860480 | C10 bisphosphonate

1-aminodecane-1,1-bisphosphonic acid

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500µg 860480P-500ug 860480P-500ug $85.00
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C10 bisphosphonate

C10 bisphosphonate

1-aminodecane-1,1-bisphosphonic acid

C10 bisphosphonate, with prolonged carbon chain, is an inhibitor for acid sphingomyelinase and may be a treatment option for inflammatory lung diseases, cystic fibrosis and atherosclerosis.

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C10H25NO6P2
Percent Composition
C 37.86%, H 7.94%, N 4.41%, O 30.26%, P 19.53%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
15049-93-1
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
317.256
Exact Mass
317.116

Martinez TN, Chen X, Bandyopadhyay S, Merrill AH, Tansey MG. Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons. Mol Neurodegener. 2012 Sep 13;7:45. doi: 10.1186/1750-1326-7-45. PMID: 22973882; PMCID: PMC3472284.

 PubMed ID: 22973882

Teichgräber V, Ulrich M, Endlich N, Riethmüller J, Wilker B, De Oliveira-Munding CC, van Heeckeren AM, Barr ML, von Kürthy G, Schmid KW, Weller M, Tümmler B, Lang F, Grassme H, Döring G, Gulbins E. Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis. Nat Med. 2008 Apr;14(4):382-91. doi: 10.1038/nm1748. Epub 2008 Mar 30. PMID: 18376404.

 PubMed ID: 18376404