860480 | C10 bisphosphonate
1-aminodecane-1,1-bisphosphonic acid

C10 bisphosphonate
1-aminodecane-1,1-bisphosphonic acid
C10 bisphosphonate, with prolonged carbon chain, is an inhibitor for acid sphingomyelinase and may be a treatment option for inflammatory lung diseases, cystic fibrosis and atherosclerosis.
CAS Registry Number is a Registered Trademark of the American Chemical Society
- ChemDraw File
- 3D Structure
- Structure
- Safety Data Sheet
- Certificate of Analysis (Lot No. 860480P-500UG-A-011 and 5946PFA011)
- Certificate of Analysis (Lot No. 860480P-500UG-B-011 and 5946PFB011)
Martinez TN, Chen X, Bandyopadhyay S, Merrill AH, Tansey MG. Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons. Mol Neurodegener. 2012 Sep 13;7:45. doi: 10.1186/1750-1326-7-45. PMID: 22973882; PMCID: PMC3472284.
PubMed ID: 22973882Teichgräber V, Ulrich M, Endlich N, Riethmüller J, Wilker B, De Oliveira-Munding CC, van Heeckeren AM, Barr ML, von Kürthy G, Schmid KW, Weller M, Tümmler B, Lang F, Grassme H, Döring G, Gulbins E. Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis. Nat Med. 2008 Apr;14(4):382-91. doi: 10.1038/nm1748. Epub 2008 Mar 30. PMID: 18376404.
PubMed ID: 18376404