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C10 bisphosphonate | 860480

1-aminodecane-1,1-bisphosphonic acid

860480P

Powder

500 μg
$72.00
1 mg
$130.00
5 mg
$460.00

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C10 bisphosphonate, with prolonged carbon chain, is an inhibitor for acid sphingomyelinase and may be a treatment option for inflammatory lung diseases, cystic fibrosis and atherosclerosis.
Molecular Formula
C10H25NO6P2
Percent Composition
C 37.86%, H 7.94%, N 4.41%, O 30.26%, P 19.53%
Purity
>99%
Stability
1 Years
Storage
-20°C
CAS Number
15049-93-1
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
317.256
Exact Mass
317.116
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Notes
GIF Graphics File. 
GIF Graphics File. 
MDL Molfile. 
CDX File. 
Martinez, T.N., X. Chen, S. Bandyopadhyay, A.H. Merrill, and M.G. Tansey. (2012). Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons. Mol Neurodegener 7:45 [PubMed]

Teichgraber, V., M. Ulrich, N. Endlich, J. Riethmuller, B. Wilker, C.C. De Oliveira-Munding, A.M. van Heeckeren, M.L. Barr, G. von Kurthy, K.W. Schmid, M. Weller, B. Tummler, F. Lang, H. Grassme, G. Doring, and E. Gulbins. (2008). Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis. Nat Med 14:382-91. [PubMed]