860498 | Sphinganine (d18:0)

D-erythro-sphinganine

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10mg 860498P-10mg 860498P-10mg 1 x 10mg $169.20
25mg 860498P-25mg 860498P-25mg 1 x 25mg $240.75
100mg 860498P-100mg 860498P-100mg 1 x 100mg $776.00
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Sphinganine (d18:0)

Sphinganine (d18:0)

D-erythro-sphinganine

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C18H39NO2
Percent Composition
C 71.70%, H 13.04%, N 4.65%, O 10.61%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
764-22-7
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
301.510
Exact Mass
301.298
Synonyms
sphinganine 2S, 3R dihydrosphingosine
(2S,3R)-2-aminooctadecane-1,3-diol
(2S,3R)-2-amino-1,3-octadecanediol
110748

Muilwijk M, Goorden SMI, Celis-Morales C, Hof MH, Ghauharali-van der Vlugt K, Beers-Stet FS, Gill JMR, Vaz FM, van Valkengoed IGM. Contributions of amino acid, acylcarnitine and sphingolipid profiles to type 2 diabetes risk among South-Asian Surinamese and Dutch adults. BMJ Open Diabetes Res Care. 2020 May;8(1):e001003. doi: 10.1136/bmjdrc-2019-001003. PMID: 32376636; PMCID: PMC7228466.

 PubMed ID: 32376636

Johnson EL, Heaver SL, Waters JL, Kim BI, Bretin A, Goodman AL, Gewirtz AT, Worgall TS, Ley RE. Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels. Nat Commun. 2020 May 18;11(1):2471. doi: 10.1038/s41467-020-16274-w. PMID: 32424203; PMCID: PMC7235224.

 PubMed ID: 32424203

Jakobi K, Beyer S, Koch A, Thomas D, Schwalm S, Zeuzem S, Pfeilschifter J, Grammatikos G. Sorafenib Treatment and Modulation of the Sphingolipid Pathway Affect Proliferation and Viability of Hepatocellular Carcinoma In Vitro. Int J Mol Sci. 2020 Mar 31;21(7):2409. doi: 10.3390/ijms21072409. PMID: 32244391; PMCID: PMC7177910.

 PubMed ID: 32244391

Santos TCB, Vaz A, Ventura AE, M Saied E, Arenz C, Fedorov A, Prieto M, Silva LC. Canonical and 1-Deoxy(methyl) Sphingoid Bases: Tackling the Effect of the Lipid Structure on Membrane Biophysical Properties. Langmuir. 2020 May 15. doi: 10.1021/acs.langmuir.0c01000. Epub ahead of print. PMID: 32369370.

 PubMed ID: 32369370

Toncic RJ, Jakasa I, Hadzavdic SL, Goorden SM, Vlugt KJG, Stet FS, Balic A, Petkovic M, Pavicic B, Zuzul K, Marinovic B, Kezic S. Altered Levels of Sphingosine, Sphinganine and Their Ceramides in Atopic Dermatitis Are Related to Skin Barrier Function, Disease Severity and Local Cytokine Milieu. Int J Mol Sci. 2020 Mar 13;21(6):1958. doi: 10.3390/ijms21061958. PMID: 32183011; PMCID: PMC7139865.

 PubMed ID: 32183011

Vutukuri R, Koch A, Trautmann S, Schreiber Y, Thomas D, Mayser F, Meyer Zu Heringdorf D, Pfeilschifter J, Pfeilschifter W, Brunkhorst R. S1P d20:1, an endogenous modulator of S1P d18:1/S1P2 -dependent signaling. FASEB J. 2020 Jan 15:10.1096/fj.201902391R. doi: 10.1096/fj.201902391R. Epub ahead of print. PMID: 31944406.

 PubMed ID: 31944406

Hwang S, Williams JF, Kneissig M, Lioudyno M, Rivera I, Helguera P, Busciglio J, Storchova Z, King MC, Torres EM. Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells. Cell Rep. 2019 Nov 19;29(8):2473-2488.e5. doi: 10.1016/j.celrep.2019.10.059.

 PubMed ID: 31747614

Brunkhorst R, Pfeilschifter W, Rajkovic N, Pfeffer M, Fischer C, Korf HW, Christoffersen C, Trautmann S, Thomas D, Pfeilschifter J, Koch A. Diurnal regulation of sphingolipids in blood. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Mar;1864(3):304-311. doi: 10.1016/j.bbalip.2018.12.001. Epub 2018 Dec 15.

 PubMed ID: 30557628

Penno A, Reilly MM, Houlden H, Laurá M, Rentsch K, Niederkofler V, Stoeckli ET, Nicholson G, Eichler F, Brown RH Jr, von Eckardstein A, Hornemann T. Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids. J Biol Chem. 2010 Apr 9;285(15):11178-87. doi: 10.1074/jbc.M109.092973. Epub 2010 Jan 22. PMID: 20097765; PMCID: PMC2856995.

 PubMed ID: 20097765