860493 | 1-deoxysphinganine

1-deoxysphinganine (m18:0)


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1-deoxysphinganine

1-deoxysphinganine

1-deoxysphinganine (m18:0)

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C18H39NO
Percent Composition
C 75.72%, H 13.77%, N 4.91%, O 5.60
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
196497-48-0
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
285.508
Exact Mass
285.303
Synonyms
Spisulosine
(2S,3R)-2-amino-3-hydroxy-octadecane
ES-285
1-deoxy SA
1-deoxySa
110884

Muilwijk M, Goorden SMI, Celis-Morales C, Hof MH, Ghauharali-van der Vlugt K, Beers-Stet FS, Gill JMR, Vaz FM, van Valkengoed IGM. Contributions of amino acid, acylcarnitine and sphingolipid profiles to type 2 diabetes risk among South-Asian Surinamese and Dutch adults. BMJ Open Diabetes Res Care. 2020 May;8(1):e001003. doi: 10.1136/bmjdrc-2019-001003. PMID: 32376636; PMCID: PMC7228466.

PubMed ID: 32376636

Wu J, Ma S, Sandhoff R, Ming Y, Hotz-Wagenblatt A, Timmerman V, Bonello-Palot N, Schlotter-Weigel B, Auer-Grumbach M, Seeman P, Löscher WN, Reindl M, Weiss F, Mah E, Weisshaar N, Madi A, Mohr K, Schlimbach T, Velasco Cárdenas RM, Koeppel J, Grünschläger F, Müller L, Baumeister M, Brügger B, Schmitt M, Wabnitz G, Samstag Y, Cui G. Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness. Immunity. 2019 Mar 23. pii: S1074-7613(19)30095-0. doi: 10.1016/j.immuni.2019.03.005. [Epub ahead of print]

PubMed ID: 30952607

Dohrn, M.F., A. Othman, S.K. Hirshman, H. Bode, I. Alecu, E. Fahndrich, W. Karges, J. Weis, J.B. Schulz, T. Hornemann, and K.G. Claeys. (2015). Elevation of plasma 1-deoxy-sphingolipids in type 2 diabetes mellitus: a susceptibility to neuropathy? Eur J Neurol 22:806-14, e55.

PubMed ID: 25623782

Jimenez-Rojo, N., J. Sot, J.V. Busto, W.A. Shaw, J. Duan, A.H. Merrill Jr, A. Alonso, and F.M. Goni. (2014). Biophysical Properties of Novel 1-Deoxy-(Dihydro)ceramides Occurring in Mammalian Cells. Biophys J 107:2850-9.

PubMed ID: 25517151

Penno, A., M.M. Reilly, H. Houlden, M. Laura, K. Rentsch, V. Niederkofler, E.T. Stoeckli, G. Nicholson, F. Eichler, R.H. Brown Jr, A. von Eckardstein, and T. Hornemann. (2010). Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids. J Biol Chem 285:11178-87.

PubMed ID: 20097765

Pruett, S.T., A. Bushnev, K. Hagedorn, M. Adiga, C.A. Haynes, M.C. Sullards, D.C. Liotta, and A.H. Merrill Jr. (2008). Thematic Review Series: Sphingolipids. Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. J Lipid Res 49:1621-39. [PubMed]

PubMed ID: 18499644

Zitomer, N.C., T. Mitchell, K.A. Voss, G.S. Bondy, S.T. Pruett, E.C. Garnier-Amblard, L.S. Liebeskind, H. Park, E. Wang, M.C. Sullards, A.H. Merrill Jr, and R.T. Riley. (2009). Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals.[Abstract]

PubMed ID: 19095642

Alecu I, Othman A, Penno A, Saied EM, Arenz C, von Eckardstein A, Hornemann T.Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway. J Lipid Res. 2017 Jan;58(1):60-71. doi: 10.1194/jlr.M072421. Epub 2016 Nov 21.

PubMed ID: 27872144