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860516 | C16 Ceramide (d18:1/16:0)

N-palmitoyl-D-erythro-sphingosine

C16 Ceramide (d18:1/16:0)

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Size SKU Packaging Price
5mg 860516P-5mg 860516P-5mg 1 x 5mg $94.45
10mg 860516P-10mg 860516P-10mg 1 x 10mg $177.70
25mg 860516P-25mg 860516P-25mg 1 x 25mg $371.25
50mg 860516P-50mg 860516P-50mg 1 x 50mg $680.50
100mg 860516P-100mg 860516P-100mg 1 x 100mg $1,066.00
Info

C16 Ceramide (d18:1/16:0)

N-palmitoyl-D-erythro-sphingosine

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C34H67NO3
Percent Composition
C 75.92%, H 12.55%, N 2.60%, O 8.92%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
24696-26-2
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
537.901
Exact Mass
537.512
Synonyms
N-(hexadecanoyl)-sphing-4-enine
Downloads
References

Eum JY, Lee JC, Yi SS, Kim IY, Seong JK, Moon MH. Aging-related lipidomic changes in mouse serum, kidney, and heart by nanoflow ultrahigh-performance liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2020 Jan 3:460849. doi: 10.1016/j.chroma.2020.460849. Epub ahead of print. PMID: 31928769.

 PubMed ID: 31928769

Zhang T, Trauger SA, Vidoudez C, Doane KP, Pluimer BR, Peterson RT. Parallel Reaction Monitoring reveals structure-specific ceramide alterations in the zebrafish. Sci Rep. 2019 Dec 27;9(1):19939. doi: 10.1038/s41598-019-56466-z. PMID: 31882772; PMCID: PMC6934720.

 PubMed ID: 31882772

Afşar E, Kırımlıoglu E, Çeker T, Yılmaz Ç, Demir N, Aslan M. Effect of ER stress on sphingolipid levels and apoptotic pathways in retinal pigment epithelial cells. Redox Biol. 2020 Feb;30:101430. doi: 10.1016/j.redox.2020.101430. Epub 2020 Jan 20. PMID: 31978676; PMCID: PMC6976939.

 PubMed ID: 31978676

Arshad H, Alfonso JCL, Franke R, Michaelis K, Araujo L, Habib A, Zboromyrska Y, Lücke E, Strungaru E, Akmatov MK, Hatzikirou H, Meyer-Hermann M, Petersmann A, Nauck M, Brönstrup M, Bilitewski U, Abel L, Sievers J, Vila J, Illig T, Schreiber J, Pessler F. Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia. J Transl Med. 2019 Nov 11;17(1):365. doi: 10.1186/s12967-019-2112-z.

 PubMed ID: 31711507

Pearson JM, Tan SF, Sharma A, Annageldiyev C, Fox TE, Abad JL, Fabrias G, Desai D, Amin S, Wang HG, Cabot MC, Claxton DF, Kester M, Feith DJ, Loughran TP. Ceramide analog SACLAC modulates sphingolipid levels and Mcl-1 splicing to induce apoptosis in acute myeloid leukemia. Mol Cancer Res. 2019 Nov 19. pii: molcanres.0619.2019. doi: 10.1158/1541-7786.MCR-19-0619. [Epub ahead of print]

 PubMed ID: 31744877

Wigger D, Gulbins E, Kleuser B, Schumacher F. Monitoring the Sphingolipid de novo Synthesis by Stable-Isotope Labeling and Liquid Chromatography-Mass Spectrometry. Front Cell Dev Biol. 2019 Oct 1;7:210. doi: 10.3389/fcell.2019.00210. eCollection 2019.

 PubMed ID: 31632963

Rivas DA, Rice NP, Ezzyat Y, McDonald DJ, Cooper BE, Fielding RA. Sphingosine-1-phosphate analog FTY720 reverses obesity but not age-induced anabolic resistance to muscle contraction. Am J Physiol Cell Physiol. 2019 Sep 1;317(3):C502-C512. doi: 10.1152/ajpcell.00455.2018. Epub 2019 Jun 26.

 PubMed ID: 31241988

Kaya S, Aslan İ, Kıraç E, Karaarslan T, Aslan M. Serum Sphingolipidomic Analysis in Acne Vulgaris Patients. Ann Clin Lab Sci. 2019 Mar;49(2):242-248.

 PubMed ID: 31028071

Preuss C, Jelenik T, Bódis K, Müssig K, Burkart V, Szendroedi J, Roden M, Markgraf DF. A New Targeted Lipidomics Approach Reveals Lipid Droplets in Liver, Muscle and Heart as a Repository for Diacylglycerol and Ceramide Species in Non-Alcoholic Fatty Liver. Cells. 2019 Mar 22;8(3). pii: E277. doi: 10.3390/cells8030277.

 PubMed ID: 30909521

González-Ramírez EJ, Artetxe I, García-Arribas AB, Goñi FM, Alonso A. Homogeneous and Heterogeneous Bilayers of Ternary Lipid Compositions Containing Equimolar Ceramide and Cholesterol. Langmuir. 2019 Apr 8. doi: 10.1021/acs.langmuir.9b00324. [Epub ahead of print]

 PubMed ID: 30924341

Lipiec E, Wnętrzak A, Chachaj-Brekiesz A, Kwiatek W, Dynarowicz-Latka P. High-resolution label-free studies of molecular distribution and orientation in ultrathin, multicomponent model membranes with infrared nano-spectroscopy AFM-IR. J Colloid Interface Sci. 2019 Apr 15;542:347-354. doi: 10.1016/j.jcis.2019.02.016. Epub 2019 Feb 6.

 PubMed ID: 30390585

Yao H, Gong J, Peterson AL, Lu X, Zhang P, Dennery PA. Fatty Acid Oxidation Protects Against Hyperoxia-Induced Endothelial Cell Apoptosis and Lung Injury in Neonatal Mice. Am J Respir Cell Mol Biol. 2018 Dec 20. doi: 10.1165/rcmb.2018-0335OC. [Epub ahead of print]

 PubMed ID: 30571144

Brunkhorst R, Pfeilschifter W, Rajkovic N, Pfeffer M, Fischer C, Korf HW, Christoffersen C, Trautmann S, Thomas D, Pfeilschifter J, Koch A. Diurnal regulation of sphingolipids in blood. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Mar;1864(3):304-311. doi: 10.1016/j.bbalip.2018.12.001. Epub 2018 Dec 15.

 PubMed ID: 30557628

Matsufuji T, Kinoshita M, Matsumori N. Preparation and Membrane Distribution of Fluorescent Derivatives of Ceramide. Langmuir. 2019 Jan 4. doi: 10.1021/acs.langmuir.8b03176. [Epub ahead of print]

 PubMed ID: 30608698

Matsufuji T, Kinoshita M, Matsumori N. Preparation and Membrane Distribution of Fluorescent Derivatives of Ceramide. Langmuir. 2019 Jan 4. doi: 10.1021/acs.langmuir.8b03176. [Epub ahead of print]

 PubMed ID: 30608698

Mouts A, Vattulainen E, Matsufuji T, Kinoshita M, Matsumori N, Slotte JP. On the importance of the C(1)-OH and C(3)-OH functional groups of the long-chain base of ceramide for interlipid interaction and lateral segregation into ceramide-rich domains. Langmuir 2018, 34, 51, 15864-15870.

PubMed ID: 30507134

Fanani ML, Busto JV, Sot J, Abad JL, Fabrías G, Saiz L, Vilar JMG, Goñi FM, Maggio B, Alonso A. Clearly Detectable, Kinetically Restricted Solid-Solid Phase Transition in cis-Ceramide Monolayers. Langmuir. 2018 Sep 24. doi: 10.1021/acs.langmuir.8b02198. [Epub ahead of print]

 PubMed ID: 30183303

Peñalva DA, Oresti GM, Dupuy F, Antollini SS, Maggio B, Aveldaño MI, Fanani ML. Atypical surface behavior of ceramides with nonhydroxy and 2-hydroxy very long-chain (C28-C32) PUFAs. Biochim Biophys Acta. 2014 Mar;1838(3):731-8. doi: 10.1016/j.bbamem.2013.11.018. Epub 2013 Dec 5.

 PubMed ID: 24315999

Ceramide-Induced Lamellar Gel Phases in Fluid Cell Lipid Extracts Aritz B. García-Arribas, Hasna Ahyayauch, Jesús Sot, Pablo L. López-González, Alicia Alonso, and Félix M. Goñi Langmuir 2016, 32, 9053−9063 Al Sazzad, M.A. and J.P. Slotte. (2016).

PubMed ID: 27486830

Effect of Phosphatidylcholine Unsaturation on the Lateral Segregation of Palmitoyl Ceramide and Palmitoyl Dihydroceramide in Bilayer Membranes. Langmuir

 PubMed ID: 27218704

Lonnfors, M., O. Langvik, A. Bjorkbom, and J.P. Slotte. (2013). Cholesteryl Phosphocholine - A Study on Its Interactions with Ceramides and Other Membrane Lipids. Langmuir

 PubMed ID: 23356741

Matsufuji T, Kinoshita M, Möuts A, Slotte JP, Matsumori N Preparation and Membrane Properties of Oxidized Ceramide Derivatives. Langmuir. 2017 Dec 27. doi: 10.1021/acs.langmuir.7b02654.

PubMed ID: 29231736

Perera MN, Ganesan V, Siskind LJ, Szulc ZM, Bielawski J, Bielawska A, Bittman R, Colombini M. Ceramide channels: influence of molecular structure on channel formation in membranes. Biochim Biophys Acta. 2012 May;1818(5):1291-301. doi: 10.1016/j.bbamem.2012.02.010. Epub 2012 Feb 15.

 PubMed ID: 22365970

Perera MN, Ganesan V, Siskind LJ, Szulc ZM, Bielawska A, Bittman R, Colombini M. Ceramide channel: Structural basis for selective membrane targeting. Chem Phys Lipids. 2016 Jan;194:110-116. doi: 10.1016/j.chemphyslip.2015.09.007. Epub 2015 Sep 25.

 PubMed ID: 26408265

Bockelmann S, Mina JGM, Korneev S, Hassan DG, Mueller D, Hilderink A, Vlieg HC, Raijmakers R, Heck AJR, Haberkant P, Holthuis JCM. A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7. J Lipid Res. 2018 Jan 17. pii: jlr.M082354. doi: 10.1194/jlr.M082354. [Epub ahead of print]

 PubMed ID: 29343537
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