860490 | Sphingosine (d18:1)

D-erythro-sphingosine


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Sphingosine (d18:1)

Sphingosine (d18:1)

D-erythro-sphingosine

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C18H37NO2
Percent Composition
C 72.19%, H 12.45%, N 4.68%, O 10.68%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
123-78-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
299.492
Exact Mass
299.282
Synonyms
Sphingosine
2S, 3R(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol
(2S,3R,4E)-2-amino-1,3-octadec-4-enediolsphing-4-enine
110750

Jakobi K, Beyer S, Koch A, Thomas D, Schwalm S, Zeuzem S, Pfeilschifter J, Grammatikos G. Sorafenib Treatment and Modulation of the Sphingolipid Pathway Affect Proliferation and Viability of Hepatocellular Carcinoma In Vitro. Int J Mol Sci. 2020 Mar 31;21(7):2409. doi: 10.3390/ijms21072409. PMID: 32244391; PMCID: PMC7177910.

PubMed ID: 32244391

Santos TCB, Vaz A, Ventura AE, M Saied E, Arenz C, Fedorov A, Prieto M, Silva LC. Canonical and 1-Deoxy(methyl) Sphingoid Bases: Tackling the Effect of the Lipid Structure on Membrane Biophysical Properties. Langmuir. 2020 May 15. doi: 10.1021/acs.langmuir.0c01000. Epub ahead of print. PMID: 32369370.

PubMed ID: 32369370

Toncic RJ, Jakasa I, Hadzavdic SL, Goorden SM, Vlugt KJG, Stet FS, Balic A, Petkovic M, Pavicic B, Zuzul K, Marinovic B, Kezic S. Altered Levels of Sphingosine, Sphinganine and Their Ceramides in Atopic Dermatitis Are Related to Skin Barrier Function, Disease Severity and Local Cytokine Milieu. Int J Mol Sci. 2020 Mar 13;21(6):1958. doi: 10.3390/ijms21061958. PMID: 32183011; PMCID: PMC7139865.

PubMed ID: 32183011

Lang J, Bohn P, Bhat H, Jastrow H, Walkenfort B, Cansiz F, Fink J, Bauer M, Olszewski D, Ramos-Nascimento A, Duhan V, Friedrich SK, Becker KA, Krawczyk A, Edwards MJ, Burchert A, Huber M, Friebus-Kardash J, Göthert JR, Hardt C, Probst HC, Schumacher F, Köhrer K, Kleuser B, Babiychuk EB, Sodeik B, Seibel J, Greber UF, Lang PA, Gulbins E, Lang KS. Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease. Nat Commun. 2020 Mar 12;11(1):1338. doi: 10.1038/s41467-020-15072-8. PMID: 32165633; PMCID: PMC7067866.

PubMed ID: 32165633

Vutukuri R, Koch A, Trautmann S, Schreiber Y, Thomas D, Mayser F, Meyer Zu Heringdorf D, Pfeilschifter J, Pfeilschifter W, Brunkhorst R. S1P d20:1, an endogenous modulator of S1P d18:1/S1P2 -dependent signaling. FASEB J. 2020 Jan 15:10.1096/fj.201902391R. doi: 10.1096/fj.201902391R. Epub ahead of print. PMID: 31944406.

PubMed ID: 31944406

Shao Z, Zhao Y, Liu L, Chen S, Li C, Meng F, Liu H, Hu S, Wang J, Wang Q. Overexpression of FBR41 enhances resistance to sphinganine analog mycotoxin-induced cell death and Alternaria stem canker in tomato. Plant Biotechnol J. 2019 Jun 3. doi: 10.1111/pbi.13182. [Epub ahead of print]

PubMed ID: 31161714

Bilog AD, Smulders L, Oliverio R, Labanieh C, Zapanta J, Stahelin RV, Nikolaidis N. Membrane Localization of HspA1A, a Stress Inducible 70-kDa Heat-Shock Protein, Depends on Its Interaction with Intracellular Phosphatidylserine. Biomolecules. 2019 Apr 17;9(4). pii: E152. doi: 10.3390/biom9040152.

PubMed ID: 30999671

Tomonaga N, Tsuduki T, Manabe Y, Sugawara T. Sphingoid bases of dietary ceramide 2-aminoethylphosphonate, a marine sphingolipid, absorb into lymph in rats. J Lipid Res. 2019 Feb;60(2):333-340. doi: 10.1194/jlr.M085654. Epub 2018 Dec 14.

PubMed ID: 30552287

Brunkhorst R, Pfeilschifter W, Rajkovic N, Pfeffer M, Fischer C, Korf HW, Christoffersen C, Trautmann S, Thomas D, Pfeilschifter J, Koch A. Diurnal regulation of sphingolipids in blood. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Mar;1864(3):304-311. doi: 10.1016/j.bbalip.2018.12.001. Epub 2018 Dec 15.

PubMed ID: 30557628