Products

Dimethyl Sphingosine (d18:1) | 860496

N,N-dimethyl-D-erythro-sphingosine

860496O

Oil

5 mg
$92.00
10 mg
$155.00
25 mg
$375.00
50 mg
$730.00
100 mg
$1340.00

860496C

Chloroform

5 mg
$107.00
10 mg
$170.00
25 mg
$390.00
50 mg
$745.00
100 mg
$1355.00

All Prices in US Dollars
Custom packaging is calculated at $4.00 per aliquot and will be charged at the time of shipping.

Custom Packaging: Before clicking add to cart, from the drop down arrow select custom packaging. Next, edit the quantities (and concentration for solutions) information. Finally, click add to cart.

  • Data
  • Downloads
  • Reference
Molecular Formula
C20H41NO2
Percent Composition
C 73.34%, H 12.62%, N 4.28%, O 9.77%
Purity
>99%
Stability
1 Years
Storage
-20°C
CAS Number
119567-63-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
327.545
Exact Mass
327.314
Synonyms
N,N-dimethylsphingosine (d18:1)
sphingosine 2S, 3R, N,N-dimethylamine
Download
Notes
GIF Graphics File. 
GIF Graphics File. 
MDL Molfile. 
CDX File. 
Jo, J.Y., Kim, H.L., Lee, Y.K., Tomura, H., Bae, Y.S., Okajima, F., Im, D.S. (2008). N,N-Dimethyl-D-erythro-sphingosine inhibits store-operated Ca2+ entry in U937 monocytes. J Pharmacol Sci. 107:303-7. [PubMed]

Kim, H.L., Han, M., Im, D.S. (2008). Differential signaling of sphingosine derivatives in U937 human monocytes depends on the degree of N-methylation. Prostaglandins Other Lipid Mediat. 86:68-72. [PubMed]

Kim, H.L., Sacket, S.J., Han, M., Im, D.S. (2008). Characterization of N,N,-dimethyl-D-erythro-sphingosine-induced apoptosis and signaling in U937 cells: independence of sphingosine kinase inhibition. Prostaglandins Other Lipid Mediat. 86:18-25. [PubMed]

Edsall, L.C., Van Brocklyn, J.R., Cuvillier, O., Kleuser, B., Spiegel, S. (1998). N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. Biochemistry 1998 37:12892-8. [PubMed]

Metabolomics: Gaining insight into pain

The endogenous metabolite N,N-dimethylsphingosine is upregulated in the dorsal horn of rats with neuropathic pain and can induce mechanical hypersensitivity in vivo. Lipidomics Gateway (22 February 2012)

[http://www.lipidmaps.org/update/2012/120301/full/lipidmaps.2012.5.html]