materials harmonize lipidomics across MS-based detection platforms and laboratories. J Lipid Res. 2020 Jan;61(1):105-115. doi: 10.1194/jlr.D119000393. Epub 2019 Nov 15.

PubMed ID: 31732502

Takeichi T, Hirabayashi T, Miyasaka Y, Kawamoto A, Okuno Y, Taguchi S, Tanahashi K, Murase C, Takama H, Tanaka K, Boeglin WE, Calcutt MW, Watanabe D, Kono M, Muro Y, Ishikawa J, Ohno T, Brash AR, Akiyama M. SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation. J Clin Invest. 2019 Oct 31. pii: 130675. doi: 10.1172/JCI130675. [Epub ahead of print]

PubMed ID: 31671075

Grafen A, Schumacher F, Chithelen J, Kleuser B, Beyersdorf N, Schneider-Schaulies J. Use of Acid Ceramidase and Sphingosine Kinase Inhibitors as Antiviral Compounds Against Measles Virus Infection of Lymphocytes in vitro. Front Cell Dev Biol. 2019 Oct 1;7:218. doi: 10.3389/fcell.2019.00218. eCollection 2019.

PubMed ID: 31632969

Freyre CAC, Rauher PC, Ejsing CS, Klemm RW. MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes. Mol Cell. 2019 Oct 14. pii: S1097-2765(19)30696-3. doi: 10.1016/j.molcel.2019.09.011. [Epub ahead of print]

PubMed ID: 31628041

Chamberlain CA, Hatch M, Garrett TJ. Metabolomic profiling of oxalate-degrading probiotic Lactobacillus acidophilus and Lactobacillus gasseri. PLoS One. 2019 Sep 23;14(9):e0222393. doi: 10.1371/journal.pone.0222393. eCollection 2019.

PubMed ID: 31545840

Millán L, Fernández-Irigoyen J, Santamaría E, Mayo R. Mass Spectrometry Applied to Human Cerebrospinal Fluid Lipidome. Methods Mol Biol. 2019;2044:353-361. doi: 10.1007/978-1-4939-9706-0_23.

PubMed ID: 31432425

Wang X, Zhang H, Song Y, Cong P, Li Z, Xu J, Xue C. Comparative Lipid Profile Analysis of Four Fish Species by Ultraperformance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry. J Agric Food Chem. 2019 Aug 21;67(33):9423-9431. doi: 10.1021/acs.jafc.9b03303. Epub 2019 Aug 8.

PubMed ID: 31329442

Zeitler S, Ye L, Andreyeva A, Schumacher F, Monti J, Nürnberg B, Nowak G, Kleuser B, Reichel M, Fejtová A, Kornhuber J, Rhein C, Friedland K. Acid sphingomyelinase - a regulator of canonical transient receptor potential channel 6 (TRPC6) activity. J Neurochem. 2019 Jul 16. doi: 10.1111/jnc.14823. [Epub ahead of print]

PubMed ID: 31310676

Morris MC, Kassam F, Bercz A, Beckmann N, Schumacher F, Gulbins E, Makley AT, Goodman MD. The Role of Chemoprophylactic Agents in Modulating Platelet Aggregability After Traumatic Brain Injury. J Surg Res. 2019 Jul 3;244:1-8. doi: 10.1016/j.jss.2019.06.022. [Epub ahead of print]

PubMed ID: 31279258

Myers WA, Rico JE, Davis AN, Fontoura ABP, Dineen MJ, Tate BN, McFadden JW. Effects of abomasal infusions of fatty acids and one-carbon donors on hepatic ceramide and phosphatidylcholine in lactating Holstein dairy cows. J Dairy Sci. 2019 Aug;102(8):7087-7101. doi: 10.3168/jds.2018-16200. Epub 2019 Jun 6.

PubMed ID: 31178188

Schilcher I, Ledinski G, Radulović S, Hallström S, Eichmann T, Madl T, Zhang F, Leitinger G, Kolb-Lenz D, Darnhofer B, Birner-Gruenberger R, Wadsack C, Kratky D, Marsche G, Frank S, Cvirn G. Endothelial lipase increases antioxidative capacity of high-density lipoprotein. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jun 17;1864(10):1363-1374. doi: 10.1016/j.bbalip.2019.06.011. [Epub ahead of print]

PubMed ID: 31220617

Teng W, Li Y, Du M, Lei X, Xie S, Ren F. Sulforaphane Prevents Hepatic Insulin Resistance by Blocking Serine Palmitoyltransferase 3-Mediated Ceramide Biosynthesis. Nutrients. 2019 May 27;11(5). pii: E1185. doi: 10.3390/nu11051185.

PubMed ID: 31137828

Miranda AM, Bravo FV, Chan RB, Sousa N, Di Paolo G, Oliveira TG. Differential lipid composition and regulation along the hippocampal longitudinal axis. Transl Psychiatry. 2019 Apr 26;9(1):144. doi: 10.1038/s41398-019-0478-6.

PubMed ID: 31028243

Dias IHK, Ferreira R, Gruber F, Vitorino R, Rivas-Urbina A, Sanchez-Quesada JL, Vieira Silva J, Fardilha M, de Freitas V, Reis A. Sulfate-based lipids: Analysis of healthy human fluids and cell extracts. Chem Phys Lipids. 2019 Mar 22;221:53-64. doi: 10.1016/j.chemphyslip.2019.03.009. [Epub ahead of print]

PubMed ID: 30910732

Kurz J, Barthelmes J, Blum L, Ulshöfer T, Wegner MS, Ferreirós N, Roser L, Geisslinger G, Grösch S, Schiffmann S. Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes. Sci Rep. 2019 Jan 24;9(1):747. doi: 10.1038/s41598-018-37342-8.

PubMed ID: 30679689

Nejatian N, Trautmann S, Thomas D, Pfeilschifter J, Badenhoop K, Koch A, Penna-Martinez M. Vitamin D effects on sphingosine 1-phosphate signaling and metabolism in monocytes from type 2 diabetes patients and controls. J Steroid Biochem Mol Biol. 2019 Feb;186:130-135. doi: 10.1016/j.jsbmb.2018.10.005. Epub 2018 Oct 15.

PubMed ID: 30336275

de Wit NM, den Hoedt S, Martinez-Martinez P, Rozemuller AJ, Mulder MT, de Vries HE. Astrocytic ceramide as possible indicator of neuroinflammation. J Neuroinflammation. 2019 Feb 25;16(1):48. doi: 10.1186/s12974-019-1436-1.

PubMed ID: 30803453

Chen S, Wang J, Wang M, Lu J, Cai Y, Li B. In vitro fertilization alters phospholipid profiles in mouse placenta. J Assist Reprod Genet. 2019 Jan 4. doi: 10.1007/s10815-018-1387-y. [Epub ahead of print]

PubMed ID: 30610659

Lee DK, Long NP, Jung J, Kim TJ, Na E, Kang YP, Kwon SW, Jang J. Integrative lipidomic and transcriptomic analysis of X-linked adrenoleukodystrophy reveals distinct lipidome signatures between adrenomyeloneuropathy and childhood cerebral adrenoleukodystrophy. Biochem Biophys Res Commun. 2019 Jan 8;508(2):563-569. doi: 10.1016/j.bbrc.2018.11.123. Epub 2018 Nov 30.

PubMed ID: 30509496

Rossi C, Cicalini I, Zucchelli M, di Ioia M, Onofrj M, Federici L, Del Boccio P, Pieragostino D. Metabolomic Signature in Sera of Multiple Sclerosis Patients during Pregnancy. Int J Mol Sci. 2018 Nov 14;19(11). pii: E3589. doi: 10.3390/ijms19113589.

PubMed ID: 30441762

Dinesh Kumar Barupal, Sili Fan, Benjamin Wancewicz, Tomas Cajka, Michael Sa, Megan R. Showalter, Rebecca Baillie, Jessica D. Tenenbaum, Gregory Louie, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Metabolomics Consortium, Rima Kaddurah-Daouk & Oliver Fiehn. Generation and quality control of lipidomics data for the alzheimer’s disease neuroimaging initiative cohort. Scientific Data volume 5, Article number: 180263 (2018).

Orsini M, Chateauvieux S, Rhim J, Gaigneaux A, Cheillan D, Christov C, Dicato M, Morceau F, Diederich M. Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cells. Cell Death Differ. 2018 Dec 13. doi: 10.1038/s41418-018-0245-x. [Epub ahead of print].

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Forest A, Ruiz M, Bouchard B, Boucher G, Gingras O, Daneault C, Robillard Frayne I, Rhainds D, Consortium TI, Genetics Consortium TNI, Tardif JC, Rioux JD, Des Rosiers C. A Comprehensive and Reproducible Untargeted Lipidomic Workflow Using LC-QTOF Validated for Human Plasma Analysis. J Proteome Res. 2018 Sep 26. doi: 10.1021/acs.jproteome.8b00270. [Epub ahead of print

PubMed ID: 30256116

Laursen, T., Borch, J., Knudsen, C., Torta, F., Martens, H.J., SIvestro, D., Hatzakis, N.S., Wenk, M.R., Dafforn, T.R., Olsen, C.E., Motawia, M.S., Hamberger, B., Moller, B.L., and Bassard, J-E. “Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum” Science 354, 890-893 (2016)

PubMed ID: 27856908
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